WO2011109882A1 - Radiopaque, coloured and absorbable polymer used in the manufacture of implantable surgical devices - Google Patents

Radiopaque, coloured and absorbable polymer used in the manufacture of implantable surgical devices Download PDF

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Publication number
WO2011109882A1
WO2011109882A1 PCT/BR2011/000064 BR2011000064W WO2011109882A1 WO 2011109882 A1 WO2011109882 A1 WO 2011109882A1 BR 2011000064 W BR2011000064 W BR 2011000064W WO 2011109882 A1 WO2011109882 A1 WO 2011109882A1
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WO
WIPO (PCT)
Prior art keywords
radiopaque
manufacture
surgical devices
polymer used
polymer
Prior art date
Application number
PCT/BR2011/000064
Other languages
French (fr)
Portuguese (pt)
Inventor
Aguedo Aragones
Steferson Luiz Stares
Márcio Celso FREDEL
Lourival Boehs
Ricardo De Souza Magini
Cláudia Maria Oliveira SIMÕES
Eliana Aparecida De Rezende Duek
Original Assignee
Agal Consultoria E Assessoria Ltda
Universidade Federal De Santa Catarina
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agal Consultoria E Assessoria Ltda, Universidade Federal De Santa Catarina filed Critical Agal Consultoria E Assessoria Ltda
Publication of WO2011109882A1 publication Critical patent/WO2011109882A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
    • A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers

Definitions

  • the present report refers to the improvement made on bioabsorbable and biodegradable plastic components, used as surgical implants, more specifically as plates and screws, as they promote their easy visualization inside and outside the body.
  • Such improvement consists in the addition of a radiopaque element to the polymer used in the manufacture of said devices and also the addition of organic dyes.
  • bioabsorbable materials which are materials developed to be absorbed by the body without producing a strong immune response, ie without rejection by the body. They are usually composed of plastics and are often used in orthopedics and dentistry.
  • bioabsorbable and biodegradable materials are being used, which in addition to being absorbed by the body are decomposed over time within the body, widely used in situations where there would be a need to remove the implant after a certain time. This eliminates the need for a second surgery to remove the implant.
  • Implantable devices on the market are not colored. This makes it difficult to identify the necessary item during the surgery due to the presence of body fluids such as blood. There are different ways of presenting these devices, as they may vary in thickness, diameter, length, time to degradation, among other characteristics.
  • Radiopacity is the impermeability that the material presents against X-rays or other forms of radiant energy allowing its visualization or radiographic image.
  • bioabsorbable Marker Having Radiopaque Constituints describes an implant-use flag made from bioabsorbable material and including radiopaque material such as bismuth trioxide and barium sulfate and that the weight percent of the material Radiopaque tissue in bioabsorbable material may range from 1% to approximately 80%.
  • CA 2579477 entitled “Implantable Device Formed From Polymer and Plasticizer Blends” describes a biocompatible material configured for use in implantable device medical devices including the known “intra-luminal stents"; It consists of a polymeric blend which may include additives such as bioactive agents, and radiopaque elements; and that the radiopaque material consists of barium sulfate.
  • CA 2579324 entitled “Implantable Device Formed From Polymer Blends” describes a biocompatible material consisting of a polymeric blend and which also uses barium sulfate as a radiopaque material.
  • biocompatible polymer prepared from “Melt Processing” which comprises a barium sulfate-type radiopaque agent.
  • other patent documents describe materials and products that somehow adds radiopacity to the product.
  • the subject of this report relates to a differentiated form from documents and products known in the state of the art. It favors the surgical practice of the professional in its detection both inside the body after implantation (radiopaque), as well as outside the body before implantation, by the different color classification.
  • This document describes a material for the manufacture of Resorbable, Color and Radiopaque Polymer devices manufactured through various production processes such as injection, hot pressing, sintering, machining, etc.
  • the radiopaque element and the dye are added to the polymer to form a radiopaque colored composite.
  • the inventive idea is the creation of the so-called "RESERVABLE, COLORFUL AND RADIOPACY POLYMER USED IN THE MANUFACTURE OF IMPLANTABLE SURGICAL DEVICES" using a chemically modified polymeric material with a radiopaque chemical dye to impart different colors to the product.
  • the product is made from the addition to the differentiated polymer of the radiopaque element, without the formation of blends, which consists in the physical mixture of two or more polymers without chemical connection between them; with the addition of ceramic additives as radiopaque agents.
  • the product is manufactured from a differentiated polymer, with the addition of organic dye to the material used in the manufacture of the devices, enabling the creation of a color standardization methodology in relation to the characteristics of each type of devices, such as plates or screws of different sizes in different color scales; plates and screws for different applications in different colors, and so on. This feature favors the professional's working condition, minimizing medical errors, surgical procedure time, etc.

