WO2011088070A1 - Preservative-free single dose inhaler systems - Google Patents
Preservative-free single dose inhaler systems Download PDFInfo
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- WO2011088070A1 WO2011088070A1 PCT/US2011/020925 US2011020925W WO2011088070A1 WO 2011088070 A1 WO2011088070 A1 WO 2011088070A1 US 2011020925 W US2011020925 W US 2011020925W WO 2011088070 A1 WO2011088070 A1 WO 2011088070A1
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- liquid
- container
- membrane
- unit dosage
- aerosol generator
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
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- A—HUMAN NECESSITIES
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- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
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- A—HUMAN NECESSITIES
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- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
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- A—HUMAN NECESSITIES
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- A61M15/0021—Mouthpieces therefor
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- A—HUMAN NECESSITIES
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0015—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors
- A61M2016/0018—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical
- A61M2016/0021—Accessories therefor, e.g. sensors, vibrators, negative pressure inhalation detectors electrical with a proportional output signal, e.g. from a thermistor
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A61M2016/0033—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical
- A61M2016/0039—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter electrical in the inspiratory circuit
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- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
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- A—HUMAN NECESSITIES
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/583—Means for facilitating use, e.g. by people with impaired vision by visual feedback
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/587—Lighting arrangements
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- A61M2209/00—Ancillary equipment
- A61M2209/04—Tools for specific apparatus
- A61M2209/045—Tools for specific apparatus for filling, e.g. for filling reservoirs
Definitions
- This invention relates generally to a single dose inhaler and insulin formation containers.
- the inhaler dispenses aerosolized pharmaceutical agents for local or systemic inhalation drug delivery to the lungs.
- the invention is particularly, but not exclusively, useful for delivery of preservative free doses of insulin for treating type I and/or type II diabetic patients.
- inhaler which comprises a dispensing apparatus in which a membrane with tapered apertures is vibrated such that liquid in contact with a rear face of the membrane is dispensed from a front face of the membrane as an aerosol.
- the invention provides inhalers for delivering doses in a repeatable and predictable fashion.
- the inhalers of the invention may find particular use in aerosolizing liquid insulin for pulmonary delivery.
- the invention provides various aerosolization systems, including containers for supplying liquid to inhalers, as well as methods for their use.
- the invention provides an aerosolization system that comprises a squeezable container having a resilient container body.
- the container is configured to deliver a unit dosage of a liquid when squeezed a single time.
- the system further includes an aerosolizer that comprises a housing defining a mouthpiece, and an aerosol generator disposed in the housing.
- the aerosol generator comprises a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane.
- the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
- the aerosolizer includes a hollow needle that is configured to pierce the squeezable container and to supply the liquid to the rear face of the vibratable membrane.
- the squeezable container may comprise a blister containing a single unit dosage.
- the blister may comprise a blow- fill-seal container that contains a preservative free solution.
- the blister may further comprise a squeezable body containing the solution, a twist off top and a tab adapted to display information about the solution.
- the single unit dosage has a concentration in the range from about 200 insulin units (“IU”)/ml to about 800 IU/ml.
- the container comprises a bottle containing of volume of the liquid.
- the bottle may include a metering valve that permits dispensing of a discrete droplet of the liquid each time the bottle is squeezed.
- the size of the droplet may be controlled based at least in part on the diameter of the tip of the bottle and the viscosity of the liquid.
- the invention further provides another aerosolization system that comprises a container in the form of an ampoule containing a capillary that holds a single unit dosage of a liquid.
- the system also includes an aerosolizer comprising a housing defining a mouthpiece, and an aerosol generator disposed in the housing.
- the aerosol generator comprises a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane.
- the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. Further, the opening provides a liquid path to the rear face of the vibratable membrane.
- the ampoule further comprises a snap-off top and a snap-off bottom.
- the capillary is sized such that surface tension in the capillary prevents leakage of the liquid after removal of the top but prior to removal of the bottom.
- a further embodiment of the invention provides an aerosolization system having a container comprising a container body that holds a supply of liquid, and a plunger device that is movable to dispense a single unit dosage of a liquid from the container upon operation of the plunger device a set distance.
- An aerosolizer comprises a housing defining a mouthpiece, and an aerosol generator disposed in the housing.
- the aerosol generator comprises a vibratable membrane having a front face and a rear face, and a vibratable element used to vibrate the membrane.
