WO2011156663A1 - Method of treating a material using a sol-gel derived composition - Google Patents

Method of treating a material using a sol-gel derived composition Download PDF

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Publication number
WO2011156663A1
WO2011156663A1 PCT/US2011/039884 US2011039884W WO2011156663A1 WO 2011156663 A1 WO2011156663 A1 WO 2011156663A1 US 2011039884 W US2011039884 W US 2011039884W WO 2011156663 A1 WO2011156663 A1 WO 2011156663A1
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WO
WIPO (PCT)
Prior art keywords
sol
sorbate
gel derived
derived composition
composition
Prior art date
Application number
PCT/US2011/039884
Other languages
French (fr)
Inventor
Paul L. Edmiston
Original Assignee
Abs Materials,Inc
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Publication of WO2011156663A1 publication Critical patent/WO2011156663A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B33/00—Silicon; Compounds thereof
    • C01B33/113—Silicon oxides; Hydrates thereof
    • C01B33/12—Silica; Hydrates thereof, e.g. lepidoic silicic acid
    • C01B33/14—Colloidal silica, e.g. dispersions, gels, sols
    • C01B33/145—Preparation of hydroorganosols, organosols or dispersions in an organic medium
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
    • A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/12—Powders or granules

Definitions

  • the present invention relates generally to the chemical arts. More particularly, the invention relates to a method for the treating a material using a sol-gel controlled release of a sorbate, such as a pesticide, a herbicide or a pharmaceutical substance .
  • a sorbate such as a pesticide, a herbicide or a pharmaceutical substance .
  • a method and system that includes treating a material by applying a sol-gel derived composition loaded with a first sorbate under conditions effective to treat the material with the first sorbate.
  • the sol-gel derived composition is substantially completely loaded with the sorbate and, in some aspects, the sol-gel derived composition is partially loaded with the sorbate.
  • the sol-gci. derived com osition is an aromatically- bridged, organosiloxane sol-gel derived composition containing a plurality of alkylsiloxy substituents.
  • the sol-gel derived composition is an aromaticaliy- bridged, organosiloxaiie sol-ge] derived composition containing a plurality of alkylsiloxy snbstituents and a cosmetically acceptable carrier.
  • the first sorbate is biologically active. And is some such embodiments, the first sorbate is a pesticide, a herbicide or a pharmaceutical. In some such embodiments, the first sorbate is atrazuie, 2,4-dichiorophcnoxyacetic acid, malathion, dicWorodiphenyltrichloroetbane, impramiiie, a vitamin or a polypeptide,
  • the loading density of the sorbate in the sol-gel derived composition ia from about 0.005 to about 5 gram sorbate per gram of the sol-gci derived composition. And in some aspects, the loading density of the sorbate in the sol-gel derived composition is from about 0.005 to about 5 gram sorbate per gram of the sol-gel derived composition.
  • the method additionally includes applying a second sorbate after application of the first sorbate.
  • the second sorbate is a water soluble organic liquid and, in some of these embodiments, the second sorbate is etiianol.
  • the soi-gel derived composition is applied to a plant or an animal. And, in some embodiments, the sol-gel derived composition is applied to a human.
  • the sol-gel derived composition is applied to a soil. And, in some, embodiments, an unloaded sol-gci derived composition is applied along with die loaded sol-gel derived composition. In some of these embodiments, the sol-gel derived composition includes inert particles having a diameter of from about 5 to about 20 DID. In some of these embodiments, the inert particle is magnetic and in some embodiments, the sol gel-derived composition containing magnetic panicles is removed from the treated material using a magnetic device.
  • sol-gel derived composition is formulated with a non-liquid pharmaceutically effective carrier or a cosmetically acceptable carrier.
  • sorbate means an organic compound that is taken up by the sol-gel derived compositions whether by adsorption, absorption, or a combination thereof.
  • swellable means an increase of at least 1.5 times the volume of the sol-gel derived composition , when placed in excess sorbate compared to the vohime when dry.
  • nanoparticle means a particle sized between about 2 and about 500 nanometers in one dimension.
  • the sol -gel derived composition is swellable to at least 1 ,5 limes its volume, when dry, in acetone.
  • Preferred sol-gei derived compositions are swellable to at least two times their ori inal volume, more preferably at least five times their original volume, and in some embodiments tip to about eight to ten ti mes their original volume.
  • the swelling of the sol-gel derived composition and the sorption of the first sorbatc are driven by the release of stored tensile force rather than, by chemical reaction.
  • the sol-gel derived composition is a porous, aiOmati cully- bridged, oi'ganosi loxane soi-gel derived composition containing a lurarity of alky) siJoxy substituents.