Abstract

A radiopaque, coloured and absorbable polymer used in the manufacture of implantable surgical devices. The biodegradable and absorbable polymer, plus radiopaque element and organic dyes, is used in the manufacture of surgical implants, such as plates and screws. By adding a radiopaque element and an organic dye to the polymer, the plastic material can be easily visualized and detected inside and outside the human body.

Description

POLÍMERO REABSORVÍVEL, COLORIDO E RADIOPACO UTILIZADO NA FABRICAÇÃO DE DISPOSITIVOS CIRÚRGICOS IMPLANTÁVEIS  RESORVABLE, COLORFUL AND RADIOPACY POLYMER USED IN THE MANUFACTURE OF IMPLANTABLE SURGICAL DEVICES
O presente relatório se refere ao aperfeiçoamento feito em componentes plásticos bioabsorvíveis e biodegradáveis, utilizados como implantes cirúrgicos, mais especificamente como placas e parafusos, pois promovem a facilidade de de visualização dos mesmos dentro e fora do corpo. Tal aperfeiçoamento consiste na adição de um elemento radiopaco ao polímero utilizado na fabricação dos ditos dispositivos e também a adição de corantes orgânicos.  The present report refers to the improvement made on bioabsorbable and biodegradable plastic components, used as surgical implants, more specifically as plates and screws, as they promote their easy visualization inside and outside the body. Such improvement consists in the addition of a radiopaque element to the polymer used in the manufacture of said devices and also the addition of organic dyes.
Implantes cirúrgicos, em sua maioria são fabricados com materiais bioabsorvíveis, que são materiais desenvolvidos para serem absorvidos pelo corpo sem produzir uma resposta imune acentuada, ou seja, sem apresentar rejeição pelo organismo. Usualmente são compostos de plásticos e são frequentemente usados em ortopedia e em odontologia.  Most surgical implants are made of bioabsorbable materials, which are materials developed to be absorbed by the body without producing a strong immune response, ie without rejection by the body. They are usually composed of plastics and are often used in orthopedics and dentistry.
Ultimamente, estão sendo utilizados materiais bioabsorvíveis e biodegradáveis, que além de serem absorvidos pelo organismo são decompostos com o tempo dentro do corpo, muito utilizados em situações em que haveria a necessidade da retirada do implante após certo tempo. Desta forma, elimina-se a necessidade da realização de uma segunda cirurgia para a retirada do implante.  Lately, bioabsorbable and biodegradable materials are being used, which in addition to being absorbed by the body are decomposed over time within the body, widely used in situations where there would be a need to remove the implant after a certain time. This eliminates the need for a second surgery to remove the implant.
A utilização desses dispositivos biodegradáveis vem sendo utilizados nas últimas décadas. Alguns materiais são os mais utilizados para a produção destes elementos, como o ácido poliglicólico(Dexon), o copolímero formado pelo ácido poliglicólico/polilático (Vicryl), a poli-dioxanona (PDS) o ácido polilático (PLA), ácido L-polilático (LPLA), ácido D, L-polilático entre outros.  The use of these biodegradable devices has been used in recent decades. Some materials are most commonly used for the production of these elements, such as polyglycolic acid (Dexon), polyglycolic / polylactic acid (Vicryl) copolymer, poly-dioxanone (PDS), polylactic acid (PLA), L-polylactic acid (LPLA), D, L-polylactic acid among others.
Na odontologia e na ortopedia, placas e parafusos compõem uma grande parte dos produtos fabricados com materiais bioabsorvíveis e biodegradáveis. Os dispositivos implantáveis presentes no mercado não possuem coloração. Isso dificulta a identificação do item necessário durante o ato operatório em função da presença dos fluidos corpóreos como o sangue. Há diferentes formas de apresentação desses dispositivos, pois, podem variar na espessura, no diâmetro, no comprimento, no tempo para degradação, entre outras características. In dentistry and orthopedics, plates and screws make up a large part of products made from bioabsorbable and biodegradable materials. Implantable devices on the market are not colored. This makes it difficult to identify the necessary item during the surgery due to the presence of body fluids such as blood. There are different ways of presenting these devices, as they may vary in thickness, diameter, length, time to degradation, among other characteristics.
