WO2012044671A3 - Method for removing residual organic solvent from microparticles - Google Patents

Method for removing residual organic solvent from microparticles Download PDF

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Publication number
WO2012044671A3
WO2012044671A3 PCT/US2011/053655 US2011053655W WO2012044671A3 WO 2012044671 A3 WO2012044671 A3 WO 2012044671A3 US 2011053655 W US2011053655 W US 2011053655W WO 2012044671 A3 WO2012044671 A3 WO 2012044671A3
Authority
WO
WIPO (PCT)
Prior art keywords
microparticles
organic solvent
removing residual
residual organic
microparticle
Prior art date
Application number
PCT/US2011/053655
Other languages
French (fr)
Other versions
WO2012044671A2 (en
Inventor
Adrian T. Raiche
Brenda H. PERKINS
Original Assignee
Evonik Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evonik Corporation filed Critical Evonik Corporation
Priority to CA2813301A priority Critical patent/CA2813301A1/en
Priority to AU2011308893A priority patent/AU2011308893B2/en
Priority to JP2013531765A priority patent/JP5808413B2/en
Priority to RU2013119811/05A priority patent/RU2013119811A/en
Priority to CN2011800471235A priority patent/CN103370057A/en
Priority to EP11771308.1A priority patent/EP2621473A2/en
Publication of WO2012044671A2 publication Critical patent/WO2012044671A2/en
Publication of WO2012044671A3 publication Critical patent/WO2012044671A3/en
Priority to IL225254A priority patent/IL225254A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Disclosed herein are methods comprising suspending microparticles in a surfactant/non-polar alkane solution to remove residual solvent that is present in the microparticle.
PCT/US2011/053655 2010-09-30 2011-09-28 Method for removing residual organic solvent from microparticles WO2012044671A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2813301A CA2813301A1 (en) 2010-09-30 2011-09-28 Method for removing residual organic solvent from microparticles
AU2011308893A AU2011308893B2 (en) 2010-09-30 2011-09-28 Method for removing residual organic solvent from microparticles
JP2013531765A JP5808413B2 (en) 2010-09-30 2011-09-28 Method for removing residual organic solvent from fine particles
RU2013119811/05A RU2013119811A (en) 2010-09-30 2011-09-28 METHOD FOR REMOVING RESIDUAL ORGANIC SOLVENT FROM MICROPARTICLES
CN2011800471235A CN103370057A (en) 2010-09-30 2011-09-28 Method for removing residual organic solvent from microparticles
EP11771308.1A EP2621473A2 (en) 2010-09-30 2011-09-28 Method for removing residual organic solvent from microparticles
IL225254A IL225254A0 (en) 2010-09-30 2013-03-17 Method for removing residual organic solvent from microparticles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38805010P 2010-09-30 2010-09-30
US61/388,050 2010-09-30

Publications (2)

Publication Number Publication Date
WO2012044671A2 WO2012044671A2 (en) 2012-04-05
WO2012044671A3 true WO2012044671A3 (en) 2013-03-14

Family

ID=45094869

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/053655 WO2012044671A2 (en) 2010-09-30 2011-09-28 Method for removing residual organic solvent from microparticles

Country Status (8)

Country Link
EP (1) EP2621473A2 (en)
JP (1) JP5808413B2 (en)
CN (1) CN103370057A (en)
AU (1) AU2011308893B2 (en)
CA (1) CA2813301A1 (en)
IL (1) IL225254A0 (en)
RU (1) RU2013119811A (en)
WO (1) WO2012044671A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104382848B (en) * 2014-10-20 2017-04-26 齐鲁制药有限公司 Tacrolimus suspending eye drop liquid and preparation method thereof
CN109718209B (en) * 2017-10-30 2021-03-05 浙江圣兆药物科技股份有限公司 Freeze-drying method of risperidone microspheres with low ethanol residues

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
US5876761A (en) * 1989-07-07 1999-03-02 Novartis Ag Sustained release formulations of water soluble peptides
US20050181059A1 (en) * 2003-09-30 2005-08-18 Spherics, Inc. Nanoparticulate therapeutic biologically active agents
US20080317865A1 (en) * 2007-06-20 2008-12-25 Alkermes, Inc. Quench liquids and washing systems for production of microparticles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69024953T3 (en) 1989-05-04 2005-01-27 Southern Research Institute, Birmingham encapsulation
HU221294B1 (en) * 1989-07-07 2002-09-28 Novartis Ag Process for producing retarde compositions containing the active ingredient in a polymeric carrier
US5739265A (en) * 1995-09-20 1998-04-14 Clariant Finance (Bvi) Ltd. Fractionation of phenol formaldehyde condensate and photoresist compositions produced therefrom
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
US5876761A (en) * 1989-07-07 1999-03-02 Novartis Ag Sustained release formulations of water soluble peptides
US20050181059A1 (en) * 2003-09-30 2005-08-18 Spherics, Inc. Nanoparticulate therapeutic biologically active agents
US20080317865A1 (en) * 2007-06-20 2008-12-25 Alkermes, Inc. Quench liquids and washing systems for production of microparticles

Also Published As

Publication number Publication date
EP2621473A2 (en) 2013-08-07
CA2813301A1 (en) 2012-04-05
WO2012044671A2 (en) 2012-04-05
IL225254A0 (en) 2013-06-27
AU2011308893A1 (en) 2013-05-09
RU2013119811A (en) 2014-11-10
CN103370057A (en) 2013-10-23
AU2011308893B2 (en) 2015-04-23
JP5808413B2 (en) 2015-11-10
JP2013538854A (en) 2013-10-17

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