  • the sol-gel derived composition contains a plurality of flexibly tethered and interconnected organosiloxane particles having diameters on the nanometer scale.
  • the organosiloxane nanoparticles form a disorganized porous matrix defined by a plurality of cross-linked aromatic si!oxarres.
  • the porous, aromatically bridged, organosiloxane sol-gel derived compositions contains a plurality of polysiloxanes that include an aromatic bridging group flexibly linking the silicon atoms of the polysiloxanes.
  • Such organosiloxane nanoparticles have a multilayer configuration comprising a hydrophilic inner layer and a. hydrophobic, aromatic-rich outer layer.
  • sol-gel derived compositions useful in accordance with the inventive method is disclosed in U .S. Pat. No. 7,790, 830 which patent is herein incorporated by reference.
  • a suitable swellable sol-gel derived composition is Osorb® swellable sol-gel derived, composition available from ABS Materials, Wooster, Ohio.
  • the porous, swellable sol-gel derived compositions is loaded with a first sorbate. It is an advantage of the invention that a wide variety of sorbates can be used.
  • the sorbate is biologically active.
  • Representative biologically active sorbates include, but are not limited to, pesticides, herbicides, such as atrazine, 2.4- dichlorophenoxyacetic acid, malathion, and dichlorodiplienyltrichloroelhane and pharmaceuticals, including drags such as impra ine, vitamins and pol peptides.
  • the sol-gel . derived compositions are loaded with a first sorbate using any suitable method.
  • the sol-gel derived composition can be contacted with the first sorbate under conditions sufficient to cause the sol-gel derived composition to sorb the sorbate.
  • a nonvolatile first sorbate such as impramiiie.can be mixed with a volatile second sorbate, such as etbanol or a mixture of ethanol and dichloromethane, where the second sorbate is chosen because of its effectiveness in swelling the sol-gel derived composition .
  • the sol-gel derived composition is contacted with the mixture, the mixture is healed, for example up to about 180° F (the decomposition temperature of the sol-gel derived composition ⁇ to remove the volatile second sorbate and produce a sol-gel derived composition loaded with (he first sorbate.
  • the sol-gel derived composition is contacted with an aqueous solution containing a water soluble first sorbate, such as atrazine.
  • the sol-gel derived composition is first swo llen with a sorbate and the sorbate is excha ged for a first water soluble sorbate by rinsing the swollen sol-gel derived composition with an aqueous solution containing the water-solubl sorbate.
  • the loading density of the first sorbate in the sol-gel derived composition depends on the required concentration, application time and physical characteristics of the sorbate. The particular loading density for a speci fic application can be readily determined by one skilled in the art without undue experimentation.
  • the loading density of the sorbate in tire sol-gel derived composition is from about 0.005 to about 5 gram sorbate per gram of the sol-gel derived composition.
  • the loading density of the sorbate in the sol-gel derived composition is from about 0.01 to about 1 gram sorbate per gram of the sol-gel derived composition.
  • the sol-gel derived composition is completely loaded with the first sorbate, I.e., the sol-gel derived composition has been treated under conditions such that substantially no additional sorbate can be sorbed by the sol-gel derived composition .
  • the sol-gel derived composition is only partially loaded with the first sorbate.
  • the sol-gel derived composition can be used in any suitable form, including in powder or pellet forms.
  • Useful polymeric binders include microcrystalline cellulose and elast meric polymers.
  • Preferred elastomeric polymers have a glass transition temperature below about 1 50 C, the temperature at which the sensor material begins to decompose.
  • polystyrene and is a currently most preferred elastomeric polymer binder are described in U.S. Patent Nos.
  • Pellets can be formed in any desired shape and size suitable for their desired application.
  • the sol-gel derived, composition are appl ied, by any suitable method.
  • the affinity of the sol-gel derived composition for the sorbate then provides for the slow desorption of the sorbate from the sol-gel derived composition at a . measured rate.
  • Other factors diat can be used to influence the rate of release include the concentration griidient and die size of the sorbate.
  • the material is treated with a second sorbate.
  • Suitable second sorbates include, without limitation, water soluble organic liquids, such as ethanol. Sufficient second sorbate is applied to cause the sol-gel derived composition to swell and thus increase the rate of desorption of the first sorbate.
  • both loaded and unloaded sol-gel derived composition arc- applied to the material.
  • the unloaded sol-gel derived composition can be applied to an area different than the area where the loaded, sol-gel derived composition is applied, e.g. an area where no treatment is desired.
  • tire sorbate is released from the loaded sol-gel derived composition , it is sorbed by the unloaded sohscl derived composition , thus providing control not only over the rate but the area of application of the sorbate.
