WO2011094586A1 - Collapsing structure for reducing the diameter of a stent - Google Patents
Collapsing structure for reducing the diameter of a stent Download PDFInfo
- Publication number
- WO2011094586A1 WO2011094586A1 PCT/US2011/022987 US2011022987W WO2011094586A1 WO 2011094586 A1 WO2011094586 A1 WO 2011094586A1 US 2011022987 W US2011022987 W US 2011022987W WO 2011094586 A1 WO2011094586 A1 WO 2011094586A1
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- Prior art keywords
- filament
- stent
- crowns
- loops
- knot
- Prior art date
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- 0 CCCC1CC(C*)C*C1 Chemical compound CCCC1CC(C*)C*C1 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/88—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils
- A61F2/885—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure the wire-like elements formed as helical or spiral coils comprising a coil including a plurality of spiral or helical sections with alternate directions around a central axis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/95—Instruments specially adapted for placement or removal of stents or stent-grafts
- A61F2002/9528—Instruments specially adapted for placement or removal of stents or stent-grafts for retrieval of stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0004—Rounded shapes, e.g. with rounded corners
- A61F2230/0013—Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/005—Rosette-shaped, e.g. star-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0063—Three-dimensional shapes
- A61F2230/0071—Three-dimensional shapes spherical
Definitions
- Stents are being used increasingly in benign indications. Such use requires the ability to remove the stent when its use has become redundant. Additionally, misplacement of the stent may be a risk during stent deployment. For example, foreshortening braided stents can be deployed at an incorrect target site within a body lumen. The ability to reposition the stent within the body lumen or remove the stent from the body lumen after deployment with minimal trauma to the patient would be advantageous. Although the inventions described below may be useful for repositioning or removing a deployed stent, the claimed inventions may also solve other problems.
- a collapsing structure comprising an outer filament interwoven with a stent end and an inner filament interwoven with the outer filament at one or more engagement points thereof, wherein the stent end is collapsed by drawing the inner filament together.
- the invention may include any of the following aspects in various combinations, and may also include any other aspect described below in the written description or in the attached drawings.
- a collapsing element for removing or repositioning a stent.
- the collapsing element comprises a first filament and a second filament.
- the first filament is interwoven through a plurality of crowns extending about a stent end.
- the interweaving of the first filament through the plurality of crowns creates a plurality of loops disposed about the stent end.
- the second filament is interwoven through two or more of the plurality of the loops of the first filament.
- the second filament is configured to be pulled so as to pull the loops of the first filament radially inwards and thereby pull the plurality of crowns towards each other to collapse the stent end.
- a collapsing structure comprising an outer filament interwoven through a plurality of crowns about a stent end to create an alternating arrangement of a plurality of inner loops and a plurality of outer loops.
- the plurality of inner loops is disposed within a lumen of the stent and the plurality of outer loops is disposed outside an exterior surface of the stent end.
- An inner filament is interwoven through each of the plurality of the inner loops to create a plurality of engagement points for pulling the outer filament. Pulling the outer filament at each of the plurality of engagement points draws the plurality of crowns inwardly toward a central longitudinal axis of the stent.
- a device for collapsing an end of a stent comprising an outer filament interwoven through at least a portion of a plurality of crowns along the stent end to create a plurality of loops is provided.
- the system also includes an inner filament passing through the outer filament to create a plurality of engagement points therebetween. As the inner filament is pulled at each of the plurality of engagement points, the outer filament is tightened against the plurality of crowns. The crowns of the stent end are thereby pulled radially inward so as to collapse the stent end.
- Figure 1 shows the end of a stent in a slightly compressed state and having an outer filament interwoven through all of the crowns of the stent end and an inner filament extending through the loops of the outer filament;
- Figure 2 is an end view of the stent of Figure 1 in a partially expanded state and showing the outer filament interwoven through each of the crowns of the stent;
- Figure 3 shows an inner filament being interwoven through the loops created by the outer filament of Figure 2;
- Figure 3a shows an end view of the stent of Figure 1 with a flared end
- Figure 4 shows the stent end of Figure 3 in which the inner filament has been pulled so as to fully collapse the crowns and the stent end;
- Figure 5 shows an inner filament engaged with an outer lasso at three locations along a proximal end of a stent
- Figure 6 shows the stent of Figure 5 with a portion of the inner filament being pulled in a distal direction so as to draw the outer lasso into the stent lumen;
- Figure 7 shows a stent in which a single outer lasso is interwoven through all the crowns of a stent end;
- Figure 8 shows a stent with a grasping loop structure
- Figure 8a shows the stent of Figure 8 with a covering disposed on the grasping loop structure
- Figure 9 shows a low-profile knot structure that may be incorporated with the stent of Figure 1;
- Figure 9a shows a low-profile knot structure that may be incorporated with the stent of Figure 1 ;
- Figure 10 shows a low-profile knot structure including a coiled wire disposed on the grasping loop structure and a covering disposed on the grasping loop structure;
- Figure 1 1 shows a low-profile knot structure including a double-filament grasping loop that may be incorporated with the stent of Figure 1;
- Figure 12 shows the low-profile knot structure of Figure 1 1 with a covering disposed on the double-filament loop.
