WO2013107207A1

WO2013107207A1 - Self-calibration multi-measurement module for portable detection instrument and use method therefor

Info

Publication number: WO2013107207A1
Application number: PCT/CN2012/084712
Authority: WO
Inventors: 张亚南
Original assignee: 湖州凯立特医疗器械有限公司
Priority date: 2012-01-19
Filing date: 2012-11-16
Publication date: 2013-07-25
Also published as: CN102565436A; CN102565436B

Abstract

A self-calibration multi-measurement module for a portable detection instrument and a use method therefor. The measurement module comprises a base (1); a movement detection module (2) which is used for detecting a calibration liquid and a liquid under detection and is provided with a detection sensor (8); a fixed module (4); a calibration liquid pool (5) which is stored with sufficient volume of calibration liquid, is in communication with the fixed module (4), and can be in communication with the movement detection module (2) when the movement detection module (2) is located in a preset position; and a waste liquid pool (7). The use method comprises the following steps: a) calibrating a calibration liquid; b) and detecting a liquid under detection. The present invention provides a simple and effective method and measurement module, so that one measurement module can accomplish multiple sample measurements after being arranged in a portable detection instrument.

Description

Self-calibrating multi-measurement module for portable test instrument and method of using same

[0001] The present invention relates to the field of liquid detection technology, and more particularly to a self-calibrating multi-measurement module for portable detection instruments and methods of use thereof.

Background technique

[0002] Current medical diagnosis, industrial production, environmental protection and other fields need to be measured quickly and accurately on the spot. It is very important for first aid, diagnosis, accident handling, process monitoring, etc., and often even life-threatening. The on-site rapid detection is also the key development area of domestic and international analytical instruments.

[0003] There are two main types in the technical field, one is to miniaturize and integrate the instrument, and to cancel the external components of the conventional instrument such as reagent bottles, calibration liquids, injectors, detectors, etc. They are all designed as modules and integrated into a smaller instrument to form a unit that can be easily moved (eg US Patent Nos.: US 5,750,881, 5,580,790, 5,637,275). In particular, components with limited service life (or number of times), such as sensors, reagent kits, etc., are available in a consumable pack mode that is easy to assemble and disassemble, and can be replaced at any time without complicated maintenance and calibration operations. The operation is very simple, the consumable package can provide multiple continuous measurements. The disadvantage is that it must be used in a stable indoor environment. AC power must be used. The multi-sensor used in the configuration generally cannot provide the convenience of being ready to use. It takes a long time. The start-up and settling time, and more importantly, its relatively large size, even if one can move, it is very inconvenient to carry and transport. To sum up, it mainly applies the development of modern technology to system design and miniaturization, and miniaturizes and integrates traditional large-scale instruments, thereby pushing the use place from the central laboratory to the operating room and ward. , so that it can be directly measured at the sample collection site.

[0004] The second type is to separate the instrument itself from the measurement unit. The instrument itself performs repeated measurements, but it is necessary to concentrate the reagents, calibration fluids, and detectors necessary to complete a test into one smaller unit to form a one-off The chip used, each chip needs to be connected to the instrument, and the chip is discarded after completion (for example, patent number us

US Patent Nos. 5,096,669, 6,755,053, and 74,1982. The feature of this method is that the instrument part only performs the electronic signal conversion function, and does not involve chemical reagents and liquid processing. Therefore, the instrument itself can be made small, reaching the hand-held size, and is more convenient for on-site and even field use. This system, because it contains all the elements needed to complete a measurement, does not require additional reagents, so it is also called a "dry" chip. Its most outstanding advantage is that it is ready to use, without any maintenance and special operations. , completely convert the instrument use process into non-specialization. Any health care provider can use it anywhere, anytime. Its shortcoming is mainly that each measurement chip can only be used once, which has obvious disadvantages in the average single measurement cost, especially in the case of continuous measurement. The cost disadvantage is more obvious, and the operation is very complicated and needs frequent The chip is replaced, so it is a user who tends to use it less frequently but does not need to have the former instrument.

[0005] The main advantages of the two methods over the conventional methods are the convenience, the actual increase in the cost per single use, and the resulting material waste and waste.

[0006] At present, in this technical field, there is no high-efficiency, high-tech handheld chip-type analysis instrument that can be reused many times and has convenient, low-cost, and no maintenance features.

Summary of the invention

[0007] It is an object of the present invention to provide a self-calibrating multi-measurement module for a portable test instrument and a method of using the same that can be installed in a portable test instrument to achieve up to hundreds of sample measurements. The operation is very simple, the cost of a single measurement is low, and the measurement accuracy is high.

Another object of the present invention is to provide a portable detecting instrument which is simple in operation, including both the simplicity and miniaturization of a dry chip type instrument, and the high reliability and multiple measurement characteristics of the modular instrument. .

[0009] In order to solve the above technical problem, the technical solution of the present invention is as follows: a self-calibration multiple measurement module of a portable detection instrument,

Including a base;

a fixed module disposed on the base;

a movement detecting module having a detecting sensor for detecting the calibration liquid and the liquid to be detected;

a calibration bath capable of storing a sufficient volume of calibration liquid and in communication with the stationary module and capable of communicating with the motion detection module when the motion detection module is in a predetermined position;

A waste liquid pool for storing the detected calibration liquid and the liquid to be detected.

[0010] Preferably, the motion detecting module includes a moving block, and the measuring block is provided with a measuring pool, and a detecting sensor for detecting liquid in the measuring pool is disposed in the measuring pool, and the moving block is provided with a The liquid capillary guide tube and the calibration liquid capillary flow tube connected to the measuring cell are connected.

[0011] Preferably, the fixing module is located in front of the movement detecting module, and comprises two liquid tube elastic sealing modules to be detected, when the free open end of the detected liquid capillary tube is inside one of the The liquid capillary guide tube is closed; the fixing module further includes a detected liquid connection port communicating with the detected liquid capillary draft tube and a calibration connection with the calibration liquid pool a liquid passage; a liquid passage communicating with the waste liquid pool between the two liquid pipe elastic sealing modules; the liquid connection port to be detected is located in the two closed liquid pipe elastic sealing modules In front of the front one; a calibration tube elastic sealing module is disposed in front of the calibration liquid channel, and the calibration liquid capillary tube is closed when the free opening end of the calibration liquid capillary tube is therein.