- the housing includes an opening that is adapted to receive a unit dosage of the liquid from the container. The opening provides a liquid path to the rear face of the vibratable membrane.
- the container further includes a metering device that is rotated to control movement of the plunger in order to set a single unit dosage amount.
- Fig. 1 is a perspective, partial cut-away view of one embodiment of a dispensing apparatus and squeezable container according to the invention.
- Fig. 2 is a more detailed view of the dispensing apparatus and container of Fig. 1.
- Fig. 3 is illustrates the dispensing device of Fig. 1, showing a more detailed view of a seat for holding the container and a needle for supplying dispensed liquid to an aerosol generator.
- Fig. 4 is a perspective view of another embodiment of a dispensing apparatus and an a squeezable bottle according to the invention.
- Fig. 5 illustrates another embodiment of a container for dispensing a unit volume of a liquid according to the invention.
- Fig. 6 illustrates the container of Fig. 5 when dispensing a unit volume of liquid into the dispensing apparatus of Fig. 4.
- Fig. 7 illustrates an embodiment of an ampoule for dispensing a unit volume of a liquid according to the invention.
- Fig. 8 illustrates the ampoule of Fig. 7 with an end removed.
- Fig. 9 illustrates the ampoule of Fig. 8 with the top end also removed and being deposited into a dispensing apparatus.
- Fig. 10 illustrates another embodiment of a container for dispensing a unit volume of a liquid into the dispensing apparatus of Fig. 4.
- an aerosolizing apparatus comprising a housing defining a dispensing outlet, a vibratable membrane having a front face exposed at the outlet and a rear face for receiving a liquid to be dispensed, and a vibrating mechanism connected to the housing and operable to vibrate the membrane to dispense aerosol of the liquid through the membrane.
- a liquid delivery system is used to deliver a metered quantity of the liquid from to the rear face of the membrane. In this way, a metered quantity of liquid is dispensable at the outlet by operating the vibrating mechanism for an operating period sufficient to completely aerosolize the metered quantity of the rear face.
- An advantage of such an apparatus is that it facilitates the dispensing of substantially all of the liquid coming into contact with the rear face of the membrane as a single dose, especially when the metered dose is relatively small in volume.
- the membrane is essentially free of liquid from one dose to the next. In this way, it is thereby possible to avoid contact between liquid and ambient air during periods of non-use between successive uses.
- this is particularly important since it may obviate the need for the use of preservatives in the liquid and avoids evaporative losses.
- various preservative free insulin formulations that may be used include those described in copending U.S. Application No. 13/004,645, entitled "Preservative Free Insulin Formulations and Systems and Methods for Aerosolizing" and filed on the same date as the present application, previously incorporated by reference.
- the liquid supply system in one embodiment may comprise a deformable thin-wall blister which contains a pharmaceutical agent.
- the supply system further comprises a mechanical press configured to deform the thin- walled blister such that a single, preservative free unit dose is delivered.
- the press mechanism is provided with a dispensing station provided with a piercing needle operable to pierce the blister and release its content upon actuation.
- the needle has two ends, with the first end protruding from the surface of the dispensing station and a second end extending to rear face of the aerosol generator.
- the blister In use the blister is seated in the dispensing station and the press mechanism forces the blister toward the needle which pierces through the thin wall. In this way, the needle provides a conduit for moving the liquid from the blister to the rear face of the vibratable membrane.
- the press mechanism When the press mechanism is released the blister expands and returns to its natural position. This expansion creates a suction action which removes the liquid from the needle and prevents dry out and clogging.
- the blister has a bellows shaped geometry which can elastically expand and compress.
- the term elastically expand and compress includes when the blister is fully compressed the internal stresses are still within the elastic range of the material in use, thus, the blister can return to its natural position when the press mechanism is released.
- the pharmaceutical agent fills at least 80% the internal volume of the blister and more preferably more than 90% of the volume. This prevents movement of liquid which in some cases may cause aggregation of the composition.
- the end of the needle may be positioned in close proximity to the rear face of the vibratable membrane.
- the housing may define a duct communicating between an air inlet and an outlet port.
- the dispensing outlet is located in the duct intermediate the air inlet and the outlet port such that the front face of the membrane is exposed to air within the duct.
- the outlet port may be a mouthpiece for inhalation or an adapter for nasal use.
- Such an arrangement is particularly useful in the administration of inhaled pharmaceutical liquid products where it is required that a fine aerosol of liquid be entrained in an inhaled air flow passing through the mouthpiece.
