WO2013006774A1

WO2013006774A1 - Genomic diagnostics using circulating endothelial cells

Info

Publication number: WO2013006774A1
Application number: PCT/US2012/045709
Authority: WO
Inventors: Yixin Wang; Baoying HUANG; Jack Yu; Yuqui Jiang; Tim Jatkoe; Yashoda RAJPUROHIT
Original assignee: Veridex, Llc
Priority date: 2011-07-07
Filing date: 2012-07-06
Publication date: 2013-01-10
Also published as: TW201311907A

Abstract

Circulating Endothelial Cells are isolated from patient blood and gene expression of the cells is analyzed to assess a medical condition or the tissue of origin of the cell. Kits for conducting the method are also provided.

Description

GENOMIC DIAGNOSTICS USING CIRCULATING ENDOTHELIAL CELLS

BACKGROUND OF THE INVENTION

Circulating endothelial cells (CECs), are present in low number in healthy individuals but an increase of CEC has been observed in a variety of human diseases including cardiovascular disorder and cancer. Characterization of CECs would be beneficial in understanding and monitoring these diseases and others. CECs can be isolated from peripheral blood by a variety of techniques including antibody capture with, for example, CD 146 antibody and magnetic separation as well as flow cytometry and other means. Unfortunately, CEC separation and analysis is complicated by the overwhelming presence of leukocytes. It would be beneficial to identify CECs, relate them to important factors such as their tissues of origin, and provide a basis to further analyze them and provide medical information based upon the analysis. SUMMARY OF THE INVENTION

In one aspect of the invention, CECs are isolated and gene expression of CECs is analyzed to assess a medical condition. Preferably, gene expression is conducted using microarray analysis or an amplification and identification method such as reverse transcription PCR (RTPCR). In another aspect of the invention, genes selected from a group of 130 specific genes whose expression is low in peripheral blood mononuclear cells (PBMCs) and high in endothelial cells are employed as CEC markers.

In yet another aspect of the invention, gene-based CEC markers are those that are associated with one or more of the following: cell motion, cell migration, angiogenesis, or cell adhesion.

Preferably, such markers are over-expressed relative to other cells.

In a yet further aspect of the invention, gene-based markers are differentially expressed depending on different vessel types enabling identification of the vessel or tissue of origin of the captured CECs. Preferably, the markers are selected from 67 genes that are over-expressed in CECs relative to other cells. In a yet further aspect of the invention, cell capture is used to obtain CECs which are analyzed for gene expression. Preferably, capture is via immunomagnetics and the analysis is used to provide a medical assessment such as disease or condition diagnostics, prediction, or

prognostics.

In a yet further aspect of the invention, CEC analysis kits are provided. Preferably, the kits include reagents for the identification and analysis of the gene expression of the CECs.

Additionally, kits can contain capture reagents for isolating CECs. The kits can also include embodiments of machine code that apply information and algorithms to the information that is produced during the conduct of the CEC isolation and/or analysis such that a medical assessment is produced or facilitated.

DETAILED DESCRIPTION

The present invention provides compositions, methods and kits for the rapid and efficient isolation and characterization of endothelial cells from biological samples. The methods described isolate and characterize CECs in a blood sample while at the same time minimizing the selection of non- specifically bound or entrapped cells. While any effective mechanism for isolating, enriching, and analyzing CECs in blood may be used to capture and enrich CECs for analysis, the preferred method for collecting them combines immunomagnetic enrichment technology and immunofluorescent labeling technology with an appropriate analytical platform. The associated tests have the sensitivity and specificity to detect these rare cells in a sample of whole blood and to use them in the analysis of the clinical course of diseases and conditions as well as assessments regarding many aspects of the same including predictions and prognostics.

The capture and separation technology employed in the preferred embodiment is already used widely to analyze circulating tumor cells (CTC) by employing, for example, a tool to investigate the significance of cells of epithelial origin in the peripheral circulation of cancer patients. This technology is described, for example, in U.S. Pat. No. 6,365,362 and U.S. Pat. No. 6,645,731. The "CellSearch" System (Veridex LLC, Raritan, NJ) that employs this technology is an automated system based on fluorescence microscopy of isolated cells from blood. It's use in capturing and isolating CECs is also already known. The system contains an integrated computer controlled fluorescence microscope and automated stage with a magnetic yoke assembly that will hold a disposable sample cartridge. The magnetic yoke is designed to enable ferro fluid-labeled candidate rare cells within the sample chamber to be magnetically localized to the upper viewing surface of the sample cartridge for microscopic viewing. Software detects cells labeled with an antibody and having endothelial cells from blood. In a preferred embodiment, a preservative such as "CellSave" cell preservative is used for isolating cells of interest using 7.5 ml of whole blood. Cell-specific magnetic particles are added and incubated, preferably for about 20 minutes. CellSave preservative can be provided in, for example, a tube to the blood sample collector or can be provided as part of the kit of the invention. After magnetic separation, the cells bound to the immunomagnetic-linked antibodies are magnetically held at the wall of the tube. Unbound sample is then aspirated and an isotonic solution is added to resuspend the sample. A nucleic acid dye, monoclonal antibodies to the specified marker and CD 45 (a broad-spectrum leukocyte marker) are incubated with the sample. After magnetic separation, the unbound fraction is again aspirated and the bound and labeled cells are resuspended in 0.2 ml of an isotonic solution. The sample is suspended in a cell presentation chamber and placed in a magnetic device whose field orients the magnetically labeled cells for fluorescence microscopic examination in the

CellSearch System. Cells can be identified automatically with control cells enumerated by the System and candidate target cells presented to the operator for checklist enumeration to identify such aspects as morphology. The captured cells can then be subjected to gene -based analysis according to the invention. Preferred magnetic particles included in the reagents for use in carrying out CEC isolation are particles that behave as colloids. Such particles are characterized by their sub-micron particle size, which is generally less than about 200 nm (0.20 microns), and their stability to gravitational separation from solution for extended periods of time. In addition to the many other advantages, this size range makes them essentially invisible to analytical techniques commonly applied to cell analysis. Particles within the range of 90-150 nm and having between 70-90% magnetic mass are contemplated for use in the present invention. Suitable magnetic particles are composed of a crystalline core of superparamagnetic material surrounded by molecules which are bonded, e.g., physically absorbed or covalently attached, to the magnetic core and which confer stabilizing colloidal properties. The coating material should preferably be applied in an amount effective to prevent non-specific interactions between biological macromolecules found in the sample and the magnetic cores. Such biological macromolecules may include carbohydrates such as sialic acid residues on the surface of non-target cells, lectins, glyproteins, and other membrane components. In addition, the material should contain as much magnetic mass per nanoparticle as possible. The size of the magnetic crystals comprising the core is sufficiently small that they do not contain a complete magnetic domain. The size of the nanoparticles is sufficiently small such that their Brownian energy exceeds their magnetic moment. As a consequence, North Pole, South Pole alignment and subsequent mutual attraction/repulsion of these colloidal magnetic particles does not appear to occur even in moderately strong magnetic fields, contributing to their solution stability. Finally, the magnetic particles should be separable in high magnetic gradient external field separators. That characteristic facilitates sample handling and provides economic advantages over the more complicated internal gradient columns loaded with ferromagnetic beads or steel wool. Magnetic particles having the above-described properties can be prepared by modification of base materials described in U.S. Pat. Nos. 4,795,698, 5,597,531 and 5,698,271.

The immunomagnetic sample preparation is important for reducing sample volume and obtaining a 10⁴ fold enrichment of the target cells. The reagents used in a preferred kit of the invention include: an antibody against the pan- leukocyte antigen, CD45 to identify leucocytes (non-target cells); a cell type specific or nucleic acid dye which allows exclusion of residual red blood cells, platelets and other non-nucleated events; and a biospecific reagent or antibody directed against the target cytostructure or an antibody having specificity for the targets membrane which differs from that used to immunomagnetically select the cells.

Morphological analysis can also be conducted on various analytical platforms and include, for example, the CELLSPOTTER system, a magnetic cell immobilization and analysis system, using microscopic detection for manual observation of cells, described in U.S. Pat. Nos. 5,876,593; 5,985,153 and 6,136,182 respectively. All of the aforementioned U.S. Patent Applications are incorporated by reference herein as disclosing the respective apparatus and methods for manual or automated quantitative and qualitative cell analysis. Other analysis platforms include, but are not limited to, laser scanning Cytometry (Compucyte), bright field base image analysis

(Chromavision), and capillary Volumetry (Biometric Imaging).

Kits of the invention preferably include or can be used in conjunction with kits having reagents to conduct a molecular analysis of the cells (CECs) obtained. These include reagents that facilitate methods for determining the gene expression patterns of relevant cells as well as protein based methods of determining gene expression including reverse transcriptase PCR (RT- PCR), competitive RT-PCR, real time RT-PCR, differential display RT-PCR, Northern Blot analysis and other related tests. While it is possible to conduct these techniques using individual PCR reactions, it is best to amplify copy DNA (cDNA) or copy RNA (cRNA) produced from mRNA and analyze it via microarray. A number of different array configurations and methods for their production are known to those of skill in the art and are described in U.S. Patents such as: 5,445,934; 5,532,128; 5,556,752; 5,242,974; 5,384,261; 5,405,783; 5,412,087; 5,424,186; 5,429,807; 5,436,327; 5,472,672; 5,527,681 ; 5,529,756; 5,545,531; 5,554,501; 5,561,071;

5,571,639; 5,593,839; 5,599,695; 5,624,711; 5,658,734; and 5,700,637; the disclosures of which are incorporated herein by reference. Microarray technology allows for the measurement of the steady-state mRNA level of thousands of genes simultaneously thereby presenting a powerful tool for identifying effects such as the onset, arrest, or modulation of uncontrolled cell proliferation. Two microarray technologies are currently in wide use. The first are cDNA arrays and the second are oligonucleotide arrays. Although differences exist in the construction of these chips, essentially all downstream data analysis and output are the same. The product of these analyses are typically measurements of the intensity of the signal received from a labeled probe used to detect a cDNA sequence from the sample that hybridizes to a nucleic acid sequence at a known location on the microarray. Typically, the intensity of the signal is proportional to the quantity of cDNA, and thus mRNA, expressed in the sample cells. A large number of such techniques are available and useful. Preferred methods for determining gene expression can be found in US Patents 6,271,002 to Linsley, et al; 6,218,122 to Friend, et al; 6,218,114 to Peck, et al; and 6,004,755 to Wang, et al., the disclosure of each of which is incorporated herein by reference. Components and reagents for conducting these procedures can be included in the kits of the invention.

In the most preferred embodiments of the invention, patient blood is collected and CECs are isolated using an immunomagnetic capture technique such as is in the CellSearch System. The CECs are then subjected to separate analysis such as with the use of RTPCR or DNA

Microarray. Gene expression patterns are determined and processed for the identification of patterns that are indicative of disease diagnosis, prediction, or prognosis which are provided to a clinician and/or the patient. Correlations can be drawn between the expression of the various genes or gene-based markers whose expression is detected and physical conditions such as the presence or absence of disease, disease course or progression, the likelihood of contracting a disease or condition, and other predictive and prognostic judgments. Pattern recognition software can be used to perform these correlations and indicate their presence. Computer instructions that include executable code for comparing assay results with the relevant expression patterns and providing a medical assessment or information useful in providing a medical assessment can be included in the kits of the invention in the form of DVDs, thumbdrives, or any other convenient form.

EXAMPLES.

In the following examples, gene expression profiles of 18 endothelial cell samples from nine anatomical locations were analyzed. A set of 130 gene-based markers with high expression in endothelial cells but not in PBMCs were identified. Detection of these markers from endothelial cells enriched by the CellSearch system was also performed. The gene-based markers were readily detected by QRT-PCR in blood sample spike-in with endothelial cells. Additionally, a set of 67 markers differentially expressed in endothelial cells from different vessel types were identified that can be used to detect the origin of CECs being analyzed.

Example 1: CECs Cryopreserved HAEC (human aorta endothelial cell), HUVEC (human umbilical vein EC), HPAEC (human pulmonary artery EC), HMVEC-ad (human microvascular EC, adult dermis) and HASMC (human artery smooth muscle cell) were obtained from Invitrogen (Invitrogen, Carlsbad, CA), cryopreserved HCAEC (human coronary artery EC), HUAEC (human umbilical artery EC), HIAEC (human iliac artery EC), HMVEC-C (Human Cardiac Microvascular EC) cells were obtained from Lonza (Lonza, Cologne, Germany). Cryopreserved HSaVEC (human saphenous vein EC) were obtained from PromoCell (PromoCell GmbH, Heidelberg, Germany). Endothelial cells were cultured with EGM®-2 Endothelial Cell Growth Medium-2 (Lonza) in 37°C incubator with 95% humidity and 5 % C0₂. Smooth muscle cells were cultured with Medium 231 supplemented with Smooth Muscle Growth Supplement (SMGS) (Invitrogen). Cell pellets of HAEC, HUVEC, HPAEC, HMVEC-ad, HCAEC, HUAEC, HMVEC-C, HSaVEC were purchased from PromoCell. Human blood peripheral leukocytes (PBMC) total RNA was purchased from Clontech (Clontech, Mountain View, CA). Blood from healthy donors was drawn into EDTA-containing vacutainer tubes and of which 4 ml was processed by CellSearch system (Veridex LLC, Raritan, NJ) to isolate CECs. This was done using the CEC Profile kit (Veridex) according to manufacturer's instruction. In spike -in experiments, 500 or 1000 endothelial cells (HAEC, HPAEC, HUVEC or HMVEC-ad) were spiked into 4 ml healthy donor blood and processed by the CellSearch system.

For cultured endothelial cell or cell pellet, about 5X10⁵ cells were used for RNA isolation using AUPrep DNA/RNA Micro Kit (Qiagen, Hilden, Germany). To isolate RNA from CECs enriched by CellSearch System, 350μ1 of RLTplus buffer (Qiagen) was added to lyse CECs, then 4 μΐ poly(I) (Epicentre, Madison, WI) of 5¾/μ1 was added as carrier RNA, DNA and RNA was isolated using AUPrep DNA/RNA Micro Kit following the manufacturer's instruction. Two samples of the same spike-in was pooled for downstream analysis. The quantity and quality of RNA was examined by NanoDrop 1000 (NanoDrop, Wilmington, DE) and Agilent Bioanalyzer 2100 (Agilent, Santa Clara, CA). Endothelial cell RNA, smooth muscle cell RNA and PBMC RNA samples were converted into labeled target antisense RNA (cRNA) using the Single-Round RNA Amplification and Enzo Biotin Labeling System. Targets were hybridized to Affymetrix human U133 Plus 2.0 array following protocols as suggested by the supplier (Affymetrix, Santa Clara, CA). Following hybridization, arrays were washed and stained using standard Affymetrix procedures before scanning on the Affymetrix GeneChip Scanner and data extraction using Expression Console.

For EC spike-in and donor blood sample processed by CellSearch profile kit, RNA was converted to labeled target cDNA using the Ovation RNA Amplification System V2 (NuGEN, San Carlos, CA). Briefly, 50ng of total RNA was converted to double stranded cDNA using a DNA/RNA chimeric primer for reverse transcription, followed by isothermal amplification. The cDNA was purified using magnetic beads and quantitated by spectrophotometry. 3.75μg of the purified cDNA subsequently undergoes a two-step fragmentation and labeling process using the Encore Biotin Module (NuGEN). First, the purified cDNA was fragmented to yield single- stranded cDNA products in the 50 to 100 base range. Second, this fragmentation product was labeled via enzymatic attachment of a biotin-labeled nucleotide to the 3-hydroxyl end of the fragmented cDNA generated in the first step. For hybridization, a hybridization cocktail was prepared and added to the fragmentation product using the Hybridization, Wash and Stain kit (Affymetrix), applied to arrays, and incubated at 45°C for 18 hours. Following hybridization, arrays were washed and stained using standard Affymetrix procedures before scanning on the Affymetrix GeneChip Scanner and data extraction using Expression Console.

Gene expression intensities were extracted with Affymetrix Expression Console (version 1.1) using MAS5 algorithm. Global scaling was performed to bring the average signal intensity of a chip to a target of 600 before data analysis. To minimize noise levels, probes with fewer than two Presence calls in the cohort were removed. As a result, 3 IK probe sets remained for subsequent analyses. It was observed that there was a source effect between samples from cell culture and samples from cell pellet. To minimize this effect, probes that showed significant difference (p < 0.05) between these two groups were removed. Thus, 23K probes were obtained. To find markers for detecting CECs in the blood, probe sets that had a presence call in the two PBMC samples or had intensity above 200 in either of the two PBMC samples were removed, and 3950 probe sets were retained for further selections. For hierarchical clustering, signal intensities were normalized to the medium per probe set;

hierarchical clustering was performed using Partek Genomics Suites (version 6.5, Partek Inc., St. Louis, MO). Hierarchical clustering was conducted on both the probes and the samples using the average linkage method. Euclidean distance metric was used for the calculation of dissimilarity. For unsupervised hierarchical clustering, the 23k probe sets after removing genes with significant difference between cell cultures and cell pellets were used. Supervised clustering was performed with either 130 CEC markers or 67 skin, artery, and vein EC specific-markers.

Functional annotation was analyzed with the Gene Ontology (GO) classification system using DAVID software (NCIF).

To evaluate the genes selected from the microarray analysis, R A were extracted from a set of 10 donor samples and 8 cell line spike-in samples (2 HAEC spike-in, 2 HPAEC spike-in , 2 HUVEC spike-in and 2 HMVEC-ad spike-in samples) processed by CellSearch using a CEC Profile kit. 2 μΐ RNA was used for cDNA synthesis using High-Capacity cDNA Reverse

Transcription Kit (Applied Biosystems, Foster City, CA) in a 20μ1 reaction. To enable multiple gene analysis, 5 μΐ of cDNA was used to conduct a 14-cycle preamplification using the

TaqMan® PreAmp Master Mix Kit (Applied Biosystems) in a 20 μΐ reaction. The

preamplification product was subjected to a 1 :20 dilution, and 5 μΐ of the diluted product was used as input for quantitative PCR. Real time-PCR was carried out using Applied Biosystems gene expression Taqman assays on an ABI PRISM 7900HT Sequence Detector (Applied Biosystems).

Example 2: Gene Experssion Analysis

RNAs from eighteen endothelial cell samples, two PBMC samples and two smooth muscle cell samples were subjected for microarray analysis using the Affymetrix Human Genome U133 Plus 2.0 Array, which contains more than 54000 probe sets covering 47,000 transcripts and variants, including 38,500 well-characterized human genes. The set of endothelial cell samples represents nine distinct anatomical locations including five different arteries (aorta, coronary artery, pulmonary artery, iliac artery, and umbilical artery), two different veins (umbilical vein and saphenous vein), and two different tissues (skin and heart). Except for iliac artery and skin, two samples including one from cultured cells and one from frozen cell pellet were obtained for each origin. For iliac artery and skin, two samples from the same cultured cells were used and served as technical replicates. To gain an overview of the gene expression pattern, an unsupervised clustering analysis of the gene array data was performed using 31k probe sets that show present call in at least two samples. Initial analysis of the endothelial cell cluster indicated that the samples from cell culture and samples from cell pellet form different clusters possibly due to difference in sample type. To eliminate this difference, a t-test was perfomred between these two groups of samples. Probe sets with P-value<0.05 were eliminated resulting in 23k probe sets. The unsupervised analysis on these 23k probe sets resulted in three major clusters, the cluster of PBMC samples, the cluster of smooth muscle cell samples and the cluster of endothelial cell samples, reflecting the overall similarity of endothelial cells as compared to PBMC and smooth muscle cells. Within the endothelial cell cluster, the samples from cell pellet and cell culture were not separated, indicating the elimination of source effect. However, samples from same anatomical location were not always cluster together, possibly due to the relative small sample size and the difference of cell culture conditions.

Example 3: Use of the CellSearch System to Enrich CECs.

The CellSearch system was used to isolate CECs from the spiked donor samples described above. The antibody against the most prominent endothelial membrane antigen CD 146 was used for the immuno-capture reagent. However, there were still about 1000 to 5000 leukocyte cells remaining in the enriched CEC population after the enrichment process. To identify potential CEC specific markers, the expression level of a specific marker in endothelial cells had to be substantially higher than its expression level in PBMC. Thus, probe sets that had a presence call in any of the two PBMC samples or its intensity was above 200 in either of the two PBMC samples were removed. 3950 probes were retained for further analysis. Probes with minimal intensity lower than 1000 in the 18 CEC samples were not considered for subsequent analyses. As a result, 130 probe sets (106 unique genes) were selected as candidates for CEC markers. Functional annotation and pathway analysis was conducted of these 130 probe sets using the DAVID functional annotation software. GO (Gene ontology) term and KEGG (Kyoto

Encyclopedia of Genes and Genomes) pathways with significant over-representation are shown in Table 1. The top bioprocess over-represented in these 130 probe sets included genes involved in regulation of cell motion (n=l 1), regulation of cell migration (n=10) and blood vessel development (n=l 1). The over-represented cellular component group include plasma membrane (n=44) and focal adhesion (n=6). The over-represented molecular function group include transmembrane receptor protein tyrosine kinase activity (n=7) and protein tyrosine kinase activity (n=8). The major pathways associated with CEC specific genes were focal adhesion (n=12) and ECM-receptor interaction (n=5). One of the functions of endothelial cell is angiogenesis, during which substantial changes in the adhesive interactions between cells and the extracellular matrix (ECM) take place to allow endothelial cell migration.

Example 3: Gene-Based Markers.

CEC specific genes were identified based on Example 2. These include: Integrin related genes Integrin alpha2 (ITGA2), AXL receptor tyrosine kinase (AXL), EPH receptor A2 (EPHA2), TEK tyrosin kinase, endothelial (TEK), met proto-oncogene (MET), neuropilin 1 (NRP1), VEGFR2 (KDR), and TIE1; angiogenesis related genes activin A receptor type II-like 1 (ACVRL1), connective tissue growth factor (CTGF), endothelial cell-specific chemotaxis regulator (ECSCR), endothelin \(EDN1) and roundabout homo log 4 (ROB04); genes relating to the maintenance of vascular integrity through cell-cell interactions, CA V1, CA V2, COL4A1,

C0L5A2,CCND1,FLNB,ITGA2, KDR, LAMA4, LAMB1, PARVA, MET; and independently, MCAM (CD 146), KDR (VEGFR-2), TEK (Tie-2). However, some genes associated with endothelial cells are not markers in the present context due to either high expression in PBMC, such as PECAM(CD3 l), CXCR4, or expression that are too low to be diagnostically useful as seen in one or more endothelial cell lines (such as KIT(SCF R/c-kit) and ffi'ZE(E-selectin)). The CEC markers identified in these examples over-represent bioprocess or pathways that are associated with endothelial cell functions.

Example 4: Tissue of Origin. The 3950 genes which showed no expression or with intensity less than 200 in both PBMC samples were used to identify gene-based markers useful to identify the tissue of origin of CECs. Artery EC-specific genes were identified as those whose median signal intensity in EC from artery was over 500 and greater than maximum expression in EC from other origins. Likewise, to identify vein EC-specific genes, genes whose median signal intensity in EC from vein was more than 500 and greater than maximum expression in EC from other origins were identified. There were 38 artery EC-specific genes and 14 vein EC-specific genes satisfied these criteria (Table 3). The representative of the artery-specific genes was the previously reported artery EC-specific gene HEY2, a member of the Hairy-related transcription factor family that has been implied to be required for embryonic cardiovascular development in mouse. Other artery specific CEC genes included CXADR; which is a component of tight junction and has been reported to express asymmetrically in heart, in which expression was shown in subendothelial layers of the vessel wall, but not on the luminal endothelial surface. SOX17, a HMG-box transcription factor has been shown to play important roles in both endoderm formation and cardiovascular

development, whose promoter activity has been shown in the vascular endothelial cells of arteries in the cardiovascular system but not in veins in a mouse model. To enable the detection of tissue specific markers particularly amenable to use with an immunomagnetic platform such as the CellSearch system, the expression level of the selected markers was significantly higher than that in PBMC. For skin EC-specific genes identification, genes whose minimum expression in EC from skin is 5 fold higher than the maximum expression of all other EC samples were selected. There were 15 such genes.

Supervised clustering was performed on the cell line microarray data using the 67 origin-specific genes. The 67 genes correctly clustered EC from different origin with only one exception (an arterial EC cell clustered with venous EC). Cross verification of the genes was also conducted. Example 5: Verification of Markers by Endothelial Cell Spike-In.

Endothelial cells were spiked into healthy donor blood, and then CECs were enriched using the CellSearch System with the CEC Profile kit. Each 4 ml healthy donor blood was spiked in with 500 or 1000 cultured endothelial cells from one origin. Four selected cultured endothelial cell samples including two from artery (HAEC and HPAEC), one from vein (HUVEC), and one from skin (HMVEC-ad) were examined. The enriched CEC samples from spike-in and 10 healthy donor samples without spike -in were subjected to R A isolation and Microarray analysis. The number of CECs from the 10 donors was determined to be from 2 to 107 in 4 ml blood. Among the 130 CEC specific markers obtained from the cell line gene expression profiling microarray data, all of them shown higher average expression in EC spike-in samples than in donor samples, with the ratio of mean expression in EC spike-in to donor ranging from 2 to 655, and 93 genes have the ratio greater than 20. Validation using QRT-PCR was conducted on 21 markers with a ratio of 8 to 654 between spike-in samples vs. donor samples, and the PCR results demonstrated that all of the selected markers had good separation between EC spike -in samples and non-spike- in donors. To validate the artery-, vein-, and skin- specific markers, a principal component analysis was performed for the spike-in microarray data using the 67 origin-specific markers. Donor samples and artery-, vein-, skin- endothelial cell spike-in samples were clearly separated in the PCA. The markers are thus useful for differentiating CECs from various origins.

Example 6: Correlating Disease State with CEC Analysis (Prophetic)

Whole blood is taken from a patient directly into a tube containing CellSave preservative. This is done according to the same protocol used to collect blood for Circulating Tumor Cell (CTC) analysis using the CellSave system. CECs are enriched via the CellSearch system with a CEC cell capture kit. In this system, immunomagnetic enrichment is first conducted with the

AUTOPREP separation system to produce an enriched fraction. The kit that is used contains CD 146 ferro fluid and reagent to stain the enriched cells with the nucleic acid dye DAPI, endoglin (CD105)-PE and the pan-leukocyte marker CD45APC. The sample is reduced to around 300 uL and placed in an analysis chamber that is mounted inside a magnetic "nest" to magnetically monolayer the cells. Enumeration and morphological analysis of the CEC is then conducted. CECs are then extracted from the magnetic nesting devices. Total RNA is extracted with the RNeasy Micro Kit (Qiagen, Hilden, Germany). The RNA is converted into cDNA as follows: First, the total amount of extracted RNA is pre-incubated with 300 ng random hexamer at 65° C. for 5 minutes. Then 200 U M-MLV Reverse Transcriptase, RNase H Minus, Point Mutant, M- MLV Reverse Transcriptase lx Reaction Buffer, 10 U RNasin® Plus RNase Inhibitor (all purchased from Promega, Madison Wis.), 50 nmol of an equimolarmix of dATP, dTTP, dCTP and dGTP (Amersham Biosciences, Freiburg, Germany) and water is added to a final reaction volume of 20 ul. The reaction is performed at 55° C. for 50 minutes after a pre -incubation step at 20° C. for 10 min. Finally, the reaction is stopped by heating up to 94° C. for 5 min.

Quantitative Reverse-Transcription PCR (qRTPCR) is then performed as follows. Gene expression analysis is conducted duplicate reactions using individual TaqMan® Pre-Developed Assay Reagents specific for the Artery markers in Table 3. In each case they consist of two unlabeled PCR primers and one FAMTM dye-labeled TaqMan® MGB probe as used with the systems described above. The total volume of the reactions is 14 |xl containing 7 ul 2x TaqMan® Universal PCR Master, 0.7 |xl TaqMan® Pre-developed Assay Reagents, and 4 |xl fivefold diluted cDNA template. The PCR amplification is performed using the AB 7900HT Fast Realtime PCR System and consists of an initial incubation at 50° C. for 2 min., then 95° C. for 10 min., followed by 50 cycles of denaturation at 95° C. for 15 s and extension at 60° C. for 1 min. The data are analyzed with the AB7900 Sequence Detection Software version 2.2.2 using automatic baseline correction and cycle threshold setting. Resulting cycle threshold (Ct) data is exported for further analysis. Consumables, equipment and software were purchased from Applied Biosystems, Foster City Calif, USA.

A number of arterial CEC tissue of origin markers show significant over-expression. The data is downloaded to a file that is used by a program that compares the expression pattern to numerous expression patterns constructed by matching CEC marker expression to known clinical outcomes. The program is contained on storage device that also contains executable code for conducting the comparison using statistically based algorithms. The pattern indicates that the CEC's are arterial in nature and, more specifically, are aortic. Together with other diagnostic information it is concluded that the patient is likely to incur a thoracic aortic aneurism if left untreated. Table 1: Pathway Analysis of Gene Signatures

Category GO Term Number of P Value genes

Biological Process regulation of cell motion 1 1 2.43E-07 regulation of cell migration 10 8.03E-07 blood vessel development 1 1 2.15E-06 regulation of locomotion 10 2.32E-06 vasculature development 1 1 2.68E-06 blood vessel morphogenesis 10 5.04E-06 angiogenesis 8 3.12E-05 cytoskeleton organization 1 1 2.93E-04 tube development 8 3.70E-04 regulation of response to external stimulus 7 4.02E-04 transmembrane receptor protein tyrosine kinase signaling pathway 8 4.12E-04

Cellular plasma membrane 44 2.47E-05

Component

focal adhesion 6 5.50E-04 plasma membrane part 28 6.12E-04 I cell-substrate adherens junction 6 6.55E-04 intrinsic to plasma membrane 19 7.74E-04 cell-substrate junction 6 8.41 E-04 extracellular matrix part 6 1.02E-03

Molecular Function transmembrane receptor protein tyrosine kinase activity 7 3.35E-06 protein tyrosine kinase activity 8 7.14E-05

KEGG PATHWAY Focal adhesion 12 7.07E-08

ECM-receptor interaction 5 2.73E-03

Table 2: Identified CEC Gene-Based Markers

Table 2: Identified CEC Gene-Based Markers

Table 3: Tissue Specific Gene-Based Markers

>refseq | NM_0155771 NM_015577 Homo sapiens retinoic acid induced 14 (RAI14), transcript variant 1, mRNA.

actgacccccgcagcgggggaggaggagggactgcggcgcaggaagccgagcaggaagcg

agcccggcggccgcgttttcctggggaagcggcgggcggggtggagcagccagctgggtc

cggggagcgccgccgccgcctcgatggggtgttgaaaagtctcctctagagctttggaag

gctgaatgcactaaacatgaagagcttgaaagcgaagttcaggaagagtgacaccaatga

gtggaacaagaatgatgaccggctactgcaggccgtggagaatggagatgcggagaaggt

ggcctcactgctcggcaagaagggggccagtgccaccaaacacgacagtgagggcaagac

cgctttccatcttgctgctgcaaaaggacacgtggaatgcctcagggtcatgattacaca

tggtgtggatgtgacagcccaagatactaccggacacagcgccttacatctcgcagccaa

gaacagccaccatgaatgcatcaggaagctgcttcagtctaaatgcccagccgaaagtgt

cgacagctctgggaaaacagctttacattatgcagcggctcagggctgccttcaagctgt

gcagattctctgcgaacacaagagccccataaacctcaaagatttggatgggaatatacc

gctgcttcttgctgtacaaaatggtcacagtgagatctgtcactttctcctggatcatgg

agcagatgtcaattccaggaacaaaagtggaagaactgctctcatgctggcctgtgagat

tggcagctctaacgctgtggaagccttaattaaaaagggtgcagacctaaaccttgtaga

ttctcttggatacaatgccttacattattccaaactctcagaaaatgcaggaattcaaag

ccttctattatcaaaaatctctcaggatgctgatttaaagaccccaacaaaaccaaagca

gcatgaccaagtctctaaaataagctcagaaagaagtggaactccaaaaaaacgcaaagc

tccaccacctcctatcagtcctacccagttgagtgatgtctcttccccaagatcaataac

ttcgactccactatcgggaaaggaatcggtattttttgctgaaccacccttcaaggctga

gatcagttctatacgagaaaacaaagacagactaagtgacagtactacaggtgctgatag

cttattggatataagttctgaagctgaccaacaagatcttctctctctattgcaagcaaa

agttgcttcccttaccttacacaataaggagttacaagataaattacaggccaaatcacc

caaggaggcggaagcagacctaagctttgactcataccattccacccaaactgacttggg

cccatccctgggaaaacctggtgaaacctctcccccagactccaaatcatctccatctgt cttaatacattctttaggtaaatccactactgacaatgatgtcagaattcagcaactgca agagattttgcaagatctacagaagagattagagagctctgaagcagagagaaaacagct acaggtcgaactccaatcccgaagggcagaactggtatgcttaaacaacactgagatttc agagaacagctctgacctcagccagaaacttaaagaaactcagagcaaatacgaggaggc tatgaaagaagtccttagtgtgcagaagcagatgaaactcggtcttgtctcacctgaaag catggataattattcacatttccacgagctgagggtcacggaagaggaaataaatgtgct aaagcaggatctgcagaatgcattagaagaaagtgaaagaaataaagagaaagtgagaga gttagaggaaaaactggtagagagggagaaaggtacagtgattaagccacctgtggaaga gtacgaggaaatgaaaagttcatattgctctgttattgagaatatgaataaggagaaagc atttttgtttgagaaataccaagaagcccaagaagaaatcatgaaattaaaagacacact aaaaagtcagatgacacaggaagccagtgatgaagctgaggacatgaaagaagccatgaa taggatgatagatgaactcaataaacaggtgagcgagctgtcacagctgtacaaagaagc ccaggctgagctggaggattacaggaagaggaaatctctagaggatgtcacagctgaata tatccataaagcagagcatgagaaactgatgcaattgacaaacgtgtccagggctaaagc agaagatgcactgtctgaaatgaagtctcagtattcaaaagtgttgaatgagttgaccca gctcaaacaactggtggatgcacaaaaagagaactctgtctctatcacagaacatttgca agtgataaccacgctgcggactgcagcaaaagagatggaagaaaaaataagcaatcttaa ggaacaccttgcaagcaaggaagtggaagtagcaaagctggagaaacaactcttagaaga gaaagctgctatgactgatgcaatggtacctcggtcttcctatgaaaaactccagtcatc cttagagagtgaagtgagtgtgttggcatcgaaattaaaggaatctgtgaaagagaaaga gaaggtccattcagaggttgtccagattagaagtgaggtctcacaggtgaaaagagaaaa ggaaaatattcagactctcttgaaatccaaagagcaagaagtaaatgaacttctgcaaaa attccagcaagctcaggaagaacttgcagaaatgaaaagatacgctgagagctcttcaaa actggaggaagataaagataaaaagataaatgagatgtcgaaggaagtcaccaaattgaa ggaggccttgaacagcctctcccagctctcctactcaacaagctcatccaaaaggcagag tcagcagctggaggcgctgcagcagcaagtcaaacagctccagaaccagctggcggaatg caagaaacaacaccaggaggtcatatcagtttacagaatgcatcttctgtatgctgtgca gggccagatggatgaagatgtccagaaagtactgaagcaaatccttaccatgtgtaaaaa ccagtctcaaaagaagtaaagtggattccttggcaggacactgccccttgtcatctgtct ttgtgttagatccagagttgtcggcagccgctgccattgttctcattcgtggtatgcact gtggcctagcgtagcttcttccctttccaaaggtttctgaggacttctcccaggagaaga ctgcccgcctcagaactgcttagagacttcaaaccagcagaggtgaaagtccctgtcatc ccttcagattccagagctgggatcagccatgcccagaggtctggtcctgatgctggcagg ggggccccctcctccatccctgactggctgagtggctttatcaccaccgagtgatgtgct gaggcctcctgcagtgaatgctccttccattcctgtactcgggcagtgccattcagcaca ggagagctctttttgcctttggctttcaattccaaaacatgatttaatttctaactaaat tagtatggcactagttatgaagtatctgcttaaaacccttcatcatgatatcctgtggat ttaaaaactctaattccatgttttcttcccatctgccttatatatctcatcaccctgctt atcaatattcagtttgatgagcactattaactaaaatatgaaacttaaaaacaaaagcaa gttgtccttaaaagttctttttttaagtaaattgttgacatactgcaaattttctatgca aacttgcctcctgctgttatctgtgaagctcaggaaatccaaacatttgtgtttcaacaa gggacagtaaactgtgtgtttacagccaaaagaaatgcctcatagttcttaacctcaact tttgtagaagtatttttttctctgtaatatttttattggctcataaagatgttttcatat ctgaactcctaaataagtgaaattacagtagattatattaacaaaatactttttaggtag ccatgcttgagactttttaaaaatataactttttccttaaagttttcagctatagcaaaa ggtagttatgtatgccagacctaatatgagctgccaccaacacccctagaactttcagcc atggtgtcttcagaattgtagcgcatttctgaatctagcaaatcctccttttacccgttg aatgttttgaatgccctgactctaccagcgcccataaatgatctctagaaggactgttag taccaatctgtttttcaactttgaagctaaaaaccctgatatggtaatattatggtgcat agcagaggtctcggaaaaaaaatatttctgttcactttactttcaggttaaaaatgtttc taacacgcttgcaacttcccttatggcattaatcttgttgagggagagagacagaatcct

ggactctccaaagtatttaactgaaagtagggcctgctctgacagggcccatgtcccaca

aggctgcttggcctcagtgggtgcttggctgtgctggatgatatgttgatctgtattgga

taaggaccaatgacagcaaagcaaaaatggctttaaagcttggtgttacttttcttaagt

tgtttaattatagttaagcaatttcaaaaatgctccaaagaaatgtgaaaggaccttttg

tcacagcacttcagaaaatacacaacagccccttctgcccccgcacagaaatgctgcaga

gtatataaaacttgagacatttttgtaggatgcctgacgaggtgtagccttttatcttgt

ttccggatgcatatttattacgagtactctggttaaatattgaaaagttatatgctgtag

tttttagtattttgtctttgtaatttacagaagttattggagaaaataaacttgtttcat

tttgcaaaaaaaaaaaaaaaaaaaaaaaaa

>refseq | NM_0050451 NM_005045 Homo sapiens reelin (RELN), transcript variant 1, mRNA. ctcggcgggggcccgctcccaggcccgctcccgagcccgttccgctcccgtccgccttct