Outro fator importante que deve ser levado em consideração na hora da fabricação destes dispositivos se refere à possibilidade de diagnosticá-los depois de implantado. Um simples exame radiográfico, de baixo custo, permite um controle por parte dos órgãos promotores de saúde, tanto públicos como privados, na fiscalização dos procedimentos apresentados pelos conveniados, evitando fraudes e desonerando o sistema. Esta ação é realizada através de aparelho Raio-X. Para isso necessita-se que estes materiais apresentem características radiopacas. A radiopacidade consiste na impermeabilidade que o material apresenta frente aos Raios-X ou outras formas de energia radiante permitindo sua visualização ou imagem radiográfica. Desta forma, vários desenvolvimentos nesta área são realizados com o intuito de adicionar elementos com características radiopacas a estes materiais bioabsorvíveis e biodegradáveis, com o objetivo da interpretação radiográfica (diagnóstico). Em sua maioria estes elementos são metais com número atómico (Z) elevado. Alguns elementos químicos conhecidos por sua características radiopacas são: Bário (Ba), lodo (I), Estrôncio (Sr), Zircônio (Zr).  Another important factor that should be taken into consideration when manufacturing these devices refers to the possibility of diagnosing them after implantation. A simple low-cost radiographic examination allows public and private health promotion agencies to control the procedures presented by the members, avoiding fraud and relieving the system. This action is performed by X-ray device. This requires that these materials have radiopaque characteristics. Radiopacity is the impermeability that the material presents against X-rays or other forms of radiant energy allowing its visualization or radiographic image. Thus, several developments in this area are carried out in order to add elements with radiopaque characteristics to these bioabsorbable and biodegradable materials for the purpose of radiographic interpretation (diagnosis). Most of these elements are metals with high atomic number (Z). Some chemical elements known for their radiopaque characteristics are: Barium (Ba), Slime (I), Strontium (Sr), Zirconium (Zr).
Dentre os materiais conhecidos podem-se mencionar os materiais poliméricos misturados com pó de osso, polímeros misturados com algum aditivo cerâmico como TiO2, BaSO4, entre outros. Alguns documentos de patentes descrevem materiais e produtos que apresentam certas características e merecem considerações, a fim de justificar a inventividade do objeto descrito neste relatório. O documento de patente US 6174330 com título "Bioabsorbable Marker Having Radiopaque Constituints" descreve um sinalizador para uso em implantes, fabricado com material bioabsorvível e com inclusão de material radiopaco como o trióxido de bismuto e o sulfato de bário e que a porcentagem peso do material radiopaco no material bioabsorvível pode apresentar faixa de 1 % a aproximadamente 80%. O documento de patente CA 2579477 com o título "Implantable Device Formed From Polymer and Plasticizer Blends" descreve um material biocompatível configurado para utilização em dispositivos médicos para dispositivo implantável incluindo os conhecidos "intra-luminal stents"; é constituído por uma blenda polimérica que pode incluir aditivos como agentes bioativos, e elementos radiopacos; e que o material radiopaco consiste no sulfato de bário. O documento de patente CA 2579324 com o título "Implantable Device Formed From Polymer Blends" descreve um material biocompatível que consiste numa blenda polimérica e que também utiliza o sulfato de bário como material radiopaco. O documento de patente CA 2579244 com o título "Implantable Device Prepar From Melt Processing" que descreve o método de preparação de uma matéria-prima para uso em implantes cirúrgicos compreendendo no mínimo por um polímero biocompatível preparado a partir "Melt Processing" (rota de fusão) e que compreende um agente radiopaco do tipo sulfato de bário. Além destes documentos apresentados, outros documentos de patentes descrevem materiais e produtos que, de alguma forma, insere característica de radiopacidade ao produto. O objeto do presente relatório refere-se a uma forma diferenciada em relação aos documentos e produtos conhecidos no estado da técnica. Favorece a prática cirúrgica do profissional na sua detecção tanto dentro do corpo depois de implantado (radiopacos), como também fora do corpo antes de ser implantado, pela classificação em cores de forma diferenciada. Among the known materials can be mentioned bone powder mixed polymeric materials, polymers mixed with some ceramic additive such as TiO 2 , BaSO 4 , among others. Some patent documents describe materials and products that have certain characteristics and deserve consideration in order to justify the inventiveness of the object described in this report. US 6174330 entitled "Bioabsorbable Marker Having Radiopaque Constituints" describes an implant-use flag made from bioabsorbable material and including radiopaque material such as bismuth trioxide and barium sulfate and that the weight percent of the material Radiopaque tissue in bioabsorbable material may range from 1% to approximately 80%. CA 2579477 entitled "Implantable Device Formed From Polymer and Plasticizer Blends" describes a biocompatible material configured for use in implantable device medical devices including the known "intra-luminal stents"; It consists of a polymeric blend