- a fine aerosol of liquid is an insulin composition.
- FIG. 1 illustrates a partially cut-away view of the single-dose-inhaler 100 and a unit dose blister 201 package for supplying a metered quantity of insulin to the inhaler.
- Inhaler 100 comprises two subassemblies 102 and 112.
- the first subassembly 102 defines a compartment for the electronic circuitry and the batteries
- the second subassembly 112 defines a housing with a dispensing outlet 105 and contains a vibratable membrane aerosol generator 108 and a dispensing mechanism 104.
- Aerosol generator 108 has a front face exposed at the outlet duct 111 and a rear face 109 contacted in use by liquid to be dispensed.
- Aerosol generator 108 is connected to the housing of subassembly 112 and is operable to dispense the active pharmaceutical agent as an aerosol through the mouthpiece 105.
- Exemplary aerosol generators that may be used are also described in U.S. Patent Nos. 5164740; 6629646; 6926208; 7108197; 5938117; 6540153; 6540154;
- the aerosol generators may comprise vibratable membranes having tapered aperture with a size in the range from about 3 ⁇ to about 8 ⁇ , preferably from about 3 ⁇ to about 6 ⁇ , and in some cases around 4 ⁇ .
- the membrane may be domed shaped and be vibrated by an annular piezoelectric element that circumscribes the apertures.
- the diameter of the membrane may be in the range from about 5 mm to about 8 mm.
- the membrane may also have a thickness in the range from about 50 microns to about 70 microns. Typically, the membrane will be vibrated at a frequency in the range from about 50 kHz to about 150 kHz.
- the dispensing system Each time the dispensing system is operated it delivers a metered quantity of the liquid from the unit dose blister 201 to the rear face 109 of the aerosol generator. Hence, for each use a metered quantity of aerosolized pharmaceutical agent is dispensed at the mouthpiece outlet 105 by operation of the aerosol generator.
- the blister 201 contains a predetermined volume of an active pharmaceutical agent to be dispensed.
- the blister 201 contains about 80 to about 120 micro-liters of insulin.
- the lower limit is typically at least about 15 micro-liters and the upper limit is typically about 1,000 micro-liters to about 2,000 micro-liters.
- One particularly useful range is about 80 micro-liters to about 120 micro-liters in a concentration of about 100 insulin units/ml or greater, and more preferably between about 200-800 units/ml, and in some cases as high as 2,500 units/ml.
- Blister 201 is made of thin- walled deformable material. Due to sensitivity of insulin to mechanical agitation, the blister 201 is filled-up to nearly its entire volume.
- Inhaler 100 further includes a dispensing station configured to dispense the content of the blister 201 to the aerosol generator 108.
- the dispensing station includes a swivel arm member 104 and a blister seat 107.
- the blister seat 107 has a concave shape which may radially match the convex shape of the blister 201.
- the blister seat 107 further includes a hypodermic needle 112 which establishes a fluid passage from the blister to the vibrating aerosol generator 108.
- the needle 112 has two sections. The first section 112A extends from the dispensing seat and protrudes outwardly perpendicularly to blister seat 107.
- the second end 112B extends inwardly toward the aerosol generator 108 and is positioned in closed proximity to rear side of the vibrating membrane of aerosol generator 108. Typically, second end 112B will be less than 5mm and more preferably less than 2mm from the vibrating membrane of the aerosol generator 108.
- the hypodermic needle 112 may be made of stainless steel alloy type 316 with a gage size ranging from 22 gage to 26 gage.
- the first section 112A has a sharp slanted piercing tip. In use, blister 201 is placed upon the concave seat 107 and then the swivel arm 104 is rotated counter clockwise in the direction of arrow 115.
- the force upon the swivel arm 104 may be applied by a thumb against the curved portion of the arm 104. This action forces the blister toward the piercing tip of the needle 112A which subsequently pierces the blister 201 and squeezes its content via the needle 112 through the outlet of the needle 112B and onto the aerosol generator 108.
- the swivel arm 104 is fully depressed, the entire dose is delivered to the vibrating membrane of the aerosol generator 108.
- Fig. 2 illustrates the vibrating membrane 109 of the aerosol generator 108 in greater detail.
- an indicator light 120 starts to blink signaling to the patient that the inhaler 100 is ready for use.
- the patient may inhale through the mouthpiece 105.
- Patient inhalation is detected by a flow sensor which in turn activates the aerosol generator 108 to produce aerosol particles into the duct 111.
