WO2010121413A1

WO2010121413A1 - Non-invasive blood glucose detection and monitoring device using impulse response and method therefor

Info

Publication number: WO2010121413A1
Application number: PCT/CN2009/071374
Authority: WO
Inventors: 董涛; 郭敏强; 周忠发; 薛萍; 李同; 罗笑南
Original assignee: 中山大学
Priority date: 2009-04-21
Filing date: 2009-04-21
Publication date: 2010-10-28

Abstract

Disclosed is a non-invasive blood glucose detection and monitoring device using impulse response and a method therefor. The device includes an impulse apparatus unit, a processor unit and a sensor unit. The impulse apparatus unit and sensor unit are both connected with the processor unit. The impulse apparatus unit forms, according to preset impulse conditions, a non-invasive impulse that alters the blood glucose reaction at the sampling location. The sensor unit samples the characteristic values of the blood glucose reaction at the sampling location. The processor unit obtains the blood glucose value according to said characteristic values. The impulse apparatus unit includes an isolating module to seal off the sampling location and to form a sealed space around said sampling location, and an oxygen-adjustment module to adjust the concentration of oxygen in said sealed space. The blood glucose detection and monitoring device does not incur a wound at the sampling location, and the blood glucose value can be obtained through sampling the characteristic value after the impulse reaction, in a non-invasive, simple and rapid procedure.

Description

Description Apparatus and method for non-invasive blood glucose detection and monitoring using impulse response [1] Technical Field

[2] The present invention relates to a non-invasive blood glucose detecting and monitoring device and method for blood glucose detecting and monitoring.

[3] Background Art

[4] The number of people with diabetes in China has ranked second in the world, 2007

The survey of epidemics in China shows that the prevalence of diabetes is as high as 10.4%.

Diabetes is also the third disease that causes death in the country. Blood glucose testing is the key to the diagnosis and treatment of diabetes. Blood sugar refers to the concentration of glucose in the blood. Blood glucose can be measured using venous blood and capillary blood. The venous blood plasma glucose concentration test is mainly used for the diagnosis of diabetes. Capsules for measuring blood vessels Whole blood glucose can be used for blood glucose monitoring in emergency patients and self-monitoring of blood glucose in diabetic patients. It is not suitable for diagnosis. At this stage, the glucose assays carried out in clinical laboratories in China are mainly glucose oxidase (GOD) method and glucose hexokinase (HK).

Method and oxygen electrode rate method. However, the current blood glucose testing technology applied to the clinic has always stayed on the invasive method, and the patient suffers from double traumatic pains of insulin injection and blood glucose testing.

[5] Summary of the invention

[6] The technical problem to be solved by the present invention is to overcome the deficiencies of the prior art, and to provide a blood glucose detecting and monitoring device and method capable of realizing blood glucose non-invasive detection monitoring and simple and rapid detection and monitoring.

[7] The technical solution adopted by the present invention to solve the technical problems thereof is:

A device for monitoring non-invasive blood glucose detection by using an impulse response, comprising an impulse device unit, a processor unit and a sensor unit, wherein the impulse device unit and the sensor unit are connected to the processor unit, and the impulse device unit is configured according to a preset impulse The stimulating condition forms a non-invasive impulse to change the blood glucose reaction in the sputum-like part, and the sensor unit collects the characteristic value of the blood glucose reaction in the sputum-like part, and the processor unit deserves the blood sugar level according to the characteristic.

[8] The impulse device unit includes a sealed module for sealing a sample site and forming a sealed space with the sample site, and an oxygen regulating module for adjusting the oxygen concentration in the sealed space. The impulse device unit also includes a pressure regulating module for regulating air pressure in the enclosed space.

[9] The impulse device unit includes a reagent addition module for applying a blood glucose sensitive reagent to the sample site. Place The impulse device unit includes a chromogenic substance adding module for applying a chromogenic substance capable of reacting with blood sugar to develop color in the sample site. The sensor unit is selected from the group consisting of: a carbon dioxide sensor, a humidity sensor, a hydrogen ion sensor, an oxygen sensor, a blood oxygen sensor, an image sensor, a temperature sensor, an electric field sensor, and a magnetic field sensor. The processor unit is also connected to the display unit. The processor unit is also connected to a communication interface unit that is connected to an external signal. The processor unit is further connected with an impulse condition setting unit for setting an impulse condition, and the processor unit controls the operation of the impulse device unit according to the impulse condition. The blood sugar is glucose in the blood.

