WO2010110602A3 - Method for regenerating dopaminergic neurons in the substantia nigra pars compacta using human adult stem cells or precursor cells - Google Patents

Method for regenerating dopaminergic neurons in the substantia nigra pars compacta using human adult stem cells or precursor cells Download PDF

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Publication number
WO2010110602A3
WO2010110602A3 PCT/KR2010/001820 KR2010001820W WO2010110602A3 WO 2010110602 A3 WO2010110602 A3 WO 2010110602A3 KR 2010001820 W KR2010001820 W KR 2010001820W WO 2010110602 A3 WO2010110602 A3 WO 2010110602A3
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WO
WIPO (PCT)
Prior art keywords
adult stem
human adult
stem cells
dopaminergic neurons
substantia nigra
Prior art date
Application number
PCT/KR2010/001820
Other languages
French (fr)
Korean (ko)
Other versions
WO2010110602A2 (en
Inventor
임진호
이영재
맹성호
고성은
Original Assignee
(주)마리아 바이오텍
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by (주)마리아 바이오텍 filed Critical (주)마리아 바이오텍
Publication of WO2010110602A2 publication Critical patent/WO2010110602A2/en
Publication of WO2010110602A3 publication Critical patent/WO2010110602A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor

Abstract

The present invention relates to a method for regenerating or restoring dopaminergic neurons from human adult stem cells or neural precursor cells obtained by the ex vivo culturing of the human adult stem cells. More particularly, the present invention relates to a method for regenerating or restoring dopaminergic neurons in the substantia nigra pars compacta using human adult stem cells or neural precursor cells differentiated therefrom. The method of the present invention can serve as an efficient source for cell replacement therapy for neurological diseases such as Parkinson's disease.
PCT/KR2010/001820 2009-03-24 2010-03-24 Method for regenerating dopaminergic neurons in the substantia nigra pars compacta using human adult stem cells or precursor cells WO2010110602A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2009-0024759 2009-03-24
KR1020090024759A KR101229536B1 (en) 2009-03-24 2009-03-24 A method for Regenerating Dopaminergic neurons in Substantia nigra pars compacta using adult stem cells or progenitor cells

Publications (2)

Publication Number Publication Date
WO2010110602A2 WO2010110602A2 (en) 2010-09-30
WO2010110602A3 true WO2010110602A3 (en) 2011-02-24

Family

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Family Applications (1)

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PCT/KR2010/001820 WO2010110602A2 (en) 2009-03-24 2010-03-24 Method for regenerating dopaminergic neurons in the substantia nigra pars compacta using human adult stem cells or precursor cells

Country Status (2)

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KR (1) KR101229536B1 (en)
WO (1) WO2010110602A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116179489A (en) * 2021-03-26 2023-05-30 广西大学 Method for efficiently inducing human cells to reprogram into neuron cells in vitro

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060233766A1 (en) * 2004-12-23 2006-10-19 Messina Darin J Treatment of Parkinson's disease and related disorders using postpartum derived cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060233766A1 (en) * 2004-12-23 2006-10-19 Messina Darin J Treatment of Parkinson's disease and related disorders using postpartum derived cells

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BURNSTEIN, R.M. ET AL.: "Differentiation and migration of long term expanded human neural progenitors in a partial lesion model of parkinson's disease", THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, vol. 36, 2004, pages 702 - 713 *
PARISH, C.L. ET AL.: "Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in parkinsonian mice", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 118, no. 1, January 2008 (2008-01-01), pages 149 - 160 *
SVENDSEN, C.N. ET AL.: "Long-term survival of human central nervous system progenitor cells transplanted into a rat model of Parkinson's disease", EXPERIMENTAL NEUROLOGY, vol. 148, 1997, pages 135 - 146, XP001180971, DOI: doi:10.1006/exnr.1997.6634 *

Also Published As

Publication number Publication date
WO2010110602A2 (en) 2010-09-30
KR20100106681A (en) 2010-10-04
KR101229536B1 (en) 2013-02-04

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