[0012] Preferably, the detected liquid tube elastic sealing module comprises two elastic blocks made of an elastic material. Two adjacent side faces of the two elastic blocks are fitted to each other to form a fitting slit, and an intermediate position of the bonding slit is aligned with the capillary guiding tube for detecting the liquid.

[0013] Preferably, the rear ends of the two elastic block bonding seams are provided with an introduction structure with a small front and a large front.

[0014] Preferably, the fixing module further comprises two 0-rings that can be passed by the detected capillary capillary tube, the inner diameter of the two 0-rings being smaller than the capillary flow of the detected liquid The outer diameter of the tube, the two 0-rings are respectively disposed behind and adhered to the two sealed liquid tube elastic sealing modules.

[0015] Preferably, the inner diameter of the 0-ring is 0.75-0.95 times the outer diameter of the capillary capillary tube to be tested.

[0016] Preferably, the elastic block is made of elastic rubber or elastic plastic or polyurethane.

[0017] Preferably, the calibration tube elastic sealing module comprises two elastic bodies made of an elastic material, and two adjacent side faces of the two elastic bodies are fitted to form a fitting seam, and the sticker The intermediate position of the joint is aligned with the calibration liquid capillary tube, and the calibration liquid channel is provided with a 0-type sealing ring which can be penetrated by the calibration liquid capillary tube, and the calibration liquid channel An opening communicating with the calibration liquid pool is located between the 0-ring and the two elastomers.

[0018] Preferably, the front end of the two elastic bodies is provided with a front 0-type sealing ring which is attached thereto and can be passed by the calibrating liquid capillary flow tube; The inner diameter of the ring is 0.75-0.95 times the outer diameter of the capillary of the calibration liquid.

[0019] Preferably, the rear end of the two elastomer-fitting seams is provided with an introduction structure that is small in front and small in size.

[0020] Preferably, the inner diameter of the 0-type sealing ring is 0.75-0.95 times the outer diameter of the calibration liquid capillary draft tube.

[0021] Preferably, the elastomer is made of elastic rubber or elastic plastic or polyurethane.

[0022] Preferably, the detected liquid capillary flow tube and the calibration liquid capillary flow tube are made of stainless steel or plastic.

[0023] Preferably, the motion detecting module includes a moving block, and the moving block is provided with a measuring pool, and the detecting sensor for detecting the liquid in the measuring pool is disposed in the measuring pool, and the moving block is A capillary draft tube is provided in communication with the measuring cell.

[0024] Preferably, the fixing module is located in front of the movement detecting module, and comprises two elastic closing modules, the capillary diversion when the free open end of the capillary draft tube is inside one of the capillary guiding tubes The tube is closed; the fixing module further includes a detected liquid connection port communicating with the capillary draft tube and a channel communicating with the calibration liquid pool, wherein the channel is located at the two elastic Between the closed modules, the detected liquid connection port is located in front of the front of the two elastic closed modules.

[0025] Preferably, the elastic sealing module comprises two elastic blocks made of an elastic material, and two adjacent side faces of the two elastic blocks are fitted to form a fitting seam, and the fitting The intermediate position of the slit is aligned with the capillary draft tube. [0026] Preferably, the rear ends of the two elastic block bonding seams are provided with an introduction structure that is small in front and small in the front.

[0027] Preferably, the fixing module further comprises two 0-rings that can be passed by the capillary guiding tube, and the two 0-rings are respectively disposed behind the two elastic sealing modules. In conjunction with the two, the inner diameter of the two 0-rings is smaller than the outer diameter of the capillary draft tube.

[0028] Preferably, the inner diameter of the 0-ring is 0.75-0.95 times the outer diameter of the capillary draft tube.

[0029] Preferably, the elastic block is made of elastic rubber or elastic plastic or polyurethane.

[0030] Preferably, the capillary draft tube is made of stainless steel or plastic.

[0031] Preferably, the calibration liquid pool and the waste liquid pool are two chambers disposed at the bottom of the base or two containers disposed on the base.

[0032] Preferably, the base is provided with a cover.

[0033] A portable detecting instrument, comprising the self-calibrating multiple measuring module described above.

[0034] A method of using a self-calibrating multiple measurement module of a portable detection instrument, comprising the steps of:

a) calibration liquid calibration; the movement detection module reaches a predetermined position to communicate with the calibration liquid pool, inhales the calibration liquid from the calibration liquid pool into the movement detection module, and then discharges the calibration liquid into the waste liquid pool, and the calibration liquid is discharged into the waste liquid During the process of the pool, the calibration liquid is detected by the detection sensor, and the detection sensor sends the detection result to the signal processing unit of the portable detection instrument in the form of an electrical signal;

b) detecting the detected liquid; the moving detecting module reaches the predetermined position and communicates with the detected liquid, and sucks the detected liquid into the movement detecting module. After the detecting sensor detects, the detecting sensor sends the detected result to the portable in the form of an electric signal. The signal processing unit of the instrument is detected, and then the detected liquid to be detected is discharged into the waste liquid pool.

[0035] Preferably, the flushing and the second calibration of the step c) are further included; the movement detecting module reaches the predetermined position in the step a) to communicate with the calibration liquid pool, and the calibration liquid is inhaled from the calibration liquid pool. The movement detection module then discharges the detected calibration liquid into the waste liquid tank to realize flushing of the movement detection module and secondary calibration of the detection sensor.

[0036] A method of using a self-calibrating multi-measurement module of a portable detection instrument, comprising the steps of:

a) calibration liquid calibration; the movement detection module reaches a predetermined position and communicates with the calibration liquid pool, and the calibration liquid is sucked into the movement detection module from the calibration liquid pool. After the detection sensor detects, the detection sensor sends the detection result in the form of an electric signal. Giving a signal processing unit to the portable test instrument, and then discharging the detected calibration liquid into the waste liquid pool;

[0037] Preferably, the flushing and the second calibration of step c) are further included; the movement detecting module reaches the step a) The predetermined position is communicated with the calibration liquid pool, and the calibration liquid is sucked into the movement detection module from the calibration liquid pool, and then the detected calibration liquid is discharged into the waste liquid pool to realize flushing of the movement detection module and the detection sensor Secondary calibration.