[10] A device for monitoring non-invasive blood glucose detection using an impulse response, comprising an impulse condition setting unit, an impulse device unit, a sensor unit and a processor unit, an impulse condition setting unit, an impulse device unit, and a sensor The unit is connected to the processor unit, the impulse condition setting unit is used to set the impulse condition, and the processor unit controls the operation of the impulse device unit according to the impulse condition, and the impulse device unit is in accordance with the set impulse condition. The site forms a non-invasive impulse that changes the state of the blood glucose reaction, and the sensor unit collects the characteristic value of the blood glucose reaction after the non-invasive impulse of the sample site, and the processor unit presets a database of the correspondence between the characteristic value and the blood glucose level, the processor unit According to this feature, the blood sugar level is worth.

[11] A method for achieving non-invasive blood glucose detection monitoring using an impulse response, comprising the following steps: a)

Accept the impulse condition of the input; b)

According to the impulse condition, a non-invasive impulse is applied to the sputum-like part to change the blood glucose reaction state of the sputum-like part; c) The eigenvalue of the sputum-like part after the non-invasive impulse is collected, and the blood sugar value is obtained according to the characteristic value. The change in the state of blood glucose reaction changes, such as the color of the sample site, the concentration of carbon dioxide, the concentration of oxygen, the humidity, and the ion concentration.

[12] The beneficial effect of the invention is that the blood sugar detecting and monitoring device does not form a wound in the sample site, and the blood sugar value can be obtained by collecting the characteristic value after the impulse reaction, thereby realizing non-invasive, simple and rapid detection of blood sugar. monitor.

[13] BRIEF DESCRIPTION OF THE DRAWINGS

[14] FIG. 1 is a block diagram showing the structure of a non-invasive blood glucose detecting and monitoring device according to the present embodiment;

[15] FIG. 2 is a block diagram showing the workflow of the non-invasive blood glucose detecting and monitoring method of the present embodiment.

[16] Detailed implementation

[17] Figure 1 and Figure 2 As shown, the non-invasive blood glucose detecting and monitoring device of the present embodiment includes a processor unit, an impulse condition setting unit, an impulse device unit, a sensor unit, a display unit, and a communication interface unit, an impulse condition setting unit, an impulse device unit, The sensor unit, the display unit, and the communication interface unit are all signaled to the processor unit. The processor unit is configured to control the operation of the impulse device unit according to the impulse condition set by the impulse condition setting unit, analyze and process the signal fed back by the sensor unit, and control the display unit to perform display. The impulse condition setting unit is used for the detection monitoring device operator to perform the impulse condition setting. The impulse device unit is configured to form a non-invasive impulse capable of changing a blood glucose reaction state in the sample site according to a preset impulse condition, and the sample site may be a sample site in the existing invasive blood glucose test. The impulse equipment unit can perform the impulse action such as sealing, pressure regulation or negative pressure on the sample part, and can also supply various test reagents and raw materials such as oxygen, glucose oxidase and the like. The impulses that can be accomplished by the impulse equipment unit are: a) the same type of closed sputum and the oxygenation of the sputum-like part; b)

Simultaneously sealing the sample site and regulating the pressure and oxygen on the sample site; c)

Apply the blood glucose sensitive reagent to the sealed sample and the sample site; d)

Producing blood sugar-consuming movements in the sputum-like area, such as a dynamometer; e)

Simultaneously close the sample site and warm or cool the sample site, such as through a specific band of signals, waveform generation module to heat the sample site, such as the existing microwave generation module capable of microwave heating, of course, the signal, waveform The generation module can also be other signal and waveform generation modules that can promote blood glucose response activity. The sensor unit is used to collect the physical, chemical, and biological signals of the sample site, that is, to obtain the characteristic value of the blood glucose reaction of the sample site, and feed back the feature value to the processor unit. The sensor unit is selected from the group consisting of: a temperature sensor, a carbon dioxide sensor, a humidity sensor, a hydrogen ion sensor, a blood oxygen sensor, an oxygen sensor, and an image sensor. The display unit is used for displaying the signal of the processor unit to realize visual display of blood sugar detection monitoring, such as existing LCD, LED, CRT

, touch screen, etc. The communication interface unit is used for realizing signal connection between the blood glucose detecting and monitoring device and the outside world, such as an existing wireless, wired network, and communication interface.

[18] Now with "Sealing +

The impulse condition of oxygen regulation is taken as an example to illustrate the detection and monitoring process of the non-invasive blood glucose detecting and monitoring device. The impulse device unit includes a sealing module for separating the sample site from the ambient atmosphere, the sealing module and the sample site (skin) Forming a confined space therebetween, the impulse device unit further includes an oxygen regulating module for adjusting the oxygen concentration in the confined space, wherein the oxygen concentration in the confined space reaches a set oxygen concentration, and the set oxygen concentration can be Above or below the oxygen content of the ambient atmosphere. Since blood glucose is sensitive to oxygen concentration, by forming a confined space in the sample site and adjusting the oxygen concentration in the confined space, oxygen is dialyzed into the blood through the respiratory function of the skin and reacts with the blood glucose, and the sensor unit collects the characteristic value obtained by the blood glucose reaction. The processor unit processes the feature value and derives a blood glucose value.

