WO2011011100A4 - A device and method for delivery of a drug depot near the nerve - Google Patents

A device and method for delivery of a drug depot near the nerve Download PDF

Info

Publication number
WO2011011100A4
WO2011011100A4 PCT/US2010/030699 US2010030699W WO2011011100A4 WO 2011011100 A4 WO2011011100 A4 WO 2011011100A4 US 2010030699 W US2010030699 W US 2010030699W WO 2011011100 A4 WO2011011100 A4 WO 2011011100A4
Authority
WO
WIPO (PCT)
Prior art keywords
nerve
cannula
drug depot
delivering
patient
Prior art date
Application number
PCT/US2010/030699
Other languages
French (fr)
Other versions
WO2011011100A1 (en
Inventor
William F. Mckay
Original Assignee
Warsaw Orthopedic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warsaw Orthopedic, Inc. filed Critical Warsaw Orthopedic, Inc.
Priority to AU2010274947A priority Critical patent/AU2010274947A1/en
Priority to ES10714760.5T priority patent/ES2544881T3/en
Priority to JP2012521632A priority patent/JP2012533402A/en
Priority to CA2767969A priority patent/CA2767969A1/en
Priority to EP10714760.5A priority patent/EP2456514B1/en
Priority to CN2010800336652A priority patent/CN102470243A/en
Priority to BR112012001360A priority patent/BR112012001360A2/en
Publication of WO2011011100A1 publication Critical patent/WO2011011100A1/en
Publication of WO2011011100A4 publication Critical patent/WO2011011100A4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/01—Introducing, guiding, advancing, emplacing or holding catheters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4836—Diagnosis combined with treatment in closed-loop systems or methods
    • A61B5/4839—Diagnosis combined with treatment in closed-loop systems or methods combined with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/4893—Nerves

Abstract

Drug depot delivery devices and methods are provided for delivering one or more drug depots in close proximity to the nerve of a patient with or without repositioning the cannula. The device includes an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot near the nerve.