- distal and distal shall denote a position, direction, or orientation that is generally away from the physician. Accordingly, the terms “proximal” and “proximally” shall denote a position, direction, or orientation that is generally towards the physician.
- the ability to collapse a stent end after the stent has been deployed in a body lumen enables the stent to be repositioned to another location within the body lumen. For example, repositioning of the stent can be advantageous when the stent has been deployed at an unintended target site, which tends to be a risk associated with stents that undergo foreshortening upon deployment. Collapsing the stent end also allows the stent to be removed from the body lumen.
- the ability to remove a deployed stent (e.g., a stent that is fully covered) from the body lumen after a predetermined time period can allow the stent to be used to treat benign indications that may be treatable with nonremovable stents.
- the collapsing structure includes an outer filament and an inner filament.
- the outer filament is affixed about or to the stent.
- the outer filament is interwoven through the crowns extending about a stent end.
- the inner filament is interwoven within openings of the outer filament.
- pulling the inner filament tightens the outer filament against the outer surface of the crowns of the stent end, which causes the crowns of the stent to move radially inward, thereby collapsing the stent end.
- filament as used throughout the specification may include suture material, and may also include thin wire, such as nitinol.
- the term “crown” as used throughout the specification includes the strut of the stent forming the edge thereof.
- Figure 1 illustrates a collapsing structure 100 attached to an end 1 10 of a stent 120.
- the collapsing structure 100 includes an outer filament 130 and an inner filament 140.
- the inner filament 140 engages with the outer filament 130 to reduce the diameter of the stent end 1 10.
- Figure 1 shows that the end 1 10 of the stent 120 is partially reduced in diameter from its fully expanded state as the inner filament 140 is pulled. Specifically, when the ends 141 and 142 of the inner filament 140 are pulled as shown in Figure 1, portions of the outer filament 130 move radially inward.
- the crowns 121 which are shown as extending circumferentially about the end 110 of the stent 120, begin to bend inwards towards the central longitudinal axis of the stent 120, thereby collapsing the end 1 10 thereof.
- the inward movement of the crowns 121 also causes end portion 150 to reduce in diameter.
- the collapsed crowns 121 and the reduction in diameter of end portion 150 may enable the stent 120 to be repositioned within a body lumen and/or removed from a body lumen after the stent 120 has been deployed.
- the outer filament 130 may be interwoven through the openings 122 adjacent to each of the crowns 121, as shown in Figure 1, to create an alternating series of outer loops 132 and inner loops 131.
- Figures 1 and 2 illustrate how the outer filament 130 is interwoven through the crowns of the stent 120.
- the inner filament 140 has been omitted from this figure for purposes of clarity to show the pattern by which outer filament 130 interweaves about the end 110 of the stent 120.
- the end 1 10 of the stent 120 has been slightly collapsed to facilitate the process of weaving the outer filament 130 there through and to illustrate the loop pattern created by the interweaving of outer filament 130 through the crowns 121 of the stent 120.
- the outer filament 130 weaves through various openings 122 of the various crowns 121 residing about the end 1 10 of the stent 120 in an undulating pattern so as to create the series of inner loops 131 which alternate with the series of outer loops 132.
- the weaving pattern for the outer filament will now be described with reference to Figure 2, although it should be understood that other weaving patterns can be utilized. Beginning with a portion of the outer filament 130 disposed within the luminal space 201 of the stent 120, the outer filament 130 first extends outwardly through an opening 222 of crown 210. The filament 130 then emerges from within the opening 222 of the crown
- the filament 130 then passes along the outside of the stent 120 as it extends away from crown 210. As the filament 130 approaches the next crown 211, the filament 130 bends inwardly towards the stent 120 and eventually passes through opening 223 of the next crown 211, which is adjacent to crown 210. The path traversed by the filament 130 between crown 210 and adjacent crown 21 1 creates an outer loop segment 232. After forming the outer loop segment 232, the filament 130 then passes through opening 223 of crown 211 and reemerges into the luminal space 201 of the stent 120.
