WO2013131010A3 - Function of chemokine receptor ccr8 in melanoma metastasis - Google Patents
Function of chemokine receptor ccr8 in melanoma metastasis Download PDFInfo
- Publication number
- WO2013131010A3 WO2013131010A3 PCT/US2013/028683 US2013028683W WO2013131010A3 WO 2013131010 A3 WO2013131010 A3 WO 2013131010A3 US 2013028683 W US2013028683 W US 2013028683W WO 2013131010 A3 WO2013131010 A3 WO 2013131010A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- subject
- function
- ccr8
- chemokine receptor
- melanoma metastasis
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/12—Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Abstract
This invention provides a method of treating a subject who has, or has been treated for, a solid tumor which comprises administering to the subject an antagonist of CCR8 receptors on the surface of tumor cells present in the solid tumor in an amount effective to reduce binding of CCL1 to the CCR8 receptors so as to thereby treat the subject. This invention also provides a method of reducing, or reducing the likelihood of, metastases in a subject who has, or has been treated for, a solid tumor which comprises administering to the subject an antagonist of CCR8 receptors on the surface of tumor cells present in the solid tumor in an amount effective to reduce binding of CCL1 to the CCR8 receptors so as to thereby reduce, or reduce the likelihood of, metastases in the subject.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261606169P | 2012-03-02 | 2012-03-02 | |
US61/606,169 | 2012-03-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2013131010A2 WO2013131010A2 (en) | 2013-09-06 |
WO2013131010A3 true WO2013131010A3 (en) | 2013-11-14 |
Family
ID=49083467
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/028683 WO2013131010A2 (en) | 2012-03-02 | 2013-03-01 | Function of chemokine receptor ccr8 in melanoma metastasis |
Country Status (1)
Country | Link |
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WO (1) | WO2013131010A2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9776979B2 (en) * | 2013-09-26 | 2017-10-03 | Sanford-Burnham Medical Research Institute | EBI2 modulators |
US10087259B1 (en) * | 2014-04-28 | 2018-10-02 | Memorial Sloan Kettering Cancer Center | Depleting tumor-specific tregs |
CR20180047A (en) | 2015-07-31 | 2018-03-07 | Pfizer | DERIVATIVES OF 1,1,1-TRIFLUORO-3-HYDROXIPROPAN-2-IL CARBAMATE AND DERIVATIVES OF 1,1,1-TRIFLUORO-4-HYDROXIBUTAN-2-IL CARBAMATE AS MAGL INHIBITORS |
EP4092045A1 (en) * | 2016-05-16 | 2022-11-23 | Checkmab S.R.L. | Markers selectively deregulated in tumor-infiltrating regulatory t cells |
RU2720203C1 (en) | 2017-01-20 | 2020-04-27 | Пфайзер Инк. | 1,1,1-trifluoro-3-hydroxypropane-2-ylcarbamate derivatives as magl inhibitors |
RU2726631C1 (en) | 2017-01-23 | 2020-07-15 | Пфайзер Инк. | Heterocyclic spiro compounds as magl inhibitors |
DK3616720T3 (en) * | 2017-03-29 | 2021-03-29 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR CANCER TREATMENT |
CN108727400B (en) * | 2017-05-24 | 2021-07-09 | 四川晶华生物科技有限公司 | Compound for treating tumor |
TW202039575A (en) * | 2018-12-27 | 2020-11-01 | 日商鹽野義製藥股份有限公司 | Novel anti-ccr8 antibody |
MX2022008341A (en) | 2020-01-06 | 2022-08-10 | Vaccinex Inc | Anti-ccr8 antibodies and uses thereof. |
MX2022009947A (en) | 2020-02-14 | 2022-11-07 | Jounce Therapeutics Inc | Antibodies and fusion proteins that bind to ccr8 and uses thereof. |
CN115989223A (en) * | 2020-07-03 | 2023-04-18 | 南京艾美斐生物医药科技有限公司 | Methods and compositions for targeting Tregs using CCR8 inhibitors |
EP4267618A1 (en) | 2020-12-24 | 2023-11-01 | Vib Vzw | Non-blocking human ccr8 binders |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20090214533A1 (en) * | 2006-08-17 | 2009-08-27 | The Trustees Of Columbia University In The City Of New York | Methods for converting or inducing protective immunity |
US20110053969A1 (en) * | 2005-04-04 | 2011-03-03 | Astrazeneca Ab | Novel diazasipiroakanes and their use for treatment of ccr8 mediated diseases |
US20110150982A1 (en) * | 2002-11-15 | 2011-06-23 | Morehouse School Of Medicine | Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms |
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2013
- 2013-03-01 WO PCT/US2013/028683 patent/WO2013131010A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110150982A1 (en) * | 2002-11-15 | 2011-06-23 | Morehouse School Of Medicine | Anti-chemokine and associated receptors antibodies for inhibition of growth of neoplasms |
US20110053969A1 (en) * | 2005-04-04 | 2011-03-03 | Astrazeneca Ab | Novel diazasipiroakanes and their use for treatment of ccr8 mediated diseases |
US20090214533A1 (en) * | 2006-08-17 | 2009-08-27 | The Trustees Of Columbia University In The City Of New York | Methods for converting or inducing protective immunity |
Also Published As
Publication number | Publication date |
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WO2013131010A2 (en) | 2013-09-06 |
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