  • the sol-gel derived composition can additionally include inert particles having a diameter of from about 5 to about 20 ran. The particles can be chosen to increase the density of the sol-gel derived composition , thus, inhibiting the travel of the sol-gel derived composition in high winds or heavy rain.
  • the inert particles are made of a magnetic material, such as metallic iron or magnetite, it is an advantage of sol-gel derived composition containing such magnetic particles that they can be readily removed from a material, once treatment is completed, using a magnetic device.
  • Representative formulations containing the sorbate loaded sol-gel derived composition include, but are not limited, cosmetics, cleansers (e.g., skin cleansers), and medicaments, including pharmaceuticals in the form of tablets, capsules, ointments, or the like.
  • Cosmetic formulations according to the invention can be contained in a wide variety of cosmetic preparations.
  • Representative formulations include, but are not limited to, skin-care preparations, e.g. skin emulsions, multi-emulsions or skin oils and body powders; cosmetic personal care preparations, e.g. facial make-up in the form of lipsticks, lip gloss, eye shadow, liquid make-up, day creams or powders, facial lotions, creams and powders (loose or pressed); and light-protective preparations, such as sun tan lotions, creams and oils, sun blocks and pretann g preparations.
  • skin-care preparations e.g. skin emulsions, multi-emulsions or skin oils and body powders
  • cosmetic personal care preparations e.g. facial make-up in the form of lipsticks, lip gloss, eye shadow, liquid make-up, day creams or powders, facial lotions, creams and powders (loose or pressed)
  • light-protective preparations such as sun
  • compositions according to the invention comprise a l iquid or non liquid cosmetically acceptable carrier to act as a diluent, dispersant or vehicle for the sorbate- Ioaded sol-gei derived composition . so as to facilitate- its distribution when the composition is applied to the skin.
  • Carriers other than or in addition to water can include liquid or solid emollients, solvents, humectants, thi ckeners and powders.
  • Particularly suitable non aqueous carriers include polydimethyi, si!oxane and/or po!ydimethyl phenyl siloxaiie.
  • Such formulations can additional ly include colorants, sequestering agents, thickening or solidifying (consistency regulating) agents, emollients.
  • UV absorbers, skin- protective agents, antioxidants find preservatives..
  • the sol-gel derived composition is formulated in at least one liquid or non liquid pharmaceutically acceptable carrier.
  • the sol-gel derived composition is formulated in at least one liquid or non liquid pharmaceutically acceptable carrier.
  • pharmaceutically acceptable carrier encompasses any of the standard pharmaceutical carriers known to those of skill in. the art.
  • Pharmaceutically acceptable carriers include. solveni(s), vehicle(s), adjuvants), excipient(s), bt.nder(s), thickener(s), suspending. agent(s), or filler substance(s) thai are known to the skilled artisan suitable for administration to human and/or animals.
  • Other useful carriers include gum acacia, agar, petrolatum, lanolin, dimethyl sulfoxide (DM.SO), normal saline ( S).
  • PBS phosphate buffered saline
  • uctoxvnol oleyl alcohol polyvinyl alcohol, povidone, propylene glycol raonostearate, sodium laiiryl sulfate, sorbitan esters, stearyl alcohol, tragacanth, xanthan gum, chondrus, glycerin, trolami te, avocado oil, almond oil, coconut oil. coconut butter, propylene glycol, ethyl alcohol, malt, and malt extract.
  • Medicares include medicaments taken into the bodies of humans or non-human vertebrate animals, or applied topically thereto, by a delivery- system.
  • a medica ent is a therapeuti c agent or substance, such as a drug, medicine, irrigaol, bandage, or other medical or dental device, that promotes recovery from injury or ailment or prevents or alleviates the symptoms of disease.
  • Medicaments containing the sorbats-ioadel sol-gel derived composition can be formulated for any suitable systemic or non-systemic delivery system, including delivery systems for oral, enteral, or parenteral delivery routes include tablets, troches, lo enges, aqueous or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules. syrups, beverages, el ixirs or enteral formulas, lavage or enema solutions, adhesive patches, infusions, injectates, intravenous drips, inhalants, or implants. Delivery systems also include topical creams, ge!s, suppositories, or ointments for non-systemic localized deiivery or systemic delivery vi a the blood stream.
  • Systemic- delivery systems that are contemplated by the present invention include, but are not limited to, implant; adhesive transdermal patches; topical creams, gels or oi tments for transdermal delivery; trausmucosal delivery matiiccs or suppositories or gels. It is contemplated that the compositions of the present invention are formulated to deliver an effective amount of the sorbaie by these or any other pharmaceutically acceptable systemic delivery system.