Claims

AMENDED CLAIMS received by the International Bureau on 16 February 2011 (16.02.11 )
1. A method of delivering a drug depot to a delivery site near a nerve of a patient, the method comprising:
detecting the nerve of the patient; and
positioning near the nerve of the patient a cannula having a proximal end and a distal end, the proximal end of- the cannula having an opening to receive the drug depot, the distal end of the cannula having an opening for passage of the drug depot from the distal end of the cannula to the delivery site near the nerve of the patient; and
delivering the drug depot at the delivery site near the nerve by sliding a plunger having a handle and a tip adapted for dispensing the drug depot, wherein the tip of the plunger is slidably receivable within the cannula to deliver the drug depot out the opening of the cannula to the delivery site near the nerve of the patient.
2. A method of delivering a drug depot according to claim 1, wherein the alarm is audible or visible or audible and visible.
3. A method of delivering a drug depot according to claim 1, wherein the detecting the nerve of the patient and delivery of the drug depot is performed by the same cannula.
4. A method of delivering a drug depot according to claim 1, wherein the nerve comprises the sciatic nerve.
5. A method of delivering a drug depot according to claim 1, wherein the distal end of the cannula comprises a blunt tip.
6. A method of delivering a drug depot according to claim 1, wherein the drug depot is delivered within 1 cm of the nerve site.
7. A method of delivering a drug depot to a delivery site near a nerve of a patient, the method comprising:
positioning a first cannula having a nerve sensing unit comprising an electrical contact and an alarm coupled to the nerve sensing unit, wherein when the cannula contacts the nerve or is in close proximity to the nerve, the alarm is activated to indicate a location of the nerve;
positioning near the nerve of the patient a second cannula having a proximal end and a distal end, the proximal end of the second cannula having an opening to receive the drug depot, the distal end of the second cannula having an opening for passage of the drug depot from the distal end of the second cannula to the delivery site near the nerve of the patient; and
delivering the drug depot at the delivery site near the nerve by sliding a plunger having a handle and a tip adapted for dispensing the drug depot, wherein the tip of the plunger is slidably receivable within the second cannula to deliver the drug depot out the opening of the second cannula to the delivery site near the nerve of the patient
8. A method of delivering a drug depot according to claim 7, wherein the first and second cannulas each comprise a blunt tip.
9. A device for delivering a drug depot at or near a nerve site beneath the skin of a patient, the device comprising: a cannula having a proximal end and a distal end, the proximal end of the cannula having an opening to receive the drug depot, the distal end of the cannula capable of insertion at or near the nerve site beneath the skin of the patient and having an opening for passage of the drug depot; a plunger being slidably receivable within the opening of the proximal end of the cannula, the plunger having a first end and a tip at a second end, the first end being capable of moving the tip of the plunger to an extended position; a nerve sensing unit disposed on or within the device, the nerve sensing unit comprising an electrical contact material configured to receive electrical impulses from the nerve site so as to detect the nerve.
10. A device for delivering a drug depot according to claim 9, wherein the electrical contact material is disposed at or in a tip of the distal end of the cannula.
11. A device for delivering a drug depot according to claim 9, wherein the nerve site comprises the sciatic nerve.
12. A device for delivering a drug depot, according to claim 9, wherein the nerve site comprises at least one muscle, ligament, tendon, cartilage, synovial joint, spinal disc, spinal foraminal space, near the spinal nerve root, facet joint or spinal canal.
13. A device for delivering a drug depot to a delivery site near a nerve of a patient, the device comprising:
a first cannula having a nerve sensing unit comprising an electrical contact and an alarm coupled to the nerve sensing unit, wherein when the cannula contacts the nerve or is in close proximity to the nerve, the alarm is activated to indicate a location of the nerve; a second cannula having a proximal end and a distal end, the proximal end of the second cannula having an opening to receive the drug depot, the distal end of the second cannula having an opening for passage of the drug depot from the distal end of the second cannula to the delivery site near the nerve of the patient; and
a plunger having a handle and a tip adapted for dispensing the drug depot, wherein the tip of the plunger is slidably receivable within the second cannula to deliver the drug depot out the opening of the second cannula to the delivery site near the nerve of the patient.
14. A device for delivering a drug depot according to claim 13, wherein the electrical contact material is disposed at or in a tip of a distal end of the first cannula and the second cannula is positioned near the first cannula after the nerve is located to deliver the drug depot near the nerve of the patient.
15. A device for delivering a drug depot according to claim 13, wherein the alarm is audible or visible or audible and visible.
PCT/US2010/030699 2009-07-22 2010-04-12 A device and method for delivery of a drug depot near the nerve WO2011011100A1 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2010274947A AU2010274947A1 (en) 2009-07-22 2010-04-12 A device and method for delivery of a drug depot near the nerve
ES10714760.5T ES2544881T3 (en) 2009-07-22 2010-04-12 A device and method to deliver a drug depot near the nerve
JP2012521632A JP2012533402A (en) 2009-07-22 2010-04-12 Device and method for delivering a depot drug near a nerve
CA2767969A CA2767969A1 (en) 2009-07-22 2010-04-12 A device and method for delivery of a drug depot near the nerve
EP10714760.5A EP2456514B1 (en) 2009-07-22 2010-04-12 A device and method for delivery of a drug depot near the nerve
CN2010800336652A CN102470243A (en) 2009-07-22 2010-04-12 A device and method for delivery of a drug depot near the nerve
BR112012001360A BR112012001360A2 (en) 2009-07-22 2010-04-12 method and device for dispensing a drug deposit

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/507,197 2009-07-22
US12/507,197 US8715223B2 (en) 2009-07-22 2009-07-22 Device and method for delivery of a drug depot near the nerve

Publications (2)

Publication Number Publication Date
WO2011011100A1 WO2011011100A1 (en) 2011-01-27
WO2011011100A4 true WO2011011100A4 (en) 2011-04-14

Family

ID=43037623

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/030699 WO2011011100A1 (en) 2009-07-22 2010-04-12 A device and method for delivery of a drug depot near the nerve

Country Status (10)

Country Link
US (1) US8715223B2 (en)
EP (1) EP2456514B1 (en)
JP (1) JP2012533402A (en)
KR (1) KR20120053005A (en)
CN (1) CN102470243A (en)
AU (1) AU2010274947A1 (en)
BR (1) BR112012001360A2 (en)
CA (1) CA2767969A1 (en)
ES (1) ES2544881T3 (en)
WO (1) WO2011011100A1 (en)

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Also Published As

Publication number Publication date
EP2456514A1 (en) 2012-05-30
CN102470243A (en) 2012-05-23
ES2544881T3 (en) 2015-09-04
EP2456514B1 (en) 2015-07-22
US20110022028A1 (en) 2011-01-27
CA2767969A1 (en) 2011-01-27
KR20120053005A (en) 2012-05-24
WO2011011100A1 (en) 2011-01-27
BR112012001360A2 (en) 2016-04-05
JP2012533402A (en) 2012-12-27
AU2010274947A1 (en) 2012-02-09
US8715223B2 (en) 2014-05-06

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