- the filament 130 continues to travel along the crown 212 in a counterclockwise direction, as shown in Figure 2, within the luminal space 201 of the stent 120. As the filament 130 continues to travel along the second crown 21 1, the filament 130 begins to bend outwardly and away from the luminal space 201 of the stent 120. When the filament 130 approaches the third crown 212, it emerges through the opening 224 thereof. The path traversed by the filament 130 between the second crown
- the filament 130 then passes through the opening 224 of the third crown 212.
- the filament 130 continues to interweave into and out of each of the successive crowns in the same manner as described above so as to create a series of inner loops 131 alternating with a series of outer loops 132, as shown in Figure 1.
- the free ends of the outer filament 130 may be twisted or tied to form a knot 135, as shown in Figure 2, so as to form a continuous loop about the end 110 of the stent 120.
- the inner filament 140 can now be interwoven through the inner loops 131 of the outer filament 130.
- the inner filament 140 can be woven though the outer loops 132 of the outer filament 130.
- Figure 3 shows the inner filament 140 being woven through a plurality of the inner loops 131 created by the weaving of the outer filament 130 into and out of the openings 122 of the crown 121, as described above.
- the inner filament 140 is only woven along the interior of the stent 120.
- Figure 3 illustrates the step of weaving inner filament 140 though the outer filament 130. Because the stent 120 is more expanded in Figure 3 than in Figure 2, the sizes of the inner loops 131 of the outer filament 140 appear to be smaller. However, and as will be understood by one skilled in the art, the sizes of the inner loops 131 will depend on the length of the outer filament 130, the diameter of the stent 120, and the state of collapse of the stent 120.
- the inner loops 131 of Figure 1 are shown in Figure 3 as 301, 302, 303, and 304.
- an outer filament 130 having a length that is less than the circumference of the end 110 of the stent 120 it may be desirable to provide an outer filament 130 having a length that is less than the circumference of the end 110 of the stent 120. In such a configuration, the outer filament 130 would cause the end 110 of the stent 120 to maintain a partially collapsed state. Similarly, it may desirable to provide an outer filament 130 having a length that is equal to the circumference of the stent 120, but interwoven through an outwardly flared end 1 10 of the stent 120 (i.e., the end 110 has a unrestrained diameter that is greater than that of the stent body).
- Such a configuration would result in a stent 120 having a uniform diameter, but having an end 1 10 that is more resistant to compression (i.e., has a greater outwardly directed spring constant).
- This configuration creates an in-built higher radial force in the end 110 that allows the stent end 1 10 to open quicker and recover its original diameter.
- the flared end 110 embodiment is illustrated in Figure 3a, along with a single outer lasso 305, but it should be understood that a double filament structure such as that shown in Figure 3 could be used with the flared end 1 10 illustrated in Figure 3a.
- inner filament 140 is woven in an undulating pattern through the first inner loop 301 within the luminal space 201 of stent 120. Having extended through the first inner loop 301, inner filament 140 is shown to then extend downwards within the luminal space of stent 120 and thereafter extend upwards through the second inner loop 302. The inner filament 140 thereafter extends upwards beyond the end 110 of stent 120 as shown at location 350 and then travels downwards towards the end 1 10 of the stent 120 through the third inner loop 303. Next, filament 140 loops upwards so as to extend through a fourth inner loop 304. The filament 140 may continue to propagate in this manner through each of the inner loops of the outer filament 130.
- Figure 3 shows that the inner filament 140 may interweave in a substantially perpendicular orientation relative to outer filament 130. However, when the stent 120 is fully expanded, the inner filament 140 may interweave in a substantially parallel orientation relative to the outer filament 130.
- the free ends 141 and 142 of the inner filament 140 may extend beyond the end 110 of the stent 120 (shown in Figure 1 as extending out of the plane of the page) for a predetermined distance.
- the free ends 141 and 142 may be tied together to form a knot 199, as shown in Figure 1.
- the knot 199 may serve as an access or engagement point to pull the inner filament 140 during operation of the collapsed structure 100.