[0038] The present invention has the following advantages: The present invention provides a simple and effective method and measurement module, which enables a measurement module to be loaded into a portable detection instrument and can perform up to hundreds of sample measurements, the overall complexity. Far less than the current modular instrument, it includes both the simplicity and miniaturization of dry chip instruments, as well as the high reliability and multiple measurement characteristics of modular instruments. The cost of a single test is very low.

DRAWINGS

[0039] The present invention will be further described below in conjunction with the accompanying drawings:

Figure 1 is a schematic view of the outline of the present invention;

2 is a schematic structural view of Embodiment 1 of the present invention; the liquid capillary tube for detecting is in a closed state; FIG. 3 is a closed and detected calibrated liquid capillary tube after the moving detection module is moved in Embodiment 1 of the present invention; A schematic diagram of a state in which a liquid capillary flow tube is in communication with a waste liquid pool;

4 is a schematic view showing a state in which the caliper capillary guide tube is closed after the movement detecting module is advanced, and the liquid capillary tube and the detected liquid connection port are in communication with each other;

Figure 5 is a schematic view showing the structure of a second embodiment of the present invention, wherein the capillary draft tube is connected to the calibration liquid pool;

6 is a schematic view showing the communication between the capillary draft tube and the liquid connection port to be detected according to the second embodiment of the present invention.

In the picture:

1-base;

2-moving detection module;

201-moving block, 202-measuring cell, 203-detected liquid capillary tube, 204-hose, 205-calibrating capillary tube, 206-capillary tube, 207-hose;

3-linear conveying device;

4-fixed module; 401-detected liquid tube elastic closure module, 401a-elastic block, 401b-guide structure, 402-detected liquid connection port, 403-calibration fluid channel, 404-liquid channel, 405-calibration tube elastic closure Module, 405a-elastomer, 405b-guide structure, 406-O ring, 407-O seal, 408-elastic closed module, 408a-elastic block, 408b-guide structure, 409-channel, 410-O ring , 411- front 0 type seal ring;

5- calibration liquid pool;

6-micro pump; 601-through cavity, 602-pump housing, 603-inlet, 604-piston, 605-linear conveying mechanism;

7- waste liquid pool;

8-detection sensor; 9-shell.

detailed description

The following description is only a preferred embodiment of the invention, and is not intended to limit the scope of the invention.

Embodiment 1, see FIG. 1, 2, 3, and 4, FIG. 2 is a schematic structural view of a measuring module in the embodiment, and when installed, it is installed in a portable testing instrument to form a complete portable detection. The instrument can be used. The measuring module includes a base 1. The base 1 is mounted with a cover 9 for protecting the components mounted on the base. The utility model further comprises a fixing module 4 disposed on the base. A movement detecting module 2 having a detecting sensor 8 for detecting the calibration liquid and the detected liquid is provided on the base, and a sufficient volume of the calibration liquid can be stored and communicated with the fixed module 4 and the moving detecting module 2 is located at a predetermined position. A calibration liquid cell 5 capable of communicating with the detection module 2, a waste liquid pool 7 for storing the detected calibration liquid and the liquid to be detected. Further, a portable pump is provided with a micropump 6 for transporting the calibration liquid and the liquid to be detected, and a linear conveying device 3 for enabling the movement detecting module 2 to linearly reciprocate on the base 1, for use in conjunction with the measuring module. In the present embodiment, the calibration liquid pool 5 and the waste liquid pool 7 are two chambers disposed at the bottom of the base 1. Of course, two containers may be provided to serve, and the two containers may be fixed or may be Disassembled, wherein the solvent of the waste liquid pool is larger than the calibration liquid pool, and the calibration liquid pool is provided with enough calibration liquid according to the number of uses and the amount of each use, and the general amount is enough to detect about 500 times.

[0042] The movement detecting module 2 is driven by the linear conveying device 3 to perform linear reciprocating motion on the base. The linear conveying device is a linear motor, a micro cylinder, a micro electric push rod, or other well-known linear reciprocating motion. The device or component is disposed in the portable detecting instrument, generally adopts a linear motor, and the moving detecting module 2 includes a moving block 201, and the moving block and the linear motor are fixedly connected, and the linear motor drives the linear reciprocating motion, and the moving block 201 A measuring cell 202 is provided therein, and a detecting sensor 8 for detecting liquid in the measuring cell 202 is disposed in the measuring cell 202. The measuring cell 202 is a place for measuring the calibration liquid and the detected liquid, and the detecting sensor 8 is simultaneously connected with the portable detecting instrument. The signal processing unit is connected, and the detected result can be sent to the signal processing unit of the portable detecting instrument in the form of an electrical signal, and is compared by the signal processing unit. The moving block 201 is provided with the detected liquid capillary connected to the measuring pool 202. The draft tube 203 and the calibrant capillary guide tube 205 are detected by the capillary flow of the liquid The tube 203, the calibrating liquid capillary tube 205 are fixed in front of the moving block, and the micropump 6 inlet 603 is also in communication with the measuring cell 202, and the calibrating liquid capillary tube 205 and the detected liquid capillary tube 203 are parallel to each other. In this embodiment, the measuring cell has two openings, one is connected to the liquid capillary tube 203 to be detected, and the other is connected to the inlet 603 of the micropump 6 and the capillary tube of the calibration liquid, and the detecting sensor 8 is located at the two. Between the openings, the detected liquid capillary tube 203 and the calibrant capillary tube 205 are hard capillary tubes made of stainless steel or plastic. Since the movement detecting module 2 is moving, the movement detecting module 2 and the micropump 6 inlet 603 are connected by a hose 207. [0043] In the present embodiment, the micropump 6 disposed in the portable instrument is a plunger pump including a pump casing 602 having a through cavity 601, the pump casing is cylindrical, and the inlet 603 is disposed on the pump casing 602, and The through-cavity 601 is in communication with a piston 604. The piston 604 is connected to a linear conveying mechanism 605 for driving the piston 604 to reciprocate linearly in the through-cavity 601. The linear conveying mechanism 605 is a linear motor or a cylinder or an electric motor. The push rod is generally a linear motor, and in order to facilitate the movement of the piston in the through cavity of the pump casing, lubricating grease can be disposed on the piston, which can also increase the sealing property, and the piston is retracted, so that the vacuum is generated in the through cavity, and the liquid can be adsorbed. In addition, it is of course another pump that can draw liquid into the pump and then discharge it.