tctcgccttctctccgcgtggctcctccgtcccggcgtctccaaaactgaatgagcgagc

ggcgcgtagggcgcgcggcggcggcggcggcggcggcggcatggagcgcagtggctgggc

ccggcagactttcctcctagcgctgttgctgggggcgacgctgagggcgcgcgcggcggc

tggctattacccccgcttttcgcccttctttttcctgtgcacccaccacggggagctgga

aggggatggggagcagggcgaggtgctcatttccctgcatattgcgggcaaccccaccta

eta cgttccggga ca aga ata cca tgtga ca a tttca a ca agca ccttttttga eggett

gctggtgacaggactatacacatctacaagtgttcaggcatcacagagcattggaggttc

cagtgctttcggatttgggatcatgtctgaccaccagtttggtaaccagtttatgtgcag

tgtggtagcctctcacgtgagtcacctgcccacaaccaacctcagtttcatctggattgc

tccacctgcgggcacaggctgtgtgaatttcatggctacagcaacacaccggggccaggt

tattttcaaagatgctttagcccagcagttgtgtgaacaaggagctccaacagatgtcac

tgtgcacccacatctagctgaaatacatagtgacagcattatcctgagagatgactttga

ctcctaccaccaactgcaattaaatccaaatatatgggttgaatgtaacaactgtgagac tggagaacagtgtggcgcgattatgcatggcaatgccgtcaccttctgtgaaccatatgg cccacgagaactgattaccacaggccttaatacaacaacagcttctgtcctccaattttc cattgggtcaggttcatgtcgctttagttattcagaccccagcatcatcgtgttatatgc caagaataactctgcggactggattcagctagagaaaattagagccccttccaatgtcag cacaatcatccatatcctctaccttcctgaggacgccaaaggggagaatgtccaatttca gtggaagcaggaaaatcttcgtgtaggtgaagtgtatgaagcctgctgggccttagataa catcttgatcatcaattcagctcacagacaagtcgttttagaagatagtctcgacccagt ggacacaggcaactggcttttcttcccaggagctacagttaagcatagctgtcagtcaga tgggaactccatttatttccatggaaatgaaggcagcgagttcaattttgccaccaccag ggatgtagatctttccacagaagatattcaagagcaatggtcagaagaatttgagagcca gcctacaggatgggatgtcttgggagctgtcattggtacagaatgtggaacgatagaatc aggcttatcaatggtcttcctcaaagatggagagaggaaattatgcactccatccatgga cactaccggttatgggaacctgaggttttactttgtgatgggaggaatttgtgaccctgg aaattctcatgaaaatgacataatcctgtatgcaaaaattgaaggaagaaaagagcatat aacactggataccctttcctattcctcatataaggttccgtctttggtttctgtggtcat caatcctgaacttcagactcctgctaccaaattttgtctcaggcaaaagaaccatcaagg acataataggaatgtctgggctgtagactttttccatgtcttgcctgttctcccttctac aatgtctcacatgatacagttttccatcaatctgggatgtggaacgcatcagcctggtaa cagtgtcagcttggaattttctaccaaccatgggcgctcctggtccctccttcacactga a tgctta cctgaga tctgtgctgga cccca cctccccca cagca ctgtcta ctcctctga aaactacagtgggtggaaccgaataacaattccccttcctaacgcagcactaacccggaa caccaggattcgctggagacaaacaggaccaatccttggaaacatgtgggcaattgataa tgtttatattggcccgtcatgtctcaaattctgttctggcagaggacagtgcactagaca tggttgcaagtgtgaccctggattttctggcccagcttgtgagatggcatcccagacatt cccaatgtttatttctgaaagctttggcagttccaggctctcctcttaccataactttta ctctatccgtggtgctgaagtcagctttggttgtggtgtcttggccagtggtaaggccct ggttttcaacaaagatgggcggcgtcagctaattacatctttccttgacagctcacaatc caggtttctccagttcacactgagactggggagcaaatctgttctgagcacgtgcagagc ccctgatcagcctggtgaaggagttttgttgcattattcttatgataatgggataacttg gaaactcctggagcattattcatatctcagctatcatgagcccagaataatctccgtaga actaccaggtgatgcaaagcagtttggaattcagttcagatggtggcaaccgtatcattc ttcccagagagaagatgtatgggctattgatgagattatcatgacatctgtgcttttcaa cagcattagtcttgactttaccaatcttgtggaggtcactcagtctctgggattctacct tggaaatgttcagccatactgtggccacgactggaccctttgttttacaggagattctaa acttgcctcaagtatgcgctatgtggaaacacaatcaatgcagataggagcatcctatat gattcagttcagtttggtgatgggatgtggccagaaatacaccccacacatggacaacca ggtgaagctggagtactcaaccaaccacggccttacctggcacctcgtccaagaagaatg ccttccaagtatgccaagttgtcaggaatttacatcagcaagtatttaccatgccagtga gtttacacagtggaggagagtcatagtgcttcttccccagaaaacttggtccagtgctac ccgtttccgctggagccagagctattacacagctcaagacgagtgggctttggacagcat ttacattgggcagcagtgccccaacatgtgcagtgggcatggctcatgcgatcatggcat atgcaggtgtgaccaggggtaccaaggcactgaatgccacccagaagctgcccttccgtc cacaattatgtcagattttgagaaccagaatggctgggagtctgactggcaagaagttat tgggggagaaattgtaaaaccagaacaagggtgtggtgtcatctcttctggatcatctct gtacttcagcaaggctgggaaaagacagctggtgagttgggacctggatacttcttgggt ggactttgtccagttctacatccagataggcggagagagtgcttcatgcaacaagcctga cagcagagaggagggcgtcctccttcagtacagcaacaatgggggcatccagtggcacct gctagcagagatgtacttttcagacttcagcaaacccagatttgtctatctggagcttcc agctgctgccaagaccccttgcaccaggttccgctggtggcagcccgtgttctcagggga ggactatgaccagtgggcagtcgatgacatcatcattctgtccgagaagcagaagcagat catcccagttatcaatccaactttacctcagaacttttatgagaagccagcttttgatta ccctatgaatcagatgagtgtgtggttgatgttggctaatgaaggaatggttaaaaatga aaccttctgtgctgccacaccatcagcaatgatatttggaaaatcagatggagatcgatt tgcagtaactcgagatttgaccctgaaacctggatatgtgctacagttcaagctaaacat aggttgtgccaatcaattcagcagtactgctccagttcttcttcagtactctcatgatgc tggtatgtcctggtttctggtgaaagaaggctgttacccggcttctgcaggcaaaggatg cgaaggaaactccagagaactaagtgagcccaccatgtatcacacaggggactttgaaga atggacaagaatcaccattgttattccaaggtctcttgcatccagcaagaccagattccg atggatccaggagagcagctcacagaaaaacgtgcctccatttggtttagatggagtgta catatccgagccttgtcccagttactgcagtggccatggggactgcatttcaggagtgtg tttctgtgacctgggatatactgctgcacaaggaacctgtgtgtcaaatgtccccaatca caatgagatgttcgataggtttgaggggaagctcagccctctgtggtacaagataacagg tgcccaggttgga a ctggctgtgga a ca ctta acga tggca a a tctctcta cttca a tgg ccctgggaaaagggaagcccggacggtccctctggacaccaggaatatcagacttgttca attttatatacaaattggaagcaaaacttcaggcattacctgcatcaaaccaagaactag aaatgaagggcttattgttcagtattcaaatgacaatgggatactctggcatttgcttcg agagttggacttcatgtccttcctggaaccacagatcatttccattgacctgccacagga cgcgaagacacctgcaacggcatttcgatggtggcaaccgcaacatgggaagcattcagc ccagtgggctttggatgatgttcttataggaatgaatgacagctctcaaactggatttca agacaaatttgatggctctatagatttgcaagccaactggtatcgaatccaaggaggtca agttgatattgactgtctctctatggatactgctctgatattcactgaaaacataggaaa acctcgttatgctgagacctgggattttcatgtgtcagcatctacctttttgcagtttga aatgagcatgggctgtagcaagcccttcagcaactcccacagtgtacagctccagtattc tctgaacaatggcaaggactggcatcttgtcaccgaagagtgtgttcctccaaccattgg ctgtctgcattacacggaaagttcaatttacacctcggaaagattccagaattggaagcg gatcactgtctaccttccactctccaccatttctcccaggacccggttcagatggattca ggccaactacactgtgggggctgattcctgggcgattgataatgttgtactggcctcagg gtgcccttggatgtgctcaggacgagggatttgtgatgctggacgctgtgtgtgtgaccg gggctttggtggaccctattgtgttcctgttgttcctctgccctcgattcttaaagacga tttcaatgggaatttacatcctgacctttggcctgaagtgtatggtgcagagagggggaa tctgaatggtgaaaccatcaaatctggaacatctctaatttttaaaggggaaggactaag gatgcttatttcaagagatctagattgtacaaatacaatgtatgtccagttttcacttag atttatagcaaaaagtaccccagagagatctcactctattctgttacaattctccatcag tggaggaatcacttggcacctgatggatgaattttactttcctcaaacaacgaatatact tttcatcaatgttcccttgccatacactgcccaaaccaatgctacaagattcagactctg gcaaccttataataacggtaagaaagaagaaatctggattgttgatgacttcattatcga tggaaataatgtaaacaaccctgtgatgctcttggatacatttgattttgggcccagaga agacaattggtttttctatcctggtggtaacatcggtctttattgtccatattcttcaaa gggggcacctgaagaagattcagctatggtgtttgtttcaaatgaagttggtgagcattc cattaccacccgtgacctaaatgtgaatgagaacaccatcatacaatttgagatcaacgt tggctgttcgactgatagctcatccgcggatccagtgagactggaattttcaagggactt cggggcgacctggcaccttctgctgcccctctgctaccacagcagcagccacgtcagctc tttatgctccaccgagcaccaccccagcagcacctactacgcaggaaccatgcagggctg gaggagggaggtcgtgcactttgggaagctgcacctttgtggatctgtccgtttcagatg gtaccagggattttaccctgccggctctcagccagtgacatgggccattgataatgtcta catcggtccccagtgtgaggagatgtgtaatggacaggggagctgtatcaatggaaccaa atgtatatgtgaccctggctactcaggtccaacctgtaaaataagcaccaaaaatcctga ttttctcaaagatgatttcgaaggtcagctagaatctgatagattcttattaatgagtgg tgggaaaccatctcgaaagtgtggaatcctttctagtggaaacaacctctttttcaatga agatggcttgcgcatgttgatgacacgagacctggatttatcacatgctagatttgtgca gttcttcatgagactgggatgtggtaaaggcgttcctgaccccaggagtcaacccgtgct cctacagtattctctcaacggtggcctctcgtggagtcttcttcaggagttccttttcag caattccagcaatgtgggcaggtacattgccctggagatacccttgaaagcccgttctgg ttcta ctcgccttcgctggtggca a ccgtctgaga a tgggca cttcta cagcccctgggt tatcgatcagattcttattggaggaaatatttctggtaatacggtcttggaagatgattt cacaacccttgatagtaggaaatggctgcttcacccaggaggcaccaagatgcccgtgtg tggctctactggtgatgccctggtcttcattgaaaaggccagcacccgttacgtggtcag cacagacgttgccgtgaatgaggattccttcctacagatagacttcgctgcctcctgctc agtcacagactcttgttatgcgattgaattggaatactcagtagatcttggattgtcatg gcacccattggtaagggactgtctgcctaccaatgtggaatgcagtcgctatcatctgca acggatcctggtgtcagacactttcaacaagtggactagaatcactctgcctctccctcc ttataccaggtcccaagccactcgtttccgttggcatcaaccagctccttttgacaagca gcagacatgggcaatagataatgtctatatcggggatggctgcatagacatgtgcagtgg ccatgggagatgcatccagggaaactgcgtctgtgatgaacagtggggtggcctgtactg tgatgaccccgagacctctcttccaacccaactcaaagacaacttcaatcgagctccatc cagtcagaactggctgactgtgaacggagggaaattgagtacagtgtgtggagccgtggc gtcgggaatggctctccatttcagtgggggttgtagtcgattattagtcactgtggatct aaacctcactaatgctgagttcatccaattttacttcatgtatgggtgcctgattacacc aaacaaccgtaaccaaggtgttctcttggaatattctgtcaatggaggcattacctggaa cctgctcatggagattttctatgaccagtacagtaagcccggatttgtgaatatccttct ccctcctgatgctaaagagattgccactcgcttccgctggtggcagccaagacatgacgg cctggatcagaacgactgggccattgacaatgtcctcatctcaggctctgctgaccaaag gaccgttatgctggacaccttcagcagcgccccagtaccccagcatgagcgctcccctgc agatgccggccctgtcgggaggatcgcctttgacatgtttatggaagacaaaacttcagt gaatgagcactggctattccatgatgattgtacagtagaaagattctgtgactcccctga tggtgtgatgctctgtggcagtcatgatggacgggaggtgtatgcagtgacccatgacct gactcccactgaaggctggattatgcaattcaagatctcagttggatgtaaggtgtctga aaaaattgcccagaatcaaattcatgtgcagtattctactgacttcggtgtgagttggaa ttatctggtccctcagtgcttgcctgctgacccaaaatgctctggaagtgtttctcagcc atctgtattctttccaactaaagggtggaaaaggatcacctacccacttcctgaaagctt agtgggaaatccggtaaggtttaggttctatcagaagtactcagacatgcagtgggcaat cgataatttctacctgggccctggatgcttggacaactgcaggggccatggagattgctt aagggaacagtgcatctgtgatccgggatactcagggccaaactgctacttgacccacac tctgaagactttcctgaaggaacgctttgacagtgaagaaatcaaacctgacttatggat gtccttagaaggtggaagtacttgcactgagtgtggaattcttgccgaggacactgcact ctattttgggggatccactgtgagacaagcggttacacaagatttggatcttcgaggtgc aaagttcctgcaatactgggggcgcatcggtagtgagaacaacatgacctcttgccatcg tcccatctgccggaaggaaggcgtgctgttggactactctaccgatggaggaattacctg gactttgctccatgagatggattaccagaaatacatttctgttagacacgactacatact tcttcctga aga tgccctca cca a ca ca a ctcga cttcgctggtggcagccttttgtga t cagcaatggaattgtggtctctggggtggagcgtgctcagtgggcactggacaacatttt gattggtggagcagaaatcaatcccagccaattggtggacacttttgatgatgaaggcac ttcccatgaagaaaactggagtttttaccctaatgctgtaaggacagcaggattttgtgg caatccatcctttcacctctattggccaaataaaaagaaggacaagactcacaatgctct ctcctcccgagaactcattatacagccaggatacatgatgcagtttaaaattgtggtggg ttgtgaagccacttcttgtggtgaccttcattccgtaatgctggaatacactaaggatgc aagatcggattcctggcagctcgtacagacccagtgccttccttcctcttctaacagcat tggctgctcccctttccagttccatgaagccaccatctacaactctgtcaacagctcaag ctggaaaagaatcaccatccagctgcctgaccatgtctcctctagtgcaacacagttccg ctggatccagaagggagaagaaactgagaagcaaagctgggcaattgaccacgtgtacat tggagaggcttgccccaagctctgcagcgggcacggatactgcacgaccggtgccatctg catctgcgacgagagcttccaaggtgatgactgctctgttttcagtcacgaccttcccag ttatattaaagataattttgagtccgcaagagtcaccgaggcaaactgggagaccattca aggtggagtcataggaagtggctgtgggcagctggccccctacgcccatggagactcact gtactttaatggctgtcagatcaggcaagcagctaccaagcctctggatctcactcgagc aagcaaaatcatgtttgttttgcaaattgggagcatgtcgcagacggacagctgcaacag tgacctgagtggcccccacgctgtggacaaggcagtgctgctgcaatacagcgtcaacaa cgggatcacctggcatgtcatcgcccagcaccagccaaaggacttcacacaagctcagag agtgtcttacaatgtccccctggaggcacggatgaaaggagtcttactgcgctggtggca accacgccacaatggaacaggtcatgatcaatgggctttggaccatgtggaggtcgtcct agtaagcactcgcaaacaaaattacatgatgaatttttcacgacaacatgggctcagaca tttctacaacagaagacgaaggtcacttaggcgatacccatgaagaatcaaaaagtttat tttttttcttccaacatgtgatgtgttgctctccattcttttaaatctcgcactacatct gatatcaggaaatatctgtgaaggacttggtgattacctgaaagcccttctcaagaccga gtgtacaccactttcccacactgtgaactaatgacaagtgacttatttgctcataagtaa atgtcttcatgttgatgtgtccgtgaaagttgtgatctgttgtaatatcagttacagtgg cagtattgacaataagaaacagtttaacagaaaaatgaaatttaagcacaaaaaatttaa gagattttatgtttaaaatggcatttagcacagtatttaacattcttggtcacaaagcta tttaagtggactgtatttcggctatgtctcatgttttatatgattaaattatcattgttt gtcctttatgtattctcttctacaatacaacacattgaaactgtatttacttgttatgtt gtaatattttgctgctgaatttggggctacttatattctgcagaaaattaattgaaatac ctattcaagaagatagttgtaaagatattgtatctcctttaatatactccttaaaaatgt atgttggtttagcgttgttttgtggataagaaaaatgcttgaccctgaaatattttctac tttaaattgtggatgaagaccctatctcccacaaataagttcccatttccttgtctaaag atctttttttaagtgttctgtggctgatttactaacagtaactgccattttttgtctgtg ataacagagtgatttgtaaaacagtggttgttttttcattgtgttttcttcgtggattgt tttttctgcgggtcatattcataccttctgatgaagttgtacaacaccagcaacattata atggccctgtagctctgaatgctatttgtgtaactgaaaggttgcactctagggtgaacc aagctataaaagcccatgcttaaataaaaattatgtccaaaagccattgaa

>ENA | AL037401 | AL037401.1 Homo sa piens m RNA; EST DKFZp564K1671_sl (from clone

DKFZp564K1671)

TT I I I I I I I I I I CT I I I I I I I TAGATATCAAATAATATTTTAATTTCTGAATACTTTCAA

TTTTCCTTGGAATATAACACACAAAGACTCGACCAAACAGTTCAGTTATTATAACTTTTA

CAGTAAACAGAAATGTTGCACTTAAAAAAAAACCTTCGGT I I I I I I AAAACACAAACNGT

AAACTCTAAGANACTGAATCAATCACGTTACCTATAAGTGCCAACAGTGTTATTTTTGTC

ATGCTGATTTCAATGGTATTTTTTAAAAAGGGAAAATATCAACAATTATAATACAAAGCG

TTTG C N AATATAC AA AC AG ATAT AG G ATTTTC AT AAC A ATTC A AG A ACTA AG CGGGGCCC

AATTCAAATTACAAAATTCACTTTTTATTCAATACCTCAGCATGTGTCTTGGACACATTC

CTTGGCTGCCAATAAAATCCACAGTTCATTCTCTTTCTTTAAATA I I I I I I AAAAGCTAG

G NTTGTC ATGGTTTCTTTTG GGGAGGGGCAGG GT AG GG G A AGTTA AGTGTTATATGTG GT

TCCTCCAGTTCTCTAATTAAAGTGCTCGNCTTCACCTAAAAANTTTGG

>ENA | BC004241 | BC004241.1 Homo sapiens laminin, alpha 4, m RNA (cDNA clone IMAGE:3623597), complete cds.

CGGCCAGGGAGAGGAGGTGGCCTAGCGCTGGCGGGGCTCACCCCAATCCGTCTGCCTTTT

GATGCCGTACTGTAAGCTCCGTCCATCTCTGCTGGTTGCGCAGCCACCTCGGGATACTGC

ACACGGAGAGGAGGGAAAATAAGCGAGGCACCGCCGCACCACGCGGGAGACCTACGGAGA

CCCACAGCGCCCGAGCCCTGGAAGAGCACTACTGGATGTCAGCGGAGAAATGGCTTTGAG

CTCAGCCTGGCGCTCGGTTCTGCCTCTGTGGCTCCTCTGGAGCGCTGCCTGCTCCCGCGC

CGCGTCCGGGGACGACAACGCTTTTCCTTTTGACATTGAAGGGAGCTCAGCGGTTGGCAG

GCAAGACCCGCCTGAGACGAGCGAACCCCGCGTGGCTCTGGGACGCCTGCCGCCTGCGGC

CGAGGTACAGTGTCCCTGCCATTGCCACCCTGCTGGGGCACCTGCGCCCCCGCGGGCTGT GCCACACTCGTCCTTCTCTCTCTCTCCGCCTCTTTCCTCTCCCCAGTGCCTTGAGAGTTT

CACCTGGGCTAGGTCAGTTCGGAAACTTGAAATAAAGAGTTTTCCTTTGTAAGTTGAAAA

AAAAAAAAAAAAAAA

>ENA | U77706 | U77706.1 Human laminin alpha 4 chain (LAMA4*-1) m NA, complete cds.

CAAACTGAATCCTGCTTTAATTCAAGCTTGTGGAGAACAAAGTCCTACAGAAACATTCCA

CAGAATTTTCTGGAAAAGAGGGATCACAACAACCCTGTAAAAAGGTGAGAAGGAAGCCAG

GACAGCGCAGTCCCCAGTCCCGAACGGCCAGGGAGAGGAGGTGGCCTAGCGCTGGCGGGG

CTCACCCCAATCCGTCTGCCTTTTGATGCCGTACTCTGCTGGTTGCGCACGCACCTCGGG

ATACTGCACACGGAGAGGAGGGAAAATAAGCGAGGCACCGCCGCACCACGCGGAGACCTA

CGGAGACCCACAGCGCCCGAGCCCTGGAAGAGCACTACTGGATGTCAGCGGAGAAATGGC

TTTGAGCTCAGCCTGGCGCTCGGTTCTGCCTCTGTGGCTCCTCTGGAGCGCTGCCTGCTC

CCGCGCCGCGTCCGGGGACGACAACGCTTTTCCTTTTGACATTGAAGGGAGCTCAGCGGT

TGGCAGGCAAGACCCGCCTGAGACGAGCGAACCCCGCGTGGCTCTGGGACGCCTGCCGCC

TGCGGCCGAGAAATGCAATGCTGGATTCTTTCACACCCTGTCGGGAGAATGTGTGCCCTG

CGACTGTAATGGCAATTCCAACGAGTGTTTGGACGGCTCAGGATACTGTGTGACTACTGA

CGGAGAAGACCCAGGTTTTTCAGCTTCTACCCTATCGTTCATTCTCAGCTCTCAGGGAGC

CAGAGAAGCCAGGGCTCCAACATGAACACTTCTTGTAGCTCACTGTCATGACCAGTGTTT

CAGTCAGTTCTTTCAGGTTGCCTGACTTACCTCATTTCTCTCATTTCCTGTAAGCAACCA

A AA ATA AA AGG CTTTCTTTTATTTC ATTTTGTCTTATTTTG CTTTT ATCTTG AAG G C ATA

TAAGACCTCTGTATCTGCCTTGTTCACCTTCAACTGCTTCTAATTCTTCCTCAATTCCAG

TGTCCAATGTCAATTTGAAATTAAAATTTACAGACTGATTTT

>ENA | U567251 U56725.1 Human heat shock protein mRNA, complete cds.

GGAATTCTT I I I I I I I I I I I I I I I I I I G A AAC AG G GTCTCGCTCTGTC ACCC AG G CTAA A

GTGTAGTGCCGCGATCTCAGCTCATTACAACCTCTGCCTCCCAGGTTCAAGGGATCCTCC

CACCTCAGCCTCCCAAGCAGTTGGGACCACAGGCATGTGCCACCATATCCGGCTAATTTT TGC I I I I I I CATAGAGACAGGGTTTCACCATGTTGCACAAGTCGGTCTTGAACTCCTGAG

CTCAAGTGAGCTACCTGCTTTGGCCTCCCAAAGTGCTGGGATTACACATGTGAACCACCG

TACCCG G CCCC AA AA ATG CTTTCTT AAG CGTA ACTACGTA ATG CTAGTTGTAGTTTAG AT

TCCTGGATGTTAACTTAAAATAGTCCCATAGGAACCCAGTGTGGTGGCTCACGCCTGTAA

TCCCAGCCTGAGGCAGGTGGATCATCTGAGGTCAGGAGTTCGAGACCAGCTGGGCCAACA

TG GTG A AACCCTGTCTCTACT AA AA AC AC AA AA AA ATTAG CTG G G C ATAGTG G C AG G C AC

CCGTAATTTCAGCTTCTCGGGACGCTGAGGCAGAAGAATTGCTTGAACCCAGGAGGCAGT

GGTTGCAGTGAGCCCAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTC

TGTCTC A AA A AA ATC AATTA ATTTAG G CTGG G CG C AGTG G CTC ATG CCTGTA AATCCC AG

CACTTTGAGAGGCTGAAGCGGGTGGATCATGAGGTCAAGAGATCGAGACCATCCTGGCTA

ACACGGTGAAACCCCATTTCTACTAAAAATACAAAAAAAAAACCCCAAAAAACAAAAAAA

C A AA A AC A A AC A A AC A A ACC AA A AA AAC AC A AC A ACTAG CC AG G CGTAGTG G C AG G CG CT

TGTAATCCCAGCTAGTCGGGAGGCTGAGGCAGGAGGAGAATGGAGTGAACCCAGGAGGCA

GAGCTTGCAGTGAGCTGAGATCGCGCCACAGCACTCCAGCCTGGGCAACAGAGCGAGACT

CCATCTCAGGAAAAAAAAAATTAATTAATTAAAAAAACAGTAAGATAAATAACACTTCTC

CCATTTCAGTAAAAGGATGAAGCCAGTTTCTCAATGAATAAAAACAAGAGACTGTTGAAT

GTCAAGTTTTATAGACAGTCCAGACAACACAGGGAGACACCATCTCTACACACACACACA

C AC AC AC AC AC AC AC AC AC AC AC AC AC AC AC AC AC AC AC AC AC AAAATAG CTG CGTATG G

TGGCATGGGCCTGTAGTCCCAGCTATTGGGGCAGGGCCAGGGGGTGGGAGGCTGAGGGGA

GAGGATGCCTTAACAGGGAGGTTGAGGCTGCAGAGAGCCATGATCACGTCACTGTACTCC

AGCCTGGGTGATACAGCAAGACTCTGTCTCAGAAAAAAAAAAAAGAAAAAAGTCAAGAAT

GCATTCTTGAGGAATTCCACCAACAAAATGCACCAAATATAGCCAAAGAGTTTTCTGCTA

TATGCCAAGTGGAAAGCTATGAAGAAAGAGAAGAACAGAAGCAGGAGGACATTGGTTTTC

ATCTCCTATTCTTTCAAGAAGTAAGATCCATTATCTTTTAAAAAGTCTAAACACTGGTAA

GGCAAGACACAACTCCCACCCATAACACTGCATCTCTGTCCTCAGGCAACAAATCAAATG TCAGATAAAAGCACAATATCTACCACTCAACCCCCAGGCTTCAGCACAGAACTCACAAAC

ATTCTGCTGGCTAAGGCAAAAAGGTGTACTGTATTTCCAGAGAGCTTGCAGAGTTCTGAG

CACTAATCCCATAATCCTCATATCTCAATCTACACAAAGCACCATCAGGCTAAGAAACAG

ATT AT AT AG C AGG C AC AAC ACTCTTG G GTATG C AA AC ATGTT AAG G ATC A AAGT AAG AA A

AGAGTAACTATAGGGGCCATACTATATTTGCCAAAAAGTGACTTGTTTAAAAATTAAAAA

GAAGCCGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGGCTGGGGTGGGTG

GATCACCTGAGGTCAGTAGTTCAAAACCAGCCTGGCCAACATAGTGAAACCCCATCTCTA

CT AA AA ATAC AA AATTAG G CGTG GTG G C AG G CG CCTGT AATCCC AG CT ACTAG GG ATG CT

GAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTGCAGTGAGCCAAAATCGCACCA

CTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCTGTCTCAAAAAAAAAAAAATAAAAAT

AAAAACAAAAAAGAAATCCAGTTTACCTCCTTGTGCAATTCCTAATAAATTGCTGAGAAG

TGATCTTACATAGGAATCTTGTATAATTTATTCTGATGCGTTCGAGGTGGCCGTTAGTTG

ACTCCGCGGAGTTCATCTCCCTGGTTTTCCCGTCCTAACGTCGCTCGCCTTTCAGTCAGG

ATGTCTGCCCGTGGCCCGGCTATCGGCATCGACCTGGGCACCACCTATTCGTGCGTCGGG

GTCTTCCAACATGGCAAGGTGGAGATCATCGCCAACGACCAGGGCAATCGCACCACCCCC

AGCTACGTGGCCTTCACGGACACCGAGCGCCTCATCGGCGACGCCGCCAAGAACCAGGTG

GCCATGAACCCCACCAACACCATCTTCGACGCCAAGAGGCTGATTGGACGGAAATTCGAG

GATGCCACAGTGCAGTCGGATATGAAACACTGGCCGTTCCGGGTGGTGAGCGAGGGAGGC

AAGCCCAAAGTGCAAGTAGAGTACAAGGGGGAGACCAAGACCTTCTTCCCAGAGGAGATA

TCCTCCATGGTCCTCACGAAGATGAAGGAGATCGCGGAAGCCTACCTGGGGGGCAAGGTG

CACAGCGCGGTCATAACGGTCCCGGCCTATTTCAACGACTCGCAGCGCCAGGCCACCAAG

GACGCAGGCACCATCACGGGGCTCAATGTGCTGCGCATCATCAACGAGCCCACGGCGGCG

GCCATCGCCTACGGCCTGGACAAGAAGGGCTGCGCGGGCGGCGAGAAGAACGTGCTCATC

TTTGACCTGGGCGGTGGCACTTTCGACGTGTCCATCCTGACCATCGAGGATGGCATCTTC

GAGGTGAAGTCCACGGCCGGCGACACCCACCTGGGCGGTGAGGACTTCGACAACCGCATG GTGAGCCACCTGGCGGAGGAGTTCAAGCGCAAGCACAAGAAGGACATTGGGCCCAACAAG

CGCGCCGTGAGGCGGTCGCGCACCGCTTGCGAGCGCGCCAAGCGCACCCTGAGCTCGTCC

ACGCAGGCGAGCATCGAGATCGACTCGCTCTACGAGGGCGTGGACTTCTATACGTCCATC

ACGCGCGCCCGCTTCGAGGAGCTCAATGCCGACCTCTTTCGCGGGACCCTGGAGCCGGTG

GAGAAGGCGCTGCGCGACGCCAAGCTGGACAAGGGCCAGATCCAGGAGATCGTGCTGGTG

GGCGGCTCCACTCGTATCCCCAAGATCCAGAAGCTGCTGCAGGATTTCTTCAACGGCAAG

GAGCTGAACAAGAGCATCAACCCCGACGAGGCGGTGGCCTATGGCGCCGCGGTGCAGGCG

GCCATCCTCATCGGCGACAAATCAGAGAATGTGCAGGACCTGCTGCTACTCGACGTGACC

CCGTTGTCGCTGGGCATCGAGACAGCTGGCGGTGTCATGACCCCACTCATCAAGAGGAAC

ACCACGATCCCCACCAAGCAGACGCAGACCTTCACCACCTACTCGGACAACCAGAGCAGC

GTACTGGTGCAGGTATACGAGGGCGAACGGGCCATGACCAAGGACAATAACCTGCTGGGC

AAGTTCGACCTGACCGGGATTCCCCCTGCGCCTCGCGGGGTCCCCCAAATCGAGGTTACC

TTCGACATTGACGCCAATGGCATCCTTAACGTTACCGCCGCCGACAAGAGCACCGGTAAG

GAAAACAAAATCACCATCACCAATGACAAAGGTCGTCTGAGCAAGGACGACATTGACCGG

ATGGTGCAGGAGGCGGAGCGGTACAAATCGGAAGATGAGGCGAATCGCGACCGAGTCGCG

GCCAAAAACGCCCTGGAGTCCTATACCTACAACATCAAGCAGACGGTGGAAGACGAGAAA

CTGAGGGGCAAGATTAGCGAGCAGGACAAAAACAAGATCCTCGACAAGTGTCAGGAGGTG

ATCAACTGGCTCGACCGAAACCAGATGGCAGAGAAAGATGAGTATGAACACAAGCAGAAA

GAGCTCGAAAGAGTTTGCAACCCCATCATCAGCAAACTTTACCAAGGTGGTCCTGGCGGC

GGCAGCGGCGGCGGCGGTTCAGGAGCCTCCGGGGGACCCACCATCGAAGAAGTGGACTAA

G CTTG C ACTC AAGTC AG CGT AA ACCTCTTTG CCTTTCTCTCTCTCTCT I I I I I I TTGTTT

GTTTCTTTGAAATGTCCTTGTGCCAAGTACGAGATCTATTGTTGGAAGTCTTTGGTATAT

GCAAATGAAAGGAGAGGTGCAACAACTTAGTTTAATTATAAAAGTTCCAAAGTTTGTTTT

TTAAAAACATTATTCGAGGTTTCTCTTTAATGCATTTTGCGTGTTTGCTGACTTGAGCAT

TTTTGATTAGTTCGTGCATGGAGATTTGTTTGAGATGAGAAACCTTAAGTTTGCACACCT GTTCTGTAGAAGCTTGGAAACAGTAAAATATATAGGAGCTTAAATTGTTTATTTTTATGT

ACTACTTTAAAACTAAACTGAACATTGCAGTAATGTTAAGGACAGGTATACTTTTTGCAA

ACAAATGCATAAAATGCAAATGTAAAGTAAAGCTGAAATTGATCTCAAAAAAAAAAAA

>refseq | N M_018214 | N M_018214 Homo sapiens leucine rich repeat containing 1 (LRRCl), m RNA. ggaagctccgcgcggcggcgggggcggcgacggcgactggcgggtgggagtggaggcacc

ggctggcgggcgggggtacagggacggggcaggggctcccgctccaggttccttgaagca

cttccgaccgcgaagcccggcgcgagaagcgagctaacccaagagccaacaacgagcgcg

gagagggcagcggactgagcggagccgccggccagagcgggctcggagcccgggtctccg

ccgctcgggacccggctaggcggcggcgggggcggcgatgttccactgcatccccctgtg

gcggtgcaaccgtcatgtggagagcatcgacaagcgccactgctcgctggtctacgtccc

cgaggagatctaccgctatgcccggagcctggaggagctgctgctggacgccaaccagct

ccgcgagctgcccgagcaatttttccagctagtcaaattacgaaagcttggacttagtga

taatgaaattcagcggctccctccagaaatagcaaacttcatgcagctggtggaactaga

tgtgtctcgaaatgagattcctgaaattccagaaagcatttcattctgtaaagcactgca

ggtagctgacttcagcggaaacccactgactaggttgccagaaagctttcctgaattaca

gaatttaacatgtctttctgtaaatgacatctcactacagtctctacctgaaaatattgg

caatctttataacctggcttcactggaactgagagagaatcttcttacatatcttcctga

ctctcttacccagctgcgaagactagaagaacttgatttaggaaacaatgaaatatataa

tttgccagaatcaattggagccctcttacatctaaaagatctctggttggatggaaatca

actgtcagaattacctcaggaaataggaaatctgaagaacctgctgtgtttagatgtctc

tgaaaacaggttggaaagacttcctgaagaaatcagtggcctgacttcattaacggattt

agtcatttcccagaacttattagaaacgattccggatggcattggaaaactaaagaaact

gtcaatcttgaaggtggatcagaatagactcacacagttgcctgaagcagttggggaatg

tgaaagtctcactgagttagttcttacagaaaatcagctcctgaccctgcctaaaagcat

tggaaaactaaagaagttgagcaacttgaatgcagacagaaataaattagtgtccttacc aaaagagatcggcgggtgctgcagcctcactgtgttctgtgtacgtgacaacagactaac tcggatacctgcagaggtgtcacaggcaacagaacttcatgtcctggatgtggcagggaa caggttgctgcatctacctttatccctgactgccttgaagttgaaggctctgtggctatc tgacaaccagtcccagcccctgcttacattccagacagacacagactacaccacaggaga gaagattttaacctgtgtcttacttcctcagctgccttctgaacctacttgtcaagagaa tctgcctcgctgtggtgca ctggaga a cttggta a atga tgtctctgatga agcctgga a cgagcgtgctgtcaacagagtcagtgcgatccgatttgtggaggatgagaaagatgaaga agacaatgagacgagaacacttctaaggcgagccactccacacccaggggagttaaagca catgaaaaagacagtggagaatttacggaatgacatgaatgctgctaaaggactggactc aaacaaaaacgaggtcaatcatgccattgaccgagtgaccacttctgtgtagagtttcac ctccaagttttacctcctgtgtcttcctctgctgtcgagacgttcctgtctgcttcccgg gagcctcacgtgctccttgtcctaaccagcccccgcgcgccatcttcccgtggagtgtgg ggaagctgctgtctcccaggaagtgccttactcatcccgcaaccagtcagcgcaccagtg gtctcccggtgtgattttttttttttttaatttcagttgtttgtaataagtagaatacac tactgtaaacatacgacctttgtttttgtcttatgttggggtaaaggaaagcaggaaggg gaatttttatcctcctcccttccgtaaagtgctgggatattttgaatcccccaagttccc ttggacctactgatgagagatagttttatgtatggggaaaaatggatactttttaaacct tttttggcagctcagatggtgtaaattttaaaattttgtataggtatttcataacaaaaa tatgtatttcttttttgttattttatcttgaaaacggtacatattttagtatttgtgcag aaaaacaagtcctaaagtatttgtttttatttgtaccatccacttgtgccttactgtatc ctgtgtcatgtccaatcagttgtaaacaatggcatctttgaacagtgtgatgagaatagg aatgtggtgttttaaagcagtgttgcattttaatcagtaatctacctggtggatttgttt ttaaccaaaaagatgaattatcaatgatttgtaattatatcagttgattttttttgaaaa gatgaaccaaaggatttgactgctaatattttattccttacactttttttctgaataagt ctctcataatgagtgcagtgtcagactgtgcctactctgatggtatgtgccatttgtaaa ataaaatagagcagaaaaacacaaaaagagaacactggttcagacattcagtgggcaagt aaattatggactgcaaaataatgatttttattcaagaaagctttaaaagttttatatcca

gatatacaaccacaataaagcaaaataacctactatcaaaatagaaatgttgctatcttt ataagtgcaatttaatttgtaaatagagtttgaatcaaagtatcacaaaatactgcttca agatttaattttaaatctgctaatttaagggatattgggaaaagttttggtgtgtttctg ttgatttcttttttgtatgctgtgataaaagagaaatgaaaagtgccagtcactgtgtgg tgtctaggaaaatcatatatatttttttctccaagaaataaattcatcctggacattggc

>refseq | NM_0050921 NM_005092 Homo sapiens tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18), m NA. catgacattgcatccttcacccatcacttgtgaatttttgttttccacagctctcatttc tccaaaaatgtgtttgagccacttggaaaatatgcctttaagccattcaagaactcaagg agctcagagatcatcctggaagctgtggctcttttgctcaatagttatgttgctatttct ttgctccttcagttggctaatctttatttttctccaattagagactgctaaggagccctg tatggctaagtttggaccattaccctcaaaatggcaaatggcatcttctgaacctccttg cgtgaataaggtgtctgactggaagctggagatacttcagaatggcttatatttaattta tggccaagtggctcccaatgcaaactacaatgatgtagctccttttgaggtgcggctgta taaaaacaaagacatgatacaaactctaacaaacaaatctaaaatccaaaatgtaggagg gacttatgaattgcatgttggggacaccatagacttgatattcaactctgagcatcaggt tctaaaaaataatacatactggggtatcattttactagcaaatccccaattcatctccta gagacttgatttgatctcctcattcccttcagcacatgtagaggtgccagtgggtggatt ggagggagaagatattcaatttctagagtttgtctgtctacaaaaatcaacacaaacaga actcctctgcacgtgaattttcatctat

>ENA I AI2798191 AI279819.1 qm26h04.xl NCI_CGAP_Lu5 Homo sapiens cDNA clone IMAGE:1882999 3', mRNA sequence.

TT I I I I I I TGCTGGGGCGTAAAGGGTTTTTATTGTAGATCCTGTGGCGCTGAAGTGCCAC CAAGGATTTGGAAGGTCACTTTCAGCAGCCGCCATTTCTGCCAGGACCAGTGGCAAGCAC CTGGCAGATGGAGCCCGGGTGTTTCTGCGTAAGGCAGAGGAATCCAGCTTTTCCATGAGA

TTCAGCTGCAGTTGTCGAAAACCCTGTGTGAGCCAGCAGTTCCAGTTCAAAGGTTGAGGG

GGCGAACAGCTGCGAGGTGGCCAGGCTCCCGTGAGTCACCACTCAGGCCTGAGTACACCG

TGGAGAGGAGAGATAAAGCAGCCACGGCTGTTCTGTTGCCAGTCCCACCCCTCTGGCAAA

CAGATGGGGGAAAACAGAGAAGGAAAGTCAACAAAGAAGGTGAAATGCAGGGAGCAGAGA

CTACACGCAGGCCCCCCGTGGCTGGCAATACCATGCGTGCTGGGCCGGCTGCGCCACCCT

CACCCA

>ENA | BE857360 | BE857360.1 7g29bl2.xl NCI_CGAP_Brn23 Homo sapiens cDNA clone I MAGE:3307871 3', m NA sequence.

TTGCCTGTGGCTCTTTTATATATATTTAAAACACACAGTAAGAACATAAGAACATCTCAA ATCATTTAGAAGGTAAAAGGGGGTTATCAACCAAAATCTTTGGAAATTTCATAAAATTTA AATATCTGCAAACAGTCCAACCAAAAACGAAAAAAAAAAAAATCCCAACATTTGGCTATG G AG G G C ACTTC AC ATGTG A ACC AA ATG G CGTTATAAC ATTTTCCTTC A ACTAGTC ACTA A ACCCAATTAGAAAGAATACAAGAGCAATATTGGAGACATCCCCAAATACCACGTACTTGA TT AG A AC ATTCTGTTATG AAG CG CTC AG CT ACCG CG G G CTTTCCTTTAC ATTG CAT AC AT TACTTTACATTTCTACAGTGCAATGTTGAAATAGCCTCCAAATTTTGCAAAGTAGATTGA TGTCCATTCTACAAAAATATTAACTTACAGTACATAACACTGAATAATTTTAATCTGTAC AT I I I I I I CCTTCCATGATAGTTGACACACGTCAGTTTGTA

>ENA | AI8019731 AI801973.1 tx29d05.xl NCI_CGAP_Lu24 Homo sa piens cDNA clone IMAGE:2270985 3', m RNA sequence.

GATGAAAACTCCAGCCTTTCCTGACTCACCTCCATCTTCGGTTCTTCAGTTTTCTGAGAA

GAGTTGGGATATGTGGGAAGGGGCATGGGAGCTCGGCAGCCTCCGCCTGCCAGGAAGGCA

GTTTCGCCTCTGCAGGAAAGAGCAGAGCCCGTGGGAAGCCCTGGGTGAGGGTGGCGCAGC

CGGCCCAGCACGCATGGTATTGCCAGCCACGGGGGGCCTGCGTGTAGTCTCTGCTCCCTG

CATTTCACCTTCTTTGTTGACTTTCCTTCTCTGTTTTCCCCCATCTGTTTGCCAGAGGGG

TGGGACTGGCAACAGAACAGCCGTGGCTGCTTTATCTCTCCTCTCCACGGTGTACTCAGG CCTGAGTGGTGACTCACGGGAGCCTGGCCACCTCGCAGCTGTTCGCCCCCTCAACCTTTG

AACTGGAACTGCTGGCTCACACAGGGTTTTCGACAACTGCAGCTGAATCTCATGGAAAAG

CTGGATTCCTCTGCCTTACGCAGAAACACCCGGGCTCCATCTGCCAGGTGCT

>ENA | AW451115 | AW451115.1 UI-H-BI3-alg-g-01-0-U l.sl NCI_CGAP_Su b5 Homo sapiens cDNA clone I MAGE:2736936 3', m RNA sequence.

TT I I I I I I I I I I I I I I I G G GTTTATCTGTTTATAATC AG AG A ATG GG G GTAC AC AG G CCC

TCCCCAAGAGATACATTTTCTGTACAATGAAAAATTCAGTTTCCTATTTCTTAACTTTGT

TTGCAAACCTACACGCCTCTTCTCTCTTCCACCATGTGTAATAAAATCCATCGCATTCTC

TTCTATCTTCAGTCATGTAGTTTTTGTGTTTAACATTTATAAAATGTGTTCTTATGAGTC

TGAAATCTTTATCAGTTCAAATCATTCCTGATTTCCCATCTACAACCTTCTAGGTCTTTC

TTCTTTCTCTG CCG CTTTCCTTGTTTGTC AGTGTTCTGTACTG AA ATTCC AC AG G G ATG G

CAGTTAGATGAGGACTTCCATCATCTCTCCATCAGGGAACTCGGGCTTGTGCAGCAAGCT

GCTGACCCGGCCTCTGTGGTCAGGCGACTTCCCATGGCCAGGAGAGTTCTCCAGTTTCTC

TGCGGTCCCTTTGGCCGCTGGGTGTTTCAGGATCGTGAGGCCCCGCTTTCACGG

>ENA I AI4723101 AI472310.1 tj87b01.xl Soares_NSF_F8_9W_OT_PA_P_Sl Homo sapiens cDNA clone I MAGE:2148457 3', m RNA sequence.

TTTTTTTCACATCTCAAAAAAAGTTTATTATGTTGGATACAACAGATTCTCAATATTAGC

AAATCATTCCACTTACCCCCAAGCGCCAGATCTTGACTGTACAGTCTAAAAACATTTGTC

AAAGTGAGAAAAATGTTACAGAACATCTCATAAAAGAATTAAGATACAAATAGTATATAC

AGATAGTAGATTGTAACAAAGTGGAACGTACTTGCAAGACATCACCTAGCTAAAATACTT

GATTCCCTATGAGGACAAACTGAAAAATAAAATATTTCAAGCACACAAAGAAAGGACAAA

AT AG G G G AA ACC AATG G G AA ATATA AAGTTTAA ACTTATTTTTA AC ATTTA AA AG C AACT

ACACTTTTCCATTTGAGCCAGTTCAAAAAGGAGAAGTCAAATAAAGACTTTAGAATCCTG

TGACCAACTATAATTTGAGCTTGATAACATGAATGGCATCTGAAAGATGCAAGCCAAGTA

TTTCTAGTACTGTGACCTTGAGAGATAATAACTGAGCAACCTGCTAGG

>gi 118089116 1 gb | BC020718.1 1 Homo sapiens complement factor I, m RNA (cDNA clone MGC:22501 I MAGE:4716122), complete cds AAATTTCAAAAGAATACCTGGAGTGGAAAAGAGTTCTCAGCAGAGACAAAGACCCCGAACACCTCCAACA

TG A AG CTTCTTC ATGTTTTCCTGTTATTTCTGTG CTTCC ACTTA AG GTTTTG C AAG GTC ACTTAT AC ATC

TCAAGAGGATCTGGTGGAGAAAAAGTGCTTAGCAAAAAAATATACTCACCTCTCCTGCGATAAAGTCTTC

TGCCAGCCATGGCAGAGATGCATTGAGGGCACCTGTGTTTGTAAACTACCGTATCAGTGCCCAAAGAATG

GCACTGCAGTGTGTGCAACTAACAGGAGAAGCTTCCCAACATACTGTCAACAAAAGAGTTTGGAATGTCT

TCATCCAGGGACAAAGTTTTTAAATAACGGAACATGCACAGCCGAAGGAAAGTTTAGTGTTTCCTTGAAG

CATGGAAATACAGATTCAGAGGGAATAGTTGAAGTAAAACTTGTGGACCAAGATAAGACAATGTTCATAT

GCAAAAGCAGCTGGAGCATGAGGGAAGCCAACGTGGCCTGCCTTGACCTTGGGTTTCAACAAGGTGCTGA

TACTCAAAGAAGGTTTAAGTTGTCTGATCTCTCTATAAATTCCACTGAATGTCTACATGTGCATTGCCGA

GGATTAGAGACCAGTTTGGCTGAATGTACTTTTACTAAGAGAAGAACTATGGGTTACCAGGATTTCGCTG

ATGTGGTTTGTTATACACAGAAAGCAGATTCTCCAATGGATGACTTCTTTCAGTGTGTGAATGGGAAATA

CATTTCTCAGATGAAAGCCTGTGATGGTATCAATGATTGTGGAGACCAAAGTGATGAACTGTGTTGTAAA

G C ATG CC AAG G C A AAG G CTTCC ATTGCAAATCG G GTGTTTG C ATTCC AAGCC AGTATC A ATG C A ATG GTG

AGGTGGACTGCATTACAGGGGAAGATGAAGTTGGCTGTGCAGGCTTTGCATCTGTGGCTCAAGAAGAAAC

AGAAATTTTGACTGCTGACATGGATGCAGAAAGAAGACGGATAAAATCATTATTACCTAAACTATCTTGT

GGAGTTAAAAACAGAATGCACATTCGAAGGAAACGAATTGTGGGAGGAAAGCGAGCACAACTGGGAAAAA

TGAAGCAAATCTCATTGGATATTTTTAAAGGTCTCCACAGAGTTTATGCCATATTGGAATTTTGTTGTAT

AATTCTCAAATAAATATTTTGGTGAAGCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>gi 1 867879111 ref | N M_004105.31 Homo sapiens EGF-containing fibulin-like extracellular matrix protein

1 (EFEM P1), transcript variant 1, m NA

CGAAGGTAGCGTGTCGGGGACCCAGACTGATAAGACAAAAGAGAATCAGTCGCTTTGGGCTGCCCCTCCA

CACAACCTGGGACTTTTAAACAAAGCTGTGCGCAGAGAAAGGCGTGGAAATGCCACTTTGAGAGTTTGTG

CTGGGGGATGTGAGAAGCTCTGAGACATGTGAGAAGGTCTAGTATTCTACTAGAACTGGAAGATTGCTCT

CCGAGTTTTGTTTTGTTATTTTGTTTAAAAAATAAAAAGCTTGAGGCCAAGGCAATTCATATTGGCTCAC

AG GTATTTTTG CTGTG CTGTGC AAG G A ACTCTG CT AGCTC AAG ATTC AC A ATGTTG AA AG CCCTTTTCCT

AACTATGCTGACTCTGGCGCTGGTCAAGTCACAGGACACCGAAGAAACCATCACGTACACGCAATGCACT GACGGATATGAGTGGGATCCTGTGAGACAGCAATGCAAAGATATTGATGAATGTGACATTGTCCCAGACG

CTTGTAAAGGTGGAATGAAGTGTGTCAACCACTATGGAGGATACCTCTGCCTTCCGAAAACAGCCCAGAT

TATTGTCAATAATGAACAGCCTCAGCAGGAAACACAACCAGCAGAAGGAACCTCAGGGGCAACCACCGGG

GTTGTAGCTGCCAGCAGCATGGCAACCAGTGGAGTGTTGCCCGGGGGTGGTTTTGTGGCCAGTGCTGCTG

CAGTCGCAGGCCCTGAAATGCAGACTGGCCGAAATAACTTTGTCATCCGGCGGAACCCAGCTGACCCTCA

GCGCATTCCCTCCAACCCTTCCCACCGTATCCAGTGTGCAGCAGGCTACGAGCAAAGTGAACACAACGTG

TGCCAAGACATAGACGAGTGCACTGCAGGGACGCACAACTGTAGAGCAGACCAAGTGTGCATCAATTTAC

GGGGATCCTTTGCATGTCAGTGCCCTCCTGGATATCAGAAGCGAGGGGAGCAGTGCGTAGACATAGATGA

ATGTACCATCCCTCCATATTGCCACCAAAGATGCGTGAATACACCAGGCTCATTTTATTGCCAGTGCAGT

CCTGGGTTTCAATTGGCAGCAAACAACTATACCTGCGTAGATATAAATGAATGTGATGCCAGCAATCAAT

GTG CTC AG C AGTG CT AC A AC ATTCTTGGTTC ATTC ATCTGTC AGTG C A ATC A AG G ATATG AG CTAAG C AG

TGACAGGCTCAACTGTGAAGACATTGATGAATGCAGAACCTCAAGCTACCTGTGTCAATATCAATGTGTC

AATGAACCTGGGAAATTCTCATGTATGTGCCCCCAGGGATACCAAGTGGTGAGAAGTAGAACATGTCAAG

ATATAAATGAGTGTGAGACCACAAATGAATGCCGGGAGGATGAAATGTGTTGGAATTATCATGGCGGCTT

CCGTTGTTATCCACGAAATCCTTGTCAAGATCCCTACATTCTAACACCAGAGAACCGATGTGTTTGCCCA

GTCTCAAATGCCATGTGCCGAGAACTGCCCCAGTCAATAGTCTACAAATACATGAGCATCCGATCTGATA

G GTCTGTG CC ATC AG AC ATCTTCC AG AT AC AG G CC AC AACT ATTTATG CC AAC ACC ATC A AT ACTTTTCG

GATTAAATCTGGAAATGAAAATGGAGAGTTCTACCTACGACAAACAAGTCCTGTAAGTGCAATGCTTGTG

CTCGTGAAGTCATTATCAGGACCAAGAGAACATATCGTGGACCTGGAGATGCTGACAGTCAGCAGTATAG

GGACCTTCCGCACAAGCTCTGTGTTAAGATTGACAATAATAGTGGGGCCATTTTCATTTTAGTCTTTTCT

AAGAGTCAACCACAGGCATTTAAGTCAGCCAAAGAATATTGTTACCTTAAAGCACTATTTTATTTATAGA

TATATCTAGTGCATCTACATCTCTATACTGTACACTCACCCATAATTCAAACAATTACACCATGGTATAA

AGTGGGCATTTAATATGTAAAGATTCAAAGTTTGTCTTTATTACTATATGTAAATTAGACATTAATCCAC

TAAACTGGTCTTCTTCAAGAGAGCTAAGTATACACTATCTGGTGAAACTTGGATTCTTTCCTATAAAAGT

GGGACCAAGCAATGATGATCTTCTGTGGTGCTTAAGGAAACTTACTAGAGCTCCACTAACAGTCTCATAA GGAGGCAGCCATCATAACCATTGAATAGCATGCAAGGGTAAGAATGAGTTTTTAACTGCTTTGTAAGAAA