- Aerosol is entrained in the inhalation air flow in the direction shown by arrows 121 and flow via the respiratory system to the lungs of the patient.
- the "end-of-dose" indicator light 121 lights a second time to signal the patient that the entire dose has been delivered.
- the opening funnel to the aerosol generator is sufficiently large such that the liquid delivery to the aerosol generator is delivered in its entirety.
- the patient may take several inhalations or a single inhalation depending on the volume delivered to the mesh and the patient's breathing capacity. Each inhalation should be a deep breath to assure that the aerosol reaches deeply to the lungs.
- the empty blister may be removed and discarded.
- the thumb pressure on the swivel arm 104 is release the blister expands to its original shape. Expansion creates a vacuum inside the blister 201 which draws back any adhered fluid from the needle back to the blister, thereby leaving the interior of the needle dry to prevent material dry-out and clogging.
- needle 112 may be coated with silver, a silver based coating or the like.
- Fig. 3 illustrates the concave seat 107 of the dispensing station in greater detail.
- Seat 107 is provided with holes 117 which provides access to the interior of the inhaler in the vicinity of the aerosol generator 108. This permits cleaning solvents and rinsing water to be supplied to the aerosol generator 108.
- Fig. 4 provides an alternative delivery system for an inhaler 500 which utilizes a preservative free dispenser 550 and a nozzle 551 to dispense a volume of a preservative free pharmaceutical agent to the aerosol generator via an opening 501.
- Inhaler 500 can be constructed in a manner similar to inhaler 100 and may include a similar aerosol generator.
- Opening 501 has a funnel shape which tapers down to a small opening 502, thus forming a slope 503.
- Dispenser 550 is a uniform drop, preservative free dispenser which upon activation displaces a single drop through the tip of its nozzle 551.
- the drop volume is smaller than about 200 micro-liters.
- a dose is dispensed by squeezing container 550 in a direction perpendicular to its longitudinal axis. Upon each actuation, a single drop of a fixed volume is displaced through the nozzle 551.
- One exemplary dispenser is the Aptar OSD dispenser, developed by Ing. Erich Pfeiffer GmbH.
- a container is constructed of a squeeze bottle that is squeeze to dispense a droplet.
- the nozzle prevents microbiological contaminants from entering into the remaining liquid. This is accomplished through a tip seal that prevents back flow of liquid into the container.
- the tip sealing mechanism includes a spring that keeps the tip seal in place in a normally closed position. When squeezing the bottle, liquid travels passes between the seal and a cap until sufficient pressure is created to overcome the force of the spring. In this way, a single droplet can be dispensed. After dispensing, the tip seal again closes to prevent liquids from moving back into the container. To relieve the accumulating vacuum within the bottle, a small hole is included in the side of the container to allow air into the spring chamber. Droplet size can be controlled based on several factors including top size and the viscosity of the liquid.
- nozzle 551 is aligned with the opening 501 such that the drop is dispensed to the slope 503 and flows through the opening 502 to the aerosol generator.
- the angle of slope 503 is greater than about 30 degrees relative to the axis of the opening 502.
- the diameter of opening 501 is about 10mm to about 15mm and the diameter of opening 502 is at least about 5 mm.
- the pharmaceutical fluid in the preservative free dispenser 550 may be contained in a collapsible sack to prevent excessive agitation and which may damaged by mechanical sloshing.
- proteins, such as insulin may be sensitive to mechanical agitation.
- Use of a collapsible sack may limit undesirable agitation.
- Container 600 comprises a blister 602 manufactured using a blow- fill-seal process.
- Container 600 is similar to the container 201 of Fig. 1 in that when the blister 602 is squeezed a unit dosage amount is delivered.
- Blister 602 comprises a squeezable body 604 having a tab 606 and a twist off top 608.
- Body 604 is sized to hold a unit dosage of liquid, and tab 66 may include various types of identifying information, such as the lot number, date, and the like.
- Twist off top 608 provides a easy way to open blister 602 so that the liquid can be dispensed. Referring also to Fig. 6, use of blister 602 in supplying a unit dose of liquid to inhaler 500 will be described.
- a user takes blister 602 and twists off top 608. Typically, blister 602 will be held upright so that no liquid escapes.
- the opening formed when top 608 is removed may be sized small enough to hinder liquid from escaping.