Abstract

Disclosed is a method and system that includes treating a material by applying a sol-gel derived composition loaded with a first sorbate under conditions effective to treat the material with the first sorbate.

Description

METHOD OF TREATING A MATERIAL USING
A SOL-GEL DERIVED COMPOSITION
Cross Reference to Related Application
This application claims the benefit of Provisional Patent Application Nos.
1/353,417, filed June 10, 2011 and 61/356,094, filed June 18, 2010.
Background of the Invention
1. Field of the Invention
The present invention relates generally to the chemical arts. More particularly, the invention relates to a method for the treating a material using a sol-gel controlled release of a sorbate, such as a pesticide, a herbicide or a pharmaceutical substance .
2. Discussion of the Related Art
Millions of pounds of chemical agents, including biologically active agents, such as pesticides , herbicides and pharmaceuticals are applied each year to mitigate damage lo crops and to promote animal and human health. Methods of application often lead to the tire chemical agent entering the surrounding environment through water run-off, evaporation, sublimation or tarongh human animal excrement. Consequently, there is a definite need for a method of controlling the rate of release of such chemical agents in order to prevent or minimize such unwanted effects.
Summary of the Invention
Now in accordance with the invention there has been found a method and system that meets these needs and provides additional advantages. Disclosed is a method and system that includes treating a material by applying a sol-gel derived composition loaded with a first sorbate under conditions effective to treat the material with the first sorbate. In some aspects , the sol-gel derived composition is substantially completely loaded with the sorbate and, in some aspects, the sol-gel derived composition is partially loaded with the sorbate. In some aspects, the sol-gci. derived com osition is an aromatically- bridged, organosiloxane sol-gel derived composition containing a plurality of alkylsiloxy substituents. And in some aspects, the sol-gel derived composition is an aromaticaliy- bridged, organosiloxaiie sol-ge] derived composition containing a plurality of alkylsiloxy snbstituents and a cosmetically acceptable carrier.
In some embodiments, the first sorbate is biologically active. And is some such embodiments, the first sorbate is a pesticide, a herbicide or a pharmaceutical. In some such embodiments, the first sorbate is atrazuie, 2,4-dichiorophcnoxyacetic acid, malathion, dicWorodiphenyltrichloroetbane, impramiiie, a vitamin or a polypeptide,
In some aspects, the loading density of the sorbate in the sol-gel derived composition ia from about 0.005 to about 5 gram sorbate per gram of the sol-gci derived composition. And in some aspects, the loading density of the sorbate in the sol-gel derived composition is from about 0.005 to about 5 gram sorbate per gram of the sol-gel derived composition.
In some embodiments, the method additionally includes applying a second sorbate after application of the first sorbate. in some of these embodiments, the second sorbate is a water soluble organic liquid and, in some of these embodiments, the second sorbate is etiianol.
Tn some embodiments, the soi-gel derived composition is applied to a plant or an animal. And, in some embodiments, the sol-gel derived composition is applied to a human.
In some embodiments, the sol-gel derived composition is applied to a soil. And, in some, embodiments, an unloaded sol-gci derived composition is applied along with die loaded sol-gel derived composition. In some of these embodiments, the sol-gel derived composition includes inert particles having a diameter of from about 5 to about 20 DID. In some of these embodiments, the inert particle is magnetic and in some embodiments, the sol gel-derived composition containing magnetic panicles is removed from the treated material using a magnetic device.
Also disclosed area skin-care preparations, personal care preparations, light- protective preparations, containing a sol-gel derived composition hi some aspects, the sol-gel derived composition is formulated with a non-liquid pharmaceutically effective carrier or a cosmetically acceptable carrier.
Detailed Description of the Preferred Embodiments
Particular embodiments of the invention are described below in considerable detail for the purpose of illustrating its principles and operation. However, various modifications may be made, and the scope of the invention is not limited to the exemplary embodiments described below.
■Unless otherwise defined, ail technical terms used, herein have the same meani ng as commonly understood by one of ordinary skill in the art to which the present invention pertains.
As used herein, the term "sorbate" means an organic compound that is taken up by the sol-gel derived compositions whether by adsorption, absorption, or a combination thereof.
As used herein, "swellable" means an increase of at least 1.5 times the volume of the sol-gel derived composition , when placed in excess sorbate compared to the vohime when dry.
As used herein, "nanoparticle" means a particle sized between about 2 and about 500 nanometers in one dimension.