- Figure 8 illustrates a grasping loop structure.
- the free ends 141 and 142 may be tied together.
- the free ends 141 and 142 are tied together to form a first knot 800 and a second knot 802, thereby forming a grasping loop 804 generally defined by a first section of suture 806 and a second section of suture 808.
- the second section of suture 808 may be longer than the first section of suture 806, which aids the grasping loop structure in remaining open. This configuration allows easier access for removal or repositioning of the stent 120.
- the first section of suture 806 may be longer than the second section of suture 808.
- Figure 8a shows the grasping loop structure of Figure 8 with a first tube 810 disposed over the first section of suture 806 and a second tube 812 disposed over the second section of suture 808 of the grasping loop structure.
- Nitinol wire 814 may be included inside of the second tube 812 to aid opening of the grasping loop 804 after it has been deployed.
- a variety of materials may be used for the covering or tube, such as PTFE, polyurethane, polyimide, nylon, coil, polymer tubing reinforced with metal braiding, braiding, etc.
- Figures 9 and 9a illustrate an alternative knot arrangement. As illustrated in Figures 9 and 9a, the free ends 141 and 142 are tied together to form a knot 900.
- Knot 900 is a low-profile knot that will not open or resist opening during use.
- the knot 900 forms a grasping loop 902.
- the low-profile of the knot 900, along with the configuration of the knot 900 and grasping loop 902, allows for removal or repositioning of the stent 120. While a certain configuration of the knot 900 is shown, any variation of a knot 900 designed to not open or resist opening during use could be implemented.
- knot 900 could be a "double overhand knot," an "overhand knot,” “figure 8 knot” or any other knot that has the characteristics to allow access for removal or reposition of the stent 120.
- Figure 10 shows the low-profile knot structure of Figure 9a, including a coiled wire 1000 disposed on the grasping loop 902 structure.
- the coiled wire 1000 may be disposed within a tube 1002, which includes a heat shrink 1004. Additionally, the coiled wire 1000 may be radiopaque coiled wire.
- the coiled wire 1000 allows for improved opening of the grasping loop 902 structure resulting from the spring force of the coil.
- the spring force of the coil may be varied depending on the coil wire implemented on the grasping loop 902, and may continuously push the grasping loop 902 into a triangular shape.
- the coiled wire 1000 can withstand a higher and consistent force when forceps are applied during repositioning/removal of, for example, the stent 120 (not shown).
- the inclusion of the coiled wire 1000 allows for retrieval of the stent 120 (not shown) post- deployment.
- Figure 1 1 shows a low-profile knot structure including a double-filament loop 1102 that may be incorporated with the stent of Figure 1.
- the free ends 141 and 142 are tied together to form a knot 1 100.
- a double-filament loop 1 102 provides additional strength for the grasping loop.
- the knot 1 100 is a low-profile knot that resists opening during use when the grasping loop 1 102 is, for example, grasped and pulled by forceps.
- the low-profile of the knot 1 100 along with the configuration of the knot 1 100 and grasping loop 1 102, allows for removal or repositioning of, for example the stent 120 (not shown).
- knot 1100 While a certain configuration of the knot 1100 is shown, any variation of a knot 1100 designed to resist opening during use can implemented.
- knot 1100 could be a "double overhand knot” or an "overhand knot.”
- the suture used to form the knot 1 100 may be made from a variety of materials such as UHMWPE (ultra-high-molecular-weight polyethylene), polyester, nylon, stainless steel, etc.
- UHMWPE ultra-high-molecular-weight polyethylene
- polyester polyester
- nylon nylon
- stainless steel etc.
- the preferred suture material is UHMWPE because this material has very fine strands and has good resistance to cutting action of forceps.
- the double-filament loop 1102 may be covered by a tube 1200, as shown in Figure 12.
- a tube 1200 A variety of materials may be used for the tube, such as PTFE, polyurethane, polyimide, nylon, coil, polymer tubing reinforced with metal braiding, braiding, etc.
- the tube 1200 provides resistance to the cutting action of forceps (not shown) by shielding the sharp edge of the forceps from the suture.
- the thickness of the tube 1200 is preferably greater than 0.003 inches, but the thickness may depend on the sharpness of the forceps that may be used in the removal or repositioning of the stent.
- the tube 1200 may be provided in a high visible color so that it is more easily seen.
- One method of creating the double-filament loop 1 102 shown in Figure 12 may be to thread the free ends 141 and 142 through the tube 1200, and the suture material may then be tightened to create the loop 1 102 and the knot 1 100.