[0044] The fixing module 4 is located in front of the movement detecting module 2, and when the movement detecting module 2 moves forward, the liquid capillary guide tube 203 and the calibration liquid capillary tube 205 can be inserted into the interior thereof, and the fixing module 4 is fixed. The invention comprises two liquid tube elastic sealing modules 401, a detected liquid connection port 402 communicating with the liquid capillary tube 203 to be detected, and a calibration liquid channel 403 communicating with the calibration liquid pool 5, when When the free open end of the liquid capillary draft tube 203 is detected in one of the two sealed liquid tube elastic sealing modules, it is closed, and the two liquid tube elastic sealing modules are arranged one after the other, wherein The liquid channel 404 is connected to the waste liquid pool 7 between the two liquid tube elastic sealing modules 401, because in the present embodiment, the calibration liquid pool 5, The waste liquid pool 7 is two chambers disposed in the base, so the calibration liquid pool and the waste liquid pool can communicate with the calibration liquid passage and the liquid passage through the process hole or the pipeline, and are The detection liquid connection port 402 is located in front of the front of the two liquid tube elastic sealing modules 401; in order to be connected with the externally-detected liquid container, the front end of the calibration liquid channel 403 is provided with a capillary flow of the calibration liquid. The calibration tube elastic closure module 405 is closed when the tube 205 is in it. The liquid tube elastic sealing module 401 to be tested comprises two elastic blocks 401a made of an elastic material, which may be elastic rubber or elastic plastic or polyurethane. The two adjacent side faces of the two elastic blocks 401a are fitted to form a fitting seam, and the intermediate position of the bonding seam is aligned with the liquid capillary guide tube 203 to be tested, and the extending direction of the fitting seam The advancing direction of the capillary capillary tube is the same, when the detected liquid capillary tube 203 is inserted between the two elastic blocks, two adjacent fitting sides of the two elastic blocks 401a The portion in contact with the detected capillary capillary tube 203 is contracted and contracted. Since the elastic block is made of an elastic material and the two elastic blocks are fixed, when the liquid capillary tube to be tested is inserted between the two elastic blocks, the sides of the two elastic blocks can be pressed to make it Shrinking, while the side portion that is not in contact with the two elastic blocks continues to be fitted, so that the two elastic blocks are in a sealed state, and the liquid capillary guide tube is sealed, for better The sealing effect can be provided with sealing oil or sealing grease on the side of the two elastic blocks to enhance the sealing effect, and both ends of the liquid passage 404 communicating with the waste liquid pool 7 are sealed by two elastic blocks, so that When the liquid capillary tube is not inserted, it is only in communication with the waste pool. At the same time, it also includes two 0-rings that can be passed through the detected capillary capillary tube 203. 406, the inner diameters of the two 0-rings 406 are smaller than the outer diameter of the liquid capillary tube 203 to be detected, and the two 0-rings 406 are respectively disposed behind and matched with the two liquid tube elastic sealing modules 401 to be tested. One of the 0-rings 406 is located in the liquid passage 404 and is fitted to the rear side of the two elastic blocks 401a constituting the liquid-tight sealing module 401 of the liquid to be tested to increase the sealing of the liquid passage, and the other two types The ring can also wipe off the residual liquid on the outer wall of the capillary tube of the liquid to be detected to avoid cross-contamination. Generally, the inner diameter of the 0-ring 406 is 0.75-0.95 times the outer diameter of the capillary capillary tube 203 to be tested. The calibration tube elastic sealing module 405 comprises an elastic body 405a made of two elastic materials, generally elastic rubber or elastic plastic or polyurethane, the elastic body is fixed and cannot move, and the two elastic bodies 405a have two adjacent sides. Fitting together, forming a conforming slit, the extending direction of the fitting slit is the same as the advancing direction of the caliper capillary guide tube, and the intermediate position of the fitting slit is aligned with the calibration liquid capillary tube 205, when the calibration When the liquid capillary tube 205 is inserted between the two elastic bodies 405a, the portions of the two adjacent bonding sides of the two elastic bodies 405a that are in contact with the calibration liquid capillary tube 205 are squeezed. Pressure contraction, this part of the contraction is the contraction of the elastic material itself, the untouched portion continues to fit, and the calibration liquid capillary guide tube 205 is sealed, and the calibration liquid channel is provided with a capillary tube capable of being calibrated The 0-type seal ring 407, the opening of the calibration liquid channel 403 communicating with the calibration liquid pool 5 is located between the 0-type seal ring 407 and the two elastic bodies 405a. Generally, the 0-type seal ring Inner diameter of 407 The calibration liquid capillary tube is 0.75-0.95 times of the outer diameter, so that when the calibration liquid capillary tube passes through the 0-type sealing ring 407 into the calibration liquid channel 403, the entire calibration liquid channel 403 is sealed. It is not connected to the outside, only communicates with the calibration liquid pool, which facilitates the calibration of the capillary capillary tube to absorb the calibration liquid. At the same time, the 0-type sealing ring 407 can also wipe the liquid on the outer wall of the calibration liquid capillary tube 205 to avoid cross-contamination.

[0045] In order to increase the seal between the two elastic bodies 405a located at the front and the calibration liquid passage, the rear ends of the two elastic bodies 405a are provided to be attached thereto and can be guided by the calibration liquid. The front 0-ring seal 411 passes through the flow tube 205; the inner diameter of the front 0-type seal ring 411 is 0.75-0.95 times the outer diameter of the calibration liquid capillary guide tube 205, and the front 0-type seal ring 411 is also The liquid on the outer wall of the calibrant capillary tube 205 can be wiped off to avoid cross-contamination.

[0046] In order to facilitate the insertion of the accommodating liquid capillary guide tube into the fitting seam of the two elastic bodies 405a, the rear end of the fitting seam of the two elastic bodies 405a is provided with a front small and large large introduction structure 405b. In this embodiment, The introduction structure 405b is an opening that gradually narrows from the rear end of the fitting slit. Similarly, in order to facilitate the insertion of the liquid capillary tube 203 to be tested, the front end of the two elastic blocks 401a is provided with a front small and large introduction structure 401b, and the introduction structure 401b is from the rear of the seam. An opening that gradually narrows forward.