In accordance with the invention, there has been discovered a novel method for treating a material by applying a sol-gel derived composition loaded with a first sorbate. In some embodiments, the sol -gel derived composition is swellable to at least 1 ,5 limes its volume, when dry, in acetone. Preferred sol-gei derived compositions are swellable to at least two times their ori inal volume, more preferably at least five times their original volume, and in some embodiments tip to about eight to ten ti mes their original volume. The swelling of the sol-gel derived composition and the sorption of the first sorbatc are driven by the release of stored tensile force rather than, by chemical reaction.
In some embodiments, the sol-gel derived composition is a porous, aiOmati cully- bridged, oi'ganosi loxane soi-gel derived composition containing a lurarity of alky) siJoxy substituents. In such, embodiments, the sol-gel derived composition contains a plurality of flexibly tethered and interconnected organosiloxane particles having diameters on the nanometer scale. The organosiloxane nanoparticles form a disorganized porous matrix defined by a plurality of cross-linked aromatic si!oxarres.
The porous, aromatically bridged, organosiloxane sol-gel derived compositions contains a plurality of polysiloxanes that include an aromatic bridging group flexibly linking the silicon atoms of the polysiloxanes. Such organosiloxane nanoparticles have a multilayer configuration comprising a hydrophilic inner layer and a. hydrophobic, aromatic-rich outer layer.
The preparation of sol-gel derived compositions useful in accordance with the inventive method is disclosed in U .S. Pat. No. 7,790, 830 which patent is herein incorporated by reference. A suitable swellable sol-gel derived composition is Osorb® swellable sol-gel derived, composition available from ABS Materials, Wooster, Ohio.
The porous, swellable sol-gel derived compositions is loaded with a first sorbate. It is an advantage of the invention that a wide variety of sorbates can be used. In some embodiments, the sorbate is biologically active. Representative biologically active sorbates include, but are not limited to, pesticides, herbicides, such as atrazine, 2.4- dichlorophenoxyacetic acid, malathion, and dichlorodiplienyltrichloroelhane and pharmaceuticals, including drags such as impra ine, vitamins and pol peptides. The sol-gel. derived compositions are loaded with a first sorbate using any suitable method. For example, the sol-gel derived composition can be contacted with the first sorbate under conditions sufficient to cause the sol-gel derived composition to sorb the sorbate. In an alternative embodiment, a nonvolatile first sorbate , such as impramiiie.can be mixed with a volatile second sorbate, such as etbanol or a mixture of ethanol and dichloromethane, where the second sorbate is chosen because of its effectiveness in swelling the sol-gel derived composition . The sol-gel derived composition is contacted with the mixture, the mixture is healed, for example up to about 180° F (the decomposition temperature of the sol-gel derived composition \ to remove the volatile second sorbate and produce a sol-gel derived composition loaded with (he first sorbate. In another alternative embodiment, the sol-gel derived composition is contacted with an aqueous solution containing a water soluble first sorbate, such as atrazine. In yet another alternative embodiment, the sol-gel derived composition is first swo llen with a sorbate and the sorbate is excha ged for a first water soluble sorbate by rinsing the swollen sol-gel derived composition with an aqueous solution containing the water-solubl sorbate.
The loading density of the first sorbate in the sol-gel derived composition depends on the required concentration, application time and physical characteristics of the sorbate. The particular loading density for a speci fic application can be readily determined by one skilled in the art without undue experimentation. In some embodiments, the loading density of the sorbate in tire sol-gel derived composition is from about 0.005 to about 5 gram sorbate per gram of the sol-gel derived composition. And in some embodiments, the loading density of the sorbate in the sol-gel derived composition is from about 0.01 to about 1 gram sorbate per gram of the sol-gel derived composition.
La some embodiments, the sol-gel derived composition is completely loaded with the first sorbate, I.e., the sol-gel derived composition has been treated under conditions such that substantially no additional sorbate can be sorbed by the sol-gel derived composition . In other embodiments, the sol-gel derived composition is only partially loaded with the first sorbate. When a sol-gel derived composition partially loaded with a first sorbate is subsequently contacted with a second sorbate, the sol-gel derived composition swells thus more quickly releasing ihe first sorbate.
The sol-gel derived composition can be used in any suitable form, including in powder or pellet forms. In some embodiments and in particular those embodiments where the sol-gel derived composition is in pellet formt the porous sweilable sol-gel derived composition is combined with a binder, Useful polymeric binders include microcrystalline cellulose and elast meric polymers. Preferred elastomeric polymers have a glass transition temperature below about 1 50 C, the temperature at which the sensor material begins to decompose. For. example, polystyrene and is a currently most preferred elastomeric polymer binder. Other suitable thermoplastic elastomers are described in U.S. Patent Nos. 7,834,093, 7,799,873, 7,799,868, 7,799,869, 7,790,805, 7,786,206, 7,776,968, 7.771 ,627, 7,744,781 , 7,737,206, 7,655,719, 7,462,309, 6,596,792, 6, 1 62,849, 5,194,480, 7,837,90 k 7,815 ,998, 7,645,399, 7,608,342,
7,550,097, 7,402,616, 6,720,369, 4,634,730, 7,834,093 , 7,799,873, 7,799,868, 7,799,869, 7,790,805, 7,786,206, 7,776,968, 7,771 ,627, 7,744,781, 7,737,206 which patents are herein incorporated by reference. Pellets can be formed in any desired shape and size suitable for their desired application.
