WO2011150323A3 - Real time csf flow measurement system & method - Google Patents

Real time csf flow measurement system & method Download PDF

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Publication number
WO2011150323A3
WO2011150323A3 PCT/US2011/038317 US2011038317W WO2011150323A3 WO 2011150323 A3 WO2011150323 A3 WO 2011150323A3 US 2011038317 W US2011038317 W US 2011038317W WO 2011150323 A3 WO2011150323 A3 WO 2011150323A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
csf
shunt
thermal
csf flow
Prior art date
Application number
PCT/US2011/038317
Other languages
French (fr)
Other versions
WO2011150323A2 (en
Inventor
Marek Swoboda
Matias Gabriel Hochman
Mark Evan Mattiucci
Frederick J. Fritz
Original Assignee
Neurodx Development, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurodx Development, Llc filed Critical Neurodx Development, Llc
Priority to JP2013512271A priority Critical patent/JP5738986B2/en
Priority to EP11787489.1A priority patent/EP2575934A4/en
Priority to US13/698,689 priority patent/US8894584B2/en
Publication of WO2011150323A2 publication Critical patent/WO2011150323A2/en
Publication of WO2011150323A3 publication Critical patent/WO2011150323A3/en
Priority to US14/513,856 priority patent/US20150045717A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
    • A61B5/031—Intracranial pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/03—Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs
    • A61B5/032—Spinal fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16831—Monitoring, detecting, signalling or eliminating infusion flow anomalies
    • A61M5/16836—Monitoring, detecting, signalling or eliminating infusion flow anomalies by sensing tissue properties at the infusion site, e.g. for detecting infiltration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F1/00—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow
    • G01F1/68—Measuring the volume flow or mass flow of fluid or fluent solid material wherein the fluid passes through a meter in a continuous flow by using thermal effects
    • G01F1/684—Structural arrangements; Mounting of elements, e.g. in relation to fluid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M27/00—Drainage appliance for wounds or the like, i.e. wound drains, implanted drains
    • A61M27/002—Implant devices for drainage of body fluids from one part of the body to another
    • A61M27/006—Cerebrospinal drainage; Accessories therefor, e.g. valves

Abstract

A system for measuring quantitative CSF flow in shunt tubing implanted under the skin. The system includes an array of thermo-sensors clustered in three sections, cooling device, placed on the skin surface and an associated data acquisition and analysis device. Two sensor sections are placed over the shunt on the skin and measure real time temperature responses related to CSF movement. One array placed adjacent the cooling device collects data on thermal properties of skin including skin thermal conductivity, specific heat, diffusivity, perfusion, and thermal inertia. The method involves assessing thermal properties of skin and measuring CSF flow in shunt tubing. The method is useful for shunt patency assessment, CSF valve adjustment procedures and CSF flow measurements related to CSF over drainage. Alternatively, only one section of sensors need be used when determining relative CSF flow, without the need to determine thermal skin properties and by applying the cooling device continuously.
PCT/US2011/038317 2010-05-28 2011-05-27 Real time csf flow measurement system & method WO2011150323A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2013512271A JP5738986B2 (en) 2010-05-28 2011-05-27 Apparatus for determining CSF flow rate in an implantable cerebrospinal fluid (CSF) shunt
EP11787489.1A EP2575934A4 (en) 2010-05-28 2011-05-27 Real time csf flow measurement system&method
US13/698,689 US8894584B2 (en) 2010-05-28 2011-05-27 Real time CSF flow measurement system and method
US14/513,856 US20150045717A1 (en) 2010-05-28 2014-10-14 Real Time CSF Flow Measurement System & Method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39643610P 2010-05-28 2010-05-28
US61/396,436 2010-05-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/698,689 A-371-Of-International US8894584B2 (en) 2010-05-28 2011-05-27 Real time CSF flow measurement system and method
US14/513,856 Continuation US20150045717A1 (en) 2010-05-28 2014-10-14 Real Time CSF Flow Measurement System & Method

Publications (2)

Publication Number Publication Date
WO2011150323A2 WO2011150323A2 (en) 2011-12-01
WO2011150323A3 true WO2011150323A3 (en) 2012-05-18