- Blister 602 is moved over opening 501 and body 604 is squeezed to expel the complete volume of liquid 610 into opening 501 where the liquid drains through opening 503 and to the aerosolizer.
- blister 602 functions as a hand squeezable, single use container for a preservative free solution.
- Use of a blow-fill-seal process is particularly advantageous in that the blister 602 can be manufactured at low cost while still allowing the storage of a preservative free solution.
- the metering process is simple, requiring only the removal of the top and squeezing of the blister. Fig.
- Ampoule 700 for dispensing a unit volume of a liquid to be aerosolized.
- Ampoule 700 comprises an elongate body 702 defining a capillary that hold a unit volume of liquid 704.
- Ampoule 700 further includes a top end 706 and a bottom end 708 that may be removed from body 702, such as by snapping them off.
- Body 702 may be constructed of a generally rigid material that has sufficient rigidity to permit the two ends to be easily snapped off.
- Fig. 8 When ready to dispense the liquid into an inhaler, top end 706 is removed as illustrated in Fig. 8.
- the surface tension in body 702 prevents leakage of any liquid 704 when ampoule 700 is inverted, such as when inserting ampoule 700 into an inhaler.
- Fig. 9 illustrates the ampoule of Fig. 8 after being inserted into an inhaler 720.
- Inhaler 720 may be constructed in a manner similar to the other embodiments described herein an includes electronics 722 that are employed to control operation of an aerosol generator 724 having a vibratable mesh 726.
- Inhaler 720 includes an elongate opening 730 into which ampoule 700 is inserted after end 706 is removed.
- end 708 is snapped off which allows liquid 704 to drain from ampoule 700 and onto the rear face of vibratable mesh 726 as illustrated in Fig. 9.
- mesh 726 vibrates, the liquid is aerosolized and directed toward a mouthpiece 732 where the patient can inhale the medicament.
- ampoule 700 may be removed from inhaler 720 and discarded.
- FIG. 10 illustrates another embodiment of a container 800 for dispensing a unit volume of a liquid into the dispensing apparatus 500 that was previously described in connection with Fig. 4.
- Container 800 comprises a container body 802 defining a reservoir 804 for holding a volume of liquid to be dispensed.
- a plunger 806 is employed to force liquid in reservoir 804 through a dispensing end 808 of container 800.
- Container 800 also includes a geared metering mechanism 812 that is rotated or "dialed” in order to control the extent of movement of plunger 806.
- an actuator 814 is pressed to move the plunger 806 by the amount permitted by metering mechanism 812. In this way, a user can simply "dial a dose" of liquid using metering mechanism 812 and then press actuator 814 in order to dispense a metered amount of liquid into hole 501 where it will be supplied to the aerosolization mechanism.
- Container 800 can be configured to be disposable or reusable.
- reservoir 804 may comprise a cartridge that is inserted into the space defined by reservoir 804.
- Exemplary volume sizes may be about 1, 1.8 or 3 ml cartridges, which may be constructed of glass, LDPE or the like.
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
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CN201180005839.9A CN102740915B (en) | 2010-01-12 | 2011-01-12 | The single dose inhaler system of preservative free |
MX2012008010A MX340395B (en) | 2010-01-12 | 2011-01-12 | Preservative-free single dose inhaler systems. |
EP11733286.6A EP2523716B1 (en) | 2010-01-12 | 2011-01-12 | Preservative-free single dose inhaler systems |
BR112012017177-1A BR112012017177B1 (en) | 2010-01-12 | 2011-01-12 | aerosolization system |
AU2011205443A AU2011205443B2 (en) | 2010-01-12 | 2011-01-12 | Preservative-free single dose inhaler systems |
CA2786128A CA2786128C (en) | 2010-01-12 | 2011-01-12 | Preservative-free single dose inhaler systems |
RU2012134422/14A RU2559171C2 (en) | 2010-01-12 | 2011-01-12 | Inhaler systems with preservative-free single dose |
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US61/335,769 | 2010-01-12 | ||
US13/004,662 US8950394B2 (en) | 2010-01-12 | 2011-01-11 | Preservative-free single dose inhaler systems |
US13/004,662 | 2011-01-11 |
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WO2011088070A1 true WO2011088070A1 (en) | 2011-07-21 |
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PCT/US2011/020926 WO2011088071A1 (en) | 2010-01-12 | 2011-01-12 | Preservative free insulin formulations and systems and methods for aerosolizing |
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EP (2) | EP2523716B1 (en) |
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