[0047] The method for detecting a plurality of measurement modules includes the following steps:

a) calibration liquid calibration; using the linear transport device 3 in the portable test instrument to move forward on the base 1 with the movement detecting module 2, so that the movement detecting module 2 reaches a predetermined position and communicates with the calibration liquid pool 5 , using a micro pump 6 Aspirate the calibration liquid in the calibration liquid pool and enter the movement detection module 2, enter the micro pump 6, and then discharge the calibration liquid in the micro pump into the waste liquid pool. During the calibration liquid discharge process, the calibration is discharged from the micro pump. The liquid fills the entire measuring cell and the liquid channel. After being detected by the detecting sensor 8, the detecting sensor 8 sends the detected result to the signal processing unit of the portable detecting device in the form of an electrical signal. In the present embodiment, the mobile detecting module arrives at a predetermined schedule. The position is the calibration liquid channel 403 communicating with the calibration liquid pool 5, and the free open end of the calibration liquid capillary tube of the movement detection module enters the calibration liquid channel, and communicates with the calibration liquid pool through the calibration liquid channel 403; The liquid capillary guide tube 203 is located in the elastic sealing module of the liquid pipe to be tested, and is sealed. Because the micro pump used is a piston pump, the calibration liquid in the calibration liquid pool 5 is first sucked into the piston pump by the piston pump, and then the straight line The motor continues to move forward with the moving block of the movement detecting module, so that the detected liquid capillary tube 20 3 is connected with the waste liquid pool through the liquid passage 404. At this time, the calibrated liquid capillary guide tube is sealed by the detection liquid tube elastic sealing module, the liquid cannot come out from the capillary draft tube, and then the piston pump starts to work, and the calibration liquid is started. Discharge from the pump into the waste pool and fill the measuring cell with the calibration solution;

b) detected liquid detection; after the calibration liquid detection is completed, the linear conveying device 3 continues to move forward with the movement detecting module 2, so that the movement detecting module 2 reaches a predetermined position and communicates with the detected liquid, in the process, the calibration liquid The capillary draft tube is always sealed by the detecting liquid tube elastic sealing module, wherein the predetermined position is the position where the detected liquid capillary guiding tube 203 communicates with the detected liquid connecting port 402, and the movement detecting module 2 is The piston pump starts to work, and the detected liquid is extracted into the measuring pool of the movement detecting module 2. After detecting by the detecting sensor 8, the detecting sensor 8 sends the detected result to the signal processing unit of the portable detecting instrument in the form of an electric signal, and then, The linear conveying device 3 moves with the movement detecting module 2, so that the detected capillary capillary tube is located in the liquid passage 404, and communicates with the waste liquid pool, and the piston pump discharges the detected liquid in the pump into the waste liquid pool 7 . Generally, after step a) and step b) are completed, step c) is further included; flushing and secondary calibration; and the movement detecting module 2 is driven by the linear conveying device to reach the predetermined condition described in the step a) The position is in communication with the calibration liquid pool 5. At this time, the liquid capillary tube of the detected liquid is closed, and the free open end of the capillary capillary tube enters the calibration liquid channel, and communicates with the calibration liquid pool through the calibration liquid channel 403; The calibration solution is sucked into the liquid detection module 2, and then the detected calibration liquid is discharged into the waste liquid tank 7, the flushing of the movement detecting module 2 and the secondary calibration of the detecting sensor 8 are performed, and the micro pump is sucked from the calibration liquid pool. The calibration solution passes through the measuring cell, and then the micropump discharges the calibration solution, passes through the measuring cell, and fills it. The two actions enable the calibration solution to flush the measuring cell to prepare for the next measurement, and at the same time, the detecting sensor 8 The calibration solution can also be measured to obtain a calibration signal.

[0048] During the above measurement process, the measurement of the two detected liquids may be separated for a long time, during which the sensitivity of the detection sensor in the measurement pool may drift, so it may be set to perform a calibration operation within a fixed time, The calibration solution in the measuring cell and channel is updated once to maintain the accuracy of the detection sensor. [0049] Step a) and step b) The ratio of the volume of the inhalation calibration solution to the liquid to be detected in the two steps is about Vl/V2 = 4, that is, the amount of the sampled liquid to be detected is the total amount of the calibration solution filling the liquid channel. About a quarter. This relationship satisfies that after each measurement, there is enough cleaning calibrant to clean the entire channel to the state to be tested, ready for the next measurement, and no waste of reagents; in step a, it can be repeated as many times as needed. The calibration solution is used to wash away the residual liquid in the measuring cell and the liquid in the capillary tube of the detected liquid to ensure the accuracy of the measurement result. The process of calibration for multiple detections can be realized by program setting, which can avoid interference. , to get the most accurate calibration results. The portable detecting instrument compares the two test results in step a) and step b) to determine the liquid property index to be detected. The so-called trait index refers to the result obtained after the comparison, and the result may be the result of the data comparison. It can also be the result of curve comparison. If blood glucose is detected, then step a) is compared with the test value obtained in step b) to know whether the blood sugar is high or low, if it is detected whether a liquid is contaminated by heavy metals. Then, after step a) is compared with the detected value/curve obtained after the step b) is detected, it is known whether the heavy metals such as iron, chromium, etc. in the liquid exceed the national detection standard, if the turbidity of the tap water is detected. Then, after comparing step a) with the test result obtained after the step b) is completed, it is known whether the turbidity of the tap water exceeds the standard.

