WO2011102913A3 - Wicking-based reagent-solution draining in an automated system - Google Patents

Wicking-based reagent-solution draining in an automated system Download PDF

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Publication number
WO2011102913A3
WO2011102913A3 PCT/US2011/000332 US2011000332W WO2011102913A3 WO 2011102913 A3 WO2011102913 A3 WO 2011102913A3 US 2011000332 W US2011000332 W US 2011000332W WO 2011102913 A3 WO2011102913 A3 WO 2011102913A3
Authority
WO
WIPO (PCT)
Prior art keywords
subsystems
present
reaction chambers
wicking
automated
Prior art date
Application number
PCT/US2011/000332
Other languages
French (fr)
Other versions
WO2011102913A2 (en
Inventor
Hsing-Yeh Parker
John Tabone
John Mulligan
Original Assignee
Oligoco
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oligoco filed Critical Oligoco
Publication of WO2011102913A2 publication Critical patent/WO2011102913A2/en
Publication of WO2011102913A3 publication Critical patent/WO2011102913A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays

Abstract

Embodiments of the present invention include processing steps and subsystems, within automated-biopolymer-synthesis systems and within other automated systems for organic-chemistry-based processing, for removing reagent solutions and solvents from reaction chambers following various synthetic reaction steps and washing steps undertaken during biopolymer synthesis. Embodiments of the present invention employ any of various different types of liquid-absorbing materials to wick, or remove by capillary action, liquids from reaction chambers. Wicking-based methods and subcomponents of the present invention remove significantly greater fractions of solutions from reaction chambers than conventional methods and subsystems and, in addition, are mechanically simpler and produce fewer deleterious side effects than currently used methods and subsystems.
PCT/US2011/000332 2010-02-22 2011-02-22 Wicking-based reagent-solution draining in an automated system WO2011102913A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30690110P 2010-02-22 2010-02-22
US61/306,901 2010-02-22
US31286210P 2010-03-11 2010-03-11
US61/312,862 2010-03-11

Publications (2)

Publication Number Publication Date
WO2011102913A2 WO2011102913A2 (en) 2011-08-25
WO2011102913A3 true WO2011102913A3 (en) 2012-02-16

Family

ID=44483524

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2011/000333 WO2011102914A2 (en) 2010-02-22 2011-02-22 Automated polymer-synthesis system
PCT/US2011/000332 WO2011102913A2 (en) 2010-02-22 2011-02-22 Wicking-based reagent-solution draining in an automated system

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2011/000333 WO2011102914A2 (en) 2010-02-22 2011-02-22 Automated polymer-synthesis system

Country Status (1)

Country Link
WO (2) WO2011102914A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472672A (en) * 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US6074613A (en) * 1996-10-29 2000-06-13 Bohdan Automation, Inc. Apparatus for multiple, simultaneous synthesis of organic compounds
US6258323B1 (en) * 1998-11-16 2001-07-10 Rohm And Haas Company Apparatus and method used in multiple, simultaneous synthesis of general compounds
US6800250B1 (en) * 1999-03-19 2004-10-05 Scott P. Hunicke-Smith Polymer synthesizer
US20090148353A1 (en) * 2007-12-07 2009-06-11 Thomas Downing Polymer Synthesizer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5252296A (en) * 1990-05-15 1993-10-12 Chiron Corporation Method and apparatus for biopolymer synthesis
AU8653901A (en) * 2000-08-18 2002-03-04 Massachusetts Inst Technology Apparatus and methods for the automated synthesis of oligosaccharides
DE10308931A1 (en) * 2003-02-28 2004-09-23 Apibio Sas System and method for the synthesis of polymers
DE102004024364A1 (en) * 2004-05-17 2005-12-15 Apibio Sas Process for the preparation of polymers

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5472672A (en) * 1993-10-22 1995-12-05 The Board Of Trustees Of The Leland Stanford Junior University Apparatus and method for polymer synthesis using arrays
US6074613A (en) * 1996-10-29 2000-06-13 Bohdan Automation, Inc. Apparatus for multiple, simultaneous synthesis of organic compounds
US6258323B1 (en) * 1998-11-16 2001-07-10 Rohm And Haas Company Apparatus and method used in multiple, simultaneous synthesis of general compounds
US6800250B1 (en) * 1999-03-19 2004-10-05 Scott P. Hunicke-Smith Polymer synthesizer
US20090148353A1 (en) * 2007-12-07 2009-06-11 Thomas Downing Polymer Synthesizer

Also Published As

Publication number Publication date
WO2011102914A2 (en) 2011-08-25
WO2011102914A3 (en) 2012-02-16
WO2011102913A2 (en) 2011-08-25

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