ATGGAAAAGGTCAATAAAGATATATTTCTTTAGAAAATGGGGATCTGCCATATTTGTGTTGGTTTTTATT

TTC ATATCC AG CCTA AAG GTG GTTGTTTATT ATATAGTA AT AA ATC ATTG CTGTAC AATATG CTG GTTTC

TGTAGGGTATTTTTAATTTTGTCAGAAATTTTAGATTGTGAATATTTTGTAAAAAACAGTAAGCAAAATT

TTCCAGAATTCCCAAAATGAACCAGATATCCCCTAGAAAATTATACTATTGAGAAATCTATGGGGAGGAT

ATGAGAAAATAAATTCCTTCTAAACCACATTGGAACTGACCTGAAGAAGCAAACTCGGAAAATATAATAA

CATCCCTGAATTCAGGACTTCCACAAGATGCAGAACAAAATGGATAAAAGGTATTTCACTGGAGAAGTTT

TAATTTCTAAGTAAAATTTAAATCCTAACACTTCACTAATTTATAACTAAAATTTCTCATCTTCGTACTT

GATGCTCACAGAGGAAGAAAATGATGATGGTTTTTATTCCTGGCATCCAGAGTGACAGTGAACTTAAGCA

AATTACCCTCCTACCCAATTCTATGGAATATTTTATACGTCTCCTTGTTTAAAATGTCACTGCTTTACTT

TGATGTATCATATTTTTAAATAAAAATAAATATTCCTTTAGAAGATCAAAAAAAAAAAAAAAAAAA

>gi 1133758181 ref | N M_024609.11 Homo sa piens nestin (N ES), m NA

AGTCGCTCAGGCTACTCCCACCCCGCCCCGCCCCGTCATTGTCCCCGTCGGTCTCTTTTCTCTTCCGTCC

TAAAAGCTCTGCGAGCCGCTCCCTTCTCCCGGTGCCCCGCGTCTGTCCATCCTCAGTGGGTCAGACGAGC

AGGATGGAGGGCTGCAGAACTGGCTCAGGAAAGCCCTCCTGGGATGGCTGGAGTGGAAAATGAGGATGAG

GCAGAGCTGAATCTGAGGGAGCAGGGTGGCTTCACTGGGAAGGAGGAGGTGGTAGAGCAGGGAGAGCTGA

ATGCCACAGAGGAGGTCTGGATCCCAGGCGAGGGGCACCCAGAGAGCCCTGAGCCCAAAGAGCAGAGAGG

CCTGGTTGAGGGAGCCAGTGTGAAGGGAGGGGCTGAGGGCCTCCAGGACCCTGAAGGGCAATCACAACAG

GTGGGGGCCCCAGGCCTCCAGGCTCCCCAGGGGCTGCCAGAGGCGATAGAGCCCCTGGTGGAAGATGATG

TGGCCCCAGGGGGTGACCAAGCCTCCCCAGAGGTCATGTTGGGGTCAGAGCCTGCCATGGGTGAGTCTGC

TGCGGGAGCTGAGCCAGGCCTGGGGCAGGGGGTGGGAGGGCTGGGGGACCCAGGCCATCTGACCAGGGAA

GAGGTGATGGAACCACCCCTGGAAGAGGAGAGTTTGGAGGCAAAGAGGGTTCAGGGCTTGGAAGGGCCTA

GAAAGGACCTAGAGGAGGCAGGTGGTCTGGGGACAGAGTTCTCCGAGCTGCCTGGAAAGAGCAGAGACCC

TTGGGAGCCTCCCAGGGAGGGTAGGGAGGAGTCAGAGGCTGAGGCCCCCAGGGGAGCAGAGGAGGCGTTC

CCTGCTGAGACCCTGGGCCACACTGGAAGTGATGCCCCTTCACCTTGGCCTCTGGGGTCAGAGGAAGCTG AGGAGGATGTACCACCAGTGCTGGTCTCCCCCAGCCCAACATACACCCCGATCCTGGAAGATGCCCCTGG

GCCTCAGCCTCAGGCTGAAGGGAGTCAGGAGGCTAGCTGGGGGGTGCAGGGGAGGGCTGAAGCCCTGGGG

AAAGTAGAGAGCGAGCAGGAGGAGTTGGGTTCTGGGGAGATCCCCGAGGGCCTCCAGGAGGAAGGGGAGG

AGAGCAGAGAAGAGAGCGAGGAGGATCAGGAGGAGGGGAGGGAGCCAGGGGCTGGGCGGTGGGGGCCAGG

GTCTTCTGTTGGCAGCCTCCAGGCTCTGAGTAGCTCCCAGAGAGGGGAATTCCTGGAGTCTGATTCTGTG

AGTGTCAGTGTCCCCTGGGATGACAGCTTGAGGGGTGCAGTGGCTGGTGCCCCCAAGACTGCCCTGGAAA

CGGAGTCCCAGGACAGTGCTGAGCCTTCTGGCTCAGAGGAAGAGTCTGACCCTGTTTCCTTGGAGAGGGA

GAACAAAGTCCCTGGCCCTCTAGAGATCCCCAGTGGGATGGAGGATGCAGCCAGGGGCAGACATCATTGG

TGTTAATGGCCAGGGTCCCAACTTGGAGGGGAAGTCACAGCATGTGAATGGGGGAGTGATGAACGGGCTG

GAGCAGTCTGAGGAAGTGGGGCAAGGAATGCCGCTAGTCTCTGAGGGAGACCGAGGGAGCCCCTTTCAGG

AGGAGGAGGGGAGTGCTCTGAAGACCTCTTGGGCAGGGGCTCCTGTTCACCTGGGCCAGGGTCAGTTCCT

GAAGTTCACTCAGAGGGAAGGAGATAGAGAGTCCTGGTCCTCAGGGGAGGACTAGGAAAAGACCATCTGC

CCGGCACTGGGGACTTAGGGGTGCGGGGAGGGGAAGGACGCCTCCAAGCCCGCTCCCTGCTCAGGAGCAG

CACTCTTAACTTACGATCTCTTGACATACGGTTTCTGGCTGAGAGGCCTGGCCCGCTAAGGTGAAAAGGG

GTGTGGCAAAGGAGCCTACTCCAAGAATGGAGGCTGTAGGAATATAACCTCCCACCCTGCAAAGGGAATC

TCTTGCCTGCTCCATCTCATAGGCTAAGTCAGCTGAATCCCGATAGTACTAGGTCCCCTTCCCTCCGCAT

CCCGTCAGCTGGAAAAGGCCTGTGGCCCAGAGGCTTCTCCAAAGGGAGGGTGACATGCTGGCTTTTGTGC

CC AAG CTC ACC AG CCCTG CG CC ACCTC ACTG C AGT AGTG C ACC ATCTC ACTG C AGTAG C ACG CCCTCCTG

GGCCGTCTGGCCTGTGGCTAATGGAGGTGACGGCACTCCCATGTGCTGACTCCCCCCATCCCTGCCACGC

TGTGGCCCTGCCTGGCTAGTCCCTGCCTGAATAAAGTAATGCCTCCGCTTCAAAAAAAAAAAAAAAAAAA

AAAAAAAAAAAAAAAAA

>ENA I W725161 W72516.1 zd64g05.sl Soares_fetal_heart_N bHH 19W Homo sapiens cDNA clone I MAGE:345464 3', m NA sequence.

TG G GTCTTG G C ATTTTA AT A AACGTTC AA AG AA AC AA AATTTACTTGT AG G G G ACGTG AC

AAAGAACAGAACCCAAAGACTGCCTGCCTTCTCGGCAGACCCTAGGGAGCTGTGGTGATG

TGACAGCTGCCACAGCGGCTATCTTCCATGGAAATAACGTACGTCATCAACACAATATAC AACACCCCTTCCACTCACCTGACCCACCCACCTCCCTCCTACATGCCCTACCCCAGCCCC

TCTGCACCCTCCACCTTGCTCCAGGCTCCCACCACCCACTCACCCCAAATAACCTGCGTC

CCTTTTGTTCATTTCCCTGACGTCCCAGCTTGTCTGGTCCCCTTGGTCATAAGATGGCAG

GCACTTACACACGNTTCTTCAACACTTATGGATAAGAGGCAGGACTCTTTTTAACTTAGT

GGGCCTGGTCTTGAATTGGCATGGCATGTNAATGGGGGGGGANGGGGGAGTTAAAAAAAA

TCAAGGNTATGGGTTAACAGGGAAACAAAGGGGATATTTTGTAAAAGCTAGGGAAAGCGG

GGGGGTANAATTTGGGGAANAAAANGGGTTGAGGGGTATTGGATTCNTTTGGATGACAAC

CGGT

>refseq | NM_0013871 NM_001387 Homo sapiens dihydropyrimidinase-like 3 (DPYSL3), transcript variant 2, m NA. gcaccattcactccacctgatctcggggcgctgtgcgctgaggaaggcgcgggcgagccg gagcagaagaaggagggagggagccagccgctgcagccaccaccgccaccatgtcctacc aaggcaagaagaacatcccgcggatcacgagtgaccgtctccttatcaagggaggcagaa tcgtcaatgatgatcagtccttttatgctgatatttacatggaagatggcttaataaaac aaattggagacaatctgattgttcctggaggagtgaagaccattgaagccaatgggaaga tggtgatccctggaggcatcgatgtccatactcacttccagatgccatataagggaatga ccacagtagatgacttcttccaagggacaaaggcggccttagcaggtggcaccaccatga tcattgaccatgtggtgcctgagcctgagtccagcctgactgaggcctatgagaaatgga gagagtgggctgatgggaagagttgctgtgactatgccctgcatgtggacatcacccact ggaatgacagcgtcaagcaggaagtgcagaacctcatcaaggacaaaggggttaactcct tcatggtttatatggcttataaggatttgtatcaagtatctaacacagagctctatgaga tcttcacctgcctgggagagctgggggccattgctcaagttcatgctgagaatggggata tcattgcccaggagcaaacccgcatgttggaaatggggataactggcccagaaggccatg tactgagcaggccagaagagctggaagctgaggctgtgttccgtgccatcaccattgcca gccaaaccaattgccctctctacgtcacaaaggtcatgagcaagagtgcagctgacctca tctcacaagccaggaaaaaaggaaatgtagtctttggtgagcccatcactgccagcctcg gcatagatggaacccattattggagcaagaactgggccaaggcggctgcatttgtgacat cccca cccctgagccctga ccca a eta etcegga eta ca tea a ctccttgctggccagcg gggatctgcagctatctgggagtgcccactgcaccttcagcactgcccagaaagcaattg ggaaggacaacttcacagccattcctgagggcaccaatggtgtggaggagcggatgtctg tcatctgggacaaggctgtggccacagggaaaatggacgaaaaccagttcgtggctgtga caagcacaaacgctgccaagatcttcaacctgtatccccgcaagggaagaatatctgtgg gttctgacagcgacctcgtcatctgggatccagatgctgtgaagatcgtctctgccaaga accaccagtctgcggcagagtacaacatctttgaagggatggagctgcgcggggctcctc tggttgtcatctgccagggcaagatcatgctggaagatggcaacctgcacgtgacccagg gggctggccgcttcataccctgcagcccgttctccgactatgtctacaagcgcattaaag cacggaggaagatggcagacctgcatgccgtcccaaggggcatgtacgatgggcctgtgt ttga cctga cca cca ccccca a aggtggca cccccgcaggctctgctcggggctctccta ctcggccgaacccacctgtgaggaatcttcatcagtcgggatttagcctgtcaggcaccc aagtggatgagggggttcgctcagccagcaagcgcatcgtggcgcccccaggcggccgtt ctaatatcacatctctgagttaagcaagccttcctcaaagagaggggcagaagcaagaag agattgttttgaagccaaaatggtacaccgatatttaagaaggaaagcgaatccaaacgg ttgtgatctaaagaatcaataagcctcaagccttatgtttctccaatgttacgctcgctt gcctagctttacgaatattgctttgttttctgtttatgcatagccttgatttgtttgact cccctccccccatttacatgcatgcaatcagacaggccactaaggtaaaagagtctgctc tatcatagtgttgagagcgtgtgtagtgctgcatcttatgacaaggggacagacaagctg ggacgtcagggaaatgaacaaaagggacgcaggttatttggggtgagtgggtggtgggag cctggagcaaggtggagggtgcagaggggctggggtagggcatgtaggagggaggtgggt gggtcaggtgagtggaaggggtgttgtatattgtgttgatgacgtacgttatttccatgg aagatagccgctgtggcagctgtcacatcaccacagctccctagggtctgccgagaaggc aggcagtctttgggttctgttctttgtcacgtcccctacaagtaaattttgtttctttga acgtttattaaaatgccaagacccaaccatttcttccacctgcttgattgtgccagtgtt tgctcaggcctctttcttagtgttgctttcaaatccttctctttcctgggttgggaaggc caggcagggacagagcaaatgacacttctcttcctcttgccctccctgcctctttggtgc tcttaaaagccagcagctgagaacatagcacaggcccacgtggtgagggcacccacagct ta a aga cgcttccttcta a a ca cggcgaggtca cctctca ctcttctgtctttgca a a cc gagaagagtggcatgcttctggcatcccaagtcaggattttagctcagatgaggcagaat gaagggcctctcttacaggcagtttgtgtttgattctctcgatcctggcacatccatgat aaataggagtttttgaaagttggttttattaggtgttccctaatttttaccgtaataggt catctcagcttatatgaaagtcaagtggggaactgggaaagccaaagtcagtcttgagca gagggagca ca ttttgtgga cctggttcca cctttcca ttcca a a cca cctgtttcccct tccattagcagaaactctgggggaactttgtgtctcagtcctagaatctccccaagtgag tggaagtgacatgatgcagtcttcctcatggggcacctgaaagaaattagtgtgggtgct tcgatctaccttgtctgtcagagttgaatatctctttccctatcatgctgcttctgaaaa ttcagttttggagcaagtcctgtgagcaagataagaatctatagaaccaagatgctcatt ttcagaagaaatatgttcaacctgggatcagacttccatgctctggggaatccaagtggt agcacctgtaaccctgtgtactaagtgctttgaagagaagagcaggcctcagacaccttt taattgcttaggagaaaccattgtctctgactgcaggtttgaataagttgaagaccagag aaaagtacacactgggctacaaaggaatttggagatagccaaggaacaggatttccccta gcaagctaccttctgttcaaatcatgaaaaaagactatttccccttagaatagggaagct tgctattttaaagctcttgtagtgcttttcttttaagggagatgtagtaaaagggaaaat gtagctcttagtttacacttcaaagatgtgggggtctttcagagaactaagaataacagt tttatgtgcagagagagtttgccagatctgaagcatatacctcattgactaggctgttac tttgggataggttgcagtaccagccacagccagcagatagaggaaaagacacacataaac tcgcttctgagcgtccacttctgcactctctgctctgctgttactcagcccctgagtctg actcatctctgcacaacctctctgtgccatgaagataagtcttccatggccaaatcggtc atccgcactgcccttgggacttccgaagtgaaccattccaccagaacctttgattctgca caagatttccttgctctgggaacaacccccaaatgcccttgggaggaacaacatgagctc

aggaagcctctctttcttcacttaccattactaactctccaagcatagaaatccctggga attgcgagaataactcccactattttaaaatttatattcagatttgtttcgtttcataag acacatcaaacaggcctatacaaaaggtttaggaaaagaaaacaatggtgagtcccggcc ctcttcgaattcactggcacctcatgcaagtgtaggaaggcacgctggatcgtctatctg attccaaagctgtcctttgccatctcatcccttggcctgccccccaaccctgaggatgcc cctgccatccccccaacctcctcatattgcctctgaacccagatggcaatccatcccggt tctctctgagggccacgggcttgggtagtggaaagggtgtttgggaaattgttaaatcag ttacccgtagtagagctatttcttgtacttctaagttttctagaagtggaaggattgtag tea tcctga a a atgggttta cttca a a a tccctcagccttgttcttca cga ctgtcta ta ctgagagtgtcatgtttccacaaagggctgacacctgagcctggattttcactcatccct gagaagccctttccagtagggtgggcaattcccaacttccttgccacaagcttcccaggc tttctcccctggaaaactccagcttgagtcccagatacactcatgggctgccctgggcag ccagcattcattgtaagttccctctttgaaaactggtgtgtgggtgttcagttctgtgtc tggtgggtatggacagacagtaatctcctgtgatctgtgctagctgtgaggcagctctgg a a cgtga agagctgtttggtttga a ccgtga a ca a a a ctgtgttttgagtttagctga ca ttaaagaaaa a agttca tea cgtga ctgtta a tgta a a cctggtta tta a a ata a eta tg aaattaccaaaaaaaaaaaaaaaaaa

>refseq | NM_0009431 NM_000943 Homo sapiens peptidylprolyl isomerase C (cyclophilin C) (PPIC), m NA. agcgcgcaggcgcagccggccggcagtcccgtcagctgtcccagagcctgtgtcgcgccc gtgccggtagcgcccgtgccggtagcgccgctgccaccgctcaccatgggcccgggtcct cggctgctgctacctctcgtgctttgcgtggggctcggcgcacttgtgttttcttcgggg gccgagggcttccgcaagcgaggcccctcggtgacggccaaggtcttctttgatgtgagg attggagacaaagatgttggcagaattgtgattggcctctttggaaaagttgtgcccaag acagtggaaaattttgttgctctagcaacaggagagaaaggatatggatataaaggaagc

aagtttcatcgtgtcatcaaggatttcatgattcaaggaggtgacatcaccactggagat

ggcactgggggtgtgagcatctatggtgagacatttccagatgagaacttcaagctgaag

cactatggcattgggtgggtcagcatggccaacgctgggcctgacaccaatggctctcag

ttcttta tea ccttga cca agccca cctggttgga eggea a a ca tgtggtgtttgga a a a

gtcattgatgggatgacagtggtgcactccatagagctccaagcaactgatgggcatgac

cgtccactcaccaactgctcgatcatcaacagtggcaagatagacgtgaaaacgcctttt

gtggttgagatcgctgattggtgacacaactggcagaaaacaaggatatgctttggcagg

ggtgtgtgtgtgtgtgtgtgtgtgtgtgtgttgtgttgtctttcaattatttgctttttt

ttttttactttctttttgtattctatcccagatcacaggaaagttataaaaatcaaaccg

tcaccctttagtttgcttgaactttagtaaaccacctgcttagggactttgaacttaaat

atatccccttcctcaagtggtgctattttaaaactaaaaaaaactttgaattggctattt

ttttaatgcaatattttttttctgaattcattatgatccccatattgggtaatgctgaac

atttatctgaaacagatgaggatattattattttgtatccaaacagaaattcagataaag

ggaaatttgactagtgtaatctgagatatgtcatagggatttctttctgacaaaagggtg

ctttgctgttctttatattaaatacttttagatcaaaaaaa

>refseq | NM_0028411 NM_002841 Homo sapiens protein tyrosine phosphatase, receptor type, G (PTP G), mRNA.

acatgttacttcctgtatggaggcatggccagtttccagccccgcgctcttcgttccttc

ccagcctgcgccggagccacaactttcaggagcatggactgaaggcgccctcgccccagc

gcccctctgagatcctttgtgttttcctccgtttcctccggccgtttctattttgggggg

ctctccgctccccctgcctctcccctccccttcccctctcgcaaacatgcctccttcctt

cccggggccctggaaggagctgcctgcctgaagcccggagacgccgcgccgcgctcagcc

ccgccgccgcccgccggctctcgggctgtgctgcgctgccgactcaagttggggatcctc

ggctgctcgccgccgccgcccgcggtccctgcctgccccaggcccggggcatcgccgccg

gccgccgactccgcgccctgcccgatcggctctctcctttttaaacggaaagcagccttt ctccgccgagaggatcgtccccagcgtggctctgcgttcccggtcactttttgagatttt ccggggggcgctcggcggcttcccggattccaaggggactcgggccgccgagcgcggggg gcccgtggagcgggcgagccggggaagcgccccggcttagcggaggctcgcacggaggca aga a ctta ttca a ca agttta cctccctgctttcctcttttcga tgtgcgttttcgga ca tgcggaggtta ctgga a ccgtgttggtgga ttttgttcctga a a a tea ccagttccgtgc tccattatgtcgtgtgcttccccgcgttgacagaaggctacgttggggccctgcacgaga atagacacggcagcgcagtgcagatccgcaggcgcaaggcttcaggcgacccgtactggg cctactctggtgcctatggtcctgagcactgggtcacgtctagtgtcagctgtgggggcc gtcaccagtctcctattgacattttagaccagtatgcgcgtgttggggaagaataccagg aactgcaactcgatggcttcgacaatgagtcttctaacaaaacctggatgaaaaacacag ggaaaacagtcgccatccttctgaaagacgactattttgtcagtggagctggtctacctg gcagattcaaagctgagaaggtggaatttcactggggccacagcaatggctcagcgggct ctgaacacagcatcaatggcaggaggtttcctgttgagatgcagattttcttttacaatc cagatgactttgacagctttcaaaccgcaatttctgagaacagaataatcggagccatgg ccatattttttcaagtcagtccgagggacaattctgcactggatcctattatccacgggt tgaagggtgtcgtacatcatgagaaggagacctttctggatcctttcgtcctccgggacc tcctgcctgcatccctgggcagctattatcggtacacaggttccttgaccacaccaccgt gtagcgaaatagtggagtggatagtcttccggagacccgtccccatctcttaccatcagc ttgaggctttttattccatcttcaccacggagcagcaagaccatgtcaagtcggtggagt atctgagaaataactttcgaccacagcagcgtctgcatgacagggtggtgtccaagtccg ccgtccgtga ctcctgga a cca cga ca tga caga cttcttaga a a a ccca ctgggga ca g aagcctctaaagtttgcagctctccacccatccacatgaaggtgcagcctctgaaccaga cggcactgcaggtgtcctggagccagccggagactatctaccacccacccatcatgaact acatgatctcctacagctggaccaagaatgaggacgagaaggagaagacgtttacaaagg acagcgacaaagacttgaaagccaccattagccatgtctcacccgatagcctttacctgt tccgagtccaggccgtgtgtcggaacgacatgcgcagcgactttagccagacgatgctgt ttcaagctaataccactcgaatattccaagggaccagaatagtgaaaacaggagtgccca cagcgtctcctgcctcttcagccgacatggcccccatcagctcggggtcttctacctgga cgtcctctggcatcccattctcatttgtttccatggcaactgggatgggcccctcctcca gtggcagccaggccacagtggcctcggtggtcaccagcacgctgctcgccggcctggggt tcggcggtggtggcatctcctctttccccagcactgtgtggcccacgcgcctcccgacgg ccgcctcagccagcaagcaggcggctaggccagtcctagccaccacagaggccttggctt ctccagggcccgatggtgattcgtcaccaaccaaggacggcgagggcaccgaggaaggag agaaggatgagaaaagcgagagtgaggatggggagcgggagcacgaggaggatggagaga aggactccgaaaagaaggagaagagtggggtgacccacgctgccgaggagcggaatcaga cggagcccagccccacaccctcgtctcctaacaggactgccgagggagggcatcagacta tacctgggcatgagcaggatcacactgccgtccccacagaccagacgggcggaaggaggg atgccggcccaggcctggaccccgacatggtcacctccacccaagtgccccccaccgcca cagaggagcagtatgcagggagtgatcccaagaggcccgaaatgccatctaaaaagccta tgtcccgcggggaccgattttctgaagacagcagatttatcactgttaatccagcggaaa aaaacacctctggaatgataagccgccctgctccagggaggatggagtggatcatccctc tgattgtggtatcagccttgaccttcgtgtgcctcatccttctcattgctgtgctcgttt actggagagggtgtaacaaaataaagtccaagggctttcccagacgtttccgtgaagtgc cttcttctggggagagaggagagaaggggagcagaaaatgttttcagactgctcatttct atgtggaagacagcagttcacctcgagtggtccctaatgaaagtatccctattattccta ttccggatgacatggaagccattcctgtcaaacagtttgtcaaacacatcggtgagctct attctaataaccagcatgggttctctgaggattttgaggaagtccagcgctgtactgctg atatgaacatcactgcagagcattccaatcatccagaaaacaagcacaaaaacagataca tcaacattttagcatatgatcacagtagggtgaagttaagacctttaccaggaaaagact ctaagcacagcgactacattaatgcaaactatgttgatggttacaacaaagcaaaagcct acattgccacccaaggacctttgaagtctacatttgaagatttctggaggatgatttggg aacaaaacactggaatcattgtgatgattacgaaccttgtggaaaaaggaagacgaaaat gtgatcagtattggccaacagagaacagtgaggaatatggaaacattattgtcacgctga agagcacaaaaatacatgcctgctacactgttcgtcgtttttcaatcagaaatacaaaag tgaaaaagggtcagaagggaaatcccaagggtcgtcagaatgaaagggtagtgatccagt atcactatacacagtggcctgacatgggagttcccgagtatgcccttccagtactgactt tcgtgaggagatcctcagcagctcggatgccagaaacgggccctgtgttggtgcactgca gtgctggtgtgggcagaacaggcacctatattgtaatagacagcatgctgcaacagataa aagacaaaagcacagttaacgtcctgggattcctgaagcatatcaggacacagcgtaact acctcgtccagactgaggagcagtacattttcatccatgatgccttgttggaagccattc ttggaaaggagactgaagtatcttcaaatcagctgcacagctatgttaacagcatcctta taccaggagtaggaggaaagacacgactggaaaagcaattcaagctggtcacacagtgta atgcaaaatatgtggaatgtttcagtgctcagaaagagtgtaacaaagaaaagaacagaa actcttcagttgtgccatctgagcgtgctcgagtgggtcttgcaccattgcctggaatga aaggaacagattacattaatgcttcttatatcatgggctattataggagcaatgaattta ttataactcagcatcctctgccacatactacgaaagatttctggcgaatgatttgggatc ataacgcacagatcattgtcatgctgccagacaaccagagcttggcagaagatgagtttg tgtactggccaagtcgagaagaatccatgaactgtgaggcctttaccgtcacccttatca gcaaagacagactgtgcctctctaatgaagaacaaattatcatccatgactttatccttg aagctacacaggatgactatgtcttagaagttcggcactttcagtgtcccaaatggccta acccagatgcccccataagtagtacctttgaacttatcaacgtcatcaaggaagaggcct taacaagggatggtcccaccattgttcatgatgagtatggagcagtttcagcaggaatgt tatgtgcccttaccaccctgtcccagcaactggagaatgaaaatgctgtggatgttttcc aggttgcaaaaatgatcaatcttatgaggcctggagtattcacagacattgaacaatacc agttcatctataaagcaatgcttagcttggtcagcactaaagaaaatggaaatggtccca tgacagtagacaaaaatggtgctgttcttattgcagatgaatcagaccctgctgagagca tggagtccctagtgtgactggaatcctgaaagggcacttaatttgtaaacttctgaagac tgagaacttttttgaggccttttttgccagactctaggttatacaataacccagttactt ttttacactgataaaagttttgatatttattttttgccattttatgtcttaatggtatcc ta ctga gcatttgca cctctgttca tttca ca cagtga a a cgca a tttta cctagtttgc actatatgatcagtgttactgcctataatcttatacaacagcaaaccctgatgtgacatt ccatgacgacatacatgctacttttttttagttcaatacagtgaaggtctttgttatgac agtgaatattgcttttattattattattgctgaagtggttgcattctactagcaggcaat gctgtacttttcttcagtcctcctctcctttttattttaggcactgttcaatactgtatg ccttctgtattttaatggagtggatagcattgttttcttttacagactagcaggctactg ggacctaaaaaggtctgttaatgtcatggccttgaaacagttccatttatgctggttaag agatcccttaagaagttagaaggcttaagaactgcttcatgtgaacatcccttattagtt acaaagttatattcacagttttttaaaaatgtgtcaaaataaaggataactctgtattac agctttcacagtagctatgtggacaatgtgttatttccattttgactctctaaaatagct acatcctaaaatcagggctatctttaacaatagcaagatagcaatattatatacaactca gttatgagaccctttagttattctccattaatgcttcttagtttgtaataccatacctca cagtaggtagaagaatgaaaacttctgcaggtgtgtaattttgaaactagtcctctaaaa attccctattactcctatagcaatctaataaaaactacctacatagttactgttttcttt ccttctttgccaaatgttttataataaatctcttaattacatacatttttctacttaaga ttaaattggaaatactgtcttagcaaaagtcttgggactatctaaactcccacacataga taaatctgatttggagagagaaatttaaaatatttaattaaaggtgatacccacattttc aagtttttaaaagagggagatggctttgtatgcttttgtgtagtttagaacagatacaca ttagtaaaagataccaataatcattagagctcaaggaagttattaggtgcagcctctgga gccatactcacgctgcagtgcataatgggaaaattaggagcattaataagaaatttcagt agtgtttgtaaggaaaataagctacttactgagatctgtttcttctattgcatgtttgct tttgagggacagcttctgtcaaaagtgaaatcatcaccagaactgggcctgttaggaaga

atagggttttatttactttttatgtcaattaacttcaacaaaaaggccacgctggctgct

gtcatgccatctgggtatgcattaaacattaatgatgatcagcactga

>refseq | NM_0134091 NM_013409 Homo sapiens follistatin (FST), transcript variant FST344, mRNA. ttgggaagggtttccagaaggtgggaaatgtcacctgattcacactgaacttttgaaagc

tccccacccccaaggagccgcgcacaccctcgctcgcggccgccctcccacagccccaca

cactgggagaccgcccaccgcaaaccgcggagacccccgtctagatttaaagcgcggctg

cgcccggcttctgacgtccattgaatcgcgcgggcggccggcggcgagcgcggggctgcg

ccgggatcgctgcgccctccgccgctggcctctgcgacgcgcgccgctcgcccgagccac

ccgccgccgcgccggctccccgcgccgctgcgctcctcgccccgcgcctgcccccaggat

ggtccgcgcgaggcaccagccgggtgggctttgcctcctgctgctgctgctctgccagtt

catggaggaccgcagtgcccaggctgggaactgctggctccgtcaagcgaagaacggccg

ctgccaggtcctgtacaagaccgaactgagcaaggaggagtgctgcagcaccggccggct

gagcacctcgtggaccgaggaggacgtgaatgacaacacactcttcaagtggatgatttt

ca a cgggggcgccccca a ctgca tcccctgta a aga a a cgtgtgaga a cgtgga ctgtgg

acctgggaaaaaatgccgaatgaacaagaagaacaaaccccgctgcgtctgcgccccgga

ttgttccaacatcacctggaagggtccagtctgcgggctggatgggaaaacctaccgcaa

tgaatgtgcactcctaaaggcaagatgtaaagagcagccagaactggaagtccagtacca

aggcagatgtaaaaagacttgtcgggatgttttctgtccaggcagctccacatgtgtggt

ggaccagaccaataatgcctactgtgtgacctgtaatcggatttgcccagagcctgcttc

ctctgagcaatatctctgtgggaatgatggagtcacctactccagtgcctgccacctgag

aaaggctacctgcctgctgggcagatctattggattagcctatgagggaaagtgtatcaa

agcaaagtcctgtgaagatatccagtgcactggtgggaaaaaatgtttatgggatttcaa

ggttgggagaggccggtgttccctctgtgatgagctgtgccctgacagtaagtcggatga

gcctgtctgtgccagtgacaatgccacttatgccagcgagtgtgccatgaaggaagctgc ctgctcctcaggtgtgctactggaagtaaagcactccggatcttgcaactccatttcgga agacaccgaggaagaggaggaagatgaagaccaggactacagctttcctatatcttctat

tctagagtggtaaactctctataagtgttcagtgttgacatagcctttgtgcaaaaaaaa aaaaaaaaaaaaagaaaaagaaaaaaagaaaaatatattgtccatactgtaaataagtgt atgcttatttatttggggggaaaactatacattaaaggacctttgtcctaaagctctctc ccaggccaccttgttactcattggacacggagaggcattcattgtgaggtctactggatg aggcccatagttgagacttgtagacatttatttatactgtgtcatgttttataatttata cataaaatgtctggttgactgtataccttgtttttgaagaaatttattcgtgaaaggaag agcagttgttatttattgtgaggtctcttgcttgtaaagtaaaagctttttttccttgta a a cca ttta agtcca ttcctta eta ttca ctca c

>refseq | NM_0062071 NM_006207 Homo sapiens platelet-derived growth factor receptor-like (PDGFRL), mRNA. acttctgccttgttatcagaggagcgaggatgtggcctgtgtgccgcctaatcatgccta gaactgtctgcacctgctgatcttttgcttctgcgaactggctgcacctgctgttctcct gctcataccctagcccgtgcttaccctaattccctgttctcctgcctcaccaccagaggc ccgggttgtctgca cagtctca ttttcca cgtta ttcctgta a tga a cccgtcctccca c ccccaccagcagttacagggctgggtgcggagaccaactctggccagacacagaggagca gca aga a cccggggca a cggtcctgtga aa a ccga a tcctcccgcttcggcgtcccagga gcccgcccctcgcccgccgcctcccctgcgtccccgccccgcgcagccgccgcgctcctg cgctccgaggtccgaggttcccgagatgaaggtctggctgctgcttggtcttctgctggt gcacgaagcgctggaggatgttactggccaacaccttcccaagaacaagcgtccaaaaga accaggagagaatagaatcaaacctaccaacaagaaggtgaagcccaaaattcctaaaat gaaggacagggactcagccaattcagcaccaaagacgcagtctatcatgatgcaagtgct gga ta a aggtcgcttccaga a a cccgccgcta ccctgagtctgctggcggggca a a ctgt agagcttcgatgtaaagggagtagaattgggtggagctaccctgcgtatctggacacctt taaggattctcgcctcagcgtcaagcagaatgagcgctacggccagttgactctggtcaa ctccacctcggcagacacaggtgaattcagctgctgggtgcagctctgcagcggctacat ctgcaggaaggacgaggccaaaacgggctccacctacatcttttttacagagaaaggaga

a ctctttgta ccttctcccagcta cttcga tgttgtcta cttga a cccgga cagacaggc tgtggttccttgtcgggtga ccgtgctgtcggcca a agtca cgctcca ca ggga a ttccc agccaaggagatcccagccaatggaacggacattgtttatgacatgaagcggggctttgt gtatctgcaacctcattccgagcaccagggtgtggtttactgcagggcggaggccggggg cagatctcagatctccgtcaagtaccagctgctctacgtggcggttcccagtggccctcc ctcaacaaccatcttggcttcttcaaacaaagtgaaaagtggggacgacatcagtgtgct ctgcactgtcctgggggagcccgatgtggaggtggagttcacctggatcttcccagggca gaaggatgaaaggcctgtgacgatccaagacacttggaggttgatccacagaggactggg acacaccacgagaatctcccagagtgtcattacagtggaagactttgagacgattgatgc aggatattacatttgcactgctcagaatcttcaaggacagaccacagtagctaccactgt tgagttttcctgacttggaaaaggaaatgtaatgaacttatggaaagcccatttgtgtac acagtcagctttggggttccttttattagtgctttgccagaggctgatgtcaagcaccac accccaaccccagcgtctcgtgagtccgacccagacatccaaactaaaaggaagtcatcc agtctattcacagaagtgttaacttttctaacagaaagcatgattttgattgcttaccta catacgtgttcctagtttttatacatgtgtaaacaattttatataatcaatcatttctat taaatgagcacgtttttgtaaaaaataaaaagtgggataagtgttaaaaaaaaaaaaaaa aaa

>refseq | NM_0047911 NM_004791 Homo sapiens integrin, beta-like 1 (with EGF-like repeat domains) (ITGBL1), m NA. accagcaccccgcccagagcagtgccgctgcccaaatcctcgcaggcagctcatcaacgc a a ttgca a ctccggctggagccccgga cctgca agcctgggtgtccgtgggtccgtctgc ccagccatctgctggtggcacctctccctcctgccgcctccctcggtgaaccccaccttg cagaagtgcagctcgcccggagcagcccaggagctcagcatgcgtcccccaggcttcagg a a cttcttgctgctggcgtcctcccttctctttgctgggttgtcagctgttcctca a age ttctcgccatctctgaggagctggccgggcgccgcctgcaggctgtcccgggccgagtcg gagcga cgctgccgcgca cctgggcagcccccgggggccgcgctgtgcca cggccggggc cgctgcgactgcggcgtctgcatctgccacgtgactgagccgggcatgttcttcgggccc ctgtgtgagtgccatgagtgggtgtgcgagacctacgacgggagcacctgtgcaggccat ggtaagtgtgactgtggcaagtgcaagtgtgaccagggatggtatggggatgcttgccag tacccaactaactgtgacttgacaaagaagaaaagtaaccaaatgtgcaagaattcacaa gacatcatctgctctaatgcaggtacatgtcactgtggcaggtgtaagtgtgataattca gatggaagtggacttgtgtatggtaaattttgtgagtgtgacgatagagaatgcatagac gatgaaacagaagaaatatgtggaggccatgggaagtgttactgtggaaactgctactgc aaggctggttggcatggagataaatgtgaattccagtgcgatatcaccccctgggaaagc aagcgaagatgcacgtctccagatggcaaaatctgcagtaacagagggacttgtgtatgt ggtgaatgtacctgtcacgatgttgatccgactggggactggggagatattcatggggac acctgtgaatgtgatgagagggactgtagagctgtctatgaccgatattctgatgacttc tgttcaggtcatggacagtgtaattgcggaagatgtgactgcaaagcaggctggtatggg aagaagtgtgagcacccacagtcctgcacgctgtcagctgaggagagcatcaggaagtgc cagggaagctcggatctgccttgctctgggaggggtaaatgtgaatgtggcaaatgcacc tgctatcctccaggagatcgccgggtgtatggcaagacttgtgagtgtgatgatcgccgc tgtgaagacctcgatggtgtggtctgtggaggccacggcacatgttcctgtggtcgctgt gtttgtgagagaggatggtttggaaagctctgccaacatccgcggaagtgtaacatgacg gaagaacaaagcaagaatctgtgtgaatcagcagatggcatattgtgctcggggaagggt tcttgtcattgtgggaagtgcatttgttctgctgaagagtggtatatttctggggagttc tgtgactgtgatgacagagactgcgacaaacatgatggtctcatttgtacagggaatgga atatgtagctgtggaaactgtgaatgctgggatggatggaatggaaatgcatgtgaaatc tggcttggctcagaatatccttaacaattacatgagagaggtctggattcttattttttc tgggccattagaacatataaatgcgaaggaaaccatgtatattcaccactaggacaggtt aaaaagaccattgtatgtttttctatttctgaattacgaatgaaatccgagtacctatta gaaatgagttatgcaaatttagatgcaaataacattagaaaaaaaagattcttccataat

taacataagtggttcctaacgagagcaatttttccacccaaaagtcatttggcaacatct acagacaattttgattgtcacactgggtcgggtaggaaggtatgctgcagacatttggtg ggtagaggccagggatgctgctgagcatcccgcagtgtacaggacagcccccaaacaagg aattatccagccccaaatgccaatagggctcagactgagaaacattgagttatatggcta ttagaaatccacattcttacacaagaaagaccatattagaatctaaggaaaacatgcata ttcacattaattaatcgatcagatttttccagaattccgtatcagtcaccattttaatat ggggacaatgaagacaagcacacaggaggtagaatatcagagtggggctggatcaagggc aaaaactggtcattaagtcatctgacattaaatcatttagccactaagttatttgtgtac tctcactttaaactcaccaaagaagattctcttaaagaaattatgaaaaatgtacaattt aacattttaaataaatagtgacagaagttgtttaaaaa

>refseq | NM_0041861 NM_004186 Homo sapiens sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F (SEMA3F), m NA. ccgcggcgccgatcccggctgaggcgcagcggcgagaggtcgcgggcagggccatggccc cggggggccgctagcgcggaccggcccaacgggagccgctccgtgccgccgccgccgccc gggcgcccaggccccgccgctgcggaagaggtttctagagagtggagcctgcttcctggg ccctaggcccctcccacaatgcttgtcgccggtcttcttctctgggcttccctactgacc ggggcctggccatccttccccacccaggaccacctcccggccacgccccgggtccggctc tcattcaaagagctgaaggccacaggcaccgcccacttcttcaacttcctgctcaacaca accgactaccgaatcttgctcaaggacgaggaccacgaccgcatgtacgtgggcagcaag gactacgtgctgtccctggacctgcacgacatcaaccgcgagcccctcattatacactgg gcagcctccccacagcgcatcgaggaatgcgtgctctcaggcaaggatgtcaacggcgag tgtggga a cttcgtcaggctca tccagccctgga a ccga a ca ca cctgta tgtgtgcggg acaggtgcctacaaccccatgtgcacctatgtgaaccgcggacgccgcgcccaggccaca ccatggacccagactcaggcggtcagaggccgcggcagcagagccacggatggtgccctc cgcccgatgcccacagccccacgccaggattacatcttctacctggagcctgagcgactc gagtcagggaagggcaagtgtccgtacgatcccaagctggacacagcatcggccctcatc aatgaggagctctatgctggtgtgtacatcgattttatgggcactgatgcagccatcttc cgcacacttggaaagcagacagccatgcgcacggatcagtacaactcccggtggctgaac gacccgtcgttcatccatgctgagctcattcctgacagtgcggagcgcaatgatgataag ctttacttcttcttccgtgagcggtcggcagaggcgccgcagagccccgcggtgtacgcc cgca tcgggcgca tttgcctga a cga tga cggtggtca ctgttgcctggtcaa ca agtgg agcacattcctgaaggcgcggctcgtctgctctgtcccgggcgaggatggcattgagact cactttgatgagctccaggacgtgtttgtccagcagacccaggacgtgaggaaccctgtc atttacgctgtctttacctcctctggctccgtgttccgaggctctgccgtgtgtgtctac tccatggctgatattcgcatggtcttcaacgggccctttgcccacaaagaggggcccaac taccagtggatgcccttctcagggaagatgccctacccacggccgggcacgtgccctggt ggaaccttcacgccatctatgaagtccaccaaggattatcctgatgaggtgatcaacttc atgcgcagccacccactcatgtaccaggccgtgtaccctctgcagcggcggcccctggta gtccgcacaggtgctccctaccgccttaccactattgccgtggaccaggtggatgcagcc gacgggcgctatgaggtgcttttcctgggcacagaccgcgggacagtgcagaaggtcatt gtgctgcccaaggatgaccaggagttggaggagctcatgctggaggaggtggaggtcttc aaggatccagcacccgtcaagaccatgaccatctcttctaagaggcaacaactctacgtg gcgtcagccgtgggtgtcacacacctgagcctgcaccgctgccaggcgtatggggctgcc tgtgctgactgctgccttgcccgggacccttactgtgcctgggatggccaggcctgctcc cgctatacagcatcctccaagaggcggagccgccggcaggacgtccggcacggaaacccc atcaggcagtgccgtgggttcaactccaatgccaacaagaatgccgtggagtctgtgcag tatggcgtggccggcagcgcagccttccttgagtgccagccccgctcgccccaagccact gttaagtggctgttccagcgagatcctggtgaccggcgccgagagattcgtgcagaggac cgcttcctgcgcacagagcagggcttgttgctccgtgcactgcagctcagcgatcgtggc ctctactcctgcacagccactgagaacaactttaagcacgtcgtcacacgagtgcagctg

catgtactgggccgggacgccgtccatgctgccctcttcccaccactgtccatgagcgcc

ccgccacccccaggcgcaggccccccaacgcctccttaccaggagttagcccagctgctg

gcccagccagaagtgggcctcatccaccagtactgccagggttactggcgccatgtgccc

cccagccccagggaggctccaggggcaccccggtctcctgagccccaggaccagaaaaag

ccccggaaccgccggcaccaccctccggacacatgaggccagctgcctgtgcctgccatg

ggccagcctagcccttgtcccttttaatataaaagatatatatatatatatatatatata

aaatatctatattctatacacaccctgcccctgcaaagacagtatttattggtgggttga

atatagcctgcctcagtggcagcatcctccaaaacttagacccatgctggtcagagacgg

cagaaaacagagcctgcctaaccaggcccagccagttggtggggccaggccaggaccaca

cagtccccagactcagctggaagtctacctgctggacagcctccgccaagatctacagga

caaagggagggagcaagccctactcggatggggcacggactgtccaccttttctgatgtg

tgttgtcagcctgtgctgtggcatagacatggatgcgaggaccactttggagactggggt

ggcctcaagagcacacagagaagggaagaaggggccatcacaggatgccagcccctgcct

gggttgggggcactcagccacgaccagccccttcctgggtatttattctctatttattgg

ggataggagaagaggcatcctgcctgggtgggacagcctcttcagccccttctcccctcc

ccgcctggcca gggcagggcca ccccactcta cctccttagctttccctgtgcca ctttg

actcagaggctgggagcatagcagaggggccaggcccaggcagagctgacgggaggcccc

agctctgaggggagggggtccgtggtagaggcctggggccggtagaggctccccagggct

cccttatgtccaccacttcaggggatgggtgtggatgtaattagctctggggggcagttg

ggtagatgggtgggggctcctggtggccttctgctgcccaggccacagccgcctttgggt

tccatcttgctaataaacactggctctgggactagaaaaaaaaaaaaaaaa

>ENA | U38276 | U38276.1 Human semaphorin III family homolog mRNA, complete cds. CTG ACTG GTG CTCCCTCTCTTTC ATCTTG G G CTGTCTG C ATGTGTCTC ATTCCCCC ACTC TCTCCTGTGCCTCCCCTCTACTCTAATAATCAGGTCCAGGTTTCTCTGTACTGGGAGAAG ACCTGTGGCTGGAGCAGGCAGGGATGCACCCTATCTGTTCCCCATTCCTCCAGGTGGGAG

