WO2010120769A3 - Method and apparatus for multimodal imaging of biological tissue - Google Patents

Method and apparatus for multimodal imaging of biological tissue Download PDF

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Publication number
WO2010120769A3
WO2010120769A3 PCT/US2010/030880 US2010030880W WO2010120769A3 WO 2010120769 A3 WO2010120769 A3 WO 2010120769A3 US 2010030880 W US2010030880 W US 2010030880W WO 2010120769 A3 WO2010120769 A3 WO 2010120769A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue
wavelength
properties
region
biological tissue
Prior art date
Application number
PCT/US2010/030880
Other languages
French (fr)
Other versions
WO2010120769A2 (en
Inventor
Anna N. Yaroslavsky
Elena Salomatina
Richard Rox Anderson
Original Assignee
The General Hospital Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The General Hospital Corporation filed Critical The General Hospital Corporation
Priority to US13/203,121 priority Critical patent/US20120029348A1/en
Priority to JP2012506126A priority patent/JP2012524276A/en
Priority to EP10765012A priority patent/EP2419712A4/en
Publication of WO2010120769A2 publication Critical patent/WO2010120769A2/en
Publication of WO2010120769A3 publication Critical patent/WO2010120769A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation

Abstract

The present invention is directed to a novel multi- wavelength imaging method and apparatus that enables rapid imaging of tissue regions with accurate identification of tissue types within the region. Optical properties, such as co- polarized or cross-polarized fluorescence or reflectance intensity, optical density and/or reflectance, can be determined at a plurality of locations within the tissue region for each wavelength. Said properties at the two wavelengths, including calculated derivatives of the optical property with respect to wavelength, can be analyzed to image tissue structures and identify tissue types within the tissue region more accurately than can be achieved based on properties measured at a single wavelength.
PCT/US2010/030880 2009-04-14 2010-04-13 Method and apparatus for multimodal imaging of biological tissue WO2010120769A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US13/203,121 US20120029348A1 (en) 2009-04-14 2010-04-13 Method and apparatus for multimodal imaging of biological tissue
JP2012506126A JP2012524276A (en) 2009-04-14 2010-04-13 Method and apparatus for multimodal imaging of biological tissue
EP10765012A EP2419712A4 (en) 2009-04-14 2010-04-13 Method and apparatus for multimodal imaging of biological tissue

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16925809P 2009-04-14 2009-04-14
US61/169,258 2009-04-14

Publications (2)

Publication Number Publication Date
WO2010120769A2 WO2010120769A2 (en) 2010-10-21
WO2010120769A3 true WO2010120769A3 (en) 2011-01-20

Family

ID=42983101

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/030880 WO2010120769A2 (en) 2009-04-14 2010-04-13 Method and apparatus for multimodal imaging of biological tissue

Country Status (4)

Country Link
US (1) US20120029348A1 (en)
EP (1) EP2419712A4 (en)
JP (1) JP2012524276A (en)
WO (1) WO2010120769A2 (en)

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ES2715633T3 (en) 2008-05-20 2019-06-05 Univ Health Network Device and method for imaging and fluorescence monitoring
DE102010021534A1 (en) * 2010-05-19 2011-11-24 Eberhard-Karls-Universität Tübingen Universitätsklinikum Direct investigation of biological material ex vivo
US10945656B2 (en) * 2013-04-05 2021-03-16 The University Of Massachusetts Device and method for imaging collagen structure in vivo
EP3108447B1 (en) * 2014-02-17 2020-03-25 Children's National Medical Center Method and system for providing recommendation for optimal execution of surgical procedures
EP3957232A1 (en) 2014-07-24 2022-02-23 University Health Network Collection and analysis of data for diagnostic purposes
WO2017009450A1 (en) * 2015-07-16 2017-01-19 Koninklijke Philips N.V. Digital pathology system
WO2018008136A1 (en) * 2016-07-07 2018-01-11 オリンパス株式会社 Image processing device and operation method for image processing device
CN107014493B (en) * 2017-04-19 2018-09-07 哈尔滨工业大学 A kind of direct measuring device and method of photon polarization state density matrix
CN110346291A (en) * 2018-04-03 2019-10-18 锐准医光股份有限公司 A kind of image synthesis method of biological sample and optical system using this method

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US20080024860A1 (en) * 2006-06-30 2008-01-31 The General Hospital Corporation Device and method for wide-field and high resolution imaging of tissue

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Also Published As

Publication number Publication date
WO2010120769A2 (en) 2010-10-21
US20120029348A1 (en) 2012-02-02
JP2012524276A (en) 2012-10-11
EP2419712A2 (en) 2012-02-22
EP2419712A4 (en) 2012-12-19

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