which may include additives such as bioactive agents, and radiopaque elements; and that the radiopaque material consists of barium sulfate. CA 2579324 entitled "Implantable Device Formed From Polymer Blends" describes a biocompatible material consisting of a polymeric blend and which also uses barium sulfate as a radiopaque material. CA 2579244 entitled "Implantable Device Preparing From Melt Processing" which describes the method of preparing a raw material for use in surgical implants comprising at least one biocompatible polymer prepared from "Melt Processing" which comprises a barium sulfate-type radiopaque agent. In addition to these filed documents, other patent documents describe materials and products that somehow adds radiopacity to the product. The subject of this report relates to a differentiated form from documents and products known in the state of the art. It favors the surgical practice of the professional in its detection both inside the body after implantation (radiopaque), as well as outside the body before implantation, by the different color classification.
O presente documento descreve um material para a fabricação de dispositivos, à base de Polímeros Reabsorvíveis, Coloridos e Radiopacos fabricados através dos diversos processos de produção, como injeção, prensagem a quente, sinterização, usinagem,...etc. O elemento radiopaco e o corante são adicionados ao polímero formando um compósito colorido e radiopaco. Constituindo-se assim um distinto material de utilização médica para a fabricação desses dispositivos implantáveis.  This document describes a material for the manufacture of Resorbable, Color and Radiopaque Polymer devices manufactured through various production processes such as injection, hot pressing, sintering, machining, etc. The radiopaque element and the dye are added to the polymer to form a radiopaque colored composite. Thus constituting a distinct material of medical use for the manufacture of such implantable devices.
O presente documento descreve ainda, como inventividade, a adição de corantes orgânicos misturados ao material formado, disponibilizando diversas cores ao produto fabricado. As cores são utilizadas para distinguir os dispositivos de diferentes tamanhos e formas construtivas; reduzindo erros durante o ato cirúrgico, criando uma sequência modular ( tamanho, dispositivo e cor).  This document further describes, as inventiveness, the addition of mixed organic dyes to the formed material, making various colors available to the manufactured product. Colors are used to distinguish devices of different sizes and shapes; reducing errors during surgery, creating a modular sequence (size, device and color).
A idéia inventiva é a criação do dito "POLÍMERO REABSORVÍVEL, COLORIDO E RADIOPACO UTILIZADO NA FABRICAÇÃO DE DISPOSITIVOS CIRÚRGICOS IMPLANTÁVEIS" com a utilização de um material polimérico modificado quimicamente com um elemento químico radiopaco e misturado com um corante orgânico para conferir diferentes colorações ao produto.  The inventive idea is the creation of the so-called "RESERVABLE, COLORFUL AND RADIOPACY POLYMER USED IN THE MANUFACTURE OF IMPLANTABLE SURGICAL DEVICES" using a chemically modified polymeric material with a radiopaque chemical dye to impart different colors to the product.
O produto é fabricado a partir da adição ao polímero diferenciado, do elemento radiopaco, sem a formação de blendas, que consiste na mistura física de dois ou mais polímeros sem que haja ligação química entre eles; com a adição de aditivos cerâmicos como agentes radiopacos. The product is made from the addition to the differentiated polymer of the radiopaque element, without the formation of blends, which consists in the physical mixture of two or more polymers without chemical connection between them; with the addition of ceramic additives as radiopaque agents.
O produto é fabricado a partir de um polímero diferenciado, já com a adição de corante orgânico ao material utilizado na fabricação dos dispositivos, possibilitando a criação de uma metodologia de padronização de cores em relação as características de cada tipo de dispositivos, como por exemplo, placas ou parafusos de diferentes tamanhos em diferentes escalas de cores; placas e parafusos para diferentes aplicações em cores diferentes, a assim sucessivamente. Esta característica favorece a condição de trabalho do profissional, minimizando erros médicos, tempo de procedimento cirúrgico, etc.  The product is manufactured from a differentiated polymer, with the addition of organic dye to the material used in the manufacture of the devices, enabling the creation of a color standardization methodology in relation to the characteristics of each type of devices, such as plates or screws of different sizes in different color scales; plates and screws for different applications in different colors, and so on. This feature favors the professional's working condition, minimizing medical errors, surgical procedure time, etc.