[0050] Embodiment 2, see FIGS. 5 and 6; FIG. 5 is a schematic structural view of Embodiment 2 of the present invention, for the sake of clarity, the micropump and the linear transport device installed in the portable detecting instrument are connected, and implemented Example 1 provides a simple and effective method and measurement module and a portable test instrument equipped with such a measurement module. After a measurement module is installed in a portable test instrument, it can perform up to hundreds of sample measurements. The complexity is far lower than the current modular instrumentation. The measurement module includes the simplicity and miniaturization of dry chip instruments, as well as the high reliability and multiple measurement characteristics of modular instruments. However, the structure is relatively complicated, not simple enough, and the method is relatively complicated. The measurement module is used for measurement. For the detection of the calibration liquid and the detected liquid, both the inhalation and the discharge need two steps, and the time is relatively long; Therefore, we have improved it to make it simple in structure, cheaper in price, and shorter in detection time;

In the present embodiment, the movement detecting module 2 includes a moving block 201, and the moving block is connected to the linear conveying device 3. The moving block 201 is provided with a measuring pool 202 for detecting the detection of the liquid in the measuring pool 202. The sensor 8 is disposed in the measuring cell 202. The moving block 201 is provided with a capillary guiding tube 206 communicating with the measuring cell 202. The capillary guiding tube is a rigid capillary guiding tube, made of stainless steel or plastic. to make.

[0051] The waste liquid pool 7 is in communication with the outlet of the micropump 6, and the inlet of the micropump is in communication with the measuring cell 202. The micropump is a plunger pump or a vane pump or a centrifugal pump or a peristaltic pump, and other well-known pumps having an inlet and an outlet. In this embodiment, a peristaltic pump is used, and the peristaltic pump inlet and the measuring tank 202 are connected through a hose 204, and the outlet is connected with The waste pool is connected by a hose, and the peristaltic pump is placed in a portable test instrument. In this embodiment, there is only one capillary tube, instead of two, the calibration solution Both the body and the liquid to be tested enter the measuring cell through the capillary draft tube and are detected by the detecting sensor.

[0052] In the present embodiment, the fixing module 4 is located in front of the movement detecting module 2, and includes two elastic closing modules 408, when the free open end of the capillary guiding tube 206 is inside one of the The capillary guide tube 206 is closed; the fixed module 4 further includes a detected liquid connection port 402 communicating with the capillary draft tube 206 and a passage 409 communicating with the calibration liquid pool 5, the passage 409 Between the two elastic sealing modules 408, sealed by two elastic sealing modules, only communicating with the calibration liquid pool, the detected liquid connection opening 402 is located in the front of the two elastic sealing modules 408 The front of one. The elastic sealing module 408 includes two elastic blocks 408a made of an elastic material, generally using elastic rubber or elastic plastic or polyurethane, and two adjacent sides of the two elastic blocks 408a are attached to each other to form a seam, the extending direction of the seam is the same as the direction of advancement of the capillary tube, and the intermediate position of the seam is aligned with the capillary tube 206 for facilitating the insertion of the capillary tube when the capillary flow is When the tube 206 is inserted between the two elastic blocks 408a, portions of the two adjacent fitting sides of the two elastic blocks 408a that are in contact with the capillary guide tube 206 are squeezed and contracted, and this portion is contracted. Is the contraction of the elastic material itself, the untouched portion continues to fit, sealing the capillary guide tube 206, and the fixing module 4 further includes two 0-rings 410 that can be passed through the capillary guide tube 206. The two O-rings 410 are respectively disposed at the rear of the two elastic sealing modules 408 and are matched with the two elastic sealing modules, so as to better seal the passages, and the two 0 The ring can also wipe off the liquid on the outer wall of the capillary draft tube to avoid cross-contamination. The inner diameter of the two O-rings 410 is smaller than the outer diameter of the capillary draft tube 206. Generally, the inner diameter of the O-ring 410 is 0.75-0.95 times the outer diameter of the capillary draft tube 206.

[0053] Also, in order to facilitate the insertion of the capillary guide tube, the rear ends of the two elastic blocks 408a are provided with a front small rear large introduction structure 408b, and the guiding structure is from the rear end of the fitting seam. The opening that gradually narrows before.

[0054] As can be seen from the above structure, compared with Embodiment 1, the structure of the present embodiment is greatly simplified, the structure is simple, the structure is easy to manufacture, the volume is smaller, the carrying and mounting are more convenient, and the number of components used is also reduced. , lowering prices and increasing competitiveness. Hereinafter, according to the structure of the measurement module according to the embodiment, a method of using the same is briefly described.

a) calibration liquid calibration; the linear conveying device 3 moves forward on the base 1 with the movement detecting module 2, so that the movement detecting module 2 reaches a predetermined position and communicates with the calibration liquid pool 5, and is sucked by the micro pump 6. The calibration liquid in the calibration liquid pool enters the movement detection module 2. After the detection sensor 8 detects, the detection sensor 8 sends the detection result to the signal processing unit of the portable detection instrument in the form of an electrical signal, and the detected calibration liquid is discharged into the waste liquid. In the present embodiment, the predetermined position that the movement detecting module reaches is the passage 409 that communicates with the calibration liquid pool 5, and the free open end of the capillary flow guiding tube of the movement detecting module communicates with the calibration liquid pool through the passage 409; The micropump used in the embodiment is a peristaltic pump, and the outlet of the peristaltic pump is connected with the waste liquid pool, and when the linear motor moves forward with the moving block of the movement detecting module, When the free open end of the capillary draft tube is located at the channel 409, the peristaltic pump rotates, and the calibration liquid in the calibration liquid pool is sucked into the pump through the capillary draft tube. During the process of entering the pump, the calibration liquid passes through the measuring pool and passes through the measuring pool. The detection sensor detects and obtains the detection result, and then the detected calibration liquid enters the waste liquid pool through the outlet of the peristaltic pump, and the whole detection action is very simple and rapid; after the completion of the calibration liquid after the calibration is completed; the detection of the detected liquid is started;

b) detecting the detected liquid; the linear conveying device 3 continues to move forward with the movement detecting module 2, so that the movement detecting module 2 reaches a predetermined position to communicate with the detected liquid, and the micropump 6 starts to work to suck the detected liquid into After detecting by the detecting sensor 8, the detecting sensor 8 sends the detected result to the signal processing unit of the portable detecting device in the form of an electrical signal, and the detected liquid to be detected is discharged into the waste liquid pool 7; The predetermined position is the position where the capillary draft tube communicates with the connected liquid connection port. At this time, the peristaltic pump starts to work, sucking the detected liquid into the measuring pool of the movement detecting module 2, and after detecting by the detecting sensor 8, the detecting sensor 8 The detected result is sent to the signal processing unit of the portable detecting instrument in the form of an electric signal. At the same time, the detected liquid enters the waste liquid pool through the outlet of the peristaltic pump to complete the action of discharging the waste liquid.