It is an advantage of the inventive method, that it is useful in treating a wide variety of materials, including, without limitation, soil, plants and animals, including mammals, and humans.
The sol-gel derived, composition are appl ied, by any suitable method. The affinity of the sol-gel derived composition for the sorbate then provides for the slow desorption of the sorbate from the sol-gel derived composition at a . measured rate. Other factors diat can be used to influence the rate of release include the concentration griidient and die size of the sorbate. hi some embodiments, after application of the sol-gel derived composition partially loaded with the first sorbate to the material, the material is treated with a second sorbate. Suitable second sorbates include, without limitation, water soluble organic liquids, such as ethanol. Sufficient second sorbate is applied to cause the sol-gel derived composition to swell and thus increase the rate of desorption of the first sorbate. in sortie embodiments, both loaded and unloaded sol-gel derived composition arc- applied to the material. For example, the unloaded sol-gel derived composition can be applied to an area different than the area where the loaded, sol-gel derived composition is applied, e.g. an area where no treatment is desired. As tire sorbate is released from the loaded sol-gel derived composition , it is sorbed by the unloaded sohscl derived composition , thus providing control not only over the rate but the area of application of the sorbate.
In some embodiments, especially in those embodiments where the sol-gel derived composition is applied as an amendment to soil, the sol-gel derived composition can additionally include inert particles having a diameter of from about 5 to about 20 ran. The particles can be chosen to increase the density of the sol-gel derived composition , thus, inhibiting the travel of the sol-gel derived composition in high winds or heavy rain.
And in some of these embodiments, the inert particles are made of a magnetic material, such as metallic iron or magnetite, it is an advantage of sol-gel derived composition containing such magnetic particles that they can be readily removed from a material, once treatment is completed, using a magnetic device.
Representative formulations containing the sorbate loaded sol-gel derived composition , include, but are not limited, cosmetics, cleansers (e.g., skin cleansers), and medicaments, including pharmaceuticals in the form of tablets, capsules, ointments, or the like.
Cosmetic formulations according to the invention can be contained in a wide variety of cosmetic preparations. Representative formulations include, but are not limited to, skin-care preparations, e.g. skin emulsions, multi-emulsions or skin oils and body powders; cosmetic personal care preparations, e.g. facial make-up in the form of lipsticks, lip gloss, eye shadow, liquid make-up, day creams or powders, facial lotions, creams and powders (loose or pressed); and light-protective preparations, such as sun tan lotions, creams and oils, sun blocks and pretann g preparations.
The compositions according to the invention comprise a l iquid or non liquid cosmetically acceptable carrier to act as a diluent, dispersant or vehicle for the sorbate- Ioaded sol-gei derived composition . so as to facilitate- its distribution when the composition is applied to the skin. Carriers other than or in addition to water can include liquid or solid emollients, solvents, humectants, thi ckeners and powders. Particularly suitable non aqueous carriers include polydimethyi, si!oxane and/or po!ydimethyl phenyl siloxaiie. Such formulations can additional ly include colorants, sequestering agents, thickening or solidifying (consistency regulating) agents, emollients. UV absorbers, skin- protective agents, antioxidants find preservatives..
In some embodiments .the sol-gel derived composition is formulated in at least one liquid or non liquid pharmaceutically acceptable carrier. As used herein,
"pharmaceutically acceptable carrier" encompasses any of the standard pharmaceutical carriers known to those of skill in. the art. Pharmaceutically acceptable carriers include. solveni(s), vehicle(s), adjuvants), excipient(s), bt.nder(s), thickener(s), suspending. agent(s), or filler substance(s) thai are known to the skilled artisan suitable for administration to human and/or animals. Other useful carriers include gum acacia, agar, petrolatum, lanolin, dimethyl sulfoxide (DM.SO), normal saline ( S). phosphate buffered saline (PBS)> sodium alginate, bentoiiite, carbomer, carboxy ethyl cellulose, carrageenan, powdered cellulose, cholesterol, gelatin, hydroxyetbyl cellulose, hydroxypropyl cellulose, hydroxypropyl metliy!cellulose, mcdiylcdlul ose. uctoxvnol oleyl alcohol, polyvinyl alcohol, povidone, propylene glycol raonostearate, sodium laiiryl sulfate, sorbitan esters, stearyl alcohol, tragacanth, xanthan gum, chondrus, glycerin, trolami te, avocado oil, almond oil, coconut oil. coconut butter, propylene glycol, ethyl alcohol, malt, and malt extract.
