WO2013103475A3 - Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis - Google Patents

Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis Download PDF

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Publication number
WO2013103475A3
WO2013103475A3 PCT/US2012/068795 US2012068795W WO2013103475A3 WO 2013103475 A3 WO2013103475 A3 WO 2013103475A3 US 2012068795 W US2012068795 W US 2012068795W WO 2013103475 A3 WO2013103475 A3 WO 2013103475A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical fiber
cancer diagnosis
fiber probe
portable optical
based spectroscopic
Prior art date
Application number
PCT/US2012/068795
Other languages
French (fr)
Other versions
WO2013103475A2 (en
Inventor
Niyom Lue
Ramachandra Dasari
Ishan Barman
Narahara Chari Dingari
Jeon Woong KANG
Michael Feld
Original Assignee
Massachusetts Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/338,920 external-priority patent/US20120302892A1/en
Application filed by Massachusetts Institute Of Technology filed Critical Massachusetts Institute Of Technology
Publication of WO2013103475A2 publication Critical patent/WO2013103475A2/en
Publication of WO2013103475A3 publication Critical patent/WO2013103475A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0205—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows
    • G01J3/0218—Optical elements not provided otherwise, e.g. optical manifolds, diffusers, windows using optical fibers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/02—Details
    • G01J3/0272—Handheld
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/4738—Diffuse reflection, e.g. also for testing fluids, fibrous materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0091—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for mammography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices

Abstract

A multimodal probe system for spectroscopic scanning of tissue for disease diagnosis. The system can use diffuse reflectance spectroscopy, fluorescence spectroscopy and Raman spectroscopy for the detection of cancerous tissue, such as tissue margin assessment.
PCT/US2012/068795 2011-12-09 2012-12-10 Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis WO2013103475A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201161569095P 2011-12-09 2011-12-09
US61/569,095 2011-12-09
US13/338,920 2011-12-28
US13/338,920 US20120302892A1 (en) 2005-07-25 2011-12-28 Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis

Publications (2)

Publication Number Publication Date
WO2013103475A2 WO2013103475A2 (en) 2013-07-11
WO2013103475A3 true WO2013103475A3 (en) 2015-06-18

Family

ID=48745530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2012/068795 WO2013103475A2 (en) 2011-12-09 2012-12-10 Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis

Country Status (1)

Country Link
WO (1) WO2013103475A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140302532A1 (en) 2011-04-12 2014-10-09 Quanterix Corporation Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury
GB201302886D0 (en) * 2013-02-19 2013-04-03 Univ Singapore Diagnostic instrument and method
US20160235372A1 (en) * 2015-02-17 2016-08-18 Telebyte, Inc. Portable cancer diagnostic device and system
US11129577B2 (en) 2015-02-17 2021-09-28 Telebyte, Inc. Optical cancer detector using deep optical scanning and multi layer neural network
JP2018515753A (en) * 2015-04-06 2018-06-14 マサチューセッツ インスティテュート オブ テクノロジー System and method for hyperspectral imaging
US10551321B2 (en) 2015-10-07 2020-02-04 Celltool Gmbh Device and method for detecting and/or evaluating pathological states
DE102017010397A1 (en) * 2017-11-09 2019-05-09 FotoFinder Systems GmbH Method for evaluating the skin pattern of a human in the context of skin cancer screening and device for its operation
EP3740121A4 (en) * 2018-01-17 2021-12-15 ODS Medical Inc. System and methods for real-time raman spectroscopy for cancer detection
US20210096140A1 (en) * 2018-04-10 2021-04-01 Quanterix Corporation Quantification of biomarkers present in dried physiological samples

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5353790A (en) * 1992-01-17 1994-10-11 Board Of Regents, The University Of Texas System Method and apparatus for optical measurement of bilirubin in tissue
US5916171A (en) * 1994-05-31 1999-06-29 Mayevsky; Avraham Tissue monitor
US6069689A (en) * 1997-04-16 2000-05-30 Derma Technologies, Inc. Apparatus and methods relating to optical systems for diagnosis of skin diseases
US20040089816A1 (en) * 2002-08-09 2004-05-13 California Institute Of Technology Method and system for scanning apertureless fluorescence microscope
US20070057211A1 (en) * 2005-05-25 2007-03-15 Karsten Bahlman Multifocal imaging systems and method
US20070167835A1 (en) * 2005-07-25 2007-07-19 Massachusetts Institute Of Technology Tri modal spectroscopic imaging
US20090015826A1 (en) * 2006-03-30 2009-01-15 Duke University Optical assay system for intraoperative assessment of tumor margins
US20100034743A1 (en) * 2008-08-08 2010-02-11 Chemlmage Corporation Raman Characterization of Transplant Tissue

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5353790A (en) * 1992-01-17 1994-10-11 Board Of Regents, The University Of Texas System Method and apparatus for optical measurement of bilirubin in tissue
US5916171A (en) * 1994-05-31 1999-06-29 Mayevsky; Avraham Tissue monitor
US6069689A (en) * 1997-04-16 2000-05-30 Derma Technologies, Inc. Apparatus and methods relating to optical systems for diagnosis of skin diseases
US20040089816A1 (en) * 2002-08-09 2004-05-13 California Institute Of Technology Method and system for scanning apertureless fluorescence microscope
US20070057211A1 (en) * 2005-05-25 2007-03-15 Karsten Bahlman Multifocal imaging systems and method
US20070167835A1 (en) * 2005-07-25 2007-07-19 Massachusetts Institute Of Technology Tri modal spectroscopic imaging
US20090015826A1 (en) * 2006-03-30 2009-01-15 Duke University Optical assay system for intraoperative assessment of tumor margins
US20100034743A1 (en) * 2008-08-08 2010-02-11 Chemlmage Corporation Raman Characterization of Transplant Tissue

Also Published As

Publication number Publication date
WO2013103475A2 (en) 2013-07-11

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