[0055] Generally, after step a) and step b) are completed, step c) is further included; flushing and secondary calibration; and the movement detecting module 2 is driven by the linear conveying device to reach the step a) The predetermined position is in communication with the calibration liquid pool 5. At this time, the free open end of the capillary draft tube enters the channel, and communicates with the calibration liquid pool through the channel; the calibration liquid is sucked from the calibration liquid pool into the measuring cell of the movement detecting module 2 Flushing the measuring cell to remove residual liquid to be detected, and detecting the sensor to detect the calibration liquid, achieving flushing of the movement detecting module 2 and secondary calibration of the detecting sensor 8 to prepare for the next measurement.

[0056] During the above measurement process, the measurement of the two detected liquids may be separated for a long time, during which the sensitivity of the detection sensor in the measurement pool may drift, so it may be set to perform a calibration operation within a fixed time, The calibration solution in the measuring cell and channel is updated once to maintain the accuracy of the detection sensor.

[0057] The portable detecting instrument compares the two test results in step a) and step b) to determine the measured liquid property index; the so-called trait index refers to the result obtained after the comparison, and the result may be data comparison. The result can also be the result of the curve comparison. If the blood glucose is detected, the step a) is compared with the detection value obtained in step b), and it is known whether the blood sugar is high or low, if it is detected whether a liquid is If the heavy metal is contaminated, then step a) is compared with the detected value/curve obtained after the step b) is detected. It is known whether the heavy metals such as iron and chromium in the liquid exceed the national testing standards. If the tap water is detected. The turbidity, after the comparison of the test results obtained in step a) and step b) after the test is completed, can all know whether the turbidity of the tap water exceeds the standard.

[0058] As can be seen from the above detection process, the detection method of the present embodiment is very rapid, and the actions during the detection process are less and faster.

Claims

Claim

1. Self-calibrating multi-measurement module for portable test instruments, characterized by:

Including a base (1);

a fixing module (4) disposed on the base (1);

a movement detecting module (2) having a detecting sensor (8) for detecting the calibration liquid and the liquid to be detected; one capable of storing a sufficient volume of the calibration liquid and communicating with the fixed module (4) and at the movement detecting module (2) A calibration liquid pool (5) capable of communicating with the movement detecting module (2) when located at a predetermined position; a waste liquid pool (7) for storing the detected calibration liquid and the liquid to be detected.

2. The self-calibrating multiple measurement module of the portable detection instrument according to claim 1, wherein: the movement detection module (2) comprises a moving block (201), and the moving block (201) is provided with a measurement a pool (202), a detecting sensor (8) for detecting liquid in the measuring cell (202) is disposed in the measuring pool (202), and the moving block (201) is provided with the measuring pool (202) Connected liquid capillary tube (203) and calibrant capillary tube (205).

3. The self-calibrating multi-measurement module of the portable detecting instrument according to claim 2, wherein: the fixing module (4) is located in front of the movement detecting module (2), and includes two detected liquids a tube elastic sealing module (401), wherein the detected liquid capillary tube (203) is closed when the free open end of the detected liquid capillary tube (203) is inside one of the blocks; (4) further comprising a detected liquid connection port (402) connectable to the detected liquid capillary draft tube (203) and a calibration liquid channel (403) communicating with the calibration liquid pool (5) Between the two liquid tube elastic sealing modules (401), there is a liquid passage (404) communicating with the waste liquid pool (7); the detected liquid connection port (402) is located at the Two front sides of the first liquid tube elastic sealing module (401) are closed; a calibration tube elastic sealing module (405) is arranged in front of the calibration liquid channel (403), when the calibration liquid capillary flow Tube (20 5) When the free open end is in it, the calibration liquid capillary tube (205) is closed.

4. The self-calibrating multi-measurement module of the portable detecting instrument according to claim 3, wherein: the detected liquid tube elastic sealing module (401) comprises two elastic blocks (401a) made of an elastic material. The two adjacent side faces of the two elastic blocks (401a) are fitted to each other to form a fitting seam, and the intermediate position of the bonding slit is aligned with the liquid capillary draft tube (203) to be detected.

The self-calibrating multi-measurement module of the portable detecting instrument according to claim 4, wherein: the rear ends of the two elastic blocks (401a) are provided with a front small and a large lead-in structure (401b). ).

6. The self-calibrating multi-measurement module of the portable test instrument according to claim 4, characterized in that Claim

The fixing module (4) further includes two O-rings (406) that can pass through the detected capillary capillary tube (203), and the inner diameters of the two O-rings (406) are smaller than An outer diameter of the capillary capillary tube (203) to be detected, and the two 0-rings (406) are respectively disposed behind the two liquid tube elastic sealing modules (401) fit.

7. The self-calibrating multiple measuring module of the portable detecting device according to claim 6, wherein: the inner diameter of the 0-ring (406) is the outer diameter of the capillary guiding tube (203) of the liquid to be detected. 0.75-0.95 times.

8. The self-calibrating multi-measurement module of the portable test instrument according to claim 4, wherein: the elastic block (401a) is made of elastic rubber or elastic plastic or polyurethane.

9. The self-calibrating multi-measurement module of the portable test instrument according to claim 3 or 4 or 5 or 6 or 7 or 8, wherein: said calibration tube elastic closure module (405) comprises two elastic An elastic body (405a) made of a material, the two adjacent sides of the two elastic bodies (405a) are fitted to each other to form a laminating seam, and the intermediate position of the laminating slit is aligned with the calibrating liquid capillary guide a flow tube (205), the calibration liquid channel (403) is provided with a 0-type sealing ring (407) capable of being passed through the calibration liquid capillary flow tube (205), and the calibration liquid channel (403) An opening in communication with the calibration bath (5) is located between the Type 0 seal (407) and the two elastomers (405a).

10. The self-calibrating multi-measurement module of the portable detecting instrument according to claim 9, wherein: the rear ends of the two elastic bodies (405a) are provided to be attached thereto and can be The first type 0 sealing ring (411) through which the calibrating liquid capillary tube (205) passes; the inner diameter of the front 0 type sealing ring (411) is 0.75 of the outer diameter of the calibrating liquid capillary tube (205)- 0.95 times.