Family

ID=45004857

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/038317 WO2011150323A2 (en) 2010-05-28 2011-05-27 Real time csf flow measurement system & method

Country Status (4)

Country Link
US (2) US8894584B2 (en)
EP (1) EP2575934A4 (en)
JP (1) JP5738986B2 (en)
WO (1) WO2011150323A2 (en)

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US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
US9072866B2 (en) 2007-04-13 2015-07-07 Neuro Diagnostic Devices, Inc. Cerebrospinal fluid evaluation system having thermal flow and flow rate measurement pad using a plurality of control sensors
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WO2014022190A1 (en) * 2012-08-02 2014-02-06 Shuntcheck, Inc. Continuous real-time csf flow monitor and method
WO2014088886A1 (en) 2012-12-06 2014-06-12 Shuntcheck, Inc. Csf shunt flow evaluation apparatus and method using a conformable expanded dynamic range thermosensor
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CA2992263A1 (en) 2014-06-25 2015-12-30 Canary Medical Inc. Devices, systems and methods for using and monitoring tubes in body passageways
US9974932B2 (en) 2014-09-05 2018-05-22 University Of Southern California Method and sensor for detecting catheter obstruction
US20180125365A1 (en) 2014-09-17 2018-05-10 Canary Medical Inc. Devices, systems and methods for using and monitoring medical devices
WO2016115208A1 (en) 2015-01-14 2016-07-21 University Of Southern California Multi-sensor platform for diagnosing catheter status
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
WO2017096228A1 (en) 2015-12-04 2017-06-08 Minnetronix, Inc. Systems and methods for the conditioning of cerebrospinal fluid
US11191479B2 (en) * 2016-03-23 2021-12-07 Canary Medical Inc. Implantable reporting processor for an alert implant
MX2018011544A (en) 2016-03-23 2019-06-24 Canary Medical Inc Implantable reporting processor for an alert implant.
US11305099B1 (en) 2016-06-21 2022-04-19 PopFlow, LLC Cerebral shunt valve
US10967158B1 (en) 2016-06-21 2021-04-06 PopFlow, LLC Cerebral shunt valve
CN106175743B (en) * 2016-07-12 2019-02-22 苏州景昱医疗器械有限公司 Encephalic state monitor system and monitoring method
CN107822594B (en) * 2017-09-28 2020-10-13 莆田学院 Cerebrospinal fluid shunt flow detection system and method
WO2022082087A2 (en) * 2020-10-16 2022-04-21 Northwestern University Hydration sensors for monitoring and diagnosis of skin diseases in any environment
AU2019245429A1 (en) * 2018-03-30 2020-10-15 Northwestern University Wireless and noninvasive epidermal electronics
US11224348B2 (en) 2018-08-21 2022-01-18 Jsr Research, Llc Implantable devices and related methods for monitoring properties of cerebrospinal fluid
US11672476B2 (en) * 2019-09-17 2023-06-13 Medtronic, Inc. Intrathecal catheter with means to measure quality of drug dispersion
JP2023530683A (en) * 2020-06-10 2023-07-19 ノースウェスタン ユニヴァーシティ Moisture content sensor and its application for monitoring and diagnosing skin diseases under any environment
WO2023279101A1 (en) * 2021-07-01 2023-01-05 Aga Khan University Remote determination of csf flowrate in vp shunt
WO2023039541A1 (en) * 2021-09-09 2023-03-16 Wayne State University Solid state shunt valve with active outflow regulator, ventricular catheters, and other embodiments
WO2024030536A2 (en) * 2022-08-03 2024-02-08 Children's Hospital Los Angeles Measuring intracranial pressure using a cerebrospinal fluid shunt device

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Also Published As

Publication number Publication date
US20150045717A1 (en) 2015-02-12
JP2013529963A (en) 2013-07-25
JP5738986B2 (en) 2015-06-24
EP2575934A4 (en) 2016-04-20
US8894584B2 (en) 2014-11-25
US20130109998A1 (en) 2013-05-02
EP2575934A2 (en) 2013-04-10
WO2011150323A2 (en) 2011-12-01

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