- Another method of creating the double-filament loop 1 102 shown in Figure 12 may be to thread one free end through the tube 1200, then loop the free end through the tube 1200 a second time. The suture may then be tightened to create the loop 1102 and the knot 1 100.
- the resultant configuration of the inner filament 140 interwoven with the outer filament 130 is shown, which in turn is affixed to the end 1 10 of stent 120.
- the inner filament 140 does not itself create any loops. Rather, the inner filament 140 forms a substantially circular shape when slidably disposed through the inner loops 131 of the outer filament 130.
- the inner filament 140 is interwoven through the inner loops 131 with sufficient slack such that the end portion 1 10 of the stent 120 may fully expand following any deployment, retrieval, and/or repositioning of the stent 120.
- inner filament 140 is preferably not woven about outer filament 130 so tightly that the filaments 130 and 140 constrain the end 1 10 of stent 120, thereby preventing the end 1 10 from fully expanding and exerting a radial force against a body lumen.
- the inner filament 140 is slidably disposed more loosely than the outer filament 130 to allow the filament 140 to be readily pulled with a grasping member (e.g., forceps).
- the outer filament 130 is also preferably configured to not constrain the end portions of the stent 120 when tension is released from the inner filament 140.
- the outer filament 130 is also free to move within the openings 122 adjacent to the crowns 121 ( Figure 1) when the end 1 10 of the stent 120 is partially or substantially expanded ( Figures 2 and 3).
- Such movement of the outer filament 130 also enables the outer loops 132 and the inner loops 131 to change shape and/or their orientation as the crowns 121 of the stent 120 collapse in response to a pulling force applied at one or both free ends 141 and 142 of the inner filament 140.
- it may be desirable to limit the length or size of the outer filament if constraining or limiting the expansion of the end 1 10 of the stent 120 is desired.
- the inner filament 140 may be pulled along free ends 141 and 142 (seen in Figure 1 as emerging out from plane of page) or at the location where the free ends 141 and 142 are tied to form a knot 199. Applying a pulling force at the free ends 141 and 142 of the inner filament 140 causes the inner filament 140 to pull at each of the apices 177 ( Figure 1) of the corresponding inner loops 131 so as to pull the inner loops 131 inwards towards the central luminal space of the stent 120.
- the inner loops 131 In response to the pulling force, the inner loops 131 become narrower and longer in length, the length being measured from the crowns 121 to the interior region of the apex 177 where the inner filament 140 is slidably disposed therein. As the inner filament 140 is tightened, the inner loops 131 transmit the pulling force from the inner filament 140 to the corresponding outer loops 132. In other words, the inner loops 140 pull on the outer loops 132 of the outer filament 130, thereby causing the outer loops 132 to tighten and move radially inwards. The outer loops 132 are thereby pulled radially inwards as shown in Figure 1 against the crowns 121.
- Figure 1 shows a partially collapsed configuration in which adjacent crowns 121 are pulled inwards by an outer loop 132.
- Figure 1 shows that the outer loop 132 squeezes and pulls the two adjacent crowns 121 together such that the spacing between adjacent crowns 121 decreases, as compared to Figure 3.
- each of the outer loops 132 around the end 1 10 of stent 120 squeezes and pulls adjacent crowns 121 closer together, thereby collapsing all of the crowns 121 and also reducing the diameter of the end portion 150.
- Figure 4 shows an increased pulling force being applied at the free ends 141 and 142 of the inner filament 140 so as to completely collapse the crowns 121.
- Figure 4 shows that the inner loops 131 have become narrower and longer compared to that of Figure 1. Additionally, the outer loops 132 have become smaller in width (i.e., the width being approximately the gap between adjacent crowns 121) as they incur an increased pulling force from the inner loops 131 and the inner filament 140.
- the apices 177 of the inner loops 131 are shown to align about the end 110 of the stent 120 to form a substantially circular shape that is substantially concentric with the circular end 1 10 of stent 120.
- the plurality of crowns 121 as shown in their fully collapsed state in Figure 4 substantially reside in a plane transverse to a central longitudinal axis extending through both the circular stent end 1 10 as defined by the crowns 121 and the shape formed by the apices 177 of the inner loops 131.
- the amount of force required to collapse the crowns 121 and reduce the diameter of the end portion 150 when using the above described two-filament collapsing structure 100 may be significantly less than that required when pulling directly on a single suture that is affixed to the end of a stent, as shown in Figure 7.