[19] Because carbon dioxide and water react to produce carbon dioxide and water, the carbon dioxide and water produced by the reaction change the carbon dioxide content and humidity in the confined space. The carbon dioxide content can be collected by the carbon dioxide sensor and fed back to the processor unit. The unit analyzes the value to obtain a blood glucose value. Similarly, the humidity value in the confined space can also be collected by the humidity sensor, and the processor unit can obtain the blood glucose value according to the humidity value.

[20] Since the blood sugar and oxygen react to generate hydrogen ions, the concentration of hydrogen ions in the confined space changes, causing the electric field and magnetic field to change. The hydrogen ion sensor can collect the hydrogen ion content and feed it back to the processor unit. The unit analyzes the value to obtain a blood glucose value. Of course, the electric field and magnetic field sensors can also be used to collect the electric field and magnetic field values and feed back to the processor unit.

[21] Due to the reaction of blood sugar and oxygen, the blood oxygen content in the blood also changes. The blood oxygen level can be collected by the blood oxygen sensor, and the blood glucose value is analyzed by the processor unit.

[22] Due to the reaction of blood sugar and oxygen, the concentration of residual oxygen and carbon dioxide in the confined space will also change. The concentration of residual oxygen and carbon dioxide can be collected by the oxygen sensor and the carbon dioxide sensor. The processor unit also according to the residual concentration value. The blood sugar value can be obtained.

[23] Due to the reaction of blood sugar and oxygen, the color of the skin in the sputum is changed. The image is collected by the image sensor, and the processor unit determines the blood glucose level based on the color change. In the case where the blood glucose value is obtained by using the color change, the impulse device unit may include a chromogenic substance adding module that reacts with the blood sugar to generate a specific color, thereby improving the accuracy of the blood sugar detecting, such as the coloring matter. Copper sulfate, thioacetamide, and the like.

[24] Figure 2

As shown in the embodiment, the operator sets the impulse condition by the impulse condition setting unit, and the impulse device unit is initialized according to the impulse condition (eg, pressure regulation, oxygen regulation, sealing of the sample site, etc.) When the impulse condition of the sample site reaches the set condition, the sensor unit works to collect the characteristic value of the blood glucose reaction, and feeds the feature value to the processor unit, and the processor unit analyzes the feature value to obtain Blood sugar level. In order to improve the accuracy of detection and monitoring, repeated detection of the sample site can be performed.

[25] For the non-invasive blood glucose detection and monitoring device, the impulse device unit includes a sealing module and an oxygen regulating module to achieve sealing and oxygen adjustment of the sample site, and after oxygen adjustment, the oxygen concentration in the sealed space reaches the set oxygen concentration; The excitation device unit may also include a sealing module, an oxygen regulating module and a pressure regulating module to realize sealing, oxygen regulating and pressure regulating of the sample part, and after the pressure regulation, the air pressure in the sealed space reaches the set air pressure. The impulse device unit may include a sealing module and a blood glucose sensitive reagent adding module, and the sealing portion is sealed by the sealing module, and the blood glucose sensitive reagent is added by the reagent adding module, thereby promoting the blood sugar reaction, such as glucose oxidase. The impulse device unit may include a signal and waveform generation module through which the temperature of the sample site or the activity of the blood glucose molecule is adjusted, such as a microwave module capable of generating microwaves. Various impulse device units can be used alone or in combination. Various sensor units can be used individually or in combination, just like a carbon dioxide sensor and a humidity sensor. For the processor unit, a correspondence relationship or a corresponding curve between the feature value and the blood glucose level may be pre-stored, and after the feature value collected by the sensor unit is fed back to the processor unit, the processor unit may obtain a blood glucose value; The unit can also be analyzed in other ways to derive blood glucose values.

[26] After performing non-invasive blood glucose monitoring and monitoring, dynamic and static methods can be used to judge blood glucose levels, such as collecting various characteristic values (such as carbon dioxide content, humidity, blood oxygen, etc.) through the sensor unit before exercise. After the exercise, the characteristic values are also collected by the sensor unit, and the blood glucose value is obtained by comparing the changes of the characteristic values. Of course, it is also possible to compare the oxygen absorption before the oxygen absorption, that is, before the oxygen absorption and after the oxygen absorption, and obtain the blood sugar value by comparing the characteristic values. It is also possible to separately collect the characteristic values of the unexcited condition and the impulse condition, and obtain the blood glucose value by comparing the change of the characteristic value, such as adding an impulse condition to the left finger, the toe, the earlobe, etc., and the right hand. The finger, the toe, the earlobe, etc. are not added with an impulse condition; or two impulse values are obtained by extracting the impulse and the impulse without extracting the two characteristic values, and the corresponding blood glucose value is obtained by comparing the characteristics. For non-invasive blood glucose monitoring devices, blood glucose can be glucose or other sugars in the blood.