GGAGAAGGAGTAACCCACTTTATTGGCCACAGATGCAGGGGAGAAAGGAGAAAGCATGCT

GGGAGCTGGAAAGAGCCCTAAGATCACCTGGTTTCTAGAGAGTGGAGCCTGCTTCCTGCC

TAGGCCCCTCCCACAATGCTTGTCGCCGGTCTTCTTCTCTGGGCTTCCCTACTGACTGGG

GCCTGGCCATCCTTCCCTACCCAGGACCACCTCCCGGCCACGCCCCGGGTACGGCTCTCA

TTCAAAGAGCTGAAGGCCACAGGCACCGCCCACTTCTTCAACTTCCTGCTCAACACAACC

GACTACCGAATCTTGCTCAAGGACGAGGACCACGACCGCATGTACGTGGGCAGCAAGGAC

TACGTGCTGTCCCTGGACCTGCACGACATCAACCGCGAGCCCCTCATTATACACTGGGCA

GCCTCCCCACAGCGCATCGAGGAATGCGTGCTCTCAGGCAAGGATGTCAACGGCGAGTGT

GGGAACTTCGTCAGGCTCATCCAGCCCTGGAACCGAACACACCTGTATGTGTGCGGGACA

GGTGCCTACAACCCCATGTGCACCTATGTGAACCGCGGACGCCGCGCCCAGGATTACATC

TTCTACCTGGAGCCTGAGCGACTCGAGTCAGGGAAGGGCAAGTGTCCGTACGATCCCAAG

CTGGACACAGCATCGGCCCTCATCAATGAGGAGCTCTATGCTGGTGTGTACATCGATTTT

ATGGGCACTGATGCAGCCATCTTCCGCACACTTGGAAAGCAGACAGCCATGCGCACGGAT

CAGTACAACTCCCGGTGGCTGAACGACCCGTCGTTCATCCATGCTGAGCTCATTCCTGAC

AGTGCGGAGAATGATGATAAGCTTTACTTCTTCTTCCGTGAGCGGTCGGCAGAGGCGCCG

CAGAGCCCCGCGGTGTACGCCCGCATCGGGCGCATTTGCCTGAACGATGACGGTGGTCAC

TGTTGCCTGGTCAACAAGTGGAGCACATTCCTGAAGGCGCGGCTCGTCTGCTCTGTCCCG

GGCGAGGATGGCATTGAGACTCACTTTGATGAGCTCCAGGACGTGTTTGTCCAGCAGACC

CAGGACGTGAGGAACCCTGTCATTTACGCTGTCTTTACCTCCTCTGGCTCCGTGTTCCGA

G G CTCTG CCGTGTGTGTCTACTCC ATG G CTG ATATTCG C ATG GTCTTC AACG G G CCCTTT

GCCCACAAAGAGGGGCCCAACTACCAGTGGATGCCCTTCTCAGGGAAGATGCCCTACCCA

CGGCCGGGCACGTGCCCTGGTGGAACCTTCACGCCATCTATGAAGTCCACCAAGGATTAT

CCTGATGAGGTGATCAACTTCATGCGCAGCCACCCACTCATGTACCAGGCCGTGTACCCT

CTGCAGCGGCGGCCCCTGGTAGTCCGCACAGGTGCTCCCTACCGCCTTACCACTATTGCC GTGGACCAGGTGGATTCAGCCGACGGGCGCTATGAGGTGCTTTTCCTGGGCACAGACCGC

GGGACAGTGCAGAAGGTCATTGTGCTGCCCAAGGATGACCAGGAGATGGAGGAGCTCATG

CTGGAGGAGGTGGAGGTCTTCAAGGATCCAGCACCCGTCAAGACCATGACCATCTCTTCT

AAGAGGCAACAACTCTACGTGGCGTCAGCCGTGGGTGTCACACACCTGAGCCTGCACCGC

TGCCAGGCGTATGGGGCTGCCTGTGCTGACTGCTGCCTTGCCCGGGACCCTTACTGTGCC

TGGGATGGCCAGGCCTGCTCCCGCTATACAGCATCCTCCAAGAGGCGGAGCCGCCGGCAG

GACGTCCGGCACGGAAACCCCATCAGGCAGTGCCGTGGGTTCAACTCCAATGCCAACAAG

AATGCCGTGGAGTCTGTGCAGTATGGCGTGGCCGGCAGCGCAGCCTTCCTTGAGTGCCAG

CCCCGCTCGCCCCAAGCCACTGTTAAGTGGCTGTTCCAGCGAGATCCTGGTGACCGGCGC

CGAGAGATTCGTGCAGAGGACCGCTTCCTGCGCACAGAGCAGGGCTTGTTGCTCCGTGCA

CTG C AG CTC AG CG ATCGTG G CCTCTACTCCTG C AC AG CC ACTG AG A AC AACTTTA AG C AC

GTCGTCACACGAGTGCAGCTGCATGTACTGGGCCGGGACGCCGTCCATGCTGCCCTCTTC

CCACCACTGTCCATGAGCGCCCCGCCACCCCCAGGCGCAGGCCCCCCAACGCCTCCTTAC

CAGGAGTTAGCCCAGCTGCTGGCCCAGCCAGAAGTGGGCCTCATCCACCAGTACTGCCAG

GGTTACTGGCGCCATGTGCCCCCCAGCCCCAGGGAGGCTCCAGGGGCACCCCGGTCTCCT

GAGCCCCAGGACCAGAAAAAGCCCCGGAACCGCCGGCACCACCCTCCGGACACATGAGGC

CAGCTGCCTGTTCTGCCATGGGCAGCCTAGCCCTTGTCCCTTTTAATATAAAAGACATAT

ATATATATATATATATATATATATAAAAATATCTATATTCTATACACACCCTGCCCCTGC

A AAG AC AGTATTT ATTG GTG G GTTG A AT AT AG CCTG CCTC AGTG G C AG C ATCCTCC A AA A

CTTAGACCCATGCTGGTCAGAGACGGCAGAAAACAGAGCCTGCCTAACCAGGCCAGCCAG

TTAGTGGGGCCAGGCCAGGACCACACAGTCCCCAGACTCAGCTGGAGTCTACCTGCTGGA

CAGGCCTTGCGCCAAGATCTACAGGACAAAGGGAGGGAGCAAGCCCTACTCGGATGGGGC

ACGGACCGTCCACCTTTCTGATGTGTGTTGTCAGCCTGTGCTGTGGCATAGACATGGATG

CGAGGACCACTTTGGAGACTGGGGTGGCCTCAAGAGCACACAGAGAAGGGAAGAAGGGGC

CATCACAGGATGCCACCCCTGCCTTGGGTTGGGGGCACTCTGCCACGACCAGCCCCTTCC TGGGTATTTATTCTCTATTTATTGGGGATAGGAGAAGAGGCATCCTGCCTGGGTGGGACA

GCCCCTTGGGCCCCTTCTCCCCTCCCCGCCTGGCCAGGGAGGGCCACCCCACTCTACCTC

CTTAGCTTTCCCTGTGCCACTTTGACTCAGAGGCTGGGAGCATAGCAGAGGCCAGGCCCA

GGCAGAGCTGACGGGAGGCCCCAGCTCTGAGGGGAGGGGGTCCGTGGTAGAGCCTGGGGC

AGGTAGAGGCTCCCCAGGGCTCCCTTATGTCCACCACTTCAGGGGATGGGTGTGGATGTA

ATTAGCTCTGGGGGGCAGTTGGGTAGATGGGTGGGGGCTCCTGGTGGCCTTCTGCTGCCC

AGGCCACAGCCGCCTTTGGGTTCCATCTTGCTAATAAACACTGGCTTTGGAACTAAAAAA

AAAAAAAAAAAA

>ENA | AF055585 I AF055585.1 Homo sapiens neurogenic extracellular slit protein Slit2 m RNA, complete cds.

TGCCCCGCGCGCTCTGCTACGGGCCCGCTGGGCCTCCGCGCCTTCTAGCTTCCGGAGCCC

ACTTTGATCGGGGCCATAATACCTATTGAGATCCCCTCTTCTGTCTTGTACCTTCGCCAC

TGGCATCGGATTTGCAGAAGCCTGCGTGGGATCAGAGGACCGCCCTCCCCACAACAACCG

GCCCCTGCATCTTAGCAGCCGTTGGAAGCCCCAGCTCTTTTACCGCCAAGTTCATCCTTG

GGAGACAGAAGACGCGTGATCTCCTCTCCGCTGCTCTTGGGGTCTCCTTGCAGCCCTGGC

CAGGCGGATTCATCCTCAGGACCTAAAGTTGCCCAAGGAGCTCCTGCTCTGCCANAGGAG

GGTGGAAAGGGCGGTGGGAGGCGTGTGCCTGAGTGGGCTCTACTGCCTTGTTCCATATTA

TTTTGTG C AC ATTTTCCCTG G C ACTCTG G GTTG CTAG CCCCGCCGGG C ACTG G G CCTC AG

ACACTGCGCGGTTCCCTCGGAGCAGCAAGCTAAAGAAAGCCCCCAGTGCCGGCGAGGAAG

GAGGCGGCGGGGAAAGATGCGCGGCGTTGGCTGGCAGATGCTGTCCCTGTCGCTGGGGTT

AGTGCTGGCGATCCTGAACAAGGTGGCACCGCAGGCGTGCCCGGCGCAGTGCTCTTGCTC

GGGCAGCACAGTGGACTGTCACGGGCTGGCGCTGCGCAGCGTGCCCAGGAATATCCCCCG

CAACACCGAGAGACTGGATTTAAATGGAAATAACATCACAAGAATTACGAAGACAGATTT

TGCTGGTCTTAGACATCTAAGAGTTCTTCAGCTTATGGAGAATAAGATTAGCACCATTGA

AAGAGGAGCATTCCAGGATCTTAAAGAACTAGAGAGACTGCGTTTAAACAGAAATCACCT

TCAGCTGTTTCCTGAGTTGCTGTTTCTTGGGACTGCGAAGCTATACAGGCTTGATCTCAG TGAAAACCAAATTCAGGCAATCCCAAGGAAAGCTTTCCGTGGGGCAGTTGACATAAAAAA

TTTGCAACTGGATTACAACCAGATCAGCTGTATTGAAGATGGGGCATTCAGGGCTCTCCG

GGACCTGGAAGTGCTCACTCTCAACAATAACAACATTACTAGACTTTCTGTGGCAAGTTT

CAACCATATGCCTAAACTTAGGACTTTTCGACTGCATTCAAACAACCTGTATTGTGACTG

CCACCTGGCCTGGCTCTCCGACTGGCTTCGCCAAAGGCCTCGGGTTGGTCTGTACACTCA

GTGTATGGGCCCCTCCCACCTGAGAGGCCATAATGTAGCCGAGGTTCAAAAACGAGAATT

TGTCTG C AGTGGTC ACC AGTC ATTTATG G CTCCTTCTTGT AGTGTTTTG C ACTG CCCTGC

CGCCTGTACCTGTAGCAACAATATCGTAGACTGTCGTGGGAAAGGTCTCACTGAGATCCC

CACAAATCTTCCAGAGACCATCACAGAAATACGTTTGGAACAGAACACAATCAAAGTCAT

CCCTCCTGGAGCTTTCTCACCATATAAAAAGCTTAGACGAATTGACCTGAGCAATAATCA

GATCTCTGAACTTGCACCAGATGCTTTCCAAGGACTACGCTCTCTGAATTCACTTGTCCT

CTATGGAAATAAAATCACAGAACTCCCCAAAAGTTTATTTGAAGGACTGTTTTCCTTACA

GCTCCTATTATTGAATGCCAACAAGATAAACTGCCTTCGGGTAGATGCTTTTCAGGATCT

CCACAACTTGAACCTTCTCTCCCTATATGACAACAAGCTTCAGACCATCGCCAAGGGGAC

CTTTTCACCTCTTCGGGCCATTCAAACTATGCATTTGGCCCAGAACCCCTTTATTTGTGA

CTGCCATCTCAAGTGGCTAGCGGATTATCTCCATACCAACCCGATTGAGACCAGTGGTGC

CCGTTGCACCAGCCCCCGCCGCCTGGCAAACAAAAGAATTGGACAGATCAAAAGCAAGAA

ATTCCGTTGTTCAGGTACAGAAGATTATCGATCAAAATTAAGTGGAGACTGCTTTGCGGA

TCTGGCTTGCCCTGAAAAGTGTCGCTGTGAAGGAACCACAGTAGATTGCTCTAATCAAAA

GCTCAACAAAATCCCGGAGCACATTCCCCAGTACACTGCAGAGTTGCGTCTCAATAATAA

TGAATTTACCGTGTTGGAAGCCACAGGAATCTTTAAGAAACTTCCTCAATTACGTAAAAT

AAACTTTAGCAACAATAAGATCACAGATATTGAGGAGGGAGCATTTGAAGGAGCATCTGG

TGTAAATGAAATACTTCTTACGAGTAATCGTTTGGAAAATGTGCAGCATAAGATGTTCAA

GGGATTGGAAAAGCCTCAAAACTTGATGTTGAGAAGCAATCGAATAACCTGTGTGGGGAA

TGACAGTTTCATAGGACTCAGTTCTGTGCGTATGCTTTCTTTGTATGATAATCAAATTAC TACAGTTGCACCAGGGGCATTTGATACTCTCCATTCTTTATCTACTCTAAACCTCTTGGC

CAATCCTTTTAACTGTAACTGCTACCTGGCTTGGTTGGGAGAGTGGCTGAGAAAGAAGAG

AATTGTCACGGGAAATCCTAGATGTCAAAAACCATACTTCCTGAAAGAAATACCCATCCA

GGATGTGGCCATTCAGGACTTCACTTGTGATGACGGAAATGATGACAATAGTTGCTCCCC

ACTTTCTCGCTGTCCTACTGAATGTACTTGCTTGGATACAGTCGTCCGATGTAGCAACAA

GGGTTTGAAGGTCTTGCCGAAAGGTATTCCAAGAGATGTCACAGAGTTGTATCTGGATGG

AAACCAATTTACACTGGTTCCCAAGGAACTCTCCAACTACAAACATTTAACACTTATAGA

CTTAAGTAACAACAGAATAAGCACGCTTTCTAATCAGAGCTTCAGCAACATGACCCAGCT

CCTCACCTTAATTCTTAGTTACAACCGTCTGAGATGTATTCCTCCTCGCACCTTTGATGG

ATTAAAGTCTCTTCGATTACTTTCTCTACATGGAAATGACATTTCTGTTGTGCCTGAAGG

TGCTTTCAATGATCTTTCTGCATTATCACATCTAGCAATTGGAGCCAACCCTCTTTACTG

TGATTGTAACATGCAGTGGTTATCCGACTGGGTGAAGTCGGAATATAAGGAGCCTGGAAT

TGCTCGTTGTGCTGGTCCTGGAGAAATGGCAGATAAACTTTTACTCACAACTCCCTCCAA

AAAATTTACCTGTCAAGGTCCTGTGGATGTCAATATTCTAGCTAAGTGTAACCCCTGCCT

ATCAAATCCGTGTAAAAATGATGGCACATGTAATAGTGATCCAGTTGACTTTTACCGATG

CACCTGTCCATATGGTTTCAAGGGGCAGGACTGTGATGTCCCAATTCATGCCTGCATCAG

TAACCCATGTAAACATGGAGGAACTTGCCACTTAAAGGAAGGAGAAGAAGATGGATTCTG

GTGTATTTGTGCTGATGGATTTGAAGGAGAAAATTGTGAAGTCAACGTTGATGATTGTGA

AGATAATGACTGTGAAAATAATTCTACATGTGTCGATGGCATTAATAACTACACATGCCT

TTGCCCACCTGAGTATACAGGTGAGTTGTGTGAGGAGAAGCTGGACTTCTGTGCCCAGGA

CCTGAACCCCTGCCAGCACGATTCAAAGTGCATCCTAACTCCAAAGGGATTCAAATGTGA

CTGCACACCAGGGTACGTAGGTGAACACTGCGACATCGATTTTGACGACTGCCAAGACAA

CAAGTGTAAAAACGGAGCCCACTGCACAGATGCAGTGAACGGCTATACGTGCATATGCCC

CGAAGGTTACAGTGGCTTGTTCTGTGAGTTTTCTCCACCCATGGTCCTCCCTCGTACCAG

CCCCTGTGATAATTTTGATTGTCAGAATGGAGCTCAGTGTATCGTCAGAATAAATGAGCC AATATGTCAGTGTTTGCCTGGCTATCAGGGAGAAAAGTGTGAAAAATTGGTTAGTGTGAA

TTTTATAAACAAAGAGTCTTATCTTCAGATTCCTTCAGCCAAGGTTCGGCCTCAGACGAA

CATAACACTTCAGATTGCCACAGATGAAGACAGCGGAATCCTCCTGTATAAGGGTGACAA

AGACCATATCGCGGTAGAACTCTATCGGGGGCGTGTTCGTGCCAGCTATGACACCGGCTC

TCATCCAGCTTCTGCCATTTACAGTGTGGAGACAATCAATGATGGAAACTTCCACATTGT

GGAACTACTTGCCTTGGATCAGAGTCTCTCTTTGTCCGTGGATGGTGGGAACCCCAAAAT

CATCACTAACTTGTCAAAGCAGTCCACTCTGAATTTTGACTCTCCACTCTATGTAGGAGG

CATGCCAGGGAAGAGTAACGTGGCATCTCTGCGCCAGGCCCCTGGGCAGAACGGAACCAG

CTTCCACGGCTGCATCCGGAACCTTTACATCAACAGTGAGCTGCAGGACTTCCAGAAGGT

GCCGATGCAAACAGGCATTTTGCCTGGCTGTGAGCCATGCCACAAGAAGGTGTGTGCCCA

TGGCACATGCCAGCCCAGCAGCCAGGCAGGCTTCACCTGCGAGTGCCAGGAAGGATGGAT

GGGGCCCCTCTGTGACCAACGGACCAATGACCCTTGCCTTGGAAATAAATGCGTACATGG

C ACCTG CTTG CCC ATC AATG CGTTCTCCT AC AG CTGTA AGTG CTTG G AG G G CC ATG G AG G

TGTCCTCTGTGATGAAGAGGAGGATCTGTTTAACCCATGCCAGGCGATCAAGTGCAAGCA

TG G G A AGTG C AG G CTTTC AG GTCTG G G G C AG CCCTACTGTG AATG C AG C AGTG GAT AC AC

GGGGGACAGCTGTGATCGAGAAATCTCTTGTCGAGGGGAAAGGATAAGAGATTATTACCA

AAAGCAGCAGGGCTATGCTGCTTGCCAAACAACCAAGAAGGTGTCCCGATTAGAGTGCAG

AGGTGGGTGTGCAGGAGGGCAGTGCTGTGGACCGCTGAGGAGCAAGCGGCGGAAATACTC

TTTCGAATGCACTGACGGCTCCTCCTTTGTGGACGAGGTTGAGAAAGTGGTGAAGTGCGG

CTGTACGAGGTGTGTGTCCTAAACACACTCCCGGCAGCTCTGTCTTTGGAAAAGGTTGTA

TACTTCTTGACCATGTGGGACTAATGAATGCTTCATAGTGGAAATATTTGAAATATATTG

TAAAATACAGAAC

>ENA | AF056085 I AF056085.1 Homo sapiens GABA-B receptor m NA, complete cds.

GCCGCCCCTGAGCAGCCTCGCCTTCGCCTCCCGCGTTTCCTGCCGTCCGCCCTCCCCCGG

CCGAGCTCCAGGGGCTGCCGCCTAGCAGCTCCCGGCGGGAGAGCGGTTCAGAGCGCGCAC GGGGGCGGGCGGAGGCGGCCCGGTGCGGGGCGGCCGCGCTGGAGAGAGGCGCGCGCGGAG

ACGCCGGCCCCCCTCTCCGCGTTTGCTCGCTTGCTCCCCGCCTCCCGCACTCCGCTCGCT

CCCACCCCTTCCCGGCGTGATTGATCCGTCACGGGCGCCGCCGCTGCCGCCGCCGCCGCG

GCCGTTCTGAGCCGAGCCGGAACCCTAGCCCGAGACGGAGCCGGGGCCCGGGCCGGCGCC

ATTGCGCGGGCGCCGCGGGAAGACCTTGGCGCGGGGCGGCGGGCCGGGCCAGGCCATGCG

GGCCGAGTGAGCCGGCGCCCGCAGCCCGCGGCGCGGCATGGCTTCCCCGCGGAGCTCCGG

GCAGCCCGGGCCGCCGCCGCCGCCGCCACCGCCGCCCGCGCGCCTGCTACTGCTACTGCT

GCTGCCGCTGCTGCTGCCTCTGGCGCCCGGGGCCTGGGGCTGGGCGCGGGGCGCCCCCCG

GCCGCCGCCCAGCAGCCCGCCGCTCTCCATCATGGGCCTCATGCCGCTCACCAAGGAGGT

GGCCAAGGGCAGCATCGGGCGCGGTGTGCTCCCCGCCGTGGAACTGGCCATCGAGCAGAT

CCGCAACGAGTCACTCCTGCGCCCCTACTTCCTCGACCTGCGGCTCTATGACACGGAGTG

CGACAACGCAAAAGGGTTGAAAGCCTTCTACGATGCAATAAAATACGGGCCGAACCACTT

GATGGTGTTTGGAGGCGTCTGTCCATCCGTCACATCCATCATTGCAGAGTCCCTCCAAGG

CTGGAATCTGGTGCAGCTTTCTTTTGCTGCAACCACGCCTGTTCTAGCCGATAAGAAAAA

ATACCCTTATTTCTTTCGGACCGTCCCATCAGACAATGCGGTGAATCCAGCCATTCTGAA

GTTGCTCAAGCACTACCAGTGGAAGCGCGTGGGCACGCTGACGCAAGACGTTCAGAGGTT

CTCTGAGGTGCGGAATGACCTGACTGGAGTTCTGTATGGCGAGGACATTGAGATTTCAGA

CACCGAGAGCTTCTCCAACGATCCCTGTACCAGTGTCAAAAAGCTGAAGGGGAATGATGT

GCGGATCATCCTTGGCCAGTTTGACCAGAATATGGCAGCAAAAGTGTTCTGTTGTGCATA

CGAGGAGAACATGTATGGTAGTAAATATCAGTGGATCATTCCGGGCTGGTACGAGCCTTC

TTGGTGGGAGCAGGTGCACACGGAAGCCAACTCATCCCGCTGCCTCCGGAAGAATCTGCT

TGCTGCCATGGAGGGCTACATTGGCGTGGATTTCGAGCCCCTGAGCTCCAAGCAGATCAA

GACCATCTCAGGAAAGACTCCACAGCAGTATGAGAGAGAGTACAACAACAAGCGGTCAGG

CGTGGGGCCCAGCAAGTTCCACGGGTACGCCTACGATGGCATCTGGGTCATCGCCAAGAC

ACTGCAGAGGGCCATGGAGACACTGCATGCCAGCAGCCGGCACCAGCGGATCCAGGACTT CAACTACACGGACCACACGCTGGGCAGGATCATCCTCAATGCCATGAACGAGACCAACTT

CTTCGGGGTCACGGGTCAAGTTGTATTCCGGAATGGGGAGAGAATGGGGACCATTAAATT

TACTCAATTTCAAGACAGCAGGGAGGTGAAGGTGGGAGAGTACAACGCTGTGGCCGACAC

ACTGGAGATCATCAATGACACCATCAGGTTCCAAGGATCCGAACCACCAAAAGACAAGAC

CATCATCCTGGAGCAGCTGCGGAAGATCTCCCTACCTCTCTACAGCATCCTCTCTGCCCT

CACCATCCTCGGGATGATCATGGCCAGTGCTTTTCTCTTCTTCAACATCAAGAACCGGAA

TCAGAAGCTCATAAAGATGTCGAGTCCATACATGAACAACCTTATCATCCTTGGAGGGAT

GCTCTCCTATGCTTCCATATTTCTCTTTGGCCTTGATGGATCCTTTGTCTCTGAAAAGAC

CTTTGAAACACTTTGCACCGTCAGGACCTGGATTCTCACCGTGGGCTACACGACCGCTTT

TGGGGCCATGTTTGCAAAGACCTGGAGAGTCCACGCCATCTTCAAAAATGTGAAAATGAA

GAAGAAGATCATCAAGGACCAGAAACTGCTTGTGATCGTGGGGGGCATGCTGCTGATCGA

CCTGTGTATCCTGATCTGCTGGCAGGCTGTGGACCCCCTGCGAAGGACAGTGGAGAAGTA

CAGCATGGAGCCGGACCCAGCAGGACGGGATATCTCCATCCGCCCTCTCCTGGAGCACTG

TG AG AAC ACCC AT ATG ACC ATCTG G CTTGG C ATCGTCTATG CCTAC AAG G G ACTTCTC AT

GTTGTTCGGTTGTTTCTTAGCTTGGGAGACCCGCAACGTCAGCATCCCCGCACTCAACGA

CAGCAAGTACATCGGGATGAGTGTCTACAACGTGGGGATCATGTGCATCATCGGGGCCGC

TGTCTCCTTCCTGACCCGGGACCAGCCCAATGTGCAGTTCTGCATCGTGGCTCTGGTCAT

CATCTTCTGCAGCACCATCACCCTCTGCCTGGTATTCGTGCCGAAGCTCATCACCCTGAG

AACAAACCCAGATGCAGCAACGCAGAACAGGCGATTCCAGTTCACTCAGAATCAGAAGAA

AGAAGATTCTAAAACGTCCACCTCGGTCACCAGTGTGAACCAAGCCAGCACATCCCGCCT

GGAGGGCCTACAGTCAGAAAACCATCGCCTGCGAATGAAGATCACAGAGCTGGATAAAGA

CTTGGAAGAGGTCACCATGCAGCTGCAGGACACACCAGAAAAGACCACCTACATTAAACA

GAACCACTACCAAGAGCTCAATGACATCCTCAACCTGGGAAACTTCACTGAGAGCACAGA

TGGAGGAAAGGCCATTTTAAAAAATCACCTCGATCAAAATCCCCAGCTACAGTGGAACAC

AACAGAGCCCTCTCGAACATGCAAAGATCCTATAGAAGATATAAACTCTCCAGAACACAT CCAGCGTCGGCTGTCCCTCCAGCTCCCCATCCTCCACCACGCCTACCTCCCATCCATCGG

AGGCGTGGACGCCAGCTGTGTCAGCCCCTGCGTCAGCCCCACCGCCAGCCCCCGCCACAG

ACATGTGCCACCCTCCTTCCGAGTCATGGTCTCGGGCCTGTAAGGGTGGGAGGCCTGGGC

CCGGGGCCTCCCCCGTGACAGAACCACACTGGGCAGAGGGGTCTGCTGCAGAAACACTGT

CGGCTCTGGCTGCGGAGAAGCTGGGCACCATGGCTGGCCTCTCAGGACCACTCGGATGGC

ACTCAGGTGGACAGGACGGGGCAGGGGGAGACTTGGCACCTGACCTCGAGCCTTATTTGT

GAAGTCCTTATTTCTTCACAAAGAAGAGGAACGGAAATGGGACGTCTTCCTTAACATCTG

CAAACAAGGAGGCGCTGGGATATCAAACTTGCAAAAAAAAAAAAAAAACAAAACAAAAAA

AAAAACTAGACAAGGAGAGAGGCACTAGAACTCCAGCTGGAAGTCACGGAGTGGCTCGAG

CAGCCTTGGGAAGAGGCAAGGAGCTTCTGAAGAAACTGCCTCTGCACACACATCACTGGC

TGTGACCCCTCAGGCTAGCCCTTCTCCACTCTGGGGGAGGAGGTGGGAAGGGCCACCAGG

CCCCCAGCTGCCAGGCCAGCTGACCCCAGCCTTCCTGGAACAGGGAGTCTGCAGGAGCGC

AGACAGGCACAGCCCTGGAGCAGGCAGGCCGAGGGCTGCGGCACTGGAGCAGGCTGACTT

ACATGCTCCACATGGGACCTGTGTCACCCAATGAGATGTTTGTTACTCTGGTAAATGCCA

CACGTTAACACAATAACACCCATTCCTGGGACCGTGGGGATTTAGGGCACGTCACTGCAG

ACACGCTCTGCAGCATTCACCGACAGTCTGTCATGCACCCACCACGTTGGCCACGTCCTT

GTGTTCCTATCGGATGCTCCCAGTAACCAGGGGGACCACCCGAGCTAATCATGGAATGTC

TGTTCCCAGCAAACACGATAAAGAAAGATTGTGCACTTTAACCTCTCTCATCAGGGCCCA

AG G G CTG GCTG G G ATTTTTTTTTTTTTTTTTTCCC ACTA ACTTTGTTTCTG ACC AA AGTG

AATTGGAGGCATTCTGCTAAAAGACATCCCCGTAGACATAGGGGAGAGAGTTGCTGGCTG

AGGGCTTCCCTTGGCTTCCAGAAGGCAGCCTTCCATCCAGACAAGCCAGTGAGCTCTCCC

CTTGGGATCACTGGGGTGATCAGTCAGCAGATTGATTCTCATTCATAAGATCATTCCTCC

CTTTAAATTGAGCCCCTAAGAGCACTGGCCTGGGAGTCAGACAGACCTGGGTTCAAGTCC

TCAGTCCCCTGCCCACTCCCTACGTGACTTTGATCAGGTCACTAGTGTCTCTCTGAGCCT

CAGTTTCCCCTCTGTAACTTGGGGTTGAACTAAAACACCTGTCCTGCCTACCTCACAAGG TCACTCTGAGGATTGAAACTTGATCTTGTCCAGGAAAGCTTTGTACCAAACAGTGAAGCC

GCCCTGATCCGTGAGGTATGAGTATGACTCTGACCTTCAGCCCTCCCTACAGCCGGGGGT

GTGGCCCAGAGAAGCTTCCAGCACAGCCCTCTACCCAGAACATCCGGGCTGGAGGGAGGC

TCCCAGTGACTTTTCTGACATTCCTAGACAGGTTCATTCTTTGCTCAAGAAAGGCCTGAA

TGACAATGTCCAGGATGTCTGCACAACTGAGCAGCTCGCTCACTCCCTAAAGAAACCTAT

TG G C AG CTTC A AC AG G C AG G C AATAATCTCTTCCC AG AACC ACTG C AGTC AG G A ATA AAC

TGTTTTCTCCACCAGGCTTTGACAAAAGGGCCCACAGGAATCTTACCAATGCCAACATTT

CAAAGCACCCTATTTCACGTAGCATAGCTTTCTGCTCCCCTTCCCCAAAGAGAGGTTATG

GAGGTACTGTAGCTTTTAGGGAAAAAAAAAATGTTAACACATCACAGGTCAAGTTGAAGT

CATTCTCTGTTTAGGCACTAAAAATCGGTGTTGTCACTCACTGTGTATTACCAGTATTTA

CTTGCTTTCTTGATTTCACCAAAACCAAATTTAATTTAAAGGACCACATTAATTTTTCAA

AGGGAAAGAGACAATTAATTGTACATAATGTATACACACACAAAAAAAAAAATACCTGTA

GAAATATTATTCCAGCATAGCAGGAAAACAAACAAAAGTATTGGACTGTCGGAGGTGAGC

CTGTGCGTCTGTAACCCTTTGTGACTCCTGAGCGTGCGCTGTCTTCTAGGTTAACTCACG

AAGTACATTCTCTGTCTTACTGATACTGTAGGTTCACCCAT I I I I I I I TAATTTCCTCGC

AAATAACAAGACCCACAGAAGTGACTCTAGCTACTTAATGGTTCTGTTCTTTTATATGCA

GCAAACACACCGTCCATTTCTGAAGAGGCTTCGGCCTGAAGGCATTTTCCAATGATGTTA

GTGCACAAAACGCTTTAAATTAGACTGGAACTGCCAGAATCAAATGTAAATGAGGAATTT

CTCGTACCCCTACTGCATGGTATCGATTTTTAATAAATTGTTGCAAATTTGTTTTTATGA

ATAAAAGGAAAAAACCTGTCGTCTTT

>ENA I AF0957841 AF095784.1 Homo sapiens GABA-B receptor R2 (GABBR2) m RNA, complete cds.

ACGGGCGGTGTGTACAAAGGGCAGGGACTTAATCAACGCAAGCTTATGACCCGCACTCCT

TGGCGCGGGGCGGCGGGCCGGGCCAGGCCATGCGGGCCGAGTGAGCCGGCGCCCGCAGCC

CGCGGCGCGGCATGGCTTCCCCGCGGAGCTCCGGGCAGCCCGGGCCGCCGCCGCCGCCGC

CACCGCCGCCCGCGCGCCTGCTACTGCTACTGCTGCTGCCGCTGCTGCTGCCTCTGGCGC CCGGGGCCTGGGGCTGGGCGCGGGGCGCCCCCCGGCCGCCGCCCAGCAGCCCGCCGCTCT

CCATCATGGGCCTCATGCCGCTCACCAAGGAGGTGGCCAAGGGCAGCATCGGGCGCGGTG

TGCTCCCCGCCGTGGAACTGGCCATCGAGCAGATCCGCAACGAGTCACTCCTGCGCCCCT

ACTTCCTCGACCTGCGGCTCTATGACACGGAGTGCGACAACGCAAAAGGGTTGAAAGCCT

TCTACGATGCGATAAAATACGGGCCGAACCACTTGATGGTGTTTGGAGGCGTCTGTCCAT

CCGTCACATCCATCATTGCAGAGTCCCTCCAAGGCTGGAATCTGGTGCAGCTTTCTTTTG

CTGCAACCACGCCTGTTCTAGCCGATAAGAAAAAATACCCTTATTTCTTTCGGACCGTCC

CATCAGACAATGCGGTGAATCCAGCCATTCTGAAGTTGCTCAAGCACTACCAGTGGAAGC

GCGTGGGCACGCTGACGCAAGACGTTCAGAGGTTCTCTGAGGTGCGGAATGACCTGACTG

GAGTTCTGTATGGCGAGGACATTGAGATTTCAGACACCGAGAGCTTCTCCAACGATCCCT

GTACCAGTGTCAAAAAGCTGAAGGGGAATGATGTGCGGATCATCCTTGGCCAGTTTGACC

AGAATATGGCAGCAAAAGTGTTCTGTTGTGCATACGAGGAGAACATGTATGGTAGTAAAT

ATCAGTGGATCATTCCGGGCTGGTACGAGCCTTCTTGGTGGGAGCAGGTGCACACGGAAG

CCAACTCATCCCGCTGCCTCCGGAAGAATCTGCTTGCTGCCATGGAGGGCTACATTGGCG

TGGATTTCGAGCCCCTGAGCTCCAAGCAGATCAAGACCATCTCAGGAAAGACTCCACAGC

AGTATGAGAGAGAGTACAACAACAAGCGGTCAGGCGTGGGGCCCAGCAAGTTCCACGGGT

ACGCCTACGATGGCATCTGGGTCATCGCCAAGACACTGCAGAGGGCCATGGAGACACTGC

ATGCCAGCAGCCGGCACCAGCGGATCCAGGACTTCAACTACACGGACCACACGCTGGGCA

GGATCATCCTCAATGCCATGAACGAGACCAACTTCTTCGGGGTCACGGGTCAAGTTGTAT

TCCGGAATGGGGAGAGAATGGAGACCATTAAATTTACTCAATTTCAAGACAGCAGGGAGG

TGAAGGTGGGAGAGTACAACGCTGTGGCCGACACACTGGAGATCATCAATGACACCATCA

GGTTCCAAGGGTCCGAACCACCAAAAGACAAGACCATCATCCTGGAGCAGCTGCGGAAGA

TCTCCCTACCTCTCTACAGCATCCTCTCTGCCCTCACCATCCTCGGGATGATCATGGCCA

GTGCTTTTCTCTTCTTCAACATCAAGAACCGGAATCAGAAGCTCATAAAGATGTCGAGTC

CATACATGAACAACCTTATCATCCTTGGAGGGATGCTCTCCTATGCTTCCATATTTCTCT TTGGCCTTGATGGATCCTTTGTCTCTGAAAAGACCTTTGAAACACTTTGCACCGTCAGGA

CCTGGATTCTCACCGTGGGCTACACGACCGCTTTTGGGGCCATGTTTGCAAAGACCTGGA

GAGTCCACGCCATCTTCAAAAATGTGAAAATGAAGAAGAAGATCATCAAGGACCAGAAAC

TGCTTGTGATCGTGGGGGGCATGCTGCTGATCGACCTGTGTATCCTGATCTGCTGGCAGG

CTGTGGACCCCCTGCGAAGGACAGTGGAGAAGTACAGCATGGAGCCGGACCCAGCAGGAC

GGGATATCTCCATCCGCCCTCTCCTGGAGCACTGTGAGAACACCCATATGACCATCTGGC

TTGGCATCGTCTATGCCTACAAGGGACTTCTCATGTTGTTCGGTTGTTTCTTAGCTTGGG

AGACCCGCAACGTCAGCATCCCCGCACTCAACGACAGCAAGTACATCGGGATGAGTGTCT

ACAACGTGGGGATCATGTGCATCATCGGGGCCGCTGTCTCCTTCCTGACCCGGGACCAGC

CC AATGTG C AGTTCTG C ATCGTG G CTCTG GTC ATC ATCTTCTG C AG C ACC ATC ACCCTCT

GCCTGGTATTCGTGCCGAAGCTCATCACCCTGAGAACAAACCCAGATGCAGCAACGCAGA

ACAGGCGATTCCAGTTCACTCAGAATCAGAAGAAAGAAGATTCTAAAACGTCCACCTCGG

TCACCAGTGTGAACCAAGCCAGCACATCCCGCCTGGAGGGCCTACAGTCAGAAAACCATC

GCCTGCGAATGAAGATCACAGAGCTGGATAAAGACTTGGAAGAGGTCACCATGCAGCTGC

AGGACACACCAGAAAAGACCACCTACATTAAACAGAACCACTACCAAGAGCTCAATGACA

TCCTCAACCTGGGAAACTTCACTGAGAGCACAGATGGAGGAAAGGCCATTTTAAAAAATC

ACCTCGATCAAAATCCCCAGCTACAGTGGAACACAACAGAGCCCTCTCGAACATGCAAAG

ATCCTATAGAAGATATAAACTCTCCAGAACACATCCAGCGTCGGCTGTCCCTCCAGCTCC

CCATCCTCCACCACGCCTACCTCCCATCCATCGGAGGCGTGGACGCCAGCTGTGTCAGCC

CCTGCGTCAGCCCCACCGCCAGCCCCCGCCACAGACATGTGCCACCCTCCTTCCGAGTCA

TGGTCTCGGGCCTGTAAGGGTGGGAGGCCTGGCCCGGGCCTCCCCCGTGACAGAACCACA

CTGGGCAGAGGGGTCTGCTGCAGAAACACTGTCGGCTCTGGCTGCGGAGAAGCTGGGCAC

C ATG G CTG G CCTCTC AG G ACC ACTCG G ATG G C ACTC AG GTG G AC AG G ACG G G G C AG G G G G

AGACTTGGCACCTGACCTCGAGCCTTATTTGTGAAGTCCTTATTTCTTCACAAAGAAGAG

GAACGGAAATGGGACGTCTTCCTTAACATCTGCAAACAAGGAGGCGCTGGGATATCAAAC >ENA | AL359052 | AL359052.1 Homo sa piens mRNA full length insert cDNA clone EUROI MAGE 1968422.

TTCCTGTGGTCGCTGTGTTTGTGAGAGAGGATGGTTTGGAAAGCTCTGCCAACATCCGCG

GAAGTGTAACATGACGGAAGAACAAAGCAAGAATCTGTGTGAATCAGCAGATGGCATATT

GTGCTCGGGGAAGGGTTCTTGTCATTGTGGGAAGTGCATTTGTTCTGCTGAAGAGTGGTA

TATTTCTGGGGAGTTCTGTGACTGTGATGACAGAGACTGCGACAAACATGATGGTCTCAT

TTGTACAGGGAATGGAATATGTAGCTGTGGAAACTGTGAATGCTGGGATGGATGGAATGG

AAATGCATGTGAAATCTGGCTTGGCTCAGAATATCCTTAACAATTACATGAGAGAGCAAT

TTTGATGACGTATTCGCTGATGCACAGACATTGGAATTCATTACATTATCTAGCCATCGT

AATACAAATGACCTTTGGATTTCTCTATCACGGCGCTTATCCTCCTATTAAGGATCAGAA

AGTTAAACTTTACGGACCACGTACGTCCCTGTCTCATATTCTTCTTTGTTGGTTTCTGTT

TAATACTTTAAAGCTGTAAAAAAAATTTAAAAAATTCCTTCTGAGCTCCCAGGCCATACA

A AAGC AACTTAAG G GTG G ATTTG G CTG G C AG CTG G G C AGTACTTTGTC AG CCTC AG CTCC

ACTG G A ACTG CCCTTG ATTCTCTATAG CTC ATC AC AA AACCTC AG GTATGTCTTATTTTT

CTTATAATCCTCTGTATGTTATTATCCTTTTTATTAACAACAACAACTACAACAAAAGTG

CTGCTCTTTTTCATAGTCTCATGTAAGAAGAGTGTCAAAAATGTCCTCGGCATTTGTTTT

CTCAGAAAAAGAATTTAGATATTGGAGAAATTATCATACCATAAAAAGTTCAAAATGTGA

TTCATCTAAAATTTTGGACAAAGATGAAAATATAGTCAGCTCTGTTCTAGTGTTCATTTA

GTTAGAAACCATAGTACCGGAACTGTATTATAGTAGAAGTTAATGGTACCTAAACTCTAA

GGAATGCTTTTTCTTTGAAAACAGAAATATTTTTACTTATTTCTGTCCACTATGTTTGTG

TGTATGTGTGTGTTTGTGTGTGTATGTGTG GTTTTG ATG CC AG C AATG C A AAC ACC AATA

TATCTATTAAGAAGTGATTGAATTTAGATTGGAAAAAATAAAATAGTTACATGTAAAGAC

ATAAACTCTTTCCTTCTTAAATGTGATTTTCAACTCTATGATAGAAACTCCCTCTAAAAA

AC AAG C AG G G C AAG AAC A A ACTTACTTGTA ATG G GTG AG AG AAA AT AAG C A AATCTC ATT

GGCTCATTCCTGTTTTTAGGAAGTTGCAGTGGGATTAATGTCAATTGGAAGGGATGCAGC AAGTTT AG AG AAG GTGTTG G C ACTA ACG CTG CTTGTTTG G C AA ATC ATC ATC ACTG AG GT

ATTCCACCCAGAGACTTTTTCAAAAAAGTCAACTAAAGTGCTAAGTCATAAGAGGAGAGC

CATTATACCCGTTGTCTTTCTGGGCTCCTTGAGTTTATCTGGATTCCAACAGCACTTGGA

AAGTACCGCCCTCCACTACCTCAAATGCAAACACAATCTCTGCCAGTAGACATTGGAATT

AGACTTAGTGAAAACCAGGAAAAAAAAAAAAAAAAAAAA

>ENA | AF095723 I AF095723.null Retired from public view on 15-FEB-2002.