11. The self-calibrating multi-measurement module of the portable detecting instrument according to claim 9, wherein: the front end of the two elastic bodies (405a) is provided with a front small and large lead-in structure.

(405b).

12. The self-calibrating multi-measurement module of the portable detecting device according to claim 9, wherein: the inner diameter of the 0-type sealing ring (407) is the outer diameter of the calibration liquid capillary guide tube (205). 0.75-0.95 times.

13. The self-calibrating multi-measurement module of the portable test apparatus according to claim 9, wherein: the elastic body (405a) is made of elastic rubber or elastic plastic or polyurethane.

14. The self-calibrating multi-measurement module of the portable detecting instrument according to claim 3, wherein: the detected liquid capillary flow tube (203) and the calibration liquid capillary flow tube (205) are made of stainless steel or Claim

Made of plastic.

15. The self-calibrating multiple measurement module of the portable detection instrument according to claim 1, wherein: the movement detection module (2) comprises a moving block (201), and the moving block (201) is provided with a measurement a pool (202), the detecting sensor (8) for detecting liquid in the measuring cell (202) is disposed in the measuring cell (202), and the moving block (201) is provided with the measuring Pool (202) Connected capillary draft tube (206).

16. The self-calibrating multi-measurement module of the portable detecting instrument according to claim 15, wherein: the fixing module (4) is located in front of the movement detecting module (2), and comprises two elastic closing modules (408), when the free open end of the capillary draft tube (206) is inside one of the ones, the capillary guide tube (206) is closed; the fixing module (4) further includes a compatible a fluid connection port (402) connected to the capillary guide tube (206) and a calibration liquid pool

(5) a communicating passage (409), the passage (409) is located between the two elastic closing modules (408), and the detected liquid connecting port (402) is located at the two elastic closed The front of the front of the module (408).

17. The self-calibrating multi-measurement module of the portable detecting instrument according to claim 16, wherein: the elastic closing module (408) comprises two elastic blocks (408a) made of an elastic material, The two adjacent sides of the two elastic blocks (408a) are fitted to each other to form a fitting seam, and the intermediate position of the fitting slit is aligned with the capillary draft tube (206).

18. The self-calibrating multi-measurement module of the portable detecting device according to claim 17, wherein: the rear ends of the two elastic blocks (408a) are provided with a front small and a large introduction structure (408b). ).

19. The self-calibrating multi-measurement module of a portable testing instrument according to claim 16 or 17 or 18, wherein: said fixing module (4) further comprises two capillary tubes capable of being said

(206) a 0-ring (410) that passes through, and the two 0-rings (410) are respectively disposed behind and conform to the two elastic sealing modules (408), and the two The inner diameter of the 0-ring (410) is smaller than the outer diameter of the capillary draft tube (206).

20. The self-calibrating multi-measurement module of the portable detecting instrument according to claim 19, wherein: the inner diameter of the 0-ring (410) is 0.75 of the outer diameter of the capillary draft tube (206). 0.95 times.

21. The self-calibrating multi-measurement module of the portable test instrument according to claim 17, wherein: the elastic block (408a) is made of elastic rubber or elastic plastic or polyurethane. Claim

22. The self-calibrating multi-measurement module of a portable test instrument according to claim 15, wherein: said capillary guide tube (206) is made of stainless steel or plastic.

23. The self-calibrating multi-measurement module of the portable test instrument according to claim 1 or 3 or 15, wherein: the calibration liquid pool (5) and the waste liquid pool (7) are disposed on a base ( 1) Two compartments at the bottom or two containers placed on the base.

24. A self-calibrating multi-measurement module for a portable test instrument according to claim 1 or 3 or 15, characterized in that the base (1) is provided with a casing (9).

25. A portable testing instrument, characterized in that: said portable detecting instrument comprises claim 1-

The self-calibrating multiple measurement module of any of the preceding claims.

26. A method of using a self-calibrating multiple measurement module of a portable test instrument according to claim 1, comprising the steps of:

a) calibration liquid calibration; the movement detection module (2) reaches a predetermined position to communicate with the calibration liquid pool (5), sucks the calibration liquid from the calibration liquid pool into the movement detection module (2), and then discharges the calibration liquid into the waste liquid pool.

(7), during the process of discharging the calibration liquid into the waste liquid pool (7), the calibration liquid is detected by the detection sensor (8), and the detection sensor (8) sends the detection result to the portable detection instrument in the form of an electrical signal. Signal processing unit;

b) detecting the detected liquid; the movement detecting module (2) reaches the predetermined position and communicates with the detected liquid, sucks the detected liquid into the movement detecting module (2), and after detecting by the detecting sensor (8), the detecting sensor (8) The detected result is sent to the signal processing unit of the portable test instrument in the form of an electrical signal, and then the detected liquid to be detected is discharged into the waste liquid pool (7).

27. The method of using a self-calibrating multiple measurement module of a portable detection instrument according to claim 26, further comprising: rinsing and secondary calibration of step c); said movement detection module

(2) reaching the predetermined position in the step a) to communicate with the calibration liquid pool (5), inhaling the calibration liquid from the calibration liquid pool into the movement detection module (2), and then discharging the detected calibration liquid into the waste. The liquid pool (7) enables flushing of the motion detection module (2) and secondary calibration of the detection sensor (8).

28. A method of using a self-calibrating multiple measurement module of a portable test instrument according to claim 1 comprising the steps of:

a) calibration liquid calibration; the movement detection module (2) reaches a predetermined position and communicates with the calibration liquid pool (5), and the calibration liquid is sucked from the calibration liquid pool into the movement detection module (2), after being detected by the detection sensor (8), The detection sensor (8) sends the detected result to the signal of the portable detection instrument in the form of an electrical signal Claim

Processing unit, and then discharging the detected calibration liquid into the waste liquid pool (7);

29. The method of using a self-calibrating multiple measurement module of a portable detection device according to claim 28, further comprising: rinsing and secondary calibration of step c); said movement detection module

(2) reaching the predetermined position described in the step a), communicating with the calibration liquid pool (5), inhaling the calibration liquid from the calibration liquid pool into the movement detecting module (2), and discharging the detected calibration liquid into the waste liquid. Pool

(7), flushing of the motion detection module (2) and secondary calibration of the detection sensor (8).