Medicares include medicaments taken into the bodies of humans or non-human vertebrate animals, or applied topically thereto, by a delivery- system. A medica ent is a therapeuti c agent or substance, such as a drug, medicine, irrigaol, bandage, or other medical or dental device, that promotes recovery from injury or ailment or prevents or alleviates the symptoms of disease. Medicaments containing the sorbats-ioadel sol-gel derived composition can be formulated for any suitable systemic or non-systemic delivery system, including delivery systems for oral, enteral, or parenteral delivery routes include tablets, troches, lo enges, aqueous or oily suspensions, dispersible powders or granules, emulsions, hard or soft capsules. syrups, beverages, el ixirs or enteral formulas, lavage or enema solutions, adhesive patches, infusions, injectates, intravenous drips, inhalants, or implants. Delivery systems also include topical creams, ge!s, suppositories, or ointments for non-systemic localized deiivery or systemic delivery vi a the blood stream.
Systemic- delivery systems that are contemplated by the present invention include, but are not limited to, implant; adhesive transdermal patches; topical creams, gels or oi tments for transdermal delivery; trausmucosal delivery matiiccs or suppositories or gels. It is contemplated that the compositions of the present invention are formulated to deliver an effective amount of the sorbaie by these or any other pharmaceutically acceptable systemic delivery system.
From the above description of the invention, those skilled in the art will perceive improvements, changes and modifications. For example, one skilled in the art will appreciate that other agents and materials, such as charged organic polymers (e.g., polyethyleneimine) and'or organosilica nanoparticJes having different surface chemistries can be included in the sensor material to facil itate detection of sotbatcs. Such improvements, changes, and modifications are within the skill of the art and are intended to be covered by the appended claims,

Claims

I claim:
1. A method of treating a material comprising the step of
applying an aromatically- bridged, organosiloxane sol-gel derived composition, containing a plurality of a11cy3.si.loxy substituents loaded with a first sorbate under conditions effective to treat the material with the Erst sorbate.
2. The method of claim 2 wherein the first sorbate is biologically active.
3. The method of claim 3 wherein the first sorbate is a pesticide, a herbicide or a pharmaceutical.
4. The method of claim 3 wherem the first sorbate is atrazme, 2,4- dichlorophenoxyacetie acid, maiathion, dichlorodiphenyltrichloroelliane, npraminc. a vitamin or a polypeptide.
5. The method of claim 1 wherein the loading density of the sorbate in the sol-gel derived composition is from about 0.005 to about 5 gram sorbate per gram of the so!-gel derived composition.
6. The method of claim J wherein the loading density of the sorbale in the so!-gel derived composition is from about 0.005 to about 5 gram sorbate per gram of the sol-gel derived composition.
7. The method of claim 1 wherein the soi-gel derived composition is substantially completely loaded with the .sorbate.
8. The method of claim 1 wherein the sol-gei derived composition is partially loaded with the sorbate.
9. The method of claim 8 further comprising applying a second sorbate after application of the first sorbate.
10. The method of claim 9 wherein the second sorbaie i s a water soluble organic liquid.
11. The method of claim ] 0 wherein the second sorbate is ethianol
12. The method of claim 1 wherein the sol-gel derived composition is applied to a plant or an animal.
13. The method of claim 1 wherein the sol-gel derived composition is applied to a human.
14. The method of claim 1 wherein the so I- gel derived composition is applied to a soil.
15. The method of claim 1 further comprising applying an unloaded aromatkaliy- bridged, organosiloxane sol-gel derived composition containing a plurality of alkylsiloxy substituents to the material along widi tire loaded sol-gel derived composition ..
16. The method of claim 1 wherein die sol-gel derived composition includes inert particles having a diameter of from about 5 to about 20 rim.
17. T e method of claim 16 where the inert particle is magnetic.
1 . The method of claim 17 further comprising removing the sol gel-derived compositio from the treated material with a magnetic device.
19. A composition of matter comprising:
an aromatically- bridged, organosiloxane sol-gel derived composition containing a plurality of alkylsiloxy substituents and a cosmetically acceptable carrier.
-I I -
20. Λ composition of matter comprising:
a sliin-care preparation, personal care preparation or light-protective preparation containing an aromaticaily- bridged, organosiloxane sol-gel derived composition containing a plurality of alkylsiioxy substituents.