N

>refseq | NM_0121931 NM_012193 Homo sapiens frizzled family receptor 4 (FZD4), mRNA. ggtgagagctgcgcagcgctggctgctggctggcctcgcggagacgccgaacggacgcgg

ccggcgccggcttgtgggctcgccgcctgcagccatgaccctcgcagcctgtccctcggc

ctcggcccgggacgtctaaaatcccacacagtcgcgcgcagctgctggagagccggccgc

tgccccctcgtcgccgcatcacactcccgtcccgggagctgggagcagcgcgggcagccg

gcgcccccgtgcaaactgggggtgtctgccagagcagccccagccgctgccgctgctacc

cccgatgctggccatggcctggcggggcgcagggccgagcgtcccgggggcgcccggggg

cgtcggtctcagtctggggttgctcctgcagttgctgctgctcctggggccggcgcgggg

cttcggggacgaggaagagcggcgctgcgaccccatccgcatctccatgtgccagaacct

cggcta ca a cgtga cca aga tgccca a cctggttgggca cga gctgcagacgga cgccga

gctgcagctgacaactttcacaccgctcatccagtacggctgctccagccagctgcagtt

cttcctttgttctgtttatgtgccaatgtgcacagagaagatcaacatccccattggccc

atgcggcggcatgtgtctttcagtcaagagacgctgtgaacccgtcctgaaggaatttgg

atttgcctggccagagagtctgaactgcagcaaattcccaccacagaacgaccacaacca

catgtgcatggaagggccaggtgatgaagaggtgcccttacctcacaaaacccccatcca

gcctggggaagagtgtcactctgtgggaaccaattctgatcagtacatctgggtgaaaag

gagcctgaactgtgtgctcaagtgtggctatgatgctggcttatacagccgctcagccaa

ggagttcactgatatctggatggctgtgtgggccagcctgtgtttcatctccactgcctt cacagtactgaccttcctgatcgattcttctaggttttcctaccctgagcgccccatcat atttctcagtatgtgctataatatttatagcattgcttatattgtcaggctgactgtagg ccgggaaaggatatcctgtgattttgaagaggcagcagaacctgttctcatccaagaagg acttaagaacacaggatgtgcaataattttcttgctgatgtacttttttggaatggccag ctcca tttggtgggtta ttctga ca ctca cttggtttttggcagca gga ctca a a tgggg tcatgaagccattgaaatgcacagctcttatttccacattgcagcctgggccatccccgc agtgaaaaccattgtcatcttgattatgagactggtggatgcagatgaactgactggctt gtgcta tgttgga a a cca a aa tctcga tgccctca ccgggttcgtggtggctcccctctt tacttatttggtcattggaactttgttcattgctgcaggtttggtggccttgttcaaaat tcggtcaaatcttcaaaaggatgggacaaagacagacaagttagaaagactgatggtcaa gattggggtgttctcagtactgtacacagttcctgcaacgtgtgtgattgcctgttattt ttatgaaatctccaactgggcactttttcggtattctgcagatgattccaacatggctgt tgaaatgttgaaaatttttatgtctttgttggtgggcatcacttcaggcatgtggatttg gtctgccaaaactcttcacacgtggcagaagtgttccaacagattggtgaattctggaaa ggtaaagagagagaagagaggaaatggttgggtgaagcctggaaaaggcagtgagactgt ggtataaggctagtcagcctccatgctttcttcattttgaaggggggaatgccagcattt tggaggaaattctactaaaagttttatgcagtgaatctcagtttgaacaaactagcaaca attaagtgacccccgtcaacccactgcctcccaccccgaccccagcatcaaaaaaccaat gattttgctgcagactttggaatgatccaaaatggaaaagccagttagaggctttcaaag ctgtgaaaaatcaaaacgttgatcactttagcaggttgcagcttggagcgtggaggtcct gcctagattccaggaagtccagggcgatactgttttcccctgcagggtgggatttgagct gtgagttggtaactagcagggagaaatattaacttttttaaccctttaccattttaaata ctaactgggtctttcagatagcaaagcaatctataaacactggaaacgctgggttcagaa aagtgttacaagagttttatagtttggctgatgtaacataaacatcttctgtggtgcgct gtctgctgtttagaactttgtggactgcactcccaagaagtggtgttagaatctttcagt gcctttgtcataaaacagttatttgaacaaacaaaagtactgtactcacacacataaggt atccagtggatttttcttctctgtcttcctctcttaaatttcaacatctctcttcttggc tgctgctgttttcttcattttatgttaatgactcaaaaaaggtatttttatagaattttt gtactgcagcatgcttaaagaggggaaaaggaagggtgattcactttctgacaatcactt aattcagaggaaaatgagatttactaagttgacttacctgacggaccccagagacctatt gcattgagcagtggggacttaatatattttacttgtgtgattgcatctatgcagacgcca gtctggaagagctgaaatgttaagtttcttggcaactttgcattcacacagattagctgt gtaatttttgtgtgtcaattacaattaaaagcacattgttggaccatgacatagtatact ca a ctga cttta a a a ctatggtca a cttca a cttgca ttctcaga a tga tagtgccttta aaaatttttttattttttaaagcataagaatgttatcagaatctggtctacttaggacaa tggagactttttcagttttataaagggaactgaggacagctaatccaactacttggtgcg taattgtttcctagtaattggcaaaggctccttgtaagatttcactggaggcagtgtggc ctggagtatttatatggtgcttaatgaatctccagaatgccagccagaagcctgattggt tagtagggaataaagtgtagaccatatgaaatgaactgcaaactctaatagcccaggtct taattgcctttagcagaggtatccaaagcttttaaaatttatgcatacgttcttcacaag ggggtacccccagcagcctctcgaaaattgcacttctcttaaaactgtaactggcctttc tcttaccttgccttaggccttctaatcatgagatcttggggacaaattgactatgtcaca ggttgctctccttgtaactcatacctgtctgcttcagcaactgctttgcaatgacattta tttattaattcatgccttaaaaaaataggaagggaagcttttttttttcttttttttttt ttcaatcacactttgtggaaaaacatttccagggactcaaaattccaaaaaggtggtcaa attctggaagtaagcatttcctcttttttaaaaatttggtttgagccttatgcccatagt ttgacatttccctttcttctttcctttttgtttttgtgtggttcttgagctctctgacat caagatgcatgtaaagtcgattgtatgttttggaaggcaaagtcttggcttttgagactg aagttaagtgggcacaggtggcccctgctgctgtgcccagtctgagtaccttggctagac tctaggtcaggctccaggagcatgagaattgatccccagaagaaccattttaactccatc tgatactccattgcctatgaaatgtaaaatgtgaactccctgtgctgcttgtagacagtt cccataactgtccacggccctggagcacgcacccaggggcagagcctgcccttactcacg ctctgctctggtgtcttgggagttgtgcagggactctggcccaggcaggggaaggaagac caggcggtaggggactggtcttgctgttagagtatagaggtttgtaatgcagttttcttc ataatgtgtcagtgattgtgtgaccaaggcagcatctagcagaaagccaggcatggagta ggtgatcgatacttgtcaatgactaaataataacaataaaagagcacttgggtgaatctg ggcacctgatttctgagttttgagttctggagctagtgttttgacaatgctttgggtttt gacatgccttttccacaaatctcttgccttttcagggcaaagtgtatttgatcagaagtg gccatttggattagtagccttagcaatgctacagggttataggcctctcctttcacattc cagacaatggagagtgtttatggtttcaggaaaagaactttgtggctgaggggtcagtta ccagtgaccttcaatcaactccatcacttcttaaatcggtatttgttaaaaaaatcagtt attttatttattgagtgccgactgtagtaaagccctgaaatagataatctctgttcttct aactgatctaggatggggacgcacccaggtctgctgaactttactgttcctctgggaaag gagcagggacctctggaattcccatctgtttcactgtctccattccataaatctcttcct gtgtgagccaccacacccagcctgggtctctctacttttaacacatctctcatccctttc ccaggattccttccaagtcagttacaggtggttttaacagaaagcatcagctctgcttcg tgacagtctctggagaaatcccttaggaagactatgagagtaggccacaaggacatgggc ccacacatctgctttggctttgccggcaattcagggcttggggtattccatgtgacttgt ataggtatatttgaggacagcatcttgctagagaaaaggtgagggttgtttttctttctc tgaaacctacagtaaatgggtatgattgtagcttcctcagaaatcccttggcctccagag attaaacatggtgcaatggcacctctgtccaacctcctttctggtagattcctttctcct gcttcatataggccaaacctcagggcaagggaacatgggggtagagtggtgctggccaga accatctgcttgagctacttggttgattcatatcctctttcctttatggagacccatttc ctga tctctgaga ctgttgctga a ctggca a ctta cttgggcctga a a ctggaga agggg tgacatttttttaatttcagagatgctttctgattttcctctcccaggtcactgtctcac ctgcactctccaaactcaggttccgggaagcttgtgtgtctagatactgaattgagattc tgttcagcaccttttagctctatactctctggctcccctcatcctcatggtcactgaatt aaatgcttattgtattgagaaccaagatgggacctgaggacacaaagatgagctcaacag tctcagccctagaggaatagactcagggatttcaccaggtcggtgcagtatttgatttct ggtgaggtgaccacagctgcagttagggaagggagccattgagcacagactttggaagga accttttttttgttgtttgtttgtttgtttgtttgtttgtttgtttgagacagggtcttg ctctgtcaccca ggctggggcgca a tggca cga tcttggctca ctgca a cctctgcctcc tgggttcaagtgattctcctgccacagcctcctgaggagctgggactacaggtgcgtgct accacgcccagctacttctgtatttttagtagagacggggtttcactgtgttggccaggc tggtctcgaactcctgacctcatgatctgcccgcctcagcctcccaaagtgctgggatta caagtgtgagccaccacacctggcctggaaggaacctcttaaaatcagtttacgtcttgt attttgttctgtgatggaggacactggagagagttgctattccagtcaatcatgtcgagt cactggactctgaaaatcctattggttcctttattttatttgagtttagagttcccttct gggtttgtattatgtctggcaaatgacctgggttatcacttttcctccagggttagatca tagatcttggaaactccttagagagcattttgctcctaccaaggatcagatactggagcc ccacataatagatttcatttcactctagcctacatagagctttctgttgctgtctcttgc catgcacttgtgcggtgattacacacttgacagtaccaggagacaaatgacttacagatc ccccgacatgcctcttccccttggcaagctcagttgccctgatagtagcatgtttctgtt tctgatgtaccttttttctcttcttctttgcatcagccaattcccagaatttccccaggc aatttgtagaggacctttttggggtcctatatgagccatgtcctcaaagcttttaaacct ccttgctctcctacaatattcagtacatgaccactgtcatcctagaaggcttctgaaaag aggggcaagagccactctgcgccacaaaggttgggtccatcttctctccgaggttgtgaa agttttcaaattgtactaataggctggggccctgacttggctgtgggctttgggaggggt aagctgctttctagatctctcccagtgaggcatggaggtgtttctgaattttgtctacct cacagggatgttgtgaggcttgaaaaggtcaaaaaatgatggccccttgagctctttgta agaaaggtagatgaaatatcggatgtaatctgaaaaaaagataaaatgtgacttcccctg

ctctgtgcagcagtcgggctggatgctctgtggcctttcttgggtcctcatgccacccca

cagctccaggaaccttgaagccaatctgggggactttcagatgtttgacaaagaggtacc

aggcaaacttcctgctacacatgccctgaatgaattgctaaatttcaaaggaaatggacc

ctgcttttaaggatgtacaaaagtatgtctgcatcgatgtctgtactgtaaatttctaat

ttatcactgtacaaagaaaaccccttgctatttaattttgtattaaaggaaaataaagtt

ttgtttgttaggtt

>refseq | NM_0219391 NM_021939 Homo sapiens FK506 binding protein 10, 65 kDa (FKBPIO), mRNA. cccgagcctctctccctggccaggccccaggtctcgcagccagggatggagatgggggga

gggggaacctagagttctttgtagtgcctccctcagactctaacacactcagcctggccc

cctcctcctattgcaaccccctcccccgctcctcccggccaggccagctcagtcttccca

gcccccattccacgtggaccagccagggcgggggtagggaaagaggacaggaagaggggg

agccagttctgggaggcggggggaaggaggttggtggcgactccctcgctcgccctcact

gccggcggtcccaactccaggcaccatgttccccgcgggcccccccagccacagcctcct

ccggctccccctgctgcagttgctgctactggtggtgcaggccgtggggagggggctggg

ccgcgccagcccggccgggggccccctggaagatgtggtcatcgagaggtaccacatccc

cagggcctgtccccgggaagtgcagatgggggattttgtgcgctaccactacaacggcac

ttttgaagatggcaagaagtttgattcaagctatgatcgcaacaccttggtggccatcgt

ggtgggtgtggggcgcctcatcactggcatggaccgaggcctcatgggcatgtgtgtcaa

cgagcggcgacgcctcattgtgcctccccacctgggctatgggagcatcggcctggcggg

gctcattccaccggatgccaccctctacttcgatgtggttctgctggatgtgtggaacaa

ggaagacaccgtgcaggtgagcacattgctgcgcccgccccactgcccccgcatggtcca

gga cggcga ctttgtccgcta cca ctaca atggca ccctgctgga cggca cctccttcga

caccagctacagtaagggcggcacttatgacacctacgtcggctctggttggctgatcaa

gggcatggaccaggggctgctgggcatgtgtcctggagagagaaggaagattatcatccc tccattcctggcctatggcgagaaaggctatgggacagtgatccccccacaggcctcgct ggtctttcacgtcctcctgattgacgtgcacaacccgaaggacgctgtccagctagagac gctggagctcccccccggctgtgtccgcagagccggggccggggacttcatgcgctacca ctacaatggctccttgatggacggcaccctcttcgattccagctactcccgcaaccacac ctacaatacctatatcgggcagggttacatcatccccgggatggaccaggggctgcaggg tgcctgcatgggggaacgccggagaattaccatccccccgcacctcgcctatggggagaa tggaactggagacaagatccctggctctgccgtgctaatcttcaacgtccatgtcattga cttccacaaccctgcggatgtggtggaaatcaggacactgtcccggccatctgagacctg caatgagaccaccaagcttggggactttgttcgataccattacaactgttctttgctgga cggca cccagctgttca cctcgca tga eta cggggccccccagga ggega ctctcggggc caacaaggtgatcgaaggcctggacacgggcctgcagggcatgtgtgtgggagagaggcg gcagctcatcgtgcccccgcacctggcccacggggagagtggagcccggggagtcccagg cagtgctgtgctgctgtttgaggtggagctggtgtcccgggaggatgggctgcccacagg eta cctgtttgtgtggca ca agga ccctcctgcca a cctgtttga aga ca tgga cctca a caaggatggcgaggtccctccggaggagttctccaccttcatcaaggctcaagtgagtga gggcaaaggacgcctcatgcctgggcaggaccctgagaaaaccataggagacatgttcca gaaccaggaccgcaaccaggacggcaagatcacagtcgacgagctcaagctgaagtcaga tgaggacgaggagcgggtccacgaggagctctgaggggcagggagcctggccaggcctga gacacagaggcccactgcgagggggacagtggcggtgggactgacctgctgacagtcacc ctccctctgctgggatgaggtccaggagccaactaaaacaatggcagaggagacatctct ggtgttccca cca ccctaga tga a a a tcca ca gca caga cctcta ccgtgtttctcttcc atccctaaaccacttccttaaaatgtttggatttgcaaagccaatttggggcctgtggag cctggggttggatagggccatggctggtcccccaccatacctcccctccacatcactgac acagctgagcttgttatccatctccccaaactttctctttctttgtacttcttgtcatcc ccactcccagccccttttcctctatgtgacagctccctaggacccctctgccttcctccc caatcctgactggctcctagggaaggggaaggctcctggagggcagccctacctctccca tgccctttgccctcctccctcgcctccagtggaggctgagctgaccctgggctgctggag

gccagactgggctgtagttagcttttcatccctaaagaaggctcctttccctaaggaacc atagaagagaggaagaaaacaaagggcatgtgtgagggaagctgcttgggtgggtgttag ggctatgaaatcttggatttggggctgaggggtgggagggagggcagagctctgcacact caaaggctaaactggtgtcagtccttttttcctttgttccaaataaaagattaaaccaat ggcaaaaa

>refseq | NM_0122591 NM_012259 Homo sapiens hairy/enhancer-of-split related with YRPW motif 2 (HEY2), mRNA. gcgtggccggcgccggctcttgcggccgagcagagttgcggcgtgggaaagagccgctag gagcagaccgcgccgccgccggagccgcgcctgcccaggcccggggagggaggaggcggg cgtcagggtgctgcgccccgctcggcgtccgagcttccggccgggctgtgccccgcgcgg tcttcgccgggatgaagcgcccctgcgaggagacgacctccgagagcgacatggacgaga ccatcgacgtggggagcgagaacaattactcggggcaaagtactagctctgtgattagat tgaattctccaacaacaacatctcagattatggcaagaaagaaaaggagagggattatag agaaaaggcgtcgggatcggataaataacagtttatctgagttgagaagacttgtgccaa ctgcttttgaaaaacaaggatctgcaaagttagaaaaagctgaaatattgcaaatgacag tggatcatttgaagatgcttcaggcaacagggggtaaaggctactttgacgcacacgctc ttgccatggacttcatgagcataggattccgagagtgcctaacagaagttgcgcggtacc tgagctccgtggaaggcctggactcctcggatccgctgcgggtgcggcttgtgtctcatc tcagcacttgcgccacccagcgggaggcggcggccatgacatcctccatggcccaccacc atcatccgctccacccgcatcactgggccgccgccttccaccacctgcccgcagccctgc tccagcccaacggcctccatgcctcagagtcaaccccttgtcgcctctccacaacttcag aagtgcctcctgcccacggctctgctctcctcacggccacgtttgcccatgcggattcag ccctccgaatgccatccacgggcagcgtcgccccctgcgtgccacctctctccacctctc tcttgtccctctctgccaccgtccacgccgcagccgcagcagccaccgcggctgcacaca gcttccctctgtccttcgcgggggcattccccatgcttcccccaaacgcagcagcagcag tggccgcggccacagccatcagcccgcccttgtcagtatcagccacgtccagtcctcagc agaccagcagtggaacaaacaataaaccttaccgaccctgggggacagaagttggagctt tttaaatttttcttgaacttcttgcaatagtaactgaatgtcctccatttcagagtcagc ttaaaacctctgcaccctgaaggtagccatacagatgccgacagatccacaaaggaacaa taaagctatttgagacacaaacctcacgagtggaaatgtggtattctcttttttttctct cccttttttgtttggttca aggcagctcggta a ctga ca tcagca a cttttga a a a cttc acacttgttaccatttagaagtttcctggaaaatatatggaccgtaccatccagcagtgc atcagtatgtctgaattggggaagtaaaatgccctgactgaattctcttgagactagatg ggacatacatatatagagagagagtgagagagtcgtgtttcgtaagtgcctgagcttagg aagttttcttctggatatataacattgcacaagggaagacgagtgtggaggataggttaa gaaaggaaagggacagaagtcttgcaataggctgcagacattttaataccatgccagaga agagtattctgctgaaaccaacaggttttactggtcaaaatgactgctgaaaataatttt caagttgaaagatctagttttatcttagtttgccttctttgtacagacatgccaagaggt gacatttagcagtgcattggtataagcaattatttcatcagttctcagattaacaagcat ttctgctctgcctgcaggcccccaggcacttttttttttggatggctcaaaatatggtgc tgctttatataaaccttacatttatatagtgcacctatgagcagttgcctaccatgtgtc caccagaggctatttaattcatgccaacttgaaaactctccagtttgtaggagtttggtt taatttattcagtttcattaggactatttttatatatttatcctcttcattttctcctaa tgatgcaacatctattcttgtcaccctttgggagaagttacatttctggaggtgatgaag caaggagggagcactaggaagagaaaagctacaatttttaaagctctttgtcaagttagt gattgcatttgatcccaaaacaagatgaatgtatgcaatgggatgtacataagttatttt tgcccatgcctaaactagtgctatgtaatggggttgtggttttgtttttttcgatttcgt ttaatgacaaaataatctcttaatatgctgaaatcaagcacgtgagagtttttgtttaaa agataagagacacagcatgtattatgcacttcatttctctactgtgtggagaaagcaata aacattatgagaatgttaaacgttatgcaaaattatacttttaaatatttgttttgaaat

tactgtacctagtcttttttgcattactttgtaacctttttctatgcaagagtctttaca

ta cca eta atta a a tga agtcctttttga eta

>refseq | NM_022454 | NM_022454 Homo sapiens SRY (sex determining region Y)-box 17 (S0X17), mRNA. gcagtgtca eta ggccggctgggggccctgggta cgctgtaga ccaga ccgega caggee

agaacacgggcggcggcttcgggccgggagacccgcgcagccctcggggcatctcagtgc

ctcactccccaccccctcccccgggtcgggggaggcggcgcgtccggcggagggttgagg

ggagcggggcaggcctggagcgccatgagcagcccggatgcgggatacgccagtgacgac

cagagccagacccagagcgcgctgcccgcggtgatggccgggctgggcccctgcccctgg

gccgagtcgctgagccccatcggggacatgaaggtgaagggcgaggcgccggcgaacagc

ggagcaccggccggggccgcgggccgagccaagggcgagtcccgtatccggcggccgatg

aacgctttcatggtgtgggctaaggacgagcgcaagcggctggcgcagcagaatccagac

ctgcacaacgccgagttgagcaagatgctgggcaagtcgtggaaggcgctgacgctggcg

gagaagcggcccttcgtggaggaggcagagcggctgcgcgtgcagcacatgcaggaccac

cccaactacaagtaccggccgcggcggcgcaagcaggtgaagcggctgaagcgggtggag

ggcggcttcctgcacggcctggctgagccgcaggcggccgcgctgggccccgagggcggc

cgcgtggccatggacggcctgggcctccagttccccgagcagggcttccccgccggcccg

ccgctgctgcctccgcacatgggcggccactaccgcgactgccagagtctgggcgcgcct

ccgctcga eggcta cccgttgccca cgcccga ca cgtccccgctgga cggcgtgga cccc

gacccggctttcttcgccgccccgatgcccggggactgcccggcggccggcacctacagc

tacgcgcaggtctcggactacgctggccccccggagcctcccgccggtcccatgcacccc

cgactcggcccagagcccgcgggtccctcgattccgggcctcctggcgccacccagcgcc

cttcacgtgtactacggcgcgatgggctcgcccggggcgggcggcgggcgcggcttccag

atgcagccgcaacaccagcaccagcaccagcaccagcaccaccccccgggccccggacag

ccgtcgccccctccggaggcactgccctgccgggacggcacggaccccagtcagcccgcc gagctcctcggggaggtggaccgcacggaatttgaacagtatctgcacttcgtgtgcaag cctgagatgggcctcccctaccaggggcatgactccggtgtgaatctccccgacagccac

ggggccatttcctcggtggtgtccgacgccagctccgcggtatattactgcaactatcct gacgtgtgacaggtccctgatccgccccagcctgcaggccagaagcagtgttacacactt cctggaggagctaaggaaatcctcagactcctgggtttttgttgttgctgttgttgtttt ttaaaaggtgtgttggcatataatttatggtaatttattttgtctgccacttgaacagtt tgggggggtgaggtttcatttaaaatttgttcagagatttgtttcccatagttggattgt caaaaccctatttccaagttcaagttaactagctttgaatgtgtcccaaaacagcttcct ccatttcctgaaagtttattgatcaaagaaatgttgtcctgggtgtgttttttcaatctt ctaaaaaataaaatctggaatcctgcttttttgctctactagtacctctgtcacactagt cttatcaaaaaccagttcttaagatcaatgttaagtttattagttaatgtaaatttctca tcctcgaaaagggtgaacataaatgcctttaaggagtatatctaaaaataaacattagga tatctaagtttgatgtaattgtttcaggaaggaaaaaagaaaagcattctggaatgagcc tacttcaagtaatcttagtttctaaaactaacagttaatattttcaattccagtatatca ctttaagtagaaggggatgtccaagtaattttggttttctaactgttgaatcataagctt gacctgccccca gaggctttttgga tgttttta tctgtgttttgcca tctcttta ca etc ctcgacattcagtttaccttaatcttcacatttttacaccttgggaagtggcaagcatcg ctgggtttaagataaaggagtcacaaaaactaatcaaaataaaatttgcattatgacaac ttttaataca

>ENA I AK0237951 AK023795.1 Homo sapiens cDNA FLJ13733 fis, clone PLACE3000147, highly similar to Homo sapiens metalloproteinase with thrombospondin type 1 motifs ADAMTSl (ADAMTSl) mRNA.

AACATGGTCATTTTTATTAAAGTAAAAAATAAGATAGTAGTAGCTCTGGACATTTGGAAA

TGTGTATGTTTGTTTACACCCTGTGAAAAGTAGACATGGTCTGCAAAAGAGCCAATCTCC

TAAATATATTTCTTTCTCTAGAAATGTTATTTTGGGACAAATGAATGAATCCCTGTTGGG

AAAAAAGAACCTGCTGCATATCATCCATATTTTATTTTATTATTAT I I I I I I TGAGATGG

AGTCTCACTCTGTCTCCCAGGCTGGAGTGGAGTGGCACAATCTCGGCTCACTGCAACTTC TGCCTCCTGGGTTCAAGCGATTCTGCTGCCTCAGCATGCCCAGTAGCTGGGATTACAGGT

G C ATG CC ACC AC ACCCG G CT AATTTTTGTATTTTAGTAG AG ACG G G GTTTC ACTATGTTG

GCCATGCTGGTCTTGAACTCCTGACCTCAAGTGATCCACCCGCCTCGGCTTCTGGAATTA

CAGGTGTGAGCCACCGCACCCAGCCATGATCCATACTTTAATGTGGGTTCTGGATTGCTT

CCTAG G CC ACGTGTTT AAC ATG CC AC ATG ATG ATG C A AAG C AGTGTG CC AG CCTTA ATG G

TGTGAACCAGGATTCCCACATGATGGCGTCAATGCTTTCCAACCTGGACCACAGCCAGCC

TTGGTCTCCTTGCAGTGCCTACATGATTACATCATTTCTGGATAATGGTCATGGGGAATG

TTTGATGGACAAGCCTCAGAATCCCATACAGCTCCCAGGCGATCTCCCTGGCACCTCGTA

CGATGCCAACCGGCAGTGCCAGTTTACATTTGGGGAGGACTCCAAACACTGCCCCGATGC

AG CC AGC AC ATGTAGC ATCTTGTG GTGT ACCG G C ACCTCTG GTG G G GTG CTG GTGTGTC A

AACCAAACACTTCCCGTGGGCGGATGGCACCAGCTGTGGAGAAGGGAAATGGTGTATCAA

CGGCAAGTGTGTGAACAAAACCGACAGAAAGCATTTTGATGTGAGTTTTTCTACTGAAAC

ACATTCAGAATTGAAAAGAACAAAGTGATGGTAAAAGATATGATACCAAGTTAAACATCC

CCATCCGTGTCCTCTAGCAGGAATGCGAGATAGCTTATTTTTAGAACTGATTCTTTGTCC

CATGTGGCTTTCTTTGATACCCTAAAAGTTCTCTTTAGATAATTCTAATGCTGATGATTT

ATGTCTCCATTTAGACGCCTTTTCATGGAAGCTGGGGAATGTGGGGGCCTTGGGGAGACT

GTTCGAGAACGTGCGGTGGAGGAGTCCAGTACACGATGAGGGAATGTGACAACCCAGTCC

CAAAGAATGGAGGGAAGTACTGTGAAGGCAAACGAGTGCGCTACAGATCCTGTAACCTTG

AGGACTGTCCAGACAATAATGGAAAAACCTTTAGAGAGGAACAATGTGAAGCACACAACG

AGTTTTCAAAAGCTTCCTTTGGGAGTGGGCCTGCGGTGGAATGGATTCCCAAGTACGCTG

G CGTCTC ACC A AAG G AC AG GTG C AAG CTC ATCTG CC A AG CC AA AG G C ATTG G CTACTTCT

TCGTTTTG C AG CCC A AG GTAGTTCGTTTTTACCTT ATTTTT ACCTA AA A ATC A AG G CCTG

G G CTTG CTACCTTTTC A AAC AATTTTTGTT AT ACTATCTTTG CTTTCC ATATTA AC AT AT

CTTCAATTTCAAATTTGAACTCCTTTTCTTTTACATTAATTGGCAACTGCCTGCTTTGAG

TTTAGTGTTTTC AGTT ATG AATG AAG CTTA AATCT AAC ACTTC AC ATG CTTG C AATTG CT CG CTATTACTCTTTTATATG C AA AG A AA AG CTTTTTG G AC AGTC AAG CG CTCCTCTGTG C

GACTAGGCTTCACATACAGCTCATAGTTAGATACATTTTATATTCACACAGTAACCAGTA

GTTTTG G AA A AT AGTCTATG C ATG GTCC A AA AT ACTTGTT ACTG G GTAACTAG C AGT AG C

AGGTGCAAACAGAATAATAGAAGTGGTAGTCTGAGTATTGATTATTTTTATGTTTGAAAA

CACATATTGAACTAGGAAAAGCATCATTTCTTTTGCTGTTTTGCTAAGGGAATACATCTG

GATCTGAGACAGAAAATGGAATTTAATGTGATTGAGATGATCGTGTGTCATTAGCACCAT

AGGCTATGAAAATATTCCCAAGTTGCAGATTCAATATTCAGCAAGTGATTTCTGAAGCAC

TTACTCTTGCCAGATACTAATTATTCTAGGCTCTGAAGATACAGCAGTAAACAAAGTGAC

AAACAGCTCTACTTTCATTGACCTTAGCTGGAGGAGACATAGGTCAATAGATAAATAATT

TTTAAAAATATCTAATTTCTTCAGATGTCTATACGTAGTACTGAAAAATATGCCAAAGTG

AAG G GTA AATG C ATG A AATG C ATA ATGTGTAG AG G GT ACTGTGTTTA ATTAG C ATG GTC A

GGAAAGTAGAGAGAAAATGTTTACACTTATCATTGCAGCATCTCCTTCCTTTGCTTGTAT

GTAACACTAGACATGTGTCC I I I I I I CAGGTTGTAGATGGTACTCCATGTAGCCCAGATT

CCACCTCTGTCTGTGTGCAAGGACAGTGTGTAAAAGCTGGTTGTGATCACATCATAGACT

CCAAAAAGAAGTTTGATAAATGTGGTGTTTGCGGGGGAAATGGATCTACTTGTAAAAAAA

TATCAGGATCAGTTACTAGTGCAAAACCTGGATATCATGATATCATCACAATTCCAACTG

GAGCCACCAACATCGAAGTGAAACAGCGGAACCAGAGGGGATCCAGGAACAATGGCAGCT

TTCTTG CC ATC AA AG CTG CTG ATG G C AC ATATATTCTT AATG GTG ACTAC ACTTTGTCC A

CCTTAGAGCAAGACATTATGTACAAAGGTGTTGTCTTGAGGTACAGCGGCTCCTCTGCGG

CATTGGAAAGAATTCGCAGCTTTAGCCCTCTCAAAGAGCCCTTGACCATCCAGGTTCTTA

CTGTGGGCAATGCCCTTCGACCTAAAATTAAATGCACCTACTTCGTAAAGAAGAAGAAGG

A ATCTTTC A ATG CTATCCCC ACTTTTTC AG C ATG G GTC ATTG A AG AGTG G G G CG A ATGTT

CTAAGTCATGTGAATTGGGTTGGCAGAGAAGACTGGTAGAATGCCGAGACATTAATGGAC

AGCCTGCTTCAGAGTGTGCAAAGGAAGTGAAGCCAGCCAGCACCAGACCTTGTGCAGACC

ATCCCTGCCCCCAGTGGCAGCTGGGGGAGTGGTCATCATGTTCTAAGACCTGTGGGAAGG GTTAAAAAAAAGAAGCTTGAAGTGTCTGTCCCTTGATGGAGGGGTGTTATCTCATGAGAG

CTGTGATCCTTTAAAGAAACCTAAACATTTCATAGACTTTTGCACAATGGCAGAATGCAG

TTAAGTGGTTTAAGTGGTGTTAGCTTTGAGGGCAAGGCAAAGAGAGGAAGGGCTGGTGCA

GGGAAAGCAAGAAGGCTGGAGGGATCCAGCGTATCTTGCCAGTAACCAGTGAGGTGTATC

AGTAAGGTGGGATTATGGGGGTAGATAGAAAAGGAGTTGAATCATCAGAGTAAACTGCCA

GTTGCAAATTTGATAGGATAGTTAGTGAGGATTATTAACCTCTGAGCAGTGATATAGCAT

AATAAAGCCCCGGGCATTATTATTATTATTTCTTTTGTTACATCTATTACAAGTTTAGAA

AAAACAAAGCAATTGTCAAAAAAAGTTAGAACTATTACAACCCCTGTTTCCTGGTACTTA

TCTAATACTTAGTATCATGGGGGTTGGGAAGTGAAAAGTAGGAGAAAAGTGAGATTTTAC

TAAGACCTGTTTTACTTTACCTCACTAACAATGGGGGGAGAAAGGAGTACAAATAGGATC

TTTGACCAGCACTGTTTATGGCTGCTATGGTTTCAGAGAATGTTTATACATTATTTCTAC

CGAGAATTAAAACTTCAGATTGTTCAACATGAGAGAAAGGCTCAGCAACGTGAAATAACG

CAAATGGCTTCCTCTTTCCT I I I I I I GGACCATCTCAGTCTTTATTTGTGTAATTCATTT

TGAGGAAAAAACAACTCCATGTATTTATTCAAGTGCATTAAAGTCTACAATGGAAAAAAA

GCAGTGAAGCATTAGATGCTGGTAAAAGCTAGAGGAGACACAATGAGCTTAGTACCTCCA

ATTTCCTTTCTTTCCTACCATGTAACCCTGCTTTGGGAATATGGATGTAAAGAAGTAACT

TGTGTCTCATGAAAATCAGTACAATCACACAAGGAGGATGAAACGCCGGAACAAAAATGA

GGTGTGTAGAACAGGGTCCCACAGGTTTGGGGACATTGAGATCACTTGTCTTGTGGTGGG

GAGGCTGCTGAGGGGTAGCAGGTCCATCTCCAGCAGCTGGTCCAACAGTCGTATCCTGGT

GAATGTCTGTTCAGCTCTTCTGTGAGAATATGATTTTTTCCATATGTATATAGTAAAATA

TGTTACTATAAATTACATGTACTTTATAAGTATTGGTTTGGGTGTTCCTTCCAAGAAGGA

CTATAGTTAGTAATAAATGCCTATAATAAC

>ENA | AF060152 | AF060152.1 Homo sapiens M ETHl protein (M ETH l) m RNA, complete cds.

TGCAGCGCCTCCTCTTAGTGACTCCGGGAGCTTCGGCTGTAGCCGGCTCTGCGCGCCCTT

CCAACGAATAATAGAAATTGTTAATTTTAACAATCCAGAGCAGGCCAACGAGGCTTTGCT CTCCCGACCCGAACTAAAGCTCCCTCGCTCCGTGCGCTGCTACGAGCGGTGTCTCCTGGG

GCTCCAATGCAGCGAGCTGTGCCCGAGGGGTTCGGAAGGCGCAAGCTGGGCAGCGACATG

GGGAACGCGGAGCGGGCTCCGGGGTCTCGGAGCTTTGGGCCCGTACCCACGCTGCTGCTG

CTCGCCGCGGCGCTACTGGCCGTGTCGGACGCACTCGGGCGCCCCTCCGAGGAGGACGAG

GAGCTAGTGGTGCCGGAGCTGGAGCGCGCCCCGGGACACGGGACCACGCGCCTCCGCCTG

CACGCCTTTGACCAGCAGCTGGATCTGGAGCTGCGGCCCGACAGCAGCTTTTTGGCGCCC

GGCTTCACGCTCCAGAACGTGGGGCGCAAATCCGGGTCCGAGACGCCGCTTCCGGAAACC

GACCTGGCGCACTGCTTCTACTCCGGCACCGTGAATGGCGATCCCAGCTCGGCTGCCGCC

CTCAGCCTCTGCGAGGGCGTGCGCGGCGCCTTCTACCTGCTGGGGGAGGCGTATTTCATC

CAGCCGCTGCCCGCCGCCAGCGAGCGCCTCGCCACCGCCGCCCCAGGGGAGAAGCCGCCG

GCACCACTACAGTTCCACCTCCTGCGGCGGAATCGGCAGGGCGACGTAGGCGGCACGTGC

GGGGTCGTGGACGACGAGCCCCGGCCGACTGGGAAAGCGGAGACCGAAGACGAGGACGAA

GGGACTGAGGGCGAGGACGAAGGGCCTCAGTGGTCGCCGCAGGACCCGGCACTGCAAGGC

GTAGGACAGCCCACAGGAACTGGAAGCATAAGAAAGAAGCGATTTGTGTCCAGTCACCGC

TATGTGGAAACCATGCTTGTGGCAGACCAGTCGATGGCAGAATTCCACGGCAGTGGTCTA

A AG C ATT ACCTTCTC ACGTTGTTTTCG GTG G C AG CC AG ATTGT AC AA AC ACCCC AG C ATT

CGTAATTCAGTTAGCCTGGTGGTGGTGAAGATCTTGGTCATCCACGATGAACAGAAGGGG

CCGGAAGTGACCTCCAATGCTGCCCTCACTCTGCGGAACTTTTGCAACTGGCAGAAGCAG

CACAACCCACCCAGTGACCGGGATGCAGAGCACTATGACACAGCAATTCTTTTCACCAGA

CAGGACTTGTGTGGGTCCCAGACATGTGATACTCTTGGGATGGCTGATGTTGGAACTGTG

TGTGATCCGAGCAGAAGCTGCTCCGTCATAGAAGATGATGGTTTACAAGCTGCCTTCACC

ACAGCCCATGAATTAGGCCACGTGTTTAACATGCCACATGATGATGCAAAGCAGTGTGCC

AGCCTTAATGGTGTGAACCAGGATTCCCACATGATGGCGTCAATGCTTTCCAACCTGGAC

C AC AG CC AG CCTTG GTCTCCTTG C AGTG CCTAC ATG ATTAC ATC ATTTCTGG ATA ATG GT

CATGGGGAATGTTTGATGGACAAGCCTCAGAATCCCATACAGCTCCCAGGCGATCTCCCT GGCACCTCGTACGATGCCAACCGGCAGTGCCAGTTTACATTTGGGGAGGACTCCAAACAC

TGCCCTGATGCAGCCAGCACATGTAGCACCTTGTGGTGTACCGGCACCTCTGGTGGGGTG

CTGGTGTGTCAAACCAAACACTTCCCGTGGGCGGATGGCACCAGCTGTGGAGAAGGGAAA

TGGTGTATCAACGGCAAGTGTGTGAACAAAACCGACAGAAAGCATTTTGATACGCCTTTT

CATGGAAGCTGGGGAATGTGGGGGCCTTGGGGAGACTGTTCGAGAACGTGCGGTGGAGGA

GTCCAGTACACGATGAGGGAATGTGACAACCCAGTCCCAAAGAATGGAGGGAAGTACTGT

GAAGGCAAACGAGTGCGCTACAGATCCTGTAACCTTGAGGACTGTCCAGACAATAATGGA

AAAACCTTTAGAGAGGAACAATGTGAAGCACACAACGAGTTTTCAAAAGCTTCCTTTGGG

AGTGGGCCTGCGGTGGAATGGATTCCCAAGTACGCTGGCGTCTCACCAAAGGACAGGTGC

AAGCTCATCTGCCAAGCCAAAGGCATTGGCTACTTCTTCGTTTTGCAGCCCAAGGTTGTA

GATGGTACTCCATGTAGCCCAGATTCCACCTCTGTCTGTGTGCAAGGACAGTGTGTAAAA

GCTGGTTGTGATCGCATCATAGACTCCAAAAAGAAGTTTGATAAATGTGGTGTTTGCGGG

GGAAATGGATCTACTTGTAAAAAAATATCAGGATCAGTTACTAGTGCAAAACCTGGATAT

CATGATATCATCACAATTCCAACTGGAGCCACCAACATCGAAGTGAAACAGCGGAACCAG

AGG G G ATCC AG G A AC AATG G C AG CTTTCTTG CC ATC AA AG CTG CTG ATG G C AC AT AT ATT

CTTAATGGTGACTACACTTTGTCCACCTTAGAGCAAGACATTATGTACAAAGGTGTTGTC

TTGAGGTACAGCGGCTCCTCTGCGGCATTGGAAAGAATTCGCAGCTTTAGCCCTCTCAAA

GAGCCCTTGACCATCCAGGTTCTTACTGTGGGCAATGCCCTTCGACCTAAAATTAAATAC

ACCTACTTCGTAAAGAAGAAGAAGGAATCTTTCAATGCTATCCCCACTTTTTCAGCATGG

GTCATTGAAGAGTGGGGCGAATGTTCTAAGTCATGTGAATTGGGTTGGCAGAGAAGACTG

GTAGAATGCCGAGACATTAATGGACAGCCTGCTTCCGAGTGTGCAAAGGAAGTGAAGCCA

GCCAGCACCAGACCTTGTGCAGACCATCCCTGCCCCCAGTGGCAGCTGGGGGAGTGGTCA

TCATGTTCTAAGACCTGTGGGAAGGGTTACAAAAAAAGAAGCTTGAAGTGTCTGTCCCAT

GATGGAGGGGTGTTATCTCATGAGAGCTGTGATCCTTTAAAGAAACCTAAACATTTCATA

GACTTTTGCACAATGGCAGAATGCAGTTAAGTGGTTTAAGTGGTGTTAGCTTTGAGGCAA GGCAAAGTGAGGAAGGGCTGGTGCAGGGAAAGCAAGAAGGCTGGAGGGATCCAGCGTATC

TTGCCAGTAACCAGTGAGGTGTATCAGTAAGGTGGGATTATGGGGGTAGATAGAAAAGGA

GTTGAATCATCAGAGTAAACTGCCAGTTGCAAATTTGATAGGATAGTTAGTGAGGATTAT

TAACCTCTGAGCAGTGATATAGCATAATAAANCCCCGGGCATTATTATTATTATTTCTTT

TGTTACATCTATTACAAGTTTAGAAAAAACAAAGCAATTGTCAAAAAAAAAAAAAAAAAA

AAAAAAAAAA

>ENA I AF2322381 AF232238.1 Homo sapiens HES-related repressor protein 1 HERPl m RNA, complete cds.

GTCGACCGCCTGCCCAGGCCCGGGGAGGGAGGAGGCGGGCGTCAGGGTGCTGCGCCCCGC

TCGGCGTCCGAGCTTCCGGCCGGGCTGTGCCCCGCGCGGTCTTCGCCGGGATGAAGCGCC

CCTGCGAGGAGACGACCTCCGAGAGCGACATGGACGAGACCATCGACGTGGGGAGCGAGA

ACAATTACTCGGGGCAAAGTACTAGCTCTGTGATTAGATTGAATTCTCCAACAACAACAT

CTCAGATTATGGCAAGAAAGAAAAGGAGAGGGATTATAGAGAAAAGGCGTCGGGATCGGA

TAAATAACAGTTTATCTGAGTTGAGAAGACTTGTGCCAACTGCTTTTGAAAAACAAGGAT

CTGCAAAGTTAGAAAAAGCTGAAATATTGCAAATGACAGTGGATCATTTGAAGATGCTTC

AGGCAACAGGGGGTAAAGGCTACTTTGACGCACACGCTCTTGCCATGGACTTCATGAGCA

TAGGATTCCGAGAGTGCCTAACAGAAGTTGCGCGGTACCTGAGCTCCGTGGAAGGCCTGG

ACTCCTCGGATCCGCTGCGGGTGCGGCTTGTGTCTCATCTCAGCACTTGCGCCACCCAGC

GGGAGGCGGCGGCCATGACATCCTCCATGGCCCACCACCATCATCCGCTCCACCCGCATC

ACTGGGCCGCCGCCTTCCACCACCTGCCCGCAGCCCTGCTCCAGCCCAACGGCCTCCATG

CCTCAGAGTCAACCCCTTGTCGCCTCTCCACAACTTCAGAAGTGCCTCCTGCCCACGGCT

CTGCTCTCCTCACGGCCACGTTTGCCCATGCGGATTCAGCCCTCCGAATGCCATCCACGG

GCAGCGTCGCCCCCTGCGTGCCACCTCTCTCCACCTCTCTCTTGTCCCTCTCTGCCACCG

TCCACGCCGCAGCCGCAGCAGCCACCGCGGCTGCACACAGCTTCCCTCTGTCCTTCGCGG

GGGCATTCCCCATGCTTCCCCCAAACGCAGCAGCAGCAGTGGCCGCGGCCACAGCCATCA

GCCCGCCCTTGTCAGTATCAGCCACGTCCAGTCCTCAGCAGACCAGCAGTGGAACAAACA ATAAACCTTACCGACCCTGGGGGACAGAAGTTGGAGCTTTTTAAATTTTTCTTGAACTTC

TTGCAATAGTAACTGAATGTCCTCCATTTCAGAGTCAGCTTAAAACCTCTGCACCCTGAA

GGTAGCCATACAGATGCCGACAGATCCACAAAGGAACAATAAAGCTATTTGAGACAC

>ENA I AI0499731 AI049973.1 an38g03.xl Gessler Wilms tumor Homo sapiens cDNA clone

I MAGE: 1700980 3', m NA sequence.

TACTTTTTAAAACATTTATATTTATATATATAAAAAAATTAAATATATATAATATATAGT

GTGTTTGAGACTAAAAATATAGTACATAATATTTTTAAAAAAAGGAAAAAAAAGTAGAAT

AGGAAAAGGTGTGAGGGACACACAGATACACATTGCTAAAAACCTACAATGGTTTGTCCT

AACAAAAATAATATCTTTTTTTCTCTTCTCTTAATTATCATCATGGATCCATTTATTTTT

GGGGTCTGGGTGGAGAAAATTCAACAGGAGCTAGAAATGGAGGTTGCAATGCCAAGAATG

GCTGGGTAGAAAATGTGACCACAGGGAGCCCTGGGCCTCTTCTGGTGAAATTGGACTTCT

CAAAATTTTCTGGGTCACTGTTGCTAACAAGATTGTGTGGAGTTTTACTGTATTGGGATT

TTGGCTGCTCTTTCCCCAGAGTTAGGGTATTCTCAGGGGGGACAGCATCTGAAGAGCTCC

AAA AG C A AAC AG AAG AG CTC AG G G CCC ATCG AT ACTC AAC A AG G CC AGTG GTTG G G G CC A

GCAAAAAACCAGGGTAGGGACAGCAGACTGGCAGGAATGAGTGACAGTTCTATGCAAATG

G AGTTATTATTATT ATTG GT ATT ATT A AT AAG G G C AG GTTTGTACC AG A ACTG CCC AGT A

TGGGCTGTGACTTCTGCGCAGCAAATATTTCTCCAGGGACCGGGCCTGAAGCTACCTCAC

AGTGATGCCAAAAAAATGGA

>ENA | BG2600871 BG260087.1 602371673F1 NI H_MGC_93 Homo sapiens cDNA clone I MAGE:4479642 5', m RNA sequence.