- the lower force may be attributed in part to the significantly lower factional resistance generated when pulling the inner filament 140 through the inner loops 131 of the outer filament 130, as compared to pulling directly on a single suture affixed to the stent end ( Figure 7).
- the path of the inner filament 140 through the inner loops 131 is more uniform and less undulating than the path of the outer filament 130 through the crowns 121 of the stent 120.
- the collapsed crowns 121 can form a substantially concentric circle with the end 1 10 of stent 120 shown in Figures 1 and 4 in which each of the crowns 121 reside in a single plane transverse to a central longitudinal axis of the stent 120.
- a side view of Figure 4 would indicate that none of the crowns 121 project significantly farther in a longitudinal direction than the other crowns 121.
- Such an arrangement of the crowns 121 may allow the stent 120 to be pulled during repositioning within a body lumen or removal from a body lumen without significant potential of buckling and entanglement of the crowns 121.
- each of the crowns 121 reside within a single transverse plane may facilitate pushing the stent 120 out from an introducer during the deployment of stent, as all crowns 121 of the stent 120 can be pushed and released from the introducer at approximately the same time.
- a non-uniform arrangement whereby some crowns are collapsed farther down than other crowns may cause only a few of the crowns which are farther collapsed to incur most of the force when pushing and releasing the stent from the introducer, which may cause some of the crowns to buckle or deform. Nevertheless, a non-uniform arrangement may have advantages for certain applications.
- Entanglement of the crowns 121 may also be avoided because the two-filament collapsing structure 100 does not cause the crowns 121 to be collapsed as far as when directly pulling on a single filament affixed to a stent end (Figure 7).
- Figure 4 shows the fully collapsed configuration of the crowns 121.
- a separation distance or gap may remain between adjacent crowns 121, thereby preventing the crowns 121 from overlapping or criss-crossing with each other and becoming entangled. Entanglement of the crowns 121 may prevent the stent 120 from re-expanding after the stent 120 has been repositioned at a new location.
- crowns 121 to collapse radially inwards towards a central longitudinal axis of the stent 120 avoids potential trauma to the patient. Entangled crowns may inadvertently point outwards and scrape against tissue of a body wall.
- the degree of collapse of the crowns 121 is a function of several factors, including the diameter of the stent end 110, the number of crowns 121, and the length of the outer filament 130.
- the degree of collapse of the stent end 1 10 can be reduced by increasing the length of the outer filament 130, by reducing the number of crowns 121 through which the outer filament 130 is woven, or by reducing the number of inner loops 131 through which the inner filament 140 is woven.
- the inner filament 140 and outer filament 130 can be formed from a variety of biocompatible materials.
- the filaments 130 and 140 may be constructed of common suture material as known in the art.
- One type of suture material that may be used is a multifilament polyester suture commercially known as 2-0 Tevdek®.
- Lower frictional resistance between the inner filament 140 and the outer filament 130 can also be achieved by using various suture materials or other types of nonabrasive materials such as flexible wire.
- Both the inner filament 140 and outer filament 130 may be formed from similar materials or different materials.
- inner filament 140 is being pulled and therefore incurring most of the force generated from the pulling, certain applications may be well suited with an inner filament 140 formed from a material possessing a higher tensile strength compared to that of the outer filament 130.
- the outer filament 130 may be formed from a lower tensile strength material as the outer filament 130 is being pulled from multiple points by the inner filament 130.
- FIG. 1 shows that the outer filament 130 is interwoven in and out of each of the crowns 121, outer filament 130 may also be interwoven in and out of every second crown 121.
- the less number of crowns 121 the outer filament 130 is interwoven therethrough the smaller the amount of collapse of the crowns 121 radially inwards.
- a smaller collapse of the crowns 121 may correspond to a smaller reduction in diameter of the end portion 150 of the stent 120.
- Such a configuration may be suitable in certain applications where maximum collapse of the crowns 121 is not needed.
- inner filament 140 may not be woven through each of the inner loops 131 of the outer filament 130.
- the inner filament 140 could be weaved through every other inner loop 140.
- Such a configuration of inner filament 140 with the outer filament 130 limits the extent to which the crowns 121 would collapse.
- the crowns 121 may only collapse to an extent that is approximately half as much as when the inner filament 140 is interwoven through every inner loop 131, assuming that all other design factors remain equal.