21. A composition of matter comprising:
an aromaticaily- bridged, organosiloxane sol-gel derived composition containing a plurality of alkyl siioxy substituents and a non-liquid pharmaceutically effective carrier.
22. A composition of matter comprising:
a sorbatc-loaded aromaticaily- bridged, organosiloxane sol-gel derived composition containing a plurality of alkylsiioxy substituents and a cosmetically acceptable carrier.
23. A composition of matter comprising:
a skin-care preparation, personal care preparation or light-protective preparations containing a sorbate loaded arornatjcally- bridged, organosiloxane sol-gel derived composition containing a plurality of alfcylsilcwty substitucnts.
24. A composition of matter compri sing:
an aromaticaily- bridgsd. organosiloxane sol-gel derived composition containing a plurality of alkylsiioxy substitucnts loaded with a first sorbate and a non-liquid pharmaceutically effective carrier.
'
25. A method of treating a material compri sing the step of
applying a sorbatc-loaded sol-gel derived composition havi ng a porous matrix, the sol-gel derived composition swellable to at least 1.5 times its volume, loaded with a first sorbate, under conditions effective to treat the material with the first soibate,
26. The method of claim 25 wherein the first sorbate is biologically active.
27. The method of claim 26 wherein the first sorbate is a pesticide, a herbicide or a pharmaceutical
28. The metliod of claim 27 wherein the fi rst sorbate is atrazine. 2;4- dichloropheiioxyacetic acid, malathion, dichloro iphenyttrichioroelhaae: unpnur.ine, a vitamin or a polypeptide.
29. The metliod of claim 25 wherein the loading density of the sorbate in the sol-gel derived composition is from about 0.005 to about 5 gram sorbate per gram of the sol-gel derived composition .
30. The method of claim 25 wherein the loading density of the sor te in the sol-gel derived composition is from about 0.005 to about 5 gram sorbate per gram of die sol-gel derived composition.
31. The metliod of claim 25 wherein the sol-gel derived composition is substantially completely loaded with the sorbate,
32. The method of claim 25 wherein the sol-gpl deri ved com osition is partially loaded with the sorbate.
33. The metliod of claim 32 further comprisi ng ap lying a second sorbate after application of the first sorbate.
34. The method of claim 33 wherein the second sorbate is a water soluble organic liquid.
35. The method of claim 34 wherein the second sorbate is ethanol.
36. The method of claim 25 wherein the sol-gel derived composilioii is applied to a plant or an animal.
37. The method of claim 25 wherein the sol-gef derived composition is applied to a human.
38. The method of claim 25 wherein the sol-gc! derived composition i applied to a soil.
39. The method of claim 25 further comprising applying an unloaded aromaticall - bridged, organosiloxane sol-gel derived composition containing a plurality of alley! siloxy substituents to the material along with the loaded sol-gel derived composition ..
40. The method of claim 25 wherein the sol-gel derived composition 3 nc hides inert particles having a diameter of from about 5 to about 20 nm.
41 . The method of claim 40 where the inert particle is magnetic.
42. The method of claim 41 further comprising removing the sol gel-derived composition from the treated material with a magnetic device.
43. A composition of matter comprising:
a sol-gel derived composition having a porous matrix, the sol-gel derived composition swdiabie to at least 1.5 times its volume, and a cosmetically acceptable carrier.
44. A composition of matter comprising:
a skin-care preparation, personal care preparation or light-protective preparation containing a sol-gel derived composition having a porous matrix, the sol-ge! derived composition swellable to at least 1..5 times its volume.
45. A composition of matter comprising: a soi-gel derived composition having a porous matrix, the sol-gel derived composition, swellable to at least 1.5 times its volume, and a non-liquid pharmaceutically effective carrier.
46. A composition of matter comprising:
a sorbate-ioaded soi-gel derived composition having a porous matrix, the sol-gel derived composition swellable to at least 1.5 times its volume, and a cosmetically acceptable carrier.
47. A composition of matter comprising:
a skin-care preparation, personal care preparation or light protecvive preparations containing a sorbate-ioaded sol-gel derived composition having a porous matrix, the sol- gel derived composition swellable to at least 1.5 times its volume.
48. A composition of matter comprising:
an aromatically- bridged, organosiloxanc sol-gel derived composition containing a sorbate-ioaded sol-gel derived composition having a porous matrix, tire sol-gel derived composition swellable to at ieast 1.5 times its volume, and a non-liquid pharmaceutically effective carrier.
PCT/US2011/039884 2010-06-10 2011-06-09 Method of treating a material using a sol-gel derived composition WO2011156663A1 (en)

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