CAAATTCCTTTTATAAATGTTATAGAAGCAGGAAGAATAATAAACACATTTGTGAATTGT G GTTC AGTTTATTTATCTTTAG G G AAG GCTG ATC ATTTATCTTATAG C AC ATA ACCCC AG CCTCTTATTCATTATGGTTAACTTTTATAATTTATCTTATTTTATAATTTAAGAATATAG TAC ATATC AGTTG G GTTTG GTTTTG GTC ATCG AG ACT AA AAG CTCC ATC AA AAC AG AACT TTGTGTTTTCTGCTAACTTATTTAATGACACAAGTTTTAAGAGAACCACAATTCATTGAT TCACTTATTCTTTTCCCTAATTGTGAATTTTAGTGATAAATACACCTGTACTACTGAGGA AAATATTCTGACACTTCACGTGTGCAAAGTATAGAACTGACAGTGTCAGTTTCAGATTTT

GTATGTACGATTTCTGGCTTATATATCCAATGGTGCAGATTTTGAAATTTGTAAGAACAA

AATTTGTTAAGAAAAACAACTTGCTCTAGTTTTGTGACCTTGTGTACTTTTGAAATAAAA

TCAAGAAAGCAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

AAAAAG

>ENA | BF438173 | BF438173.1 7q68a03.xl NCI_CGAP_Lu 24 Homo sapiens cDNA clone I MAGE:3703205 3', m NA sequence.

TTTG G CTTTTT AA AATTTTTTTATTTTTTC ACTC ATC ATTTATTTAC AA ATAC AC ATTAT

AACTTTTATATACATTGCACATTTACATGGTAGAAAAGTACAAAACTATATATTTAAATG

AATTTATATTTTAACTTGCCATGTTTGAAAATATAAAATTGCATCAGAAAAAAGTATTAT

GAAAAGCAAGAAACTTGAACTGATAAAGCTTTGATATAACTTTTAGTGATATACTGGTTG

AAAAAGAACTAATTTAAAAGGTACAGCTGAGTAGCTTAAAGGAAACACCTAACAAAAGGT

TGAATGTGTAGCCTTCAACATCCTTTAGTCTCCTGACACCCACATCATTTCTTTGTATCT

GTAACATCTTAAAAGTACATTACTAGAATTCTAATCATCTCCTCTCTCACAAATGTCTTC

ATCATAACAAAAGAACTGAAGTAGGAGTTTCCTCAAAGATGCTTATCTTCTGTACCTTGT

ATTTGAGTCAGAGTTATAATGCCTTTTGGTCAGTCAAGGTTCCTTGTA

>ENA | H 16409 | H 16409.1 ym22h04.sl Soares infant brain IN IB Homo sapiens cDNA clone IMAGE:49055 3', m RNA sequence.

TT I I I I I I I I I GACTTTAAATGAATAAACTTTTATTCTGAATATACTGTTTTTGCCACAA

GATTTAACACAACATTTTTCTGGGATTATAAATATTTTATAACAGTATTATACAAATTTT

TACAAAATGTTTTTATCAGGCTAGGTAATTTTCACAAAAGTGTCAAGAGNAACAAAATAA

AGGGGAGAAAAGATCTATTGTTCACAAAAGCCAGTTGGCCTTTTGCATGAATGCACACCA

TTTTAATAAAAGTATTCCTAAAAGCATGATCCNACACTCATACAACACAACAAAAAGGAC

AGCTTTACTAGGTCACATTATAAACTCAACTGGCATCTACACAAGACAGTATCCCATTAG

TTTCAGTGGAATTTGAGGATAACTGTGTGAACTGGAAATAAGGTAGGATGAAGAGTTGTC

TA ATTCTTC A AA AATCTG G AATTTTTTTC AAC ACTC A AA AC ATT AT ATT N G GTT N CTCTT NACAGAAATGTACTGTGAATATTGACATCTGCTATGGGGACCAATCCAGGTTGGNTGAAA AATATTTAA ATTTTG G C AGGTG A ATG GTATTC ATCTATCTTT

>ENA | BF338870 | BF338870.1 602036126F1 NCI_CGAP_Brn64 Homo sapiens cDNA clone

I MAGE:4183999 5', m NA sequence.

ATGAAGCCTTAAGAAAAAAAAC I I I I I I TAACTTTCCCTGAAACTTTATCATTTGATAAG

TAAATTTACTTTTCAAGAAGAGTATAACCAAAGAGTAAAGATAATGTGACACTAAGTTAT

C A AT ATTTTATG A AT AC AC ATA AG G C ATA A ATTTC AG CTGTA AA AA AG CTAC ATTC A ATC

TGACTCTGGTTTTAAAACAAAACTGCTGTCATAATTATACATGATACTGCAACTTTTGGA

AGGCTAATTTGGTGGAATGTTGCCTCATCATAGAACACCATAGATCATTAAAAATTCTAT

AAAAATTTTACCAAGCTACCATATAGTTAATAAAAGGGTATACAGTCACTTTTATTTCTG

AAAATATAAAACATTGAGCCTTTCAGTGTATCTGATGCTTCTCTTNTGGTAAGGAATACT

TTTATTTCATGGATCCCAGGCAGGCATATAAAAGTTACGGAATTTATAAAATCATTTGGG

ATAATTAGAAAATGCAATTATTCATAACAGAAAAATAAAGACTTTCTAGAAAGCTTCAAA

AAAAAAAAAAACAACAAAAAAAAAAAACGAACAACAAAAAAAAAACAGAAAAAAAAAAAA

ACAACTACAACAAGAAACACGACACACCAGAAACACCAGGACAAAAACACACAAGACGCA

ACAAAAACAAACATACACACAAGACAGACAAAAAGAAAACCCGGAAGAAACAACACACAA

AAAACAGAACAAAGACAAACAATAAAACATGAAAAGAGAACACAAAACCGAGAAAAACCA

CACGGCGCCGACCAATAACACCGACCATAAAGAAAGAACCCAAAGCAGAGAAAACACAAC

ACACCGCGAGAGAAAACGAAACAACGAGAGAGACCCAGAAAAAAAAGAGAAAAGAACACA

AAAAAAACGAAACAAGCAACAAAGACAAAAACAAAACAAGAACAAAAAGAAAGCGCGCAG

CAGGCAACGACCGCCAACGGAGAGGAGGAAGCCCACAGACAACACAAAGTAGAA

>ENA I AI7420431 AI742043.1 wg38c09.xl Soares_NSF_F8_9W_OT_PA_P_Sl Homo sapiens cDNA clone I MAGE:2367376 3', m RNA sequence.

TTTTTTATAATGATAATTTTTATACTTTTATTACTTAGAAAATAATTTATATTTTTCCAT

CATTTAAACAAAGAGTAGGCCTGAGTCTCATGCCTTTTGCACAGCTTTTACCTTCAAAGA

AAGTTATCTGGGTAAGATAGGCAGGAAATATGGGGAAACTGCAAATTAACAGTCTACATA CATCTAATATGAACAGTCTGTAAGATATTCCTTTTCTTTCGTTTTACTGGGATTGCAACG

GAAAGATTTGTTCTGGGTTTTAACCAAAATAGACAGAATCGGGAATTCTATTTTTAGGAA

GTAAATACTTTCTTGAACATAATATGAGAAAATTTCTTCATTCATCAGATGAAGACTAAT

ATAGATATATCCCTGTACAGAGCTACTGTCTTCATCTTTTATTGAGAGCCAAACCAGGTC

TTATCTAAATGACAAAAAATATTACAGCTAACAAAAGCAAAAGTGGTGCTTTTATCAAGG

AAACCAATATTTTAAAGGTTAATTTAGATAGATATATAACCGGAAAGACATTTATTAGCA

TGCTGAAAATAACACTGATGACACTCAGAATACACCTGGTCTCTTAC

>ENA | BE6448091 BE644809.1 7e57e09.xl Soares_NSF_F8_9W_OT_PA_P_Sl Homo sapiens cDNA clone I MAGE:3286600 3' similar to contains element M ER37 repetitive element, m RNA sequence.

TAACCATTTGACCATGTTATATTTTAATTGGCAGAGACAAAAATGACAAGCAATTTATTT

ACATAAAACTGTACAAAAGCAAATTAAATTATGCAAAGTATTTCATAAATAGTTGGACGA

GTGTTTAATACATTTCGCCATGTTAAGCATAGTTGCGTGCATAGTGACTCATAATAAACG

ATGATAAATTGTTCTCTGCTTCACTATCAACATCCAAGTAGCAGAACAATAGTCAATGAT

TAACATTACAAACAGATCGTACCACACTGAACGCAAGTGCTTTAAACTGTAGGAAAAGTC

TGAAAGTAAACCCTAGGTAGCTGAACAAATGATGCTTCCTCCAGATGTTATCATTACACC

TTCACCTAGGTCACAACTCACAAGATTTACTATATTCATGATCATGCTCACTTTTTATTA

TTTATTTATTTATTTATTTATTTATTTATTTTTGCTTAAGGACACATTTTCTTATTTCTC

ACTGAGAGCATATACCTAAGATTATTTAGGTCTTTAGATNTCTCATGAC

>ENA I AI9633041 AI963304.1 wt61d01.xl NCI_CGAP_Panl Homo sapiens cDNA clone I MAGE:2511937 3' similar to gb:J03464 PROCOLLAGEN ALPHA 2(1) CHAI N PRECU RSOR (HUMAN), mRNA sequence.

AATGAAGTAAATATCTGTTTAATTTACAAACATCAGCAGTGTAACCGATATTAATCTGGA

GAAAGACAAAGCACACTGAATTATACATGTACATCTAATTTTCTTTGTAAAAAAAGAAGT

TTTCAGGAAGAAACATCTGCATCTTTACAGGGCACCCTGGGATTTTAATGAGGGAAGAGC

AC AGTTC ACT ATA AACC ATTATC A ATTCT AC ATTGTA ATTTAG C AG C A AAC ATGTTA AC A

TGGGAGCATTAAGATAAATAAGGGAGTTTTATTGTTTGAGGGAAAGAAAAGTCACAGTTC

TTGATATGACAGTCTTTTTATCCCCACCTCACCCCCAGAAAAGGGCAAAAAAGGTCAAGG ACATATTAATTTGCAAAAGGTCTACTTTCTAGTGTTGATTGCTACACACCATTTCGTTTC

TGTGAGGACATGTTGCAGAGGGGCCACTTCTTTCTGTACAATGACCATCTCACATACAGA

TTTCTGTTTTCCTTTCTCGGACTTTGCATACTCTCTGCAGTGTCCTGAATGAGGCCAGTA

GGTCATTGACATCAGTGATCATCTGGCCCTTCTGGTCCCCCTGGTTCTTGCTGGAAAGAA

GGGCTTCGTGTTCCTCGTGTGACCAAGGTCAGTTGGCCGAACTTGAGAAGAAGGTGCAGT

>ENA I AW0061821 AW006182.1 wz93c05.xl NCI_CGAP_Brn25 Homo sapiens cDNA clone I MAGE:2566376 3', m NA sequence.

GGGTAGTCTTTCCTCTGTTTACTCTTTACTTCATTTGATCAATTCCAA I I I I I I TCATAA

TGCCATTATTATTGAGGGAAGGGGAGTAACTTCAAGGTAATCCAGAGAGAAGCAAATGCA

ATACAGTTCTGACTGAGATGCAGATTCCTTTTTGTTAAATGCTGACTGTGTCCTTGGTTT

CCCATTCACCTGGGAAGTAGAAGAATAAAAATCATTCCATAGTTCCATCCAAGGAGGGCA

GCTGCAACAGTGTGCTCTTGAGCAGGCTGTCTGGGTCATCAGGAAAAGCCATTCCAGTTA

CTCACGCATTCTCTGAGAAACCTTGTCATCTCTGCCATCTGTCTCTGTGTAGGAACTGCC

A AAGTCCTTCG GTTCCCC ATCTC AA ATA AG C AGTG C ATG G GTTACTTCCCTC ATTCTA AT

CCTTCAGTCCCTCCTTGTGTCCGTTTGGATCTTCCAGGAAGCAGCTTTCAAGATGGAGTT

AGAAGTACGAGTAATGAGGGGTGATTACCGTGAAAGATAAAGGGGA

>ENA | AB037820 | AB037820.1 Homo sapiens m RNA for KIAA1399 protein, partial cds.

CCCACCTCGGCCACACTGCTTCGCTCCCCCCTCCCCACCTTCAGCTGGCACCGCAAACAA

GCCTTACCTCGTTGCATCTGCGAGGAGAGGTAGCAACAGCGAGCCTAGCCAGCCAGAGGC

GGTGGAGAGGAGGAAGGGGCGGGGTGGGGGGGCAGAGAGCGGGCCGAGGCCGCCCTTGGT

GGGGGTAGCGGGGGCAGAGCTGCCGAGCAGACCCGGCAGCCGCCCTCCTCCGCCCCCACC

CTCCAGAAGCACTCTTGCCTGAGAACCGAATTATTCCACTAGTATTATTTCATTTTTTAT

TACTCCCCCTCCTCACTCCCCAGCCGCCCCCACCCCCACGCCGGCCTCGCCTCTGGTTGC

ATGGCAGCGCTGCCCGGGCGCGGGGGCTCAGGGCTGGCCCCCAGGGAAGGGGGAGGAGGA

GGAGGATCATGAAGGCCGGAGTCGCGACCGCGCCGGACGGCGGGCAGCAGCCAGAGGACG AGCCGGAGCAGCCCCCGCCCCGGAGACACCCGGACGCCGAGCAGCAGTCGCCTCCGCCGC

CGCAGCAGCAGCTGCGGGCGCGGGCCGACCCGGAGCCGGAGGAGGAGGGCGACCGCGACC

CAGAGGAGGAAGAGGAGGAGAAGGCGAGGCCACTCGCCCGCCCGGACCTGCCCTTCTCTC

GGCTCTTGCCCCTCGACCGAAGGGACCTTTGATGGAACCGAGGGGAGGGCGCCACGGATT

TGCCGACTGCAGCAGGGGTGGGCTGGGGGCTGAGATAATGTAACCACTCCTTTCTCCTGT

TCTCTCCCACACGCCCCTCTCCTCTACCCCTATTCTCTGCTCCACTGCCCTCTCACCCCG

GTACACACACCCTTCCTCTAGCCAGGATCTTCATGCTCAGGAAGGAGGCGCCTCTGCAAG

GGTTAAACGATCTTTTCTTTTTCTCCCATCCTTTTTCCTTCCCAAACCTCTATTTTACCT

CCCTTCTCCTAATTGGCTTTCCCCTCTTCGGTGTAACCCTTTGGCTGCGGAGGCAAAGCA

CAAGCCCCTAGCCCAGTTTCACCTGCAACACCCCTCCCCCACCCAACTGCTCTCTTAAAA

GCAACTCTGGTGCTTCTGGGGGTTAATTGCCCCAGTTTTCTGCCCAGGAGAATTAAAACT

TCTCCCAATCTTCTCTCCTCCCCTACCTTGACTCCCCCAACCCCTACCACCTGAGAAAAA

CGATCTTTTCTCTCTCACACATGCAGTCCTCAATTCTTCATTGAGCTAGTTTTCTCTAAG

CCCAGCTCAATCCACTCCAGATTTGATTTACAATTGTCCCCACCCTTTTATATAAAAGAA

AGATTTCTCACTGCGTAGGAATTTGAGAAGAACCCAATAATCCTTTCCTGGGGAACTTTT

AAACAATTCGACATTGATTTAAACAATTCGACAGAGGCTCTAGTGGCCCCTCCACCACGC

TTCTTCAATCCCTCTGCTCCTACCAGTGTCCTCAGGTCAAAAGCAGAAAGGAGACACACT

GAACAAAGTTGGAGGTTGGGGTGGGTGTGTGAGGGCAAGAAAAAC I I I I I I GTTATTGGG

CTTTCCAGGTGGAGTTCAGAACCAGTGACTCACACTTCTCAGTCCTGGGAGCAATTTATT

TGCTACTTGGAGGGGTTGTAAGAAAAGCCAGTGAGAAAGCAGACTCCCCCCACAACACAG

ATCCACTGTGGACCCCCAAAACCTGTCCTGTCCCCCTCTTTTAAGACTCCAGCCACCCCT

CTTGGGCTCTCTACTTCCACGGGGCACATGCTGATGCCCCTGTGTGGGCTGCTCTGGTGG

TGGTGGTGCTGCTGCTCCGGCTGGTACTGCTATGGATTGTGTGCCCCAGCCCCCCAGATG

TTGCGCCACCAGGGTCTCCTCAAGTGCCGCTGCCGCATGCTCTTCAATGACCTGAAGGTT

TTCTTACTGCGGCGCCCTCCTCAAGCGCCCCTGCCCATGCACGGCGACCCCCAGCCCCCC GGTTTGGCGGCCAACAACACCCTTCCGGCTCTGGGCGCCGGGGGGTGGGCAGGCTGGAGG

GGCCCCCGAGAAGTGGTGGGCAGGGAGCCCCCTCCTGTGCCACCTCCACCCCCCTTGCCA

CCTTCTTCTGTGGAAGATGACTGGGGTGGCCCAGCCACAGAGCCACCTGCCTCGCTGCTC

AGCAGTGCCTCCTCAGATGACTTCTGTAAGGAGAAGACCGAGGATCGCTACTCACTGGGC

AGCAGCTTGGACAGTGGTATGAGGACCCCACTCTGCCGCATCTGCTTCCAGGGGCCAGAA

CAGGGGGAGCTGCTGAGCCCATGCCGCTGTGATGGCTCGGTCAAGTGCACACACCAGCCT

TGCCTCATCAAGTGGATCAGCGAGCGGGGCTGCTGGAGCTGCGAGCTGTGCTACTACAAG

TACCACGTCATCGCCATAAGCACAAAAAATCCTCTGCAGTGGCAGGCCATCTCTCTGACG

GTCATTGAGAAGGTTCAGGTTGCAGCCGCCATCCTGGGCTCCCTCTTCCTCATCGCCAGT

ATTTCTTGGCTCATCTGGTCAACTTTCAGCCCCTCGGCAAGATGGCAGCGCCAAGACCTT

CTCTTCCAGATCTGCTACGGGATGTATGGCTTCATGGACGTGGTGTGCATAGGTCTCATC

ATCCATGAAGGACCCTCGGTGTACCGCATCTTTAAACGGTGGCAGGCTGTCAACCAGCAG

TGGAAAGTGCTGAACTATGACAAGACAAAAGACCTGGAGGATCAAAAGGCAGGAGGCAGG

ACCAACCCCCGGACCTCCTCATCCACCCAGGCCAATATCCCCTCCTCGGAAGAGGAGACC

GCAGGCACCCCTGCCCCTGAGCAGGGCCCTGCCCAGGCTGCCGGCCACCCCTCAGGCCCT

CTGTCCCATCACCACTGTGCTTATACCATCCTGCACATCCTGAGTCACTTGAGACCTCAT

GAACAGCGAAGTCCCCCAGGCAGCAGCCGAGAGCTGGTCATGAGAGTCACGACAGTGTGA

GAGCAGAGGCCCGGAAGGAAGGCCATGACCACCACTGAGGGCCCGGAGCAGGGTGGGGAG

GTGCAGTGGCACCCCCGGAGCCAACAGAGGGAGCAGGCAGAGGGTGGGGGACCTGGCGGG

AGCCCTGGGGTAGTGTCAGAGCGGGAGTGAGGCTGGTGCAGGAGCAGTTCTGCTATTTCC

AATCAGTCAATGCCACTCTCCACAACAACAATGAAAACCAACACCAACTCAACAACAAAG

TGCAATACAGGCTGAACCTGGCCCAACAGAAAAACCCTGCCCCAATGCACCTGCAGGCAA

GGTACCCGAAGAAGCAGAGGCTGAGGGCAGGCAAAGCCTGTGTGACTGTGGCAGTGCCGG

AGGCCAAGGGGGCCAAGAGGAAAAGCATCTGTGGTCTGCCCTGCTCTCACCCTGTTTGGT

TTTGTTTCTCCTGGGGCTGTGTTCTGCAGGCAGCCAGAAAAGGAGGAGGCACGGGTGAGC TGGCAGGGACACACTGCCTTTGGGGCTCCTGGGCTCATTTGGATGAGCAAGATTCGCTGA

CAAATGGCTGTGGGGATGGTGGGGTGGATGGTCAGGGAGGGATCCTCAGGGAGGGATATG

CTGGTGTGAGCAGCCAGAGGGAGAGTGTGTCTCCTTCCTGAAGGAACTTCCAAATGGAAC

TCCCGATTTCAGGTGGGCTAAAAGAGGGCTTAGGTTTGGAAAAGGGTGTCCTTCTGTGCC

CTTGTTAATTTATTTTATAGTGATTTGGTTCAAAGATGTTTACAGGACACACACACACAC

ACACACACACACACACACACACACACACCCCTAGAGAAAAGTACAGATTTCCAGTGGATA

TTTCAAGCACAGTTCTGCTGCTGTGGCTTCAGCTTTGGAAGCTGTCAATCCCGGAGCAAC

TTTCCCAACTACCCAACCCCACCATGGCCAGGACATGTGCAATGCCAGCCCCTTCTTGTC

TTGGCACATGCACAGACCCAGTCCCCTCACGGTAGGGCACCCCTGACCTACGGGCTTCCA

AGAGAGCAGCTGCAGTGGTTGGGAGGAGCTTGACCAGTGTGCCCCAAGGAGTGGAGTAGA

GCCCAATCTAAGTATTCCTTGCTGCTTGGAACCCTCCCTGTTTGGAACCCTCCCCAAAGA

G G C AGTC AG G CTG ATG CTC AGTG CTTTGTG CTCCCTG CTCCTTCCCG CGTAG CC AG GTG G

GCCCAAGGGTGCCTGGCAGGGAGCACTACCCCTGGACCCCTCCTGCTCGCTCTGGGGACC

CTG CC AG G G AAG G CC ACTG G GTGTTC ACCTGC AA AGTTTCTG GTTGTC ACTG C AC AGTG G

TCG CGTC ATCC ATG G GTATT AA AAG G AC ACTGTC A AGT AC I I I I I I AAACTAGTTTTTAG

GG I I I I I I AAAACTCTCTGTTGTTTGTAATATTCTCTTAAAAGCTTGAAAATAAAACTTC

TTTCCCTACC

>ENA | AI9121221 AI912122.1 wd63a l2.xl NCI_CGAP_Lu24 Homo sapiens cDNA clone I MAGE:2336254 3', m NA sequence.

TTGGAAATCTTGGTAATATTTATTCATGATAATAAACACGTTTTTAATGAAAGCCATAGA

TGTCCAAACACAAACTGAATCATGACAACCCAATGGTCTTTTTTACAAAAACCATGACAT

ATGTCCCATTAATTTGCTAAATGATATGAATGCAGAGAAAGGATGAATCAAAACCACTAA

AATCCTTTTAAACACACCATCTAGTTTAGATGTCAACTCTGAAAATGGCATTCAAAAATG

GTCCCTCTCTTTTAAATTTATCTGCTGAGTTTTTGTTACGGTACCTTTACCAATTTCTTA

AA AG CTTT AATTGTTATC ATTC ATTTC AACTC AA AACTG CTAG C A ATTTG GTTTG ACTTT

CCATAAAGGACTAAATTCTGTCACATTAATACATATGTAGGTAGTTATACAATGTTATTT GTA AGT AT ATG G GTCTG AA AG GG CC ATTATA AATGTTATATA AACC ATATAGTAT AT AG G GTATATATATTA

>ENA | AI3764331 AI376433.1 tc36a08.xl Soares_total_fetus_N b2H F8_9w Homo sapiens cDNA clone I MAGE:2066678 3', m RNA sequence.

TT I I I I I I I I I I I TTGAGATTAAATAATTTATTACCATTGCTAAGATGAACACATATACT TAATACTCAATTTTATGCAGAACTTTAAAAAAATAGTTTTAATACAGTATCAAAATTTAC AC AAGTTT ATTTTGTC A AA AG ACC AGTGTCCCTTGT ATTAG CTTCTG C AG G CTCTGCTG C AGG C AC AA AAG CTT ATTTT AA ATGTCTTC AG AG G GTAG G AATAC AAC AATTTA AG G ATG A A AG CTTTCCTAG G A A AG A AG GTGT AA ATATAG C AAG C A ATTTTCTTTTATAG AGTA ATAA CATTTTAAAATATAACATTTAAAAGGGGAGCTTAAATTGTAACCCAATTATGATAATTAG AGAGATAATTCTATAGTAAATTAATTCATAAATATTTTCTGAAAATAGATGATTTTTCAT CACAGTAACATTTTTGAAAGTATAACAAAATTCCTTCACAGTCTCCTACTAGTGACAATT AACTCGTTATGTAATGAGCCCATCTAAAACAACAACAACAGAGAATATCT

>ENA I AW9607481 AW960748.1 EST372819 MAGE resequences, MAGF Homo sapiens cDNA, m RNA sequence.

CAGAAACCACATGAGGAGTGGCTCTTTGAGAGCATTTGAGGTTCCAGAACACCTCCATTC

CTGAGGGGAGTCTCTTGAGCAGCGATTTGGGGCTGCGCCAGTTGCTTGGTCCTTCTTCCT

TTGGACCAAAGAAACGGAATTACAGAGAGCTGCAATGGATGCTAGCCGAACAAGTCGTCA

TCTGGAGGAAACTATTAACAACTTTGAAAGGCAGAAAATGAAGGATATAAAGACTATATT

TTCTG A ATTT ATC AC AATCG A A ATGTTATTTC ACG G C A AAG CTTTAG AG GTCTAC ACTG C

TGCCTACCAGAATATACAAAACATTGATGAAGATGAAGATTTAGAGGTTTTCCGAAATTC

TCTGTATGCACCAGATTATTCATCTCGTTTAGATATTGTAAGAGCAAATTCAAAGTCACC

TCTTCAGAGATCACTGTCAGCTAAGTGTGTATCTGGAACAGGACAGGTATCCACTTGTCG

ACTAAGAAAGGATCAACAAGCAGAAGATGATGAGGATGACGAGTTAGATGTTACAGAAGA

AGAAAATTTTCTTAAGTAAACTACACATTTCCATTTTCATCATAAATGACTTGAAATCCA

CAATGACTAAATTGTAGAACTTTATACTCACTTTGCTATGTTAAGCCTTAAAGTGAAGTC CAACTGGAAAACAGAAAAATAATTAAAGGGAAACTTATGCTGACCCAAAAATGAAGGCTT

TAAAAAATTATTGCATACCAGTCATTTTAACATTCTTACCTAATGGTACCATGATTTTTG

GGTAA

>ENA I AW0584591 AW058459.1 wx21bl2.xl NCI_CGAP_Kid ll Homo sapiens cDNA clone I MAGE:2544287 3', m RNA sequence.

TT I I I I I I I I I I TTGCCAATGCTATTGTATTTTTTATTTAAAAAAAATTAAATAAAATAG

TGATCCATTGCATATAAAACTGAACTAGAGTCCATAGTTTACGGGGGGGAAGGCTCAAAA

AATAG AG G C AAG A ATGTAG CTG C AG C ATTTTCTTTTTCTTC ATATCTAG G AG G C AATTC A

AATGGAAGATGTGGAGTGTGTGAGGCCTCAAAAGATGAATTCGTCCCAGAAATGGTATAT

ATAGATTCACAGTCTCTTTCAGAGGCTGCACCCTCTGAAGTTGGGGTCCTGCTAAAGAGA

AGGAGAGAGAACATGAAGGGGAGGGGATGAAAACAGTGACACCCCTTTAGTACTAGGTTC

TTTTCAAATGTTTGATTACATGCACTTAAGAGTATTTGCAAGAATCTGAGGAGTAATTTC

TCCCTCACTCTACTTTTCATAGATTTGTTTTGATTTCTTACCTCTTCCTTTTCCTAGAGC

TGAGTGTAACATTAAGACAGTCTCACTCCTGC

>ENA I AA9044301 AA904430.1 ok07fl2.sl Soares_N FL_T_GBC_Sl Homo sapiens cDNA clone I MAGE: 1507151 3' similar to TR:Q00808 Q00808 BETA TRANSDUCIN-LI KE PROTEI N, mRNA seq

TTTTACAAGGAATTTCCTCCAAACACTTTATTCAACAGAAATTATAACAATAGGCTTCAA

AGTAAAATCCAGGAGACACGTTGTTAAGTTGTTCTGGTCTCCTTTTTCAGTATCATAATG

CTTTT AA AA AAC A AAC AC A ACTG AA ATA ACTG GTG G C ATTAG C AA AC ATTATG CTGTGTC

CTGCCATCGCCATCAAATAATAATATTGGAGTGGCATAACTTTGTCATGTTTAATGGTCA

TATCTGTGAAATGAAGGACAGTTGTAGAAATAGTTGACTTGCAGAAAAAGAGAAAGTATA

AGAAATATTAAGAGAGCTGCTGTCTGTGAAGTTCCAGTTCTTGATTACCATTGCTAGCAA

GGTTGCTCACTGACCAGCTTCCTTCAGTCAACGCCATATCCTACAGGTATTATCCTTGCT

GCCTGTAATGACTATGTTGCCTTTATAGTTGAGAGCACATGAAAAGATTTCATCAGTGTG

CCCCTCAAGAACCTGGAGGCACTGGCCAGTCTGAGCATCCCAGATTCTAGCCGTATTGTC

AGAGCTGCCAGT >ENA | AF4938791 AF493879.1 Homo sapiens guanine nucleotide binding protein gamma 12 (GNG12) mRNA, complete cds.

ATGTCC AG C AA AAC AG C A AG C ACC AAC A AT ATAG CCC AG G C A AG G AG A ACTGTG C AGC AG TTAAGATTAGAAGCCTCCATTGAAAGAATAAAGGTTTCGAAGGCATCAGCGGACCTCATG TCCTACTGTGAGGAACATGCCAGGAGTGACCCTTTGCTGATAGGAATACCAACTTCAGAA AACCCTTTCAAGGATAAAAAAACTTGCATCATCTTATAG

>ENA | AI7531431 AI753143.1 cr05h01.xl Human bone marrow stromal cells Homo sapiens cDNA clone HBMSC_cr05h01 3', mRNA sequence.

CGAG I I I I I I I I I I I I I I I I I I GTTGTAGTTGTTGTTGTTAATAAAAAGGATANTNACAT

NCAGAGGATTATAAGAAAAATAAGACATACCTGAGGTTTTGTGATGAGCTATAGAGAATC

AAGGGCAGTTCCAGTGGAGCTGAGGCTGACAAAGTACTGCCCAGCTGCCAGCCAAATCCA

CCCTT AAGTTG CTTTTGTATG G CCTG G G AG CTC AG A AG G A ATTTTTT AA AT I I I I I I TAC

AGCTTTAAAGTATTAAACAGAAACCAACAAAGAAGAATATGAGACAGGGACCGTACGTGG

TCCGTAAAGTTTAACTTTCTGATCCTTAATAGGAGGATAAGCGCCGTGATAGAGAAATCC

AAAGGTCATTTGTATT

>refseq | NM_0155771 NM_015577 Homo sapiens retinoic acid induced 14 (RAI14), transcript variant 1, mRNA. actgacccccgcagcgggggaggaggagggactgcggcgcaggaagccgagcaggaagcg agcccggcggccgcgttttcctggggaagcggcgggcggggtggagcagccagctgggtc cggggagcgccgccgccgcctcgatggggtgttgaaaagtctcctctagagctttggaag gctgaatgcactaaacatgaagagcttgaaagcgaagttcaggaagagtgacaccaatga gtggaacaagaatgatgaccggctactgcaggccgtggagaatggagatgcggagaaggt ggcctcactgctcggcaagaagggggccagtgccaccaaacacgacagtgagggcaagac cgctttccatcttgctgctgcaaaaggacacgtggaatgcctcagggtcatgattacaca tggtgtggatgtgacagcccaagatactaccggacacagcgccttacatctcgcagccaa gaacagccaccatgaatgcatcaggaagctgcttcagtctaaatgcccagccgaaagtgt cgacagctctgggaaaacagctttacattatgcagcggctcagggctgccttcaagctgt gcagattctctgcgaacacaagagccccataaacctcaaagatttggatgggaatatacc gctgcttcttgctgtacaaaatggtcacagtgagatctgtcactttctcctggatcatgg agcagatgtcaattccaggaacaaaagtggaagaactgctctcatgctggcctgtgagat tggcagctctaacgctgtggaagccttaattaaaaagggtgcagacctaaaccttgtaga ttctcttggatacaatgccttacattattccaaactctcagaaaatgcaggaattcaaag ccttctattatcaaaaatctctcaggatgctgatttaaagaccccaacaaaaccaaagca gcatgaccaagtctctaaaataagctcagaaagaagtggaactccaaaaaaacgcaaagc tccaccacctcctatcagtcctacccagttgagtgatgtctcttccccaagatcaataac ttcgactccactatcgggaaaggaatcggtattttttgctgaaccacccttcaaggctga gatcagttctatacgagaaaacaaagacagactaagtgacagtactacaggtgctgatag cttattggatataagttctgaagctgaccaacaagatcttctctctctattgcaagcaaa agttgcttcccttaccttacacaataaggagttacaagataaattacaggccaaatcacc caaggaggcggaagcagacctaagctttgactcataccattccacccaaactgacttggg cccatccctgggaaaacctggtgaaacctctcccccagactccaaatcatctccatctgt cttaatacattctttaggtaaatccactactgacaatgatgtcagaattcagcaactgca agagattttgcaagatctacagaagagattagagagctctgaagcagagagaaaacagct acaggtcgaactccaatcccgaagggcagaactggtatgcttaaacaacactgagatttc agagaacagctctgacctcagccagaaacttaaagaaactcagagcaaatacgaggaggc tatgaaagaagtccttagtgtgcagaagcagatgaaactcggtcttgtctcacctgaaag catggataattattcacatttccacgagctgagggtcacggaagaggaaataaatgtgct aaagcaggatctgcagaatgcattagaagaaagtgaaagaaataaagagaaagtgagaga gttagaggaaaaactggtagagagggagaaaggtacagtgattaagccacctgtggaaga gtacgaggaaatgaaaagttcatattgctctgttattgagaatatgaataaggagaaagc atttttgtttgagaaataccaagaagcccaagaagaaatcatgaaattaaaagacacact aaaaagtcagatgacacaggaagccagtgatgaagctgaggacatgaaagaagccatgaa taggatgatagatgaactcaataaacaggtgagcgagctgtcacagctgtacaaagaagc ccaggctgagctggaggattacaggaagaggaaatctctagaggatgtcacagctgaata tatccataaagcagagcatgagaaactgatgcaattgacaaacgtgtccagggctaaagc agaagatgcactgtctgaaatgaagtctcagtattcaaaagtgttgaatgagttgaccca gctcaaacaactggtggatgcacaaaaagagaactctgtctctatcacagaacatttgca agtgataaccacgctgcggactgcagcaaaagagatggaagaaaaaataagcaatcttaa ggaacaccttgcaagcaaggaagtggaagtagcaaagctggagaaacaactcttagaaga gaaagctgctatgactgatgcaatggtacctcggtcttcctatgaaaaactccagtcatc cttagagagtgaagtgagtgtgttggcatcgaaattaaaggaatctgtgaaagagaaaga gaaggtccattcagaggttgtccagattagaagtgaggtctcacaggtgaaaagagaaaa ggaaaatattcagactctcttgaaatccaaagagcaagaagtaaatgaacttctgcaaaa attccagcaagctcaggaagaacttgcagaaatgaaaagatacgctgagagctcttcaaa actggaggaagataaagataaaaagataaatgagatgtcgaaggaagtcaccaaattgaa ggaggccttgaacagcctctcccagctctcctactcaacaagctcatccaaaaggcagag tcagcagctggaggcgctgcagcagcaagtcaaacagctccagaaccagctggcggaatg caagaaacaacaccaggaggtcatatcagtttacagaatgcatcttctgtatgctgtgca gggccagatggatgaagatgtccagaaagtactgaagcaaatccttaccatgtgtaaaaa ccagtctcaaaagaagtaaagtggattccttggcaggacactgccccttgtcatctgtct ttgtgttagatccagagttgtcggcagccgctgccattgttctcattcgtggtatgcact gtggcctagcgtagcttcttccctttccaaaggtttctgaggacttctcccaggagaaga ctgcccgcctcagaactgcttagagacttcaaaccagcagaggtgaaagtccctgtcatc ccttcagattccagagctgggatcagccatgcccagaggtctggtcctgatgctggcagg ggggccccctcctccatccctgactggctgagtggctttatcaccaccgagtgatgtgct gaggcctcctgcagtgaatgctccttccattcctgtactcgggcagtgccattcagcaca ggagagctctttttgcctttggctttcaattccaaaacatgatttaatttctaactaaat tagtatggcactagttatgaagtatctgcttaaaacccttcatcatgatatcctgtggat