- the exact number of crowns 121 through which the outer filament 130 interweaves and the exact number of inner loops 131 through which the inner filament 140 interweaves and extends therethrough may depend, at least in part, on the extent to which the crowns 121 are required to collapse for a particular application.
- the exact required length for the outer filament 130 may vary depending on its respective interweaving pattern. By way of example, if the outer filament 130 interweaves through all the crowns 121, then the outer filament 140 may be longer than a circumference of the end 110 of stent 120 when fully expanded so as to not constrain the end 1 10 of the expanded stent 120.
- the length of the inner filament 140 may depend, in part, on the number of inner loops 131 that inner filament 140 extends there through and the separation distance between the end 1 10 and the knot (located beyond the end 1 10).
- the length of the inner filament 140 may be less than that of the outer filament 130 but preferably is sufficiently long enough to possess adequate slack for accessing the region of the inner filament 140 beyond end 1 10 (e.g., the knot) for grasping and pulling thereat.
- the above described collapsing structure 100 may comprise more than two filaments.
- a third filament may be incorporated into the two-filament collapsing structure 100.
- the third filament (not shown) could be interwoven through the loops of the inner filament 140.
- the third filament would become the innermost filament of the three-filament collapsing structure.
- the third filament would be pulled along a free end extending beyond the end 110 of stent 120.
- the effect would be a reduction in the collapse of the crowns 121 as compared to the two-filament collapsing structure 100.
- the exact number of filaments to use in a particular collapsing structure would depend, at least in part, on the degree of collapse of the crowns 121 required for a particular procedure.
- the collapsing structure 100 may also be incorporated onto other stent structures, such as, for example, a z-stent having zigzag struts. If the contemplated stent structure is a z-stent, the outer filament 130 could be extended through the eyelets at one of the ends of the z-stent. The inner filament 140 could subsequently be interwoven through loops created by the outer filament 130 extending through eyelets.
- the collapsing structure 100 can be utilized in a number of different applications.
- the collapsing structure 100 can be affixed to an end of the stent 120 to enable grasping of the inner filament 140 with a retrieval member for removal from a body lumen or repositioning within the body lumen.
- Figure 5 shows a collapsing structure 500 comprising an inner filament 501 engaged to an outer filament or lasso 502 at a proximal end 510 of a stent 51 1, which is shown in its expanded state.
- the collapsing structure 500 may control the positioning of the outer lasso 502 during loading of the stent 51 1 into a delivery system (not shown).
- Figure 5 shows that the inner filament 501 is wrapped around three inner loops 503, 504 and 505 of the outer lasso 502.
- the inner filament 501 may be pulled along portion 599 of the inner filament 501 in a distal direction as shown in Figure 6. Portion 599 extends from the proximal end 510 to a distal end of the stent 51 1, as shown in Figure 6. The pulling force is transmitted to the inner loops 503, 504, and 505 (as shown by the three arrows in Figure 5) to cause the outer lasso 502 to move into the lumen 590 of the stent 511 ( Figure 6).
- an outer sheath (not shown) can be slidably disposed over the stent 511 to constrain the stent 51 1 for subsequent delivery and deployment.
- the ability to selectively move the outer lasso 502 into the lumen 590 protects the lasso 502 from becoming potentially damaged during advancement of the outer sheath over the stent 511 or during the loading of the stent 502 into the delivery system (e.g., by advancing the stent 511 through a funnel component).
- the inner filament 501 may be cut and removed from the stent 511 and from the delivery system.
- the outer lasso 502 remains woven to the proximal end 510 of the stent and serves as the means for repositioning and/or removing the stent 511 after deployment.
- FIG. 5 shows that the inner loops 503, 504, and 505 are created by interweaving the outer lasso 502 through crowns of the stent 51 1.
- a first inner loop 503 is created as outer lasso 502 moves into opening of crown 524 and into opening of crown 525.
- a second inner loop 504 is created as outer lasso 502 moves into opening of crown 520 and into opening of crown 521.
- a third inner loop 505 is created as outer lasso 502 moves into opening of crown 519 and into opening of crown 518.
- the size of each of the loops 503, 504, and 505 is determined at least in part by the spacing between the two crowns forming each of the loops.
- Figure 5 shows that the distance between adjacent crowns forming each loop 503, 504, and 505 is about two crowns.
- the engagement of the inner filament 501 with the outer lasso 502 at three locations enables the outer lasso 502 to collapse within the lumen 590 of the stent 51 1 ( Figure 6).