Claims

REIVINDICAÇÕES
1 . POLÍMERO REABSORVÍVEL, COLORIDO E RADIOPACO UTILIZADO NA FABRICAÇÃO DE DISPOSITIVOS CIRÚRGICOS IMPLANTÁVEIS, constituído por componente bioabsorvivel e biodegradável, utilizado em implantes cirúrgicos, caracterizado pelo material bioabsorvivel e biodegradável possuir elemento radiopaco adicionado.  1 . RESORVABLE, COLORFUL AND RADIOPACY POLYMER USED IN THE MANUFACTURE OF IMPLANTABLE SURGICAL DEVICES, consisting of bioabsorbable and biodegradable component, used in surgical implants, characterized by the bioabsorbable and biodegradable material having added radiopaque element.
2. POLÍMERO REABSORVÍVEL, COLORIDO E RADIOPACO UTILIZADO NA FABRICAÇÃO DE DISPOSITIVOS CIRÚRGICOS IMPLANTÁVEIS, de acordo com a reivindicação 1 , caracterizado pelo material bioabsorvivel, biodegradável com elemento radiopaco, possuir aditivo orgânico de coloração diversa.  Resorbable, colored and radiopaque polymer used in the manufacture of implantable surgical devices according to Claim 1, characterized in that the bioabsorbable material, biodegradable with radiopaque element, has a differently colored organic additive.
3. POLÍMERO REABSORVÍVEL, COLORIDO E RADIOPACO UTILIZADO NA FABRICAÇÃO DE DISPOSITIVOS CIRÚRGICOS IMPLANTÁVEIS, de acordo com a reivindicação 1 , caracterizado pelo elemento radiopaco adicionado ao polímero, ser o produto químico na proporção de 0,1 a 50%.  Resorbable, colored and radiopaque polymer used in the manufacture of implantable surgical devices according to Claim 1, characterized in that the radiopaque element added to the polymer is the chemical in the proportion of 0.1 to 50%.
PCT/BR2011/000064 2010-03-09 2011-03-02 Radiopaque, coloured and absorbable polymer used in the manufacture of implantable surgical devices WO2011109882A1 (en)

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BRPI1000625-7 2010-03-09
BRPI1000625-7A BRPI1000625A2 (en) 2010-03-09 2010-03-09 resorbable, colored and radiopaque polymer used in the manufacture of implantable surgical devices

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60100527A (en) * 1983-11-04 1985-06-04 Haruyuki Kawahara Impression material composition for sole use to operational field tissue and bone surface
US4689424A (en) * 1981-08-06 1987-08-25 Ethicon, Inc. Radiation sterilizable absorbable polymeric materials and methods for manufacturing the same
WO1998018408A1 (en) * 1996-10-25 1998-05-07 Bionix Implants Oy Surgical implant
US5997568A (en) * 1996-01-19 1999-12-07 United States Surgical Corporation Absorbable polymer blends and surgical articles fabricated therefrom
US6165202A (en) * 1998-07-06 2000-12-26 United States Surgical Corporation Absorbable polymers and surgical articles fabricated therefrom
WO2005034726A2 (en) * 2003-09-23 2005-04-21 Ortho Therapeutics, Llc Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
US7135025B2 (en) * 2002-04-22 2006-11-14 Inion Ltd. Surgical implant
CA2699660A1 (en) * 2007-09-17 2009-03-26 Synergy Biosurgical Ag Medical implant ii

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4689424A (en) * 1981-08-06 1987-08-25 Ethicon, Inc. Radiation sterilizable absorbable polymeric materials and methods for manufacturing the same
JPS60100527A (en) * 1983-11-04 1985-06-04 Haruyuki Kawahara Impression material composition for sole use to operational field tissue and bone surface
US5997568A (en) * 1996-01-19 1999-12-07 United States Surgical Corporation Absorbable polymer blends and surgical articles fabricated therefrom
WO1998018408A1 (en) * 1996-10-25 1998-05-07 Bionix Implants Oy Surgical implant
US6165202A (en) * 1998-07-06 2000-12-26 United States Surgical Corporation Absorbable polymers and surgical articles fabricated therefrom
US7135025B2 (en) * 2002-04-22 2006-11-14 Inion Ltd. Surgical implant
WO2005034726A2 (en) * 2003-09-23 2005-04-21 Ortho Therapeutics, Llc Absorbable implants and methods for their use in hemostasis and in the treatment of osseous defects
CA2699660A1 (en) * 2007-09-17 2009-03-26 Synergy Biosurgical Ag Medical implant ii

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