ttaaaaactctaattccatgttttcttcccatctgccttatatatctcatcaccctgctt

atcaatattcagtttgatgagcactattaactaaaatatgaaacttaaaaacaaaagcaa

gttgtccttaaaagttctttttttaagtaaattgttgacatactgcaaattttctatgca

aacttgcctcctgctgttatctgtgaagctcaggaaatccaaacatttgtgtttcaacaa

gggacagtaaactgtgtgtttacagccaaaagaaatgcctcatagttcttaacctcaact

tttgtagaagtatttttttctctgtaatatttttattggctcataaagatgttttcatat

ctgaactcctaaataagtgaaattacagtagattatattaacaaaatactttttaggtag

ccatgcttgagactttttaaaaatataactttttccttaaagttttcagctatagcaaaa

ggtagttatgtatgccagacctaatatgagctgccaccaacacccctagaactttcagcc

atggtgtcttcagaattgtagcgcatttctgaatctagcaaatcctccttttacccgttg

aatgttttgaatgccctgactctaccagcgcccataaatgatctctagaaggactgttag

taccaatctgtttttcaactttgaagctaaaaaccctgatatggtaatattatggtgcat

agcagaggtctcggaaaaaaaatatttctgttcactttactttcaggttaaaaatgtttc

taacacgcttgcaacttcccttatggcattaatcttgttgagggagagagacagaatcct

ggactctccaaagtatttaactgaaagtagggcctgctctgacagggcccatgtcccaca

aggctgcttggcctcagtgggtgcttggctgtgctggatgatatgttgatctgtattgga

taaggaccaatgacagcaaagcaaaaatggctttaaagcttggtgttacttttcttaagt

tgtttaattatagttaagcaatttcaaaaatgctccaaagaaatgtgaaaggaccttttg

tcacagcacttcagaaaatacacaacagccccttctgcccccgcacagaaatgctgcaga

gtatataaaacttgagacatttttgtaggatgcctgacgaggtgtagccttttatcttgt

ttccggatgcatatttattacgagtactctggttaaatattgaaaagttatatgctgtag

tttttagtattttgtctttgtaatttacagaagttattggagaaaataaacttgtttcat

tttgcaaaaaaaaaaaaaaaaaaaaaaaaa

>refseq | NM_0050451 NM_005045 Homo sapiens reelin (RELN), transcript variant 1, mRNA. ctcggcgggggcccgctcccaggcccgctcccgagcccgttccgctcccgtccgccttct tctcgccttctctccgcgtggctcctccgtcccggcgtctccaaaactgaatgagcgagc ggcgcgtagggcgcgcggcggcggcggcggcggcggcggcatggagcgcagtggctgggc ccggcagactttcctcctagcgctgttgctgggggcgacgctgagggcgcgcgcggcggc tggctattacccccgcttttcgcccttctttttcctgtgcacccaccacggggagctgga aggggatggggagcagggcgaggtgctcatttccctgcatattgcgggcaaccccaccta eta cgttccggga ca aga ata cca tgtga ca a tttca a ca agca ccttttttga eggett gctggtgacaggactatacacatctacaagtgttcaggcatcacagagcattggaggttc cagtgctttcggatttgggatcatgtctgaccaccagtttggtaaccagtttatgtgcag tgtggtagcctctcacgtgagtcacctgcccacaaccaacctcagtttcatctggattgc tccacctgcgggcacaggctgtgtgaatttcatggctacagcaacacaccggggccaggt tattttcaaagatgctttagcccagcagttgtgtgaacaaggagctccaacagatgtcac tgtgcacccacatctagctgaaatacatagtgacagcattatcctgagagatgactttga ctcctaccaccaactgcaattaaatccaaatatatgggttgaatgtaacaactgtgagac tggagaacagtgtggcgcgattatgcatggcaatgccgtcaccttctgtgaaccatatgg cccacgagaactgattaccacaggccttaatacaacaacagcttctgtcctccaattttc cattgggtcaggttcatgtcgctttagttattcagaccccagcatcatcgtgttatatgc caagaataactctgcggactggattcagctagagaaaattagagccccttccaatgtcag cacaatcatccatatcctctaccttcctgaggacgccaaaggggagaatgtccaatttca gtggaagcaggaaaatcttcgtgtaggtgaagtgtatgaagcctgctgggccttagataa catcttgatcatcaattcagctcacagacaagtcgttttagaagatagtctcgacccagt ggacacaggcaactggcttttcttcccaggagctacagttaagcatagctgtcagtcaga tgggaactccatttatttccatggaaatgaaggcagcgagttcaattttgccaccaccag ggatgtagatctttccacagaagatattcaagagcaatggtcagaagaatttgagagcca gcctacaggatgggatgtcttgggagctgtcattggtacagaatgtggaacgatagaatc aggcttatcaatggtcttcctcaaagatggagagaggaaattatgcactccatccatgga cactaccggttatgggaacctgaggttttactttgtgatgggaggaatttgtgaccctgg aaattctcatgaaaatgacataatcctgtatgcaaaaattgaaggaagaaaagagcatat aacactggataccctttcctattcctcatataaggttccgtctttggtttctgtggtcat caatcctgaacttcagactcctgctaccaaattttgtctcaggcaaaagaaccatcaagg acataataggaatgtctgggctgtagactttttccatgtcttgcctgttctcccttctac aatgtctcacatgatacagttttccatcaatctgggatgtggaacgcatcagcctggtaa cagtgtcagcttggaattttctaccaaccatgggcgctcctggtccctccttcacactga a tgctta cctgaga tctgtgctgga cccca cctccccca cagca ctgtcta ctcctctga aaactacagtgggtggaaccgaataacaattccccttcctaacgcagcactaacccggaa caccaggattcgctggagacaaacaggaccaatccttggaaacatgtgggcaattgataa tgtttatattggcccgtcatgtctcaaattctgttctggcagaggacagtgcactagaca tggttgcaagtgtgaccctggattttctggcccagcttgtgagatggcatcccagacatt cccaatgtttatttctgaaagctttggcagttccaggctctcctcttaccataactttta ctctatccgtggtgctgaagtcagctttggttgtggtgtcttggccagtggtaaggccct ggttttcaacaaagatgggcggcgtcagctaattacatctttccttgacagctcacaatc caggtttctccagttcacactgagactggggagcaaatctgttctgagcacgtgcagagc ccctgatcagcctggtgaaggagttttgttgcattattcttatgataatgggataacttg gaaactcctggagcattattcatatctcagctatcatgagcccagaataatctccgtaga actaccaggtgatgcaaagcagtttggaattcagttcagatggtggcaaccgtatcattc ttcccagagagaagatgtatgggctattgatgagattatcatgacatctgtgcttttcaa cagcattagtcttgactttaccaatcttgtggaggtcactcagtctctgggattctacct tggaaatgttcagccatactgtggccacgactggaccctttgttttacaggagattctaa acttgcctcaagtatgcgctatgtggaaacacaatcaatgcagataggagcatcctatat gattcagttcagtttggtgatgggatgtggccagaaatacaccccacacatggacaacca ggtgaagctggagtactcaaccaaccacggccttacctggcacctcgtccaagaagaatg ccttccaagtatgccaagttgtcaggaatttacatcagcaagtatttaccatgccagtga gtttacacagtggaggagagtcatagtgcttcttccccagaaaacttggtccagtgctac ccgtttccgctggagccagagctattacacagctcaagacgagtgggctttggacagcat ttacattgggcagcagtgccccaacatgtgcagtgggcatggctcatgcgatcatggcat atgcaggtgtgaccaggggtaccaaggcactgaatgccacccagaagctgcccttccgtc cacaattatgtcagattttgagaaccagaatggctgggagtctgactggcaagaagttat tgggggagaaattgtaaaaccagaacaagggtgtggtgtcatctcttctggatcatctct gtacttcagcaaggctgggaaaagacagctggtgagttgggacctggatacttcttgggt ggactttgtccagttctacatccagataggcggagagagtgcttcatgcaacaagcctga cagcagagaggagggcgtcctccttcagtacagcaacaatgggggcatccagtggcacct gctagcagagatgtacttttcagacttcagcaaacccagatttgtctatctggagcttcc agctgctgccaagaccccttgcaccaggttccgctggtggcagcccgtgttctcagggga ggactatgaccagtgggcagtcgatgacatcatcattctgtccgagaagcagaagcagat catcccagttatcaatccaactttacctcagaacttttatgagaagccagcttttgatta ccctatgaatcagatgagtgtgtggttgatgttggctaatgaaggaatggttaaaaatga aaccttctgtgctgccacaccatcagcaatgatatttggaaaatcagatggagatcgatt tgcagtaactcgagatttgaccctgaaacctggatatgtgctacagttcaagctaaacat aggttgtgccaatcaattcagcagtactgctccagttcttcttcagtactctcatgatgc tggtatgtcctggtttctggtgaaagaaggctgttacccggcttctgcaggcaaaggatg cgaaggaaactccagagaactaagtgagcccaccatgtatcacacaggggactttgaaga atggacaagaatcaccattgttattccaaggtctcttgcatccagcaagaccagattccg atggatccaggagagcagctcacagaaaaacgtgcctccatttggtttagatggagtgta catatccgagccttgtcccagttactgcagtggccatggggactgcatttcaggagtgtg tttctgtgacctgggatatactgctgcacaaggaacctgtgtgtcaaatgtccccaatca caatgagatgttcgataggtttgaggggaagctcagccctctgtggtacaagataacagg tgcccaggttgga a ctggctgtgga a ca ctta acga tggca a a tctctcta cttca a tgg ccctgggaaaagggaagcccggacggtccctctggacaccaggaatatcagacttgttca attttatatacaaattggaagcaaaacttcaggcattacctgcatcaaaccaagaactag aaatgaagggcttattgttcagtattcaaatgacaatgggatactctggcatttgcttcg agagttggacttcatgtccttcctggaaccacagatcatttccattgacctgccacagga cgcgaagacacctgcaacggcatttcgatggtggcaaccgcaacatgggaagcattcagc ccagtgggctttggatgatgttcttataggaatgaatgacagctctcaaactggatttca agacaaatttgatggctctatagatttgcaagccaactggtatcgaatccaaggaggtca agttgatattgactgtctctctatggatactgctctgatattcactgaaaacataggaaa acctcgttatgctgagacctgggattttcatgtgtcagcatctacctttttgcagtttga aatgagcatgggctgtagcaagcccttcagcaactcccacagtgtacagctccagtattc tctgaacaatggcaaggactggcatcttgtcaccgaagagtgtgttcctccaaccattgg ctgtctgcattacacggaaagttcaatttacacctcggaaagattccagaattggaagcg gatcactgtctaccttccactctccaccatttctcccaggacccggttcagatggattca ggccaactacactgtgggggctgattcctgggcgattgataatgttgtactggcctcagg gtgcccttggatgtgctcaggacgagggatttgtgatgctggacgctgtgtgtgtgaccg gggctttggtggaccctattgtgttcctgttgttcctctgccctcgattcttaaagacga tttcaatgggaatttacatcctgacctttggcctgaagtgtatggtgcagagagggggaa tctgaatggtgaaaccatcaaatctggaacatctctaatttttaaaggggaaggactaag gatgcttatttcaagagatctagattgtacaaatacaatgtatgtccagttttcacttag atttatagcaaaaagtaccccagagagatctcactctattctgttacaattctccatcag tggaggaatcacttggcacctgatggatgaattttactttcctcaaacaacgaatatact tttcatcaatgttcccttgccatacactgcccaaaccaatgctacaagattcagactctg gcaaccttataataacggtaagaaagaagaaatctggattgttgatgacttcattatcga tggaaataatgtaaacaaccctgtgatgctcttggatacatttgattttgggcccagaga agacaattggtttttctatcctggtggtaacatcggtctttattgtccatattcttcaaa gggggcacctgaagaagattcagctatggtgtttgtttcaaatgaagttggtgagcattc cattaccacccgtgacctaaatgtgaatgagaacaccatcatacaatttgagatcaacgt tggctgttcgactgatagctcatccgcggatccagtgagactggaattttcaagggactt cggggcgacctggcaccttctgctgcccctctgctaccacagcagcagccacgtcagctc tttatgctccaccgagcaccaccccagcagcacctactacgcaggaaccatgcagggctg gaggagggaggtcgtgcactttgggaagctgcacctttgtggatctgtccgtttcagatg gtaccagggattttaccctgccggctctcagccagtgacatgggccattgataatgtcta catcggtccccagtgtgaggagatgtgtaatggacaggggagctgtatcaatggaaccaa atgtatatgtgaccctggctactcaggtccaacctgtaaaataagcaccaaaaatcctga ttttctcaaagatgatttcgaaggtcagctagaatctgatagattcttattaatgagtgg tgggaaaccatctcgaaagtgtggaatcctttctagtggaaacaacctctttttcaatga agatggcttgcgcatgttgatgacacgagacctggatttatcacatgctagatttgtgca gttcttcatgagactgggatgtggtaaaggcgttcctgaccccaggagtcaacccgtgct cctacagtattctctcaacggtggcctctcgtggagtcttcttcaggagttccttttcag caattccagcaatgtgggcaggtacattgccctggagatacccttgaaagcccgttctgg ttcta ctcgccttcgctggtggca a ccgtctgaga a tgggca cttcta cagcccctgggt tatcgatcagattcttattggaggaaatatttctggtaatacggtcttggaagatgattt cacaacccttgatagtaggaaatggctgcttcacccaggaggcaccaagatgcccgtgtg tggctctactggtgatgccctggtcttcattgaaaaggccagcacccgttacgtggtcag cacagacgttgccgtgaatgaggattccttcctacagatagacttcgctgcctcctgctc agtcacagactcttgttatgcgattgaattggaatactcagtagatcttggattgtcatg gcacccattggtaagggactgtctgcctaccaatgtggaatgcagtcgctatcatctgca acggatcctggtgtcagacactttcaacaagtggactagaatcactctgcctctccctcc ttataccaggtcccaagccactcgtttccgttggcatcaaccagctccttttgacaagca gcagacatgggcaatagataatgtctatatcggggatggctgcatagacatgtgcagtgg ccatgggagatgcatccagggaaactgcgtctgtgatgaacagtggggtggcctgtactg tgatgaccccgagacctctcttccaacccaactcaaagacaacttcaatcgagctccatc cagtcagaactggctgactgtgaacggagggaaattgagtacagtgtgtggagccgtggc gtcgggaatggctctccatttcagtgggggttgtagtcgattattagtcactgtggatct aaacctcactaatgctgagttcatccaattttacttcatgtatgggtgcctgattacacc aaacaaccgtaaccaaggtgttctcttggaatattctgtcaatggaggcattacctggaa cctgctcatggagattttctatgaccagtacagtaagcccggatttgtgaatatccttct ccctcctgatgctaaagagattgccactcgcttccgctggtggcagccaagacatgacgg cctggatcagaacgactgggccattgacaatgtcctcatctcaggctctgctgaccaaag gaccgttatgctggacaccttcagcagcgccccagtaccccagcatgagcgctcccctgc agatgccggccctgtcgggaggatcgcctttgacatgtttatggaagacaaaacttcagt gaatgagcactggctattccatgatgattgtacagtagaaagattctgtgactcccctga tggtgtgatgctctgtggcagtcatgatggacgggaggtgtatgcagtgacccatgacct gactcccactgaaggctggattatgcaattcaagatctcagttggatgtaaggtgtctga aaaaattgcccagaatcaaattcatgtgcagtattctactgacttcggtgtgagttggaa ttatctggtccctcagtgcttgcctgctgacccaaaatgctctggaagtgtttctcagcc atctgtattctttccaactaaagggtggaaaaggatcacctacccacttcctgaaagctt agtgggaaatccggtaaggtttaggttctatcagaagtactcagacatgcagtgggcaat cgataatttctacctgggccctggatgcttggacaactgcaggggccatggagattgctt aagggaacagtgcatctgtgatccgggatactcagggccaaactgctacttgacccacac tctgaagactttcctgaaggaacgctttgacagtgaagaaatcaaacctgacttatggat gtccttagaaggtggaagtacttgcactgagtgtggaattcttgccgaggacactgcact ctattttgggggatccactgtgagacaagcggttacacaagatttggatcttcgaggtgc aaagttcctgcaatactgggggcgcatcggtagtgagaacaacatgacctcttgccatcg tcccatctgccggaaggaaggcgtgctgttggactactctaccgatggaggaattacctg gactttgctccatgagatggattaccagaaatacatttctgttagacacgactacatact tcttcctga aga tgccctca cca a ca ca a ctcga cttcgctggtggcagccttttgtga t cagcaatggaattgtggtctctggggtggagcgtgctcagtgggcactggacaacatttt gattggtggagcagaaatcaatcccagccaattggtggacacttttgatgatgaaggcac ttcccatgaagaaaactggagtttttaccctaatgctgtaaggacagcaggattttgtgg caatccatcctttcacctctattggccaaataaaaagaaggacaagactcacaatgctct ctcctcccgagaactcattatacagccaggatacatgatgcagtttaaaattgtggtggg ttgtgaagccacttcttgtggtgaccttcattccgtaatgctggaatacactaaggatgc aagatcggattcctggcagctcgtacagacccagtgccttccttcctcttctaacagcat tggctgctcccctttccagttccatgaagccaccatctacaactctgtcaacagctcaag ctggaaaagaatcaccatccagctgcctgaccatgtctcctctagtgcaacacagttccg ctggatccagaagggagaagaaactgagaagcaaagctgggcaattgaccacgtgtacat tggagaggcttgccccaagctctgcagcgggcacggatactgcacgaccggtgccatctg catctgcgacgagagcttccaaggtgatgactgctctgttttcagtcacgaccttcccag ttatattaaagataattttgagtccgcaagagtcaccgaggcaaactgggagaccattca aggtggagtcataggaagtggctgtgggcagctggccccctacgcccatggagactcact gtactttaatggctgtcagatcaggcaagcagctaccaagcctctggatctcactcgagc aagcaaaatcatgtttgttttgcaaattgggagcatgtcgcagacggacagctgcaacag tgacctgagtggcccccacgctgtggacaaggcagtgctgctgcaatacagcgtcaacaa cgggatcacctggcatgtcatcgcccagcaccagccaaaggacttcacacaagctcagag agtgtcttacaatgtccccctggaggcacggatgaaaggagtcttactgcgctggtggca accacgccacaatggaacaggtcatgatcaatgggctttggaccatgtggaggtcgtcct agtaagcactcgcaaacaaaattacatgatgaatttttcacgacaacatgggctcagaca tttctacaacagaagacgaaggtcacttaggcgatacccatgaagaatcaaaaagtttat tttttttcttccaacatgtgatgtgttgctctccattcttttaaatctcgcactacatct

gatatcaggaaatatctgtgaaggacttggtgattacctgaaagcccttctcaagaccga gtgtacaccactttcccacactgtgaactaatgacaagtgacttatttgctcataagtaa atgtcttcatgttgatgtgtccgtgaaagttgtgatctgttgtaatatcagttacagtgg cagtattgacaataagaaacagtttaacagaaaaatgaaatttaagcacaaaaaatttaa gagattttatgtttaaaatggcatttagcacagtatttaacattcttggtcacaaagcta tttaagtggactgtatttcggctatgtctcatgttttatatgattaaattatcattgttt gtcctttatgtattctcttctacaatacaacacattgaaactgtatttacttgttatgtt gtaatattttgctgctgaatttggggctacttatattctgcagaaaattaattgaaatac ctattcaagaagatagttgtaaagatattgtatctcctttaatatactccttaaaaatgt atgttggtttagcgttgttttgtggataagaaaaatgcttgaccctgaaatattttctac tttaaattgtggatgaagaccctatctcccacaaataagttcccatttccttgtctaaag atctttttttaagtgttctgtggctgatttactaacagtaactgccattttttgtctgtg ataacagagtgatttgtaaaacagtggttgttttttcattgtgttttcttcgtggattgt tttttctgcgggtcatattcataccttctgatgaagttgtacaacaccagcaacattata atggccctgtagctctgaatgctatttgtgtaactgaaaggttgcactctagggtgaacc aagctataaaagcccatgcttaaataaaaattatgtccaaaagccattgaa

>ENA | AL037401 | AL037401.1 Homo sa piens m RNA; EST DKFZp564K1671_sl (from DKFZp564K1671)

TT I I I I I I I I I I CT I I I I I I I TAGATATCAAATAATATTTTAATTTCTGAATACTTTCAA TTTTCCTTGGAATATAACACACAAAGACTCGACCAAACAGTTCAGTTATTATAACTTTTA CAGTAAACAGAAATGTTGCACTTAAAAAAAAACCTTCGGT I I I I I I AAAACACAAACNGT AAACTCTAAGANACTGAATCAATCACGTTACCTATAAGTGCCAACAGTGTTATTTTTGTC ATGCTGATTTCAATGGTATTTTTTAAAAAGGGAAAATATCAACAATTATAATACAAAGCG TTTG C N AATATAC AA AC AG ATAT AG G ATTTTC AT AAC A ATTC A AG A ACTA AG CGGGGCCC AATTCAAATTACAAAATTCACTTTTTATTCAATACCTCAGCATGTGTCTTGGACACATTC CTTGGCTGCCAATAAAATCCACAGTTCATTCTCTTTCTTTAAATA I I I I I I AAAAGCTAG G NTTGTC ATGGTTTCTTTTG GGGAGGGGCAGG GT AG GG G A AGTTA AGTGTTATATGTG GT TCCTCCAGTTCTCTAATTAAAGTGCTCGNCTTCACCTAAAAANTTTGG

CGGCCAGGGAGAGGAGGTGGCCTAGCGCTGGCGGGGCTCACCCCAATCCGTCTGCCTTTT

GATGCCGTACTGTAAGCTCCGTCCATCTCTGCTGGTTGCGCAGCCACCTCGGGATACTGC

ACACGGAGAGGAGGGAAAATAAGCGAGGCACCGCCGCACCACGCGGGAGACCTACGGAGA

CCCACAGCGCCCGAGCCCTGGAAGAGCACTACTGGATGTCAGCGGAGAAATGGCTTTGAG

CTCAGCCTGGCGCTCGGTTCTGCCTCTGTGGCTCCTCTGGAGCGCTGCCTGCTCCCGCGC

CGCGTCCGGGGACGACAACGCTTTTCCTTTTGACATTGAAGGGAGCTCAGCGGTTGGCAG

GCAAGACCCGCCTGAGACGAGCGAACCCCGCGTGGCTCTGGGACGCCTGCCGCCTGCGGC

CGAGGTACAGTGTCCCTGCCATTGCCACCCTGCTGGGGCACCTGCGCCCCCGCGGGCTGT

GCCACACTCGTCCTTCTCTCTCTCTCCGCCTCTTTCCTCTCCCCAGTGCCTTGAGAGTTT

CACCTGGGCTAGGTCAGTTCGGAAACTTGAAATAAAGAGTTTTCCTTTGTAAGTTGAAAA

AAAAAAAAAAAAAAA

>ENA | U77706 | U77706.1 Human laminin alpha 4 chain (LAMA4*-1) m RNA, complete cds.

CAAACTGAATCCTGCTTTAATTCAAGCTTGTGGAGAACAAAGTCCTACAGAAACATTCCA

CAGAATTTTCTGGAAAAGAGGGATCACAACAACCCTGTAAAAAGGTGAGAAGGAAGCCAG

GACAGCGCAGTCCCCAGTCCCGAACGGCCAGGGAGAGGAGGTGGCCTAGCGCTGGCGGGG

CTCACCCCAATCCGTCTGCCTTTTGATGCCGTACTCTGCTGGTTGCGCACGCACCTCGGG

ATACTGCACACGGAGAGGAGGGAAAATAAGCGAGGCACCGCCGCACCACGCGGAGACCTA

CGGAGACCCACAGCGCCCGAGCCCTGGAAGAGCACTACTGGATGTCAGCGGAGAAATGGC

TTTGAGCTCAGCCTGGCGCTCGGTTCTGCCTCTGTGGCTCCTCTGGAGCGCTGCCTGCTC

CCGCGCCGCGTCCGGGGACGACAACGCTTTTCCTTTTGACATTGAAGGGAGCTCAGCGGT TGGCAGGCAAGACCCGCCTGAGACGAGCGAACCCCGCGTGGCTCTGGGACGCCTGCCGCC

TGCGGCCGAGAAATGCAATGCTGGATTCTTTCACACCCTGTCGGGAGAATGTGTGCCCTG

CGACTGTAATGGCAATTCCAACGAGTGTTTGGACGGCTCAGGATACTGTGTGACTACTGA

CGGAGAAGACCCAGGTTTTTCAGCTTCTACCCTATCGTTCATTCTCAGCTCTCAGGGAGC

CAGAGAAGCCAGGGCTCCAACATGAACACTTCTTGTAGCTCACTGTCATGACCAGTGTTT

CAGTCAGTTCTTTCAGGTTGCCTGACTTACCTCATTTCTCTCATTTCCTGTAAGCAACCA

A AA ATA AA AGG CTTTCTTTTATTTC ATTTTGTCTTATTTTG CTTTT ATCTTG AAG G C ATA

TAAGACCTCTGTATCTGCCTTGTTCACCTTCAACTGCTTCTAATTCTTCCTCAATTCCAG

TGTCCAATGTCAATTTGAAATTAAAATTTACAGACTGATTTT

>ENA | U567251 U56725.1 Human heat shock protein m NA, complete cds.

GTGTAGTGCCGCGATCTCAGCTCATTACAACCTCTGCCTCCCAGGTTCAAGGGATCCTCC

CACCTCAGCCTCCCAAGCAGTTGGGACCACAGGCATGTGCCACCATATCCGGCTAATTTT

TGC I I I I I I CATAGAGACAGGGTTTCACCATGTTGCACAAGTCGGTCTTGAACTCCTGAG

CTCAAGTGAGCTACCTGCTTTGGCCTCCCAAAGTGCTGGGATTACACATGTGAACCACCG

TACCCG G CCCC AA AA ATG CTTTCTT AAG CGTA ACTACGTA ATG CTAGTTGTAGTTTAG AT

TCCTGGATGTTAACTTAAAATAGTCCCATAGGAACCCAGTGTGGTGGCTCACGCCTGTAA

TCCCAGCCTGAGGCAGGTGGATCATCTGAGGTCAGGAGTTCGAGACCAGCTGGGCCAACA

CCGTAATTTCAGCTTCTCGGGACGCTGAGGCAGAAGAATTGCTTGAACCCAGGAGGCAGT

GGTTGCAGTGAGCCCAGATCGTGCCATTGCACTCCAGCCTGGGCAACAAGAGCAAAACTC

TGTCTC A AA A AA ATC AATTA ATTTAG G CTGG G CG C AGTG G CTC ATG CCTGTA AATCCC AG

CACTTTGAGAGGCTGAAGCGGGTGGATCATGAGGTCAAGAGATCGAGACCATCCTGGCTA

ACACGGTGAAACCCCATTTCTACTAAAAATACAAAAAAAAAACCCCAAAAAACAAAAAAA

C A AA A AC A A AC A A AC A A ACC AA AA A AAC AC A AC A ACTAG CC AG G CGTAGTG G C AG G CG CT TGTAATCCCAGCTAGTCGGGAGGCTGAGGCAGGAGGAGAATGGAGTGAACCCAGGAGGCA

GAGCTTGCAGTGAGCTGAGATCGCGCCACAGCACTCCAGCCTGGGCAACAGAGCGAGACT

CCATCTCAGGAAAAAAAAAATTAATTAATTAAAAAAACAGTAAGATAAATAACACTTCTC

CCATTTCAGTAAAAGGATGAAGCCAGTTTCTCAATGAATAAAAACAAGAGACTGTTGAAT

GTCAAGTTTTATAGACAGTCCAGACAACACAGGGAGACACCATCTCTACACACACACACA

TGGCATGGGCCTGTAGTCCCAGCTATTGGGGCAGGGCCAGGGGGTGGGAGGCTGAGGGGA

GAGGATGCCTTAACAGGGAGGTTGAGGCTGCAGAGAGCCATGATCACGTCACTGTACTCC

AGCCTGGGTGATACAGCAAGACTCTGTCTCAGAAAAAAAAAAAAGAAAAAAGTCAAGAAT

GCATTCTTGAGGAATTCCACCAACAAAATGCACCAAATATAGCCAAAGAGTTTTCTGCTA

TATGCCAAGTGGAAAGCTATGAAGAAAGAGAAGAACAGAAGCAGGAGGACATTGGTTTTC

ATCTCCTATTCTTTCAAGAAGTAAGATCCATTATCTTTTAAAAAGTCTAAACACTGGTAA

GGCAAGACACAACTCCCACCCATAACACTGCATCTCTGTCCTCAGGCAACAAATCAAATG

TCAGATAAAAGCACAATATCTACCACTCAACCCCCAGGCTTCAGCACAGAACTCACAAAC

ATTCTGCTGGCTAAGGCAAAAAGGTGTACTGTATTTCCAGAGAGCTTGCAGAGTTCTGAG

CACTAATCCCATAATCCTCATATCTCAATCTACACAAAGCACCATCAGGCTAAGAAACAG

AGAGTAACTATAGGGGCCATACTATATTTGCCAAAAAGTGACTTGTTTAAAAATTAAAAA

GAAGCCGGGTGCAGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGGCTGGGGTGGGTG

GATCACCTGAGGTCAGTAGTTCAAAACCAGCCTGGCCAACATAGTGAAACCCCATCTCTA

GAGGCAGGAGAATCGCTTGAACCCGGAAGGCAGAGGTTGCAGTGAGCCAAAATCGCACCA

CTGCACTCCAGCCTGGGCAACAAGAGCAAAACTCTGTCTCAAAAAAAAAAAAATAAAAAT

AAAAACAAAAAAGAAATCCAGTTTACCTCCTTGTGCAATTCCTAATAAATTGCTGAGAAG

TGATCTTACATAGGAATCTTGTATAATTTATTCTGATGCGTTCGAGGTGGCCGTTAGTTG ACTCCGCGGAGTTCATCTCCCTGGTTTTCCCGTCCTAACGTCGCTCGCCTTTCAGTCAGG

ATGTCTGCCCGTGGCCCGGCTATCGGCATCGACCTGGGCACCACCTATTCGTGCGTCGGG

GTCTTCCAACATGGCAAGGTGGAGATCATCGCCAACGACCAGGGCAATCGCACCACCCCC

AGCTACGTGGCCTTCACGGACACCGAGCGCCTCATCGGCGACGCCGCCAAGAACCAGGTG

GCCATGAACCCCACCAACACCATCTTCGACGCCAAGAGGCTGATTGGACGGAAATTCGAG

GATGCCACAGTGCAGTCGGATATGAAACACTGGCCGTTCCGGGTGGTGAGCGAGGGAGGC

AAGCCCAAAGTGCAAGTAGAGTACAAGGGGGAGACCAAGACCTTCTTCCCAGAGGAGATA

TCCTCCATGGTCCTCACGAAGATGAAGGAGATCGCGGAAGCCTACCTGGGGGGCAAGGTG

CACAGCGCGGTCATAACGGTCCCGGCCTATTTCAACGACTCGCAGCGCCAGGCCACCAAG

GACGCAGGCACCATCACGGGGCTCAATGTGCTGCGCATCATCAACGAGCCCACGGCGGCG

GCCATCGCCTACGGCCTGGACAAGAAGGGCTGCGCGGGCGGCGAGAAGAACGTGCTCATC

TTTGACCTGGGCGGTGGCACTTTCGACGTGTCCATCCTGACCATCGAGGATGGCATCTTC

GAGGTGAAGTCCACGGCCGGCGACACCCACCTGGGCGGTGAGGACTTCGACAACCGCATG

GTGAGCCACCTGGCGGAGGAGTTCAAGCGCAAGCACAAGAAGGACATTGGGCCCAACAAG

CGCGCCGTGAGGCGGTCGCGCACCGCTTGCGAGCGCGCCAAGCGCACCCTGAGCTCGTCC

ACGCAGGCGAGCATCGAGATCGACTCGCTCTACGAGGGCGTGGACTTCTATACGTCCATC

ACGCGCGCCCGCTTCGAGGAGCTCAATGCCGACCTCTTTCGCGGGACCCTGGAGCCGGTG

GAGAAGGCGCTGCGCGACGCCAAGCTGGACAAGGGCCAGATCCAGGAGATCGTGCTGGTG

GGCGGCTCCACTCGTATCCCCAAGATCCAGAAGCTGCTGCAGGATTTCTTCAACGGCAAG

GAGCTGAACAAGAGCATCAACCCCGACGAGGCGGTGGCCTATGGCGCCGCGGTGCAGGCG

GCCATCCTCATCGGCGACAAATCAGAGAATGTGCAGGACCTGCTGCTACTCGACGTGACC

CCGTTGTCGCTGGGCATCGAGACAGCTGGCGGTGTCATGACCCCACTCATCAAGAGGAAC

ACCACGATCCCCACCAAGCAGACGCAGACCTTCACCACCTACTCGGACAACCAGAGCAGC

GTACTGGTGCAGGTATACGAGGGCGAACGGGCCATGACCAAGGACAATAACCTGCTGGGC

AAGTTCGACCTGACCGGGATTCCCCCTGCGCCTCGCGGGGTCCCCCAAATCGAGGTTACC TTCGACATTGACGCCAATGGCATCCTTAACGTTACCGCCGCCGACAAGAGCACCGGTAAG

GAAAACAAAATCACCATCACCAATGACAAAGGTCGTCTGAGCAAGGACGACATTGACCGG

ATGGTGCAGGAGGCGGAGCGGTACAAATCGGAAGATGAGGCGAATCGCGACCGAGTCGCG

GCCAAAAACGCCCTGGAGTCCTATACCTACAACATCAAGCAGACGGTGGAAGACGAGAAA

CTGAGGGGCAAGATTAGCGAGCAGGACAAAAACAAGATCCTCGACAAGTGTCAGGAGGTG

ATCAACTGGCTCGACCGAAACCAGATGGCAGAGAAAGATGAGTATGAACACAAGCAGAAA

GAGCTCGAAAGAGTTTGCAACCCCATCATCAGCAAACTTTACCAAGGTGGTCCTGGCGGC

GGCAGCGGCGGCGGCGGTTCAGGAGCCTCCGGGGGACCCACCATCGAAGAAGTGGACTAA

G CTTG C ACTC AAGTC AG CGT AA ACCTCTTTG CCTTTCTCTCTCTCTCT I I I I I I TTGTTT

GTTTCTTTGAAATGTCCTTGTGCCAAGTACGAGATCTATTGTTGGAAGTCTTTGGTATAT

GCAAATGAAAGGAGAGGTGCAACAACTTAGTTTAATTATAAAAGTTCCAAAGTTTGTTTT

TTAAAAACATTATTCGAGGTTTCTCTTTAATGCATTTTGCGTGTTTGCTGACTTGAGCAT

TTTTGATTAGTTCGTGCATGGAGATTTGTTTGAGATGAGAAACCTTAAGTTTGCACACCT

GTTCTGTAGAAGCTTGGAAACAGTAAAATATATAGGAGCTTAAATTGTTTATTTTTATGT

ACTACTTTAAAACTAAACTGAACATTGCAGTAATGTTAAGGACAGGTATACTTTTTGCAA

ACAAATGCATAAAATGCAAATGTAAAGTAAAGCTGAAATTGATCTCAAAAAAAAAAAA

ggctggcgggcgggggtacagggacggggcaggggctcccgctccaggttccttgaagca

cttccgaccgcgaagcccggcgcgagaagcgagctaacccaagagccaacaacgagcgcg

gagagggcagcggactgagcggagccgccggccagagcgggctcggagcccgggtctccg

ccgctcgggacccggctaggcggcggcgggggcggcgatgttccactgcatccccctgtg

gcggtgcaaccgtcatgtggagagcatcgacaagcgccactgctcgctggtctacgtccc

cgaggagatctaccgctatgcccggagcctggaggagctgctgctggacgccaaccagct

ccgcgagctgcccgagcaatttttccagctagtcaaattacgaaagcttggacttagtga taatgaaattcagcggctccctccagaaatagcaaacttcatgcagctggtggaactaga tgtgtctcgaaatgagattcctgaaattccagaaagcatttcattctgtaaagcactgca ggtagctgacttcagcggaaacccactgactaggttgccagaaagctttcctgaattaca gaatttaacatgtctttctgtaaatgacatctcactacagtctctacctgaaaatattgg caatctttataacctggcttcactggaactgagagagaatcttcttacatatcttcctga ctctcttacccagctgcgaagactagaagaacttgatttaggaaacaatgaaatatataa tttgccagaatcaattggagccctcttacatctaaaagatctctggttggatggaaatca actgtcagaattacctcaggaaataggaaatctgaagaacctgctgtgtttagatgtctc tgaaaacaggttggaaagacttcctgaagaaatcagtggcctgacttcattaacggattt agtcatttcccagaacttattagaaacgattccggatggcattggaaaactaaagaaact gtcaatcttgaaggtggatcagaatagactcacacagttgcctgaagcagttggggaatg tgaaagtctcactgagttagttcttacagaaaatcagctcctgaccctgcctaaaagcat tggaaaactaaagaagttgagcaacttgaatgcagacagaaataaattagtgtccttacc aaaagagatcggcgggtgctgcagcctcactgtgttctgtgtacgtgacaacagactaac tcggatacctgcagaggtgtcacaggcaacagaacttcatgtcctggatgtggcagggaa caggttgctgcatctacctttatccctgactgccttgaagttgaaggctctgtggctatc tgacaaccagtcccagcccctgcttacattccagacagacacagactacaccacaggaga ga aga tttta a cctgtgtctta cttcctca gctgccttctga a ccta cttgtca agaga a tctgcctcgctgtggtgca ctggaga a cttggta a atga tgtctctgatga agcctgga a cgagcgtgctgtcaacagagtcagtgcgatccgatttgtggaggatgagaaagatgaaga agacaatgagacgagaacacttctaaggcgagccactccacacccaggggagttaaagca catgaaaaagacagtggagaatttacggaatgacatgaatgctgctaaaggactggactc aaacaaaaacgaggtcaatcatgccattgaccgagtgaccacttctgtgtagagtttcac ctccaagttttacctcctgtgtcttcctctgctgtcgagacgttcctgtctgcttcccgg gagcctcacgtgctccttgtcctaaccagcccccgcgcgccatcttcccgtggagtgtgg ggaagctgctgtctcccaggaagtgccttactcatcccgcaaccagtcagcgcaccagtg gtctcccggtgtgattttttttttttttaatttcagttgtttgtaataagtagaatacac

tactgtaaacatacgacctttgtttttgtcttatgttggggtaaaggaaagcaggaaggg gaatttttatcctcctcccttccgtaaagtgctgggatattttgaatcccccaagttccc ttggacctactgatgagagatagttttatgtatggggaaaaatggatactttttaaacct tttttggcagctcagatggtgtaaattttaaaattttgtataggtatttcataacaaaaa tatgtatttcttttttgttattttatcttgaaaacggtacatattttagtatttgtgcag aaaaacaagtcctaaagtatttgtttttatttgtaccatccacttgtgccttactgtatc ctgtgtcatgtccaatcagttgtaaacaatggcatctttgaacagtgtgatgagaatagg aatgtggtgttttaaagcagtgttgcattttaatcagtaatctacctggtggatttgttt ttaaccaaaaagatgaattatcaatgatttgtaattatatcagttgattttttttgaaaa gatgaaccaaaggatttgactgctaatattttattccttacactttttttctgaataagt ctctcataatgagtgcagtgtcagactgtgcctactctgatggtatgtgccatttgtaaa ataaaatagagcagaaaaacacaaaaagagaacactggttcagacattcagtgggcaagt aaattatggactgcaaaataatgatttttattcaagaaagctttaaaagttttatatcca gatatacaaccacaataaagcaaaataacctactatcaaaatagaaatgttgctatcttt ataagtgcaatttaatttgtaaatagagtttgaatcaaagtatcacaaaatactgcttca agatttaattttaaatctgctaatttaagggatattgggaaaagttttggtgtgtttctg ttgatttcttttttgtatgctgtgataaaagagaaatgaaaagtgccagtcactgtgtgg tgtctaggaaaatcatatatatttttttctccaagaaataaattcatcctggacattggc

>refseq | NM_0050921 NM_005092 Homo sapiens tumor necrosis factor (ligand) superfamily, member 18 (TNFSF18), m NA. catgacattgcatccttcacccatcacttgtgaatttttgttttccacagctctcatttc tccaaaaatgtgtttgagccacttggaaaatatgcctttaagccattcaagaactcaagg agctcagagatcatcctggaagctgtggctcttttgctcaatagttatgttgctatttct ttgctccttcagttggctaatctttatttttctccaattagagactgctaaggagccctg tatggctaagtttggaccattaccctcaaaatggcaaatggcatcttctgaacctccttg cgtgaataaggtgtctgactggaagctggagatacttcagaatggcttatatttaattta

tggccaagtggctcccaatgcaaactacaatgatgtagctccttttgaggtgcggctgta taaaaacaaagacatgatacaaactctaacaaacaaatctaaaatccaaaatgtaggagg gacttatgaattgcatgttggggacaccatagacttgatattcaactctgagcatcaggt tctaaaaaataatacatactggggtatcattttactagcaaatccccaattcatctccta gagacttgatttgatctcctcattcccttcagcacatgtagaggtgccagtgggtggatt ggagggagaagatattcaatttctagagtttgtctgtctacaaaaatcaacacaaacaga actcctctgcacgtgaattttcatctat

>ENA I AI2798191 AI279819.1 qm26h04.xl NCI_CGAP_Lu5 Homo sapiens cDNA clone IMAGE:1882999 3', m NA sequence.

TT I I I I I I TGCTGGGGCGTAAAGGGTTTTTATTGTAGATCCTGTGGCGCTGAAGTGCCAC

CAAGGATTTGGAAGGTCACTTTCAGCAGCCGCCATTTCTGCCAGGACCAGTGGCAAGCAC

CTGGCAGATGGAGCCCGGGTGTTTCTGCGTAAGGCAGAGGAATCCAGCTTTTCCATGAGA

TTCAGCTGCAGTTGTCGAAAACCCTGTGTGAGCCAGCAGTTCCAGTTCAAAGGTTGAGGG

GGCGAACAGCTGCGAGGTGGCCAGGCTCCCGTGAGTCACCACTCAGGCCTGAGTACACCG

TGGAGAGGAGAGATAAAGCAGCCACGGCTGTTCTGTTGCCAGTCCCACCCCTCTGGCAAA

CAGATGGGGGAAAACAGAGAAGGAAAGTCAACAAAGAAGGTGAAATGCAGGGAGCAGAGA

CTACACGCAGGCCCCCCGTGGCTGGCAATACCATGCGTGCTGGGCCGGCTGCGCCACCCT

CACCCA

>ENA | BE857360 | BE857360.1 7g29bl2.xl NCI_CGAP_Brn23 Homo sapiens cDNA clone IMAGE:3307871 3', mRNA sequence.

>ENA | AI8019731 AI801973.1 tx29d05.xl NCI_CGAP_Lu24 Homo sa piens cDNA clone IMAGE:2270985 3', m NA sequence.

GATGAAAACTCCAGCCTTTCCTGACTCACCTCCATCTTCGGTTCTTCAGTTTTCTGAGAA

GAGTTGGGATATGTGGGAAGGGGCATGGGAGCTCGGCAGCCTCCGCCTGCCAGGAAGGCA

GTTTCGCCTCTGCAGGAAAGAGCAGAGCCCGTGGGAAGCCCTGGGTGAGGGTGGCGCAGC

CGGCCCAGCACGCATGGTATTGCCAGCCACGGGGGGCCTGCGTGTAGTCTCTGCTCCCTG

CATTTCACCTTCTTTGTTGACTTTCCTTCTCTGTTTTCCCCCATCTGTTTGCCAGAGGGG

TGGGACTGGCAACAGAACAGCCGTGGCTGCTTTATCTCTCCTCTCCACGGTGTACTCAGG

CCTGAGTGGTGACTCACGGGAGCCTGGCCACCTCGCAGCTGTTCGCCCCCTCAACCTTTG

AACTGGAACTGCTGGCTCACACAGGGTTTTCGACAACTGCAGCTGAATCTCATGGAAAAG

CTGGATTCCTCTGCCTTACGCAGAAACACCCGGGCTCCATCTGCCAGGTGCT

TCCCCAAGAGATACATTTTCTGTACAATGAAAAATTCAGTTTCCTATTTCTTAACTTTGT

TTGCAAACCTACACGCCTCTTCTCTCTTCCACCATGTGTAATAAAATCCATCGCATTCTC

TTCTATCTTCAGTCATGTAGTTTTTGTGTTTAACATTTATAAAATGTGTTCTTATGAGTC

TGAAATCTTTATCAGTTCAAATCATTCCTGATTTCCCATCTACAACCTTCTAGGTCTTTC

TTCTTTCTCTG CCG CTTTCCTTGTTTGTC AGTGTTCTGTACTG AA ATTCC AC AG G G ATG G

CAGTTAGATGAGGACTTCCATCATCTCTCCATCAGGGAACTCGGGCTTGTGCAGCAAGCT

GCTGACCCGGCCTCTGTGGTCAGGCGACTTCCCATGGCCAGGAGAGTTCTCCAGTTTCTC TGCGGTCCCTTTGGCCGCTGGGTGTTTCAGGATCGTGAGGCCCCGCTTTCACGG

TTTTTTTCACATCTCAAAAAAAGTTTATTATGTTGGATACAACAGATTCTCAATATTAGC

AAATCATTCCACTTACCCCCAAGCGCCAGATCTTGACTGTACAGTCTAAAAACATTTGTC

AAAGTGAGAAAAATGTTACAGAACATCTCATAAAAGAATTAAGATACAAATAGTATATAC

AGATAGTAGATTGTAACAAAGTGGAACGTACTTGCAAGACATCACCTAGCTAAAATACTT

GATTCCCTATGAGGACAAACTGAAAAATAAAATATTTCAAGCACACAAAGAAAGGACAAA

AT AG G G G AA ACC AATG G G AA ATATA AAGTTTAA ACTTATTTTTA AC ATTTA AA AG C AACT

ACACTTTTCCATTTGAGCCAGTTCAAAAAGGAGAAGTCAAATAAAGACTTTAGAATCCTG

TGACCAACTATAATTTGAGCTTGATAACATGAATGGCATCTGAAAGATGCAAGCCAAGTA

TTTCTAGTACTGTGACCTTGAGAGATAATAACTGAGCAACCTGCTAGG

>gi 118089116 1 gb | BC020718.1 1 Homo sapiens complement factor I, m RNA (cDNA clone MGC:22501 I MAGE:4716122), complete cds

AAATTTCAAAAGAATACCTGGAGTGGAAAAGAGTTCTCAGCAGAGACAAAGACCCCGAACACCTCCAACA

TCAAGAGGATCTGGTGGAGAAAAAGTGCTTAGCAAAAAAATATACTCACCTCTCCTGCGATAAAGTCTTC

TGCCAGCCATGGCAGAGATGCATTGAGGGCACCTGTGTTTGTAAACTACCGTATCAGTGCCCAAAGAATG

GCACTGCAGTGTGTGCAACTAACAGGAGAAGCTTCCCAACATACTGTCAACAAAAGAGTTTGGAATGTCT

TCATCCAGGGACAAAGTTTTTAAATAACGGAACATGCACAGCCGAAGGAAAGTTTAGTGTTTCCTTGAAG

CATGGAAATACAGATTCAGAGGGAATAGTTGAAGTAAAACTTGTGGACCAAGATAAGACAATGTTCATAT

GCAAAAGCAGCTGGAGCATGAGGGAAGCCAACGTGGCCTGCCTTGACCTTGGGTTTCAACAAGGTGCTGA

TACTCAAAGAAGGTTTAAGTTGTCTGATCTCTCTATAAATTCCACTGAATGTCTACATGTGCATTGCCGA

GGATTAGAGACCAGTTTGGCTGAATGTACTTTTACTAAGAGAAGAACTATGGGTTACCAGGATTTCGCTG

ATGTGGTTTGTTATACACAGAAAGCAGATTCTCCAATGGATGACTTCTTTCAGTGTGTGAATGGGAAATA

CATTTCTCAGATGAAAGCCTGTGATGGTATCAATGATTGTGGAGACCAAAGTGATGAACTGTGTTGTAAA G C ATG CC AAG G C A AAG G CTTCC ATTGC AA ATCG G GTGTTTG C ATTCC AAGCC AGTATC A ATG C A ATG GTG

AGGTGGACTGCATTACAGGGGAAGATGAAGTTGGCTGTGCAGGCTTTGCATCTGTGGCTCAAGAAGAAAC

AGAAATTTTGACTGCTGACATGGATGCAGAAAGAAGACGGATAAAATCATTATTACCTAAACTATCTTGT

GGAGTTAAAAACAGAATGCACATTCGAAGGAAACGAATTGTGGGAGGAAAGCGAGCACAACTGGGAAAAA

TGAAGCAAATCTCATTGGATATTTTTAAAGGTCTCCACAGAGTTTATGCCATATTGGAATTTTGTTGTAT

AATTCTCAAATAAATATTTTGGTGAAGCCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

>ENA | BF9676571 BF967657.1 602287358T1 N IH_MGC_96 Homo sapiens cDNA clone IMAGE:4374495 3', m NA sequence.