[27] The above is a further detailed description of the present invention in connection with a specific preferred embodiment, and cannot be recognized. The specific implementation of the invention is limited only to these descriptions. It will be apparent to those skilled in the art that the present invention may be made without departing from the spirit and scope of the invention.

Claims

Claim

1.

The device for implementing non-invasive blood glucose detection and monitoring by using an impulse response, comprising: an impulse device unit, a processor unit and a sensor unit, wherein the impulse device unit and the sensor unit are connected to the processor unit, and the impulse device unit is The preset impulse condition forms a non-invasive impulse to change the blood glucose reaction in the sample site, and the sensor unit collects the characteristic value of the blood glucose reaction in the sample site, and the processor unit derives the blood glucose value according to the feature.

2. According to claim 1

The device for realizing non-invasive blood glucose detection and monitoring by using an impulse response, wherein: the impulse device unit includes a sealing module for sealing a sample-like portion and forming a sealed space with the sample-like portion, and for adjusting the sealing Oxygen adjustment module for oxygen concentration in space.

3. According to claim 2

The device for realizing non-invasive blood glucose detection and monitoring by using an impulse response is characterized in that: the impulse device unit further comprises a voltage regulating module for adjusting the air pressure in the sealed space.

4. According to claim 1

The device for monitoring non-invasive blood glucose detection using an impulse response, characterized in that: the impulse device unit comprises a reagent adding module for applying a blood glucose sensitive reagent to the sample site.

5. According to claim 1

The device for monitoring non-invasive blood glucose detection using an impulse response is characterized in that: the impulse device unit includes a coloring matter adding module for applying a coloring substance capable of reacting with blood sugar to develop color in the sample site.

6. According to claim 1

The device for monitoring non-invasive blood glucose detection by using an impulse response is characterized in that: the sensor unit is selected from the group consisting of: a carbon dioxide sensor, a humidity sensor, a hydrogen ion sensor, an oxygen sensor, a blood oxygen sensor, an image sensor, a temperature sensor, and an electric field. Sensor, magnetic field sensor.

7. According to claim 1

The device for implementing non-invasive blood glucose detection and monitoring by using an impulse response, wherein: the processor unit is further connected with an impulse condition setting unit for setting an impulse condition, and the processor is The element controls the operation of the impulse device unit according to the impulse condition.

8. According to claim 7

The device for implementing non-invasive blood glucose detection and monitoring by using an impulse response is characterized in that: the processor unit is further connected with a display unit.

9. According to claim 8

The device for monitoring non-invasive blood glucose detection by using an impulse response is characterized in that: the processor unit is further connected with a communication interface unit connected to an external signal.

10. According to claim 1

The device for monitoring non-invasive blood glucose detection using an impulse response is characterized in that: the blood sugar is glucose in blood.

11.

The utility model relates to a device for realizing non-invasive blood glucose detection and monitoring by using an impulse response, comprising: an impulse condition setting unit, an impulse device unit, a sensor unit and a processor unit, an impulse condition setting unit, an impulse device unit and The sensor unit is connected to the processor unit, the impulse condition setting unit is used to set the impulse condition, and the processor unit controls the operation of the impulse device unit according to the impulse condition, and the impulse device unit is in accordance with the set impulse condition. The sample site forms a non-invasive impulse that changes the state of the blood glucose reaction, and the sensor unit collects the characteristic value of the blood glucose reaction after the non-invasive injection of the sample site, and the processor unit presets a database of the correspondence between the characteristic value and the blood glucose level, the processor The unit derives a blood glucose value based on this characteristic.

12. According to claim 11

13. According to claim 12

14. According to claim 13

The device for realizing non-invasive blood glucose detection and monitoring by using an impulse response, wherein: The processor unit is also connected to the display unit and the communication interface unit connected to the external signal.

15. According to claim 11

16.

A method for realizing non-invasive blood glucose detection and monitoring by using an impulse response, comprising: the following steps:

a) receiving an impulse condition of the input;

b) Applying a non-invasive impulse to change the blood glucose response state of the sputum-like site according to the impulse condition; c) cultivating the characteristic value of the sputum-like site after non-invasive pulsation, and obtaining the blood glucose value according to the eigenvalue.

17. According to claim 16

The method for achieving non-invasive blood glucose detection monitoring using an impulse response is characterized in that: the blood sugar is glucose in blood.

18. According to claim 16

The method for achieving non-invasive blood glucose detection monitoring using an impulse response is characterized in that: the characteristic value is a physical, chemical or biological signal of a sample site.