- Figure 6 shows that pulling portion 599 in a distal direction causes the inner loops 503, 504, and 505 to also be pulled distally into the lumen 590.
- the inner loops 503, 504, and 505 transmit the pulling force from the inner filament 130 to the outer lasso 502.
- the inner loops 503, 504, and 505 pull on the outer lasso 502, thereby causing the outer lasso 502 to tighten and be drawn distally inwards towards the lumen 590 of the stent 51 1.
- the pulling of the outer lasso 502 into the lumen 590 causes the crowns 565 to collapse radially inwards a predetermined amount, as shown in Figure 6.
- the application of the force along portion 599 of the inner filament 501 may be less than the force required to pull or draw an outer lasso 700 as configured in Figure 7.
- the single outer lasso 700 shown in Figure 7 needs to be woven through at least every other crown to allow the lasso 700 to adequately collapse within the stent lumen.
- Such a configuration may create a significantly higher force requirement to collapse the outer lasso 700 within the stent lumen because of the higher frictional resistance created as the lasso 700 is pulled through the crowns about the end of the stent.
- the lower frictional resistance of the outer lasso 502 with the proximal end 510 of the stent 51 1 in the configuration shown in Figures 5 and 6 allows the stent 511 to radially expand upon either deployment or release of tension from the inner filament 501 during a repositioning procedure of the stent 511.
- Figure 5 shows that the free ends of the outer lasso may be tied to form a knot 506.
- the absence of a portion of the outer lasso 502 extending beyond the proximal end 510 of the stent 51 1 (as compared to the lasso 700 in Figure 7 which has a grasping portion 701) may reduce the likelihood of the lasso loop 502 being inadvertently damaged during loading of the stent 51 1 into the delivery system.
- a shorter length of the outer lasso 502 extending beyond the proximal end 510 of the stent 51 1 may reduce the likelihood that the lasso 502 inadvertently is pinched between the body of the stent 511 and the body lumen or ends up at another unintended location within the delivery system that is difficult to access when the stent 511 is ready to be released therefrom and deployed.
- Figure 5 can be used on a variety of stent architectures that are either self-expandable or balloon-expandable.
- Other structures in addition to that of Figure 5 are contemplated to engage an outer lasso and thereafter draw it into the stent lumen during a loading or re-sheathing procedure.
- engagement between an inner filament and outer lasso at more than three locations is possible. Greater than three locations or points of engagement between the inner filament and the outer lasso may further reduce the amount of resistance the stent has to overcome to radially expand to its expanded state.
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
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AU2011210720A AU2011210720B2 (en) | 2010-01-29 | 2011-01-28 | Collapsing structure for reducing the diameter of a stent |
CA2788111A CA2788111C (en) | 2010-01-29 | 2011-01-28 | Collapsing structure for reducing the diameter of a stent |
JP2012551341A JP5898630B2 (en) | 2010-01-29 | 2011-01-28 | Structure for reducing the diameter of a stent |
EP11705322.3A EP2528554B1 (en) | 2010-01-29 | 2011-01-28 | Collapsing structure for reducing the diameter of a stent |
Applications Claiming Priority (2)
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US29986410P | 2010-01-29 | 2010-01-29 | |
US61/299,864 | 2010-01-29 |
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WO2011094586A1 true WO2011094586A1 (en) | 2011-08-04 |
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PCT/US2011/022987 WO2011094586A1 (en) | 2010-01-29 | 2011-01-28 | Collapsing structure for reducing the diameter of a stent |
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US (1) | US9271854B2 (en) |
EP (1) | EP2528554B1 (en) |
JP (1) | JP5898630B2 (en) |
AU (1) | AU2011210720B2 (en) |
CA (1) | CA2788111C (en) |
WO (1) | WO2011094586A1 (en) |
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Also Published As
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AU2011210720A1 (en) | 2012-08-23 |
EP2528554A1 (en) | 2012-12-05 |
EP2528554B1 (en) | 2014-01-15 |
AU2011210720B2 (en) | 2014-07-24 |
CA2788111C (en) | 2016-04-05 |
CA2788111A1 (en) | 2011-08-04 |
JP2013517912A (en) | 2013-05-20 |
US9271854B2 (en) | 2016-03-01 |
JP5898630B2 (en) | 2016-04-06 |
US20120041538A1 (en) | 2012-02-16 |
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