CCCACTAATGAAGAGTAAATATGCAAGGCAGCAACCTTCAGGAGTAGGGAGATTGGGGAG

A AACG ACTTC A AA ACTG CG ATAG GTC ACTATATG GTAG G GTC ACCTG GTG AT ACTTAGTA

TGGCACAAATGCCCTGCCTAGCCCCCTTCACTGCGATACAGCTTCACAGAATGGAGTGTT

ACAGTAAGTAAGGTGTTCGTTAAGTAGGCAGGATTGCCTTAACACTAGGGGAAAAAAAGA

CCAGACTTGAAGATGAAAGTACCGCAGAGTGTATAAGATATATATGTATTGGTATGTGTG

GTTATTAATAGCAAACAACCCAGTCTCACAGATATTACCAAAGTAGGACAACAATAATTC

CACGTAAGACATAAATAGTNACTATGATACCTAATAGGTAACAGACGCTATAAAATGAAC

CATCACACAATTCATGGACATCACACAAATTAAGCCCACCGTAAAACATTTAACATTAAA

TACATATACCATCAAAAGAACTTAAACTAACAAAATTAAGCCCACATTTATGAAAGACAC

GATTAACACGGCATGACTGTGGAAACCATGACAGAATATAGAGAATTGCGATGATTACAG

GAACATTAAAAAAGGGTTCAACATATATGAGCTTCATACCCCAAAATTGAGTCATAAGAG

AACAGACATACTAAGTCCAACCACATTTCTAAAAGCCAAAACACCAGATAGAACACACAA

ATAATCCCCGGAAGAGACCAGAAAAGAACAATAGAAACCACACAAAGAGGAAATAACCAA

AACCACGAAAAAAGAGAGATAAAAAGAACCAGAAACAATAGATAAAAAGCAAAAAAACAT

GAAAAGAGACAGAAGCAGAAAAACAACACAGAGAAAACAAGAAAGGACCTACGCAAGAAG

CAAAAAAACAAAACCATACAAGGACACAAACACAAGAGCAATAAAAACACAAAAAGGCAA

TGGACCAAAAACAAAGAAAGAAAAAAAATAAGAAGCCAAAAAACGAAACAAAACCCCACT

CAAACAAATAAACATAAGAAATAAAAATAAAAACAAAAACATATAAAAAAATAATTCCAA ACAAATAACAAAATAGTAACAATATAAAAAAAATAATAATAATATAACTAAAAAAGGGTA TGACACAAATATTTTTTCTTTTC I I I I I I CTTACTAAAAAAAAAAAG

>refseq | NM_006474 | NM_006474 Homo sapiens podoplanin (PDPN), transcript variant 1, mRNA. agaccaccttgcggccgaccccgctcccccgcctcctcgggagagataaatgctgactcc

gctcgga a agttctca a ctgca a agtttgctgtccggctgcctagggtctggga agctcg

ggcaccctccctctccggggctcctgctcccacccctccggcccccccaccgtcgcgctc

ctccaggctgggcctgtggccgcggtgctttttaattttcccccagctcagaatcttgct

gctcggcccccaggagagcaacaactcaacgggaacgatgtggaaggtgtcagctctgct

cttcgttttgggaagcgcgtcgctctgggtcctggcagaaggagccagcacaggccagcc

agaagatgacactgagactacaggtttggaaggcggcgttgccatgccaggtgccgaaga

tgatgtggtgactccaggaaccagcgaagaccgctataagtctggcttgacaactctggt

ggcaacaagtgtcaacagtgtaacaggcattcgcatcgaggatctgccaacttcagaaag

cacagtccacgcgcaagaacaaagtccaagcgccacagcctcaaacgtggccaccagtca

ctccacggagaaagtggatggagacacacagacaacagttgagaaagatggtttgtcaac

agtgaccctggttggaatcatagttggggtcttactagccatcggcttcattggtgcaat

catcgttgtggttatgcgaaaaatgtcgggaaggtactcgccctaaagagctgaagggtt

a cgccctgctgcca a cgtgctta a a a a a aga ccgtttctga ctctgtgccctgtccctga

gctcgtgggagaagatgacccgtggaacacttgcctggcccactcagaatccacggtgac

ctctccgcttgccaaaataaccgaaggaaagaccgttcaccagacttggctcctctaaac

atttgctgttcaaacatgtttttgaatatacattctataaaagattatttgaaagacaaa

attcatagaaaatggagcaaaactgtataaactgatttgtaactaacactggaccattgg

atcgatattatatgctgtaaccatgtgtctccgtctgaccattcttgttattgttaaaat

gcagaggaatctggaaatatttatatccacggagtccttggatccagtgctacgtcagta

aatagcaccagcattttgcaattgctgatctgctgaaatgtacacattctggtctagttt

ggtctatcttttaaagcctgatctggtgtgaataatcaactaggaaatctaaacttggat aacacgtggtgaacaactgcctttagctggtccagattaatcatttcaaagacatccatt ttagatcacaagcaggaagtcgatagtctcaaaggcactttgtttctcccaagtaggcca ccaggcagcctctagagttgctttacccaaatccttctccagccatgacttggtgactct aagcttgctcccacctgccccctccacttccctcagatgatgaggagccagggctaaggg ggcagccttctctcttcccagtgatgcacatccttcacattggctgctttgttctggaat atggatatctcagcctggatgccgaggaagctgctggatgcttaatggtgctagaggctc aagtgtgtttgaaaccaagagccagttgtcccccatgcagaaagaaatcctgtgtgagcc tctggtatgagaaataaaatctgccagttttataacattcactttctgcctctgaggaaa gatacagggaacaaaaatcaatttgtacagtcttaatattaaaagcagcttgactaaata cctgatttaaaaatagaagacatccccagtcctcatgacataccgcaaatatctgtgggg tcctgttgaaaagaacaaaataaaggagcccaaggggtcattctgtctcagcaccatcca gcctggca cttctcttccca ta ta tcca ttggatttttttttttttttccta a a ca a agt ttttacactgagcagatgctctgtcatgatggcggttgtgcaattctggtatcctctaaa tttgtaagcattcataaaacaggaaaaagtaaactatcattcggaagcacagcccattcc tcccattttttgcaatgatgtctggatgttattttaaacagtgtgtctgtgtgttcccaa atccagctggccccaccagctcagattccattttttttgtgtgtgtgtgtgaaacgtagt ctgcaactctgcctcccggcaattatacatgtgtcaggatgtcaaaaagcaattctcctg cctcagcctcctgagtagctggga eta caggttccta cca cca ca cccggcca a tttttg tatttttagtagagatggggtttcaccgtatcggcgaggatgatctctatctcttgacct cgtgatctgcccgcctcggcctcccaaagtgctgggattacaggcgtgtgccactgcgct cggcctcagattccatatttgaacaccagctgattgagagaaggggaatgagaagagctg gatgagtttaaataactcattgttcagattcctgaacaggagttgggataatggccatct tttctttccta tcctttcttcccccctca ctgtga a a a a ta a cagtcca cccca agtca t a ca ctgga cccagtgcctgcgggga cagga ctgtgggtttcttggtca ca cctgtgttgg tgctcaatgcagtgtagacatgttttcaaataaaacaaatgattgtgtacaaaaaaaaaa aaaaaaaa

>refseq | NM_0036191 NM_003619 Homo sapiens protease, serine, 12 (neurotrypsin, motopsin) (P SS12), mRNA. gcccgagaagctggggagcatggaccagaccccgcagcgctggcaccatgacgctcgccc gcttcgtgctagccctgatgttaggggcgctccccgaagtggtcggctttgattctgtcc tcaatgattccctccaccacagccaccgccattcgccccctgcgggtccgcactacccct attaccttcccacccagcagcggcccccgaggacgcgtccgccgccgcctctcccgcgct tcccgcgccccccgcgggcgctccctgcccagcgcccgcacgccctccaggccgggcaca cgccccggccgca cccctggggctgccccgccggcgagcca tgggtca gcgtga cgga ct tcggcgccccgtgtctgcggtgggcggaggtgccacccttcctggagcggtcgcccccag cgagctgggctcagctgcgaggacagcgccacaacttttgtcggagccccgacggcgcgg gcaga ccctggtgtttcta cggaga cgcccgtggca aggtgga ctggggcta ctgcga ct gcagacacggatcagtacgacttcgtggcggcaaaaatgagtttgaaggcacagtggaag tatatgcaagtggagtttggggcactgtctgtagcagccactgggatgattctgatgcat cagtcatttgtcaccagctgcagctgggaggaaaaggaatagcaaaacaaaccccgtttt ctggactgggccttattcccatttattggagcaatgtccgttgccgaggagatgaagaaa atatactgctttgtgaaaaagacatctggcagggtggggtgtgtcctcagaagatggcag ctgctgtcacgtgtagcttttcccatggcccaacgttccccatcattcgccttgctggag gcagcagtgtgcatgaaggccgggtggagctctaccatgctggccagtggggaaccgttt gtgatgaccaatgggatgatgccgatgcagaagtgatctgcaggcagctgggcctcagtg gcattgccaaagcatggcatcaggcatattttggggaagggtctggcccagttatgttgg atgaagtacgctgcactgggaatgagctttcaattgagcagtgtccaaagagctcctggg gagagcataactgtggccataaagaagatgctggagtgtcctgtacccctctaacagatg gggtcatcagacttgcaggtgggaaaggcagccatgagggtcgcttggaggtatattaca gaggccagtggggaactgtctgtgatgatggctggactgagctgaatacatacgtggttt gtcgacaattgggatttaaatatggtaaacaagcatctgccaaccattttgaagaaagca cagggcccatatggttggatgacgtcagctgctcaggaaaggaaaccagatttcttcagt gttccaggcgacagtggggaaggcatgactgcagccaccgcgaagatgttagcattgcct gctaccctggcggcgagggacacaggctctctctgggttttcctgtcagactgatggatg gagaaaataagaaagaaggacgagtggaggtttttatcaatggccagtggggaacaatct gtgatgatggatggactgataaggatgcagctgtgatctgtcgtcagcttggctacaagg gtcctgccagagcaagaaccatggcttactttggagaaggaaaaggacccatccatgtgg ataatgtgaagtgcacaggaaatgagaggtccttggctgactgtatcaagcaagatattg gaagacacaactgccgccacagtgaagatgcaggagttatttgtgattattttggcaaga aggcctcaggtaacagtaataaagagtccctctcatctgtttgtggcttgagattactgc accgtcggcagaagcggatcattggtgggaaaaattctttaaggggtggttggccttggc aggtttccctccggctgaagtcatcccatggagatggcaggctcctctgcggggctacgc tcctgagtagctgctgggtcctcacagcagcacactgtttcaagaggtatggcaacagca ctaggagctatgctgttagggttggagattatcatactctggtaccagaggagtttgagg aagaaattggagttcaacagattgtgattcatcgggagtatcgacccgaccgcagtgatt atgacatagccctggttagattacaaggaccagaagagcaatgtgccagattcagcagcc atgttttgccagcctgtttaccactctggagagagaggccacagaaaacagcatccaact gttacataacaggatggggtgacacaggacgagcctattcaagaacactacaacaagcag ccattcccttacttcctaaaaggttttgtgaagaacgttataagggtcggtttacaggga gaatgctttgtgctggaaacctccatgaacacaaacgcgtggacagctgccagggagaca gcggaggaccactcatgtgtgaacggcccggagagagctgggtggtgtatggggtgacct cctgggggtatggctgtggagtcaaggattctcctggtgtttataccaaagtctcagcct ttgtaccttggataaaaagtgtcaccaaactgtaattcttcatggaaacttcaaagcagc atttaaacaaatggaaaactttgaacccccactattagcactcagcagagatgacaacaa a tggca aga tctgtttttgctttgtgttgtggta a a a a a ttgtgta ccccctgctgcttt tgagaaatttgtgaacattttcagaggcctcagtgtagtggaagtgataatccttaaatg aacattttctaccctaatttcactggagtgacttattctaagcctcatctatcccctacc tatttctcaaaatcattctatgctgattttacaaaagatcatttttacatttgaactgag aaccccttttaattgaatcagtggtgtctgaaatcatattaaatacccacatttgacata aatgcggtaccctttactacactcatgagtggcatatttatgcttaggtcttttcaaaag acttgacaagaaatcttcatattctctgtagcctttgtcaagtgaggaaatcagtggtta aagaattccactataaacttttaggcctgaataggagtagtaaagcctcaaggacatctg cctgtcacaatatattctcaaagtgatctgatatttggaaacaagtatccttgttgagta ccaagtgctacagaaaccataagataaaaatactttctacctacagcgtataaactagca aaatttgaaaggatttctggtaactaaatgccagctggacatacaacctattttatccaa cacattaacatatctactatatttgcttttaacaagcacctcatcatagtccacgttccc cgaccatgatgtaagagtgccacccactgacacttccctgtaactgacttatacctgcag gttttcccaagcccaacctgatacaatccaatcttaaaatatactagtcaaaatgctttc ctggcctacacattgaaaagttctaatacatacagcagttataacatatgccaggcactg cattaggcagctttgcacatcactgacaatttgcaaaaggccagtaaatcttatggtagt agcccttgttttcaaatgggggaaaacaggcttgcctcaaagtgagaccagttggtgaaa ctgattccaaactccagaaaaaatgctgatttttttccccatggttctcctacctaaatg attggtttccctatggctatttctccaagagttaagggatagctgcttaactatgcacct ttacagaacattcttagcagtaatgctcaaatttaaaaggcacactcaagatacttccat gtcatggatccttccccaggtcccagtagtataaatatagggaagaggttagcatgaact tacaaattgttttaagtaatcctcttgaatgccagtcattaaaggactttgcccttctac atcaaattacatccttttcacaaatccccatttctgtaataactggtgcaaacctaaagg tgctttatagttttactactttgcagatttgcaatgctgcatataatgcagaagagcatt aaaaacttttgtaaaaactcatgattttgataaacttttaaagtagcgtttatatgtaaa tagaactacacatggcacacacacttgcacaagggcttcagaaaaacgtgcaatataggt gagaaaaatgtctattgaaactttctcacaggctgcccttataattaaactagtgttggg gcaagcaacatctgtttcaagtagatcagggactagcaaacctaaaaggcagcaagcagc

ctgcagtttgctcaatccttaagaatacatggttcatacaacatgcttttactatgtctt

aagtgtgacttttgaaagatacaagtgttctgtgcatatttgtgtaaataaatacataat

tttccaccttgta

>refseq | NM_003149 | NM_003149 Homo sapiens SH3 and cysteine rich domain (STAC), mRNA. gttcctccgggagcccaacaccgttcccgcgcggccacgatgatccctccgagcagcccc

cgcgagga cggcgtgga cgggctgccca aggaggcggtgggcgccgagca a ccgccctct

cctgcatccaccagcagccaggaatccaagctccagaaactaaaacgatcactttctttc

aagaccaagagtttacggagcaaaagtgctgacaacttcttccagcgaaccaacagcgaa

gacatgaaactgcaagcacacatggtggctgagatcagccccagctccagcccactccct

gctccaggaagcctgacgtccacacccgccagggctggtctgcatccaggtggcaaggct

catgcctttcaggaatacatcttcaagaagcccactttctgtgatgtctgcaaccacatg

atagtgggaacaaatgctaagcatggactgcgctgcaaagcctgtaagatgagcatccac

cacaagtgcacagatggcctggcaccccagcggtgcatgggcaagctgccaaaggggttt

cggcgttactacagctcccccttgctcattcatgaacagtttggctgcattaaagaagtt

atgcccattgcctgtggcaataaggtggaccctgtctacgagaccctccgcttcggcacc

tccctggcccagaggacaaagaagggcagctccggcagtggctctgactcacctcacaga

acctctacttcagatcttgtggaggttcctgaggaagccaatgggccaggaggcgggtat

gacctaaggaaacgcagcaacagcgtgtttacatatccagaaaatggcactgatgatttc

agagatccagcgaagaacataaaccaccagggatctctttccaaagacccattacagatg

aacacctatgttgccttgtacaaatttgtaccacaggagaatgaagatttggaaatgagg

ccaggagacataattactcttttagaggattccaatgaagactggtggaaagggaaaatt

caagacagaattggcttctttccagccaactttgttcagagactacaacaaaatgagaag

atttttagatgtgttagaaccttcattgggtgtaaggaacaggggcagataacactgaaa

gagaatcagatctgcgtgagttctgaagaagaacaagatggttttatcagagtcctcagt ggaaaaaagaaaggcctcatcccccttgatgtactagaaaacatctgattgctggctcct cctccgtttgcagtaggcaagctctgctgcgatgcctctgcctcatctcacactgcgtca acccaaaggagctgccgcactgacccagccccccaggaaacagtgagacaagaatcaagt atctgagactgtggagtaatagccacaaaacagagggcccactgcacagcatatccaggc tgccacaggtggggacgaggctgagagagtcagcaggcagagccagatgccatgcttggc agcagcagtaggactataaaccacagctgtcccccaggatcccactcctttcctgtctgt gtggtgtaagttaacacactggagtgtgctccagtttgcagggtagcccagtgcaaggtt cagatccatgtagctaagtattatcctgcttccagacctatgtcaccagtaccaatcagt cagtgtcatcacatttcaggccccaagcaatctctgtgcaaagcatcagaaagacctgct tcccagcccccagcattccagtgctctccaggcttcctctctttgtgattgtgctgtcca gagtgtccagcttgttctttctttctcttcagtcctctgagtacatctggtggtgtgcat tagatgtgagggctatgttgacatggcatcacctccaaagacctgacctgcctaaagact gatgacaggccatccttcctgctgttctaggtactggcctgggtgacagagcaggacatg agacatagatacagtggggaggagaagtggggaaaggtggagcagagagttcttacttat tgaagattatacagccctttcggttatgaagtccctgcttgaaggcaatggacctgggga agagactatcacaaaaagtctccattttcattttacatcctctctattggaggcagcact tttccctca tgctgtcctatagga ctcca ctttga aggttgtgccta cgttgcaggga a c taggaacatggaggggaaccaacaacagcatcttagaagaaatgtagccaaattggagtc cattcttctttagggcagtatatgaaatcctagcagatgtaaaatggaaaagaatcctaa tgcttcttccttcagaaagtagaggaactaggggcccaattagcatcatctaggggaatc tctattactctgtacttatactaatgtttacaagaatgcaatatactgtgatgccttcct actcaagcctcctagcattcaaacttccatcctattagtcattaacgtggttaaacttca attcacaatcaccttggaatcaatgtcagtttgatttattttgttacagagcaataaaat cattagaacaatggtttttaaaagacttaagtggatgcatcctatgcatgtaagcattat ttcccaaaccaaagcatcattcatctccatttatttcttttgttcccgctcagtgtgaag ttgggaactgagaggggatggctgctggtttcacagaagtttggatgccttactcttatc ttaaagccagcatccagaatttcctccctctctgatgccacatgcaaaaccaggtgtacg atgtcaagatggattctttgagagccagggtagatcatatgactgcctttctgtaaaatt ggatgcctagtacaaatgctctttgcctctaattcagtattccatttaataaaaacaata cagtggctggaaaggagcatcag

>ENA I AW0075321 AW007532.1 ws52h07.xl NCI_CGAP_Brn25 Homo sapiens cDNA clone

I MAGE:2500861 3', m NA sequence.

TTTTTCACCAGTAAAGATTATCATCGTTTATTTTTGTTTTTAAAGTTGAAAACAAAAAAG

AGGAGAGAACAGAGTTATGGTATGAATGTATGTAAAACTATAGAGAACTACAGTAATATG

TACTGTGGTTATTGCTGTCTTCAAAAAAAAAAAGAAAAAGAAAAACAACAACAACAACAA

CGAAAACAACCGGTAGGCAACTCGGAATCTGAAGGAATCTTGTCTGACAACTGTGCTATC

CATGTGGGCTACGGTGTGACAGTGGCGGTAGAGAGGAGACTCCGGCTGGCGACCGGGGAC

TGGTGGAGTGGGGTGAGCGGGCACAGGGAAAGCTGGGGTCCCCTTCCCCTCGGACCCTCC

CCACCTTCCCTTTCCCCATCCAAAAGGATTTCAGGAGAGGAGGCCAGAGTCTGTGAAATG

ACTAAACTATATACTCCATTAGAAAACCAAGAAAGTATGTTTGAAATAGAAACAAAAGCC

TAAGAGAAAATAAAAAGTGGAGAAACAGT

>ENA I AI8107671 AI810767.1 tu04d02.xl NCI_CGAP_Pr28 Homo sapiens cDNA clone I MAGE:2250051 3', m RNA sequence.

TTTTTACAAGGGGGAAAATTATGTATTTATTTACACAAATATGCACAGAACACTTGTATC TTTCAAAAGTCACACTTAAGACATAGTAAAAGCATGTTGTATGAACCATGTATTCTTAAG GATTGAGCAAACTGCAGGCTGCTTGCTGCCTTTTAGGTTTGCTAGTCCCTGATCTACTTG A AAC AG ATGTTG CTTG CCCC AAC ACTAGTTT AATTATA AG G G C AG CCTGTG AG A A AGTTT CAATAGACATTTTTCTCACCTATATTGCACGTTTTTCTGAAGCCCTTGGGCAAGTGTGTG TGCCATGTGTAGTTCTATTTACATATAAACGCTACTTTAAAAGTTTATCAAAATCATGAG TTTTT AC A AA AGTTTTTA ATG CTCTTCTG C ATT AT ATGT AG C ATTG C A AATCTG C A AAGT AGT AA AACT ATA AAG C ACCTTTAG GTTTG C ACC AGTT ATTAC AG A AATG G G G ATTTGTG A AAAGGATGTAATTTGATGTAGAAGGGCAAAGTCCTTTAATGACTGGCATTCAAGAGGATT ACTTAAAACA

>ENA I AF1540541 AF154054.1 Homo sapiens D M (DRM) m RNA, complete cds.

ATAATAATTAGGCCAAGCGTTGAATAGTACGGGGGGGGGGGGGGGGCGAGCCCCGGCGGC

TCTGGCCGCGGCCGCACTCAGCGCCACGCGTCGAAAGCGCAGGCCCCGAGGACCCGCCGC

ACTGACAGTATGAGCCGCACAGCCTACACGGTGGGAGCCCTGCTTCTCCTCTTGGGGACC

CTGCTGCCGGCTGCTGAAGGGAAAAAGAAAGGGTCCCAAGGTGCCATCCCCCCGCCAGAC

AAGGCCCAGCACAATGACTCAGAGCAGACTCAGTCGCCCCAGCAGCCTGGCTCCAGGAAC

CGGGGGCGGGGCCAAGGGCGGGGCACTGCCATGCCCGGGGAGGAGGTGCTGGAGTCCAGC

CAAGAGGCCCTGCATGTGACGGAGCGCAAATACCTGAAGCGAGACTGGTGCAAAACCCAG

CCGCTTAAGCAGACCATCCACGAGGAAGGCTGCAACAGTCGCACCATCATCAACCGCTTC

TGTTACGGCCAGTGCAACTCTTTCTACATCCCCAGGCACATCCGGAAGGAGGAAGGTTCC

TTTCAGTCCTGCTCCTTCTGCAAGCCCAAGAAATTCACTACCATGATGGTCACACTCAAC

TGCCCTGAACTACAGCCACCTACCAAGAAGAAGAGAGTCACACGTGTGAAGCAGTGTCGT

TGCATATCCATCGATTTGGATTAAGCCAAATCCAGGTGCACCCAGCATGTCCTAGGAATG

CAGACCCAGGAAGTCCCAGACCTAAAACAACCAGATTCTTACTTGGCTTAAACCTAGAGG

CCAGAAGAACCCCCAGCTGCCTCCTGGCAGGAGCCTGCTTGTGCGTAGTTCGTGTGCATG

AGTGTGGATGGGTGCCTGTGGGTGTTTTTAGACACCAGAGAAAACACAGTCTCTGCTAGA

GAGCACTTCCTATTTTGTAAACCTATCTGCTTTAATGGGGATGTACCAGAAACCCACCTC

ACCCCGGCTCACATCTAAAGGGGCGGGGCCGTGGTCTGGTTCTGACTTTGTGTTTTTGTG

CCCTCCTGGGGACCAGAATCTCCTTTCGGAATGAATGTTCATGGAAGAGGCTCCTCTGAG

GGCAAGAGACCTGTTTTAGTGCTGCATTCGACATGGAAAAGTCCTTTTAACCTGTGCTTG

CATCCTCCTTTCCTCCTCCTCCTCACAATCCATCTCTTCTTAAGTTGACAGTGACTATGT

CAGTCTAATCTCTTGTTTGCCAGGGTTCCTAAATTAATTCACTTAACCATGATGCAAATG

TTTTTCATTTGGTGAAGACCTCCAGACTCTGGGAGAGGCTGGTGTGGGCAAGGACAAGCA GGATAGTGGAGTGAGAAAGGGAGGGTGGAGGGTGAGGCCAAATCAGGTCCAGCAAAAGTC

AGTAGGGACATTGCAGAAGCTTGAAAGGCCAATACCAGAACACAGGCTGATGCTTCTGAG

AAAGTCTTTTCCTAGTATTTAACAAAACCCAAGTGAACAGAGGAGAAATGAGATTGCCAG

AAAGTGATTAACTTTGGCCGTTGCAATCTGCTCAAACCTAACACCAAACTGAAAACATAA

ATACTGACCACTCCTATGTTCGGACCCAAGCAAGTTAGCTAAACCAAACCAACTCCTCTG

CTTTGTCCCTCAGGTGGAAAAGAGAGGTAGTTTAGAACTCTCTGCATAGGGGTGGGAATT

AATCAAAAACCTCAGAGGCTGAAATTCCTAATACCTTTCCTTTATCGTGGTTATAGTCAG

CTCATTTCCATTCCACTATTTCCCATAATGCTTCTGAGAGCCACTAACTTGATTGATAAA

GATCCTGCCTCTGCTGAGTGTACCTGACAGTAGTCTAAGATGAGAGAGTTTAGGGACTAC

TCTGTTTTA AC AAG AA AT ATTTTGG G G GTCTTTTTGTTTT AACTATTGTC AG G AG ATTG G

GCTAAAGAGAAGACGACGAGAGTAAGGAAATAAAGGGAATTGCCTCTGGCTAGAGAGTAG

TTAGGTGTTAATACCTGGTAGAGATGTAAGGGATATGACCTCCCTTTCTTTATGTGCTCA

CTTGAGGATCTGAGGGGACCCTGTTAGGAGAGCATAGCATCATGATGTATTAGCTGTTCA

TCTG CTACTG GTTG G ATG G AC ATA ACTATTGTA ACTATTC AGT ATTTACTG GT AG G C ACT

GTCCTCTGATTAAACTTGGCCTACTGGCAATGGCTACTTAGGATTGATCTAAGGGCCAAA

GTG C AG G GTG G GTG AACTTTATTGT ACTTTG G ATTTG GTT AACCTGTTTTCCTC A AG CCT

GAGGTTTTATATACAAACTCCCTGAATACTCTTTTTGCCTTGTTACTTCTCAGCCTCCTA

GCCAAGTCCTATGTAATATGGAAAACAAACACTGCAGACTTGAGATTCAGTTGCCGATCA

AGGCTCTGGCATTCAGAGAACCCTTGCAACTCGAGAAGCTGTTTTTGATTTCGTTTTTGT

TTTGAACCGGTGCTCTCCCATCTAACAACTAACAAGGACCATTTCCAGGCGGGAGATATT

TTAAACACCCAAAATGTTGGGTCTGATTTCCAAACTTTTAAACTCACTACTGATGATTCT

CACGCTAGGCGAATTTGTCCAAACACATAGTGTGTGTGTTTTGTATACACTGTATGACCC

CACCCCAAATCTTTGTATTGTCCACATTCTCCAACAATAAAGCACAGAGTGGATTTAATT

AAGCACACAAATGCTAAGGCAGAATTTTGAGGGTGGGAGAGAAGAAAAGGGAAAGAAGCT

GAAAATGTAAAACCACACCAGGGAGGAAAAATGACATTCAGAACCACCAAACACTGAATT TCTCTTGTTGTTTTAACTCTCCCACAAGAATGCAATTTCGTTAATGGAGATGACTTAAGT

TG G C AG C AGTA ATCTTCTTTTAG G AG CTTGTACC AC AGTCTTG C AC ATA AGTG C AG ATTT

GCCCCAAGTAAAGAGAATTTCCTCAACACTAACTTCACGGGGATAATCACCACGTAACTA

CCCTTAA AG C ATATC ACTAG CC AA AG AG G G G A AT ATCTGTTCTTCTT ACTGTG CCTATAT

TAAGACTAGTACAAATGTGGTGTGTCTTCCAACTTTCATTGAAAATGCCATATCTATACC

ATATTTTATTCGAGTCACTGATGATGTAATGATATATTTTTTCATTATTATAGTAGAATA

TTTTTATGGCAAGAGATTTGTGGTCTTGATCATACCTATTAAAATAATGCCAAACACCAA

ATATG A ATTTT ATG ATGT AC ACTTTGTG CTTG G C ATTA AA AG A AA AA AAC AC AC ACG CC

>refseq | NM_0133721 NM_013372 Homo sapiens gremlin 1 (GREMl), transcript variant 1, mRNA. a ctcggtgcgccttccgcgga ccgggcga cccagtgca cggccgccgcgtca ctctcggt

cccgctgaccccgcgccgagccccggcggctctggccgcggccgcactcagcgccacgcg

tcgaaagcgcaggccccgaggacccgccgcactgacagtatgagccgcacagcctacacg

gtgggagccctgcttctcctcttggggaccctgctgccggctgctga aggga aaaagaaa

gggtcccaaggtgccatccccccgccagacaaggcccagcacaatgactcagagcagact

cagtcgccccagcagcctggctccaggaaccgggggcggggccaagggcggggcactgcc

atgcccggggaggaggtgctggagtccagccaagaggccctgcatgtgacggagcgcaaa

tacctgaagcgagactggtgcaaaacccagccgcttaagcagaccatccacgaggaaggc

tgca a cagtcgca ccatca tea a ccgcttctgtta cggccagtgca a ctctttcta ca tc

cccaggcacatccggaaggaggaaggttcctttcagtcctgctccttctgcaagcccaag

aaattcactaccatgatggtcacactcaactgccctgaactacagccacctaccaagaag

aagagagtcacacgtgtgaagcagtgtcgttgcatatccatcgatttggattaagccaaa

tccaggtgcacccagcatgtcctaggaatgcagccccaggaagtcccagacctaaaacaa

ccagattcttacttggcttaaacctagaggccagaagaacccccagctgcctcctggcag

gagcctgcttgtgcgtagttcgtgtgcatgagtgtggatgggtgcctgtgggtgttttta

gacaccagagaaaacacagtctctgctagagagcactccctattttgtaaacatatctgc tttaatggggatgtaccagaaacccacctcaccccggctcacatctaaaggggcggggcc gtggtctggttctgactttgtgtttttgtgccctcctggggaccagaatctcctttcgga atgaatgttcatggaagaggctcctctgagggcaagagacctgttttagtgctgcattcg a ca tgga a a agtcctttta a cctgtgcttgca tcctcctttcctcctcctcctca ca a tc catctcttcttaagttgatagtgactatgtcagtctaatctcttgtttgccaaggttcct aaattaattcacttaaccatgatgcaaatgtttttcattttgtgaagaccctccagactc tgggagaggctggtgtgggcaaggacaagcaggatagtggagtgagaaagggagggtgga gggtgaggccaaatcaggtccagcaaaagtcagtagggacattgcagaagcttgaaaggc caataccagaacacaggctgatgcttctgagaaagtcttttcctagtatttaacagaacc caagtgaacagaggagaaatgagattgccagaaagtgattaactttggccgttgcaatct gctcaaacctaacaccaaactgaaaacataaatactgaccactcctatgttcggacccaa gcaagttagctaaaccaaaccaactcctctgctttgtccctcaggtggaaaagagaggta gtttagaactctctgcataggggtgggaattaatcaaaaacctcagaggctgaaattcct aatacctttcctttatcgtggttatagtcagctcatttccattccactatttcccataat gcttctgagagccactaacttgattgataaagatcctgcctctgctgagtgtacctgaca gtagtctaagatgagagagtttagggactactctgttttagcaagagatattttgggggt ctttttgttttaactattgtcaggagattgggctaaagagaagacgacgagagtaaggaa ataaagggaattgcctctggctagagagtagttaggtgttaatacctggtagagatgtaa gggatatgacctccctttctttatgtgctcactgaggatctgaggggaccctgttaggag agcatagcatcatgatgtattagctgttcatctgctactggttggatggacataactatt gtaactattcagtatttactggtaggcactgtcctctgattaaacttggcctactggcaa tggctacttaggattgatctaagggccaaagtgcagggtgggtgaactttattgtacttt ggatttggttaacctgttttcttcaagcctgaggttttatatacaaactccctgaatact ctttttgccttgtatcttctcagcctcctagccaagtcctatgtaatatggaaaacaaac actgcagacttgagattcagttgccgatcaaggctctggcattcagagaacccttgcaac tcgagaagctgtttttatttcgtttttgttttgatccagtgctctcccatctaacaacta aacaggagccatttcaaggcgggagatattttaaacacccaaaatgttgggtctgatttt caaacttttaaactcactactgatgattctcacgctaggcgaatttgtccaaacacatag tgtgtgtgttttgtatacactgtatgaccccaccccaaatctttgtattgtccacattct ccaacaataaagcacagagtggatttaattaagcacacaaatgctaaggcagaattttga gggtgggagagaagaaaagggaaagaagctgaaaatgtaaaaccacaccagggaggaaaa atgacattcagaaccagcaaacactgaatttctcttgttgttttaactctgccacaagaa tgcaatttcgttaacggagatgacttaagttggcagcagtaatcttcttttaggagcttg taccacagtcttgcacataagtgcagatttggctcaagtaaagagaatttcctcaacact aacttcactgggataatcagcagcgtaactaccctaaaagcatatcactagccaaagagg gaaatatctgttcttcttactgtgcctatattaagactagtacaaatgtggtgtgtcttc caactttcattgaaaatgccatatctataccatattttattcgagtcactgatgatgtaa tgatatattttttcattattatagtagaatatttttatggcaagatatttgtggtcttga tcatacctattaaaataatgccaaacaccaaatatgaattttatgatgtacactttgtgc ttggcattaaaagaaaaaaacacacatcctggaagtctgtaagttgttttttgttactgt aggtcttcaaagttaagagtgtaagtgaaaaatctggaggagaggataatttccactgtg tggaatgtgaatagttaaatgaaaagttatggttatttaatgtaattattacttcaaatc ctttggtcactgtgatttcaagcatgttttctttttctcctttatatgactttctctgag ttgggcaaagaagaagctgacacaccgtatgttgttagagtcttttatctggtcagggga aacaaaatcttgacccagctgaacatgtcttcctgagtcagtgcctgaatctttattttt taaattgaatgttccttaaaggttaacatttctaaagcaatattaagaaagactttaaat gttattttggaagacttacgatgcatgtatacaaacgaatagcagataatgatgactagt tcacacataaagtccttttaaggagaaaatctaaaatgaaaagtggataaacagaacatt tataagtgatcagttaatgcctaagagtgaaagtagttctattgacattcctcaagatat ttaatatcaactgcattatgtattatgtctgcttaaatcatttaaaaacggcaaagaatt atatagactatgaggtaccttgctgtgtaggaggatgaaaggggagttgatagtctcata aaactaatttggcttcaagtttcatgaatctgtaactagaatttaattttcaccccaata atgttctatatagcctttgctaaagagcaactaataaattaaacctattctttctgtgaa aaaaaaaaaa

>ENA | AU154455 | AU154455.1 Homo sapiens cDNA clone:NT2RP4001145, 3' end, expressed in NT2 neuronal precursor cells after 2-weeks retinoic acid (RA) induction.

GTACACAATCATTTGTTTTATTTGAAAACATGTCTACACTGCATTGAGCACCAACACAGG

TGTGACCAAGAAACCCACAGTCCTGTCCCCGCAGGCACTGGGTCCAGTGTATGACTTGGG

GTGGACTGTTATTTTTCACAGTGAGGGGGGAAGAAAGGATAGGAAAGAAAAGATGGCCAT

TATCCCAACTCCTGTTCAGGAATCTGAACAATGAAAGTTATTTAAACTCATCCAGCTCTT

CTCATTCCCCTTCTCTCAATCAGCTGGTGTTCAAATATGGAATCTGAGGCCGAGCGCAGT

GGCACACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACGAGGTCAAG

AGATAGAGATCATCCTCGCCGATACGGTGAAACCCCATCTCTACTAAAAATACAAAAATT

GGCCGGGTGTGGTGGTAGGAACCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAA

TTGCTTTTGACATCCTGACACATGTATAATTGCCGGGAGGCAAATTGCAGACTACGTTTA

C ACC AC AC N C N C AA AA ATG G

>ENA I AW5901961 AW590196.1 hg41a02.xl NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE:2948138 3', m RNA sequence.

TTGTTAT AA A ACTG G C AG ATTTTATTTCTC ATACC AG AG G CTC AC AC AG G ATTTCTTTCT

G C ATG G G G G AC AACTG G CTCTTG GTTTC A AAC AC ACTTG AG CCTCTAG C ACC ATT A AG C A

TCCAGCAGCTTCCTCGGCATCCAGGCTGAGATATCCATATTCCAGAACAAAGCAGCCAAT

GTGAAGGATGTGCATCACTGGGAAGAGAGAAGGCTGCCCCCTTAGCCCTGGCTCCTCATC

ATCTGAGGGAAGTGGAGGGGGCAGGTGGGAGCAAGCTTATAGTCACCAAGTCATGGCTGG

AGAAGGATTTGGGTAAAGCAACTCTAGAGGCTGCCTGGTGGCCTACTTGGGAGAAACAAA

GTGCCTTTGAGACTATCGACTTCCTGCTTGTGATCTAAAATGGATGTCTTTGAAATGATT

AATCTGGACCAGCTAAAGGCAGTTGTTCACCACGTGTTATCCAAGTTTAGATTTCCTAGT TGATTATTCACACCAGATCAGGCTTTAAAAGATAGACCAAACTAGACAGAATGTGTACAT

TTCAGCAGATCAGCAATTGCAAAATGCTGGTGCTATNTACTGACGTAGCACTGGATCCA

>ENA | BG4940071 BG494007.1 602542289F1 NI H_MGC_59 Homo sapiens cDNA clone I MAGE:4673182 5', m RNA sequence.

GTGATGATCGACATTTGAATCTCTTTGCCCTTTCCAACGGCTATGGCATCAGGTTCTAAA

ATAAGCTCGTAATTTTTCCTGTTATTTTAATAATATGGAAATATTAGCATAGTGTTTCTT

TTGATAGTGATAGACTATAATCCATATTTAAATTTTATAGAGAAGAAATTTTATTGTACT

GTGATGTAGATATTTATTATCCAGGTAAGGATTTGCCCGGTGTGTATTTTTTACAATTGA

GACATTTTACTTTAATCTTTAACAAAAAATGCATTAAAAACACACTCAAAAAAAAACAAA

AAAAAAAAAAAAAGACAACCCAAACGGGGGGGGAAAAAAGAGGTGATTGGCACCCTTTAT

C ACG A AA ATCTTCCTG CG G G CG G CCCTCT AATA ACC AGTCTTCTG G A AC A ACTGTG CCC A

AACCGAGGTGTCGCTCTTTAAAATAGGCGTGGTCTCCCACCATATCTAACACTCAAATGG

CGCCGCCTCTTCTCAAAAGAACCCACAAATATGTGTGCCGACCAAGAGTTAAAAAACCCG

CCTTGCGTTGGACGGGGCGGACATTATCTTGGATTGGCACCAACACTATTAAAAGAGGCG

ATGCGACACCCAACCCCGATTAATTGGCAGCAGACAGAAATCCTTTCTCAACTAGTATAG

AAAACTGTTGTGGCCCTCCACCACACAAAAGGACGAATCCTACCCAACTAATGTATTAGC

TCCTCTCCAGTGTGAACAATATACTAATCTGGATGCGCCCACACCCAAGCTGGTTAGCTA

ACACAAACACCAGGGAGGGAAGACACACGCATTTTGTAACACAAATAGATCTAATATTAG

ACTCGTGCCGTATAACATCGGACACTAATCTCTAGCACCAGCGGGCGTCGACTGTAATTA

TGTCCCGCCACTGCTGCTGTTCGTCGGCATGTTATCATGCCCCACGCTCTCTGTGATCCT

ACACGAGAGGGATCACCCCACGCTTAT

>ENA | AI540210 | AI540210.1 te55e07.xl Soares_N FL_T_GBC_Sl Homo sapiens cDNA clone

I MAGE:2090628 3' similar to TR:Q63571 Q63571 RAT GROWTH AND TRANSFORMATION-DEPENDENT, m RNA sequence.

ATGTATAAATCCATTTATATAAAGTTCAAAAACAGGCAAAATGAATCAAAGGTGATGAAA CTCAGAAAAACTGCTATGTTTGGGAGGTAATGGCTGAGAAAAGGCAGGAATGAGGCTGTG AAGTGTTG CC AATATTCT AC ATCTTC ACTTTG G C AGTG GTT AC AC AG GTGTTC ACG AC AT AAATATCTATCAGACTGTATACAGTTTTGTCCACTTTTTGAATGCATGGTATACTTCAGT AAAAGTTTACTAAAAAATAAAAATAAAAAAGACATTGTGCTTCTTGTTACCAAAATAAAA CCATGGCAGATATTTTGGTAAATATTCTATTTTTCCCATCTTCTACTGTTGCTGATGACA G G G ATG GT ATTC AG GTG A AC ACTCTGTC ACTTAG A AT ATC ATTTAG CTTTAG CCTGTG C A G CC AATG C AG CTTCTTC ACG CC ACTTAG CTTTTCTTG CC AAGTTCC A ACTTTGTAAG G AT TC ATGTCGTTCTAC AG CCCTTTTG G CTG AC ACT ATC AC AG CAN AG C AG G CG ATA ATTGTG AGTCC A ATC ATTATCGTAC AAG CT NTC ACTCG AG CT NTGTTTCTTG CG GTGTCTATC ATT TCTGGCGGGATCCGAAGCGGGATCTACTNCATCGATTTGAAACGCCTGTCCACAGCAGGA TTTTCTTGTCGAAATGCGA

>ENA | BF589515 | BF589515.1 naa05c06.xl NCI_CGAP_Pr28 Homo sapiens cDNA clone I MAGE:3254002 3', m NA sequence.

A AATATTCC ATGTG C AG AA ATTTATTTTA A ATTTTATTG CATC AC ATT ATAC AAG C ATTA

ATCATGGCTTCATATTGATGACTATTTAAATGTGAAAATTCACTCATGTCAGTACTTTTT

G G CTATTTAC AAGTA AG G A ATTTCTATGTACTTTATATATCTCTGTATTTGTATGTAC AT

ATGCAGGAATACATGACTATACATATGTACACACAGAAATACATCTATGGCCATACACAT

AGCTATAGATATGTCATATATAATAATCTTCTCAGAAAGGTCTAAAATTAAAAAAAAGGA

AAGAAAAAGTTGTAAACAGGGTCTTGTCTGTGTTGTTGGTGACATGGAATTAGGACCATA

TGATGACATTCTAGGAATGTGTGTCCATGTGTCTGAATACCCTTTTTAGCCCAGTGTCTG

TAAAATTCACATGGGATAGAATGCAAAAAAGGTAGCAAACAGGCTGAAAAACAGGCCCAG

TATACAAGTTCCCCTTGATTTTAAAAACTTGAGAATGTAACTGCCCATAATGTGCATGCT

TGCTTGGTCAAG AATG GTCT ATG G AT AG AT

>gi 1114443201 gb | BF432206.11 BF432206 nab81ell.xl Soares_NSF_F8_9W_OT_PA_P_Sl Homo sapiens cDNA clone IMAGE:3274101 3', m RNA sequence

TTTTCTTTTTCTAGTTTAAAATACAATTTAATAAGAAAATCCGGGATACATTTTATATGATTCCATTTAT

TAAAGAAAAAGAAACTTCTTTCCAATATATTCTACCCAATTATTAAATTCATTTTAGATTTTTGGGAAGA

GCAAATCCAACTTAAAAAAAAAACTTGCTAGGCAGTTGAAATCCTCTGGTTCCAAAGTTTTAAAAAATGA GGCAAGATTGTATAGTGAGAGTAGAAAAAATAAGATGAAGTGGAATCACCCATGACAATTTGTCATATTT

GTCATTACGAATTTCAACATCTGCAACTGAAAAGCTACAGAAATCAAAAAATAAAACACAAAGAAGATTC

TCAAGGACCAAAGACTGTTTGATGATGTTGCTCTAAGATTTCGTCCTCCATTTATTTCACACAAAAATAA

GTTAAGTATAAATAAGAAGATGAGGAGAGCTGGTATGTACTCAGATGTGTTCACTGGTGCATAGTCAGAG

GGGGTGTGAGAACAGCCAAATGTATTTCTTCGCCCACACTCACTACACAAAACTCTCCTCCATGTTG

>gi 12838066651 ref | N M_153448.3 | Homo sapiens ESX homeobox 1 (ESX1), m NA

CCCGGGATCGCCGCGGAACCACGCACAGAGTCTGCAGAAGTGCACAGCTTTATCGACAGCGCTTGAAGCA

TGGAGTCTCTTCGCGGGTACACCCACAGTGATATTGGCTACCGCAGCCTGGCAGTCGGCGAGGACATCGA

GGAAGTGAATGATGAGAAACTTACCGTGACCTCGCTGATGGCAAGGGGAGGAGAGGACGAGGAGAATACA

CGGTCCAAACCTGAGTACGGAACAGAAGCGGAAAACAACGTTGGCACGGAAGGGTCCGTCCCCTCGGACG

ACCAAGACCGTGAGGGTGGCGGCGGCCACGAGCCGGAGCAACAGCAGGAGGAGCCGCCCCTGACCAAGCC

GGAGCAACAGCAGGAGGAGCCGCCCCTGCTCGAGCTGAAGCAAGAGCAGGAGGAGCCGCCCCAGACGACC

GTGGAGGGGCCACAGCCGGCGGAGGGGCCACAAACCGCTGAGGGACCACAGCCCCCAGAGAGGAAACGCC

GCCGCCGCACCGCGTTCACGCAGTTTCAGCTGCAGGAGCTAGAGAACTTTTTCGATGAATCTCAATATCC

CGACGTTGTGGCGCGAGAGAGACTTGCAGCACGCCTGAATTTGACTGAAGACAGAGTGCAGGTTTGGTTT

CAGAACAGAAGAGCCAAGTGGAAACGAAATCAGAGGGTGCTAATGTTGAGAAACACTGCTACTGCTGACC

TGGCCCACCCTTTGGACATGTTCTTGGGTGGGGCCTATTATGCTGCTCCTGCTCTGGATCCTGCTTTGTG

TGTTCATCTGGTGCCACAACTACCTAGACCACCTGTGCTGCCTGTGCCACCTATGCCACCCAGGCCACCC

ATGGTCCCTATGCCACCCAGGCCACCCATAGCACCTATGCCACCCATGGCGCCTGTGCCACCCGGCTCAC

GCATGGCGCCTGTGCCACCCGGGCCACGCATGGCGCCTGTGCCACCCTGGCCGCCCATGGCGCCTGTGCC

ACCCTGGCCGCCCATGGCGCCTGTGCCAACCGGGCCGCCCATGGCGCCTGTGCCACCCGGGCCGCCCATG

GCGCGTGTGCCACCCGGGCCGCCCATGGCGCGTGTGCCACCCGGGCCGCCCATGGCGCCTCTGCCACCCG

GGCCGCCCATGGCGCCTCTGCCACCCGGGCCGCCCATGGCGCCTCTGCCACCCGGGCCGCCCATGGCGCC

TCTG CC ACCC AG GTC AC ATGTG CCTC AC ACTG G CCTG G CTCCTGTAC AC ATC AC ATG G G CCCCTGTC ATC

AACAGTTATTATGCATGTCCCTTTTTCTAAAGTAAGGTATTCATAACAGTTTTTCCAAAGTTCTTTCCTG CCAGATAGAAATTGTGCACAGCACAGCATCAAGTAATTCGTTAGATGCTTGTTAAATGAAGTGGGTAGGT GAACAAAGTTAACGAATGCCCTGTTATTTTTGTAGGCCACATAATTGTAGTATTTTCAATAAAGATGTGA CTTAATAGTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Claims

We claim:

1. A method of assessing medical condition comprising identifying differential expression of gene-based markers (relative to the expression of the same genes in a normal population) in CECs.

2. The method of claim 1 wherein the markers are not differentially expressed in PBMCs.

3. The method of claim 1 wherein there is at least a 2 fold difference in the expression of the modulated genes.

4. The method of claim 1 wherein the p-value indicating differential modulation is less than .05.

5. The method of claim 1 wherein the markers are selected from Table 2.

6. A method of identifying the tissue of origin of a CEC comprising identifying differential expression of tissue specific gene -based markers (relative to the expression of the same genes in a normal population) in CECs.

7. The method of claim 6 wherein the markers are not differentially expressed in PBMCs.

8. The method of claim 1 wherein there is at least a 2 fold difference in the expression of the modulated genes.

9. The method of claim 1 wherein the p-value indicating differential modulation is less than .05.

10. The method of claim 1 wherein the markers are selected from Table 3.

11. The method of claim 4 wherein there is at least a 2 fold difference in the expression of the modulated genes.

12. The method of claim 4 wherein the p-value indicating differential modulation is less than .05.

13. A diagnostic kit comprising reagents for isolating CECs and reagents for detecting the expression of the markers of Table 2.

14. The diagnostic kit of claim 13 wherein the reagents for detecting markers are those of Table 3.

15. The kit of claim 13 further comprising reagents for conducting a microarray analysis.

16. The kit of claim 13 further comprising reagents for amplifying the markers.

17. The kit of claim 13 further comprising a component containing executable instructions that correlate expression detection with a pattern.

18. The kit of claim 13 wherein said reagents for isolating CECs include immunomagnetic reagents.

19. A method for assessing medical condition comprising isolating CECs, amplifying gene expression markers from said CECs, detecting the expression of said markers, and correlating the expression of said markers with a diagnosis or prognosis; wherein isolation and amplification is conducted using the kit of claim 13.

20. A method for assessing medical condition comprising isolating CECs, amplifying gene expression markers from said CECs, detecting the expression of said markers, and correlating the expression of said markers with a diagnosis or prognosis; wherein isolation and amplification is conducted using the kit of claim 14.