WO2010097694A1 - A heart valve - Google Patents
A heart valve Download PDFInfo
- Publication number
- WO2010097694A1 WO2010097694A1 PCT/IB2010/000398 IB2010000398W WO2010097694A1 WO 2010097694 A1 WO2010097694 A1 WO 2010097694A1 IB 2010000398 W IB2010000398 W IB 2010000398W WO 2010097694 A1 WO2010097694 A1 WO 2010097694A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stent
- heart valve
- valve
- sleeve
- struts
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0482—Needle or suture guides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/0483—Hand-held instruments for holding sutures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2415—Manufacturing methods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
Definitions
- This invention relates to an artificial heart replacement valve.
- Heart valves It is known to replace heart valves with artificial valves.
- One form of heart valve includes a valve located within a collapsible mesh tube or stent.
- the stent is supplied in a collapsed condition and typically inserted into the body through a vein or artery. Once in position it is expanded using an inflatable balloon.
- the valve is secured in position by the friction between the native tissue and the stent. After a few weeks the valve becomes more firmly secured through tissue in-growth. Prior to tissue in-growth initial valve migration is however a concern with these type of valves.
- Heart valves are generally secured within the heart valve annulus within the native valve. In so doing they maintain the native valve open and obviate the need to remove it.
- One of the problems typically experienced with such heart valves is that there is limited space for the introduction of the valve in a collapsed or crimped state prior to being expanded by the balloon.
- valve member usually is made up of three flexible leaflets (or cusps as they are sometimes referred to for certain applications but herein referred to as leaflets irrespective of the application) joined along their sides to form a triangular shape.
- leaflets or cusps as they are sometimes referred to for certain applications but herein referred to as leaflets irrespective of the application.
- the construction of these leaflets is not always optimal and the materials used to date do not exhibit characteristics required for extended use, such as wear resistance and resistance to calcification.
- a heart valve which includes a valve member secured within a stent with the valve member including a plurality of valve leaflets secured together, the heart valve being characterised in that the leaflets are made of biological material having a maximum thickness of 0.3 mm.
- the biological material to have a maximum thickness of 0.25 mm; for each leaflet to have an arcuate, preferably generally parabolically shaped side for attachment to the stent; for the stent, in its crimped condition, to have a maximum diameter of 7.5 mm and preferably about 7 mm; for the biological material to be suitably treated kangaroo tissue; and for the kangaroo tissue to be a tissue treated using the ADAPTTM technology of Celxcel Pty Limited (BbMD Limited) of Perth,
- the invention also provides for a sleeve made of a porous, biocompatible material to extend about the outer surface of the stent at least partially along its length.
- the material of the sleeve is preferably selected from porous polyester and expanded polytetraflouroethylene (PTFE) 1 preferably ultrathin porous polyester.
- PTFE polytetraflouroethylene
- the sleeve may extend the length of the stent and the sleeve typically has a thickness of 0.1 mm to 0.5mm, preferably 0.2mm.
- the sleeve may be secured to the stent by stitching typically extending along each end thereof.
- the invention also provides a heart valve which includes a valve member secured within an expandable stent having two ends and a central region with the valve member including a plurality of valve leaflets secured together, the heart valve being characterised in that the stent is configured to initially expand at both ends.
- the stent to be in the form of a mesh defined by interconnected struts; for the material of the stent to be strengthened in the central region thereof especially by making the struts in that region stronger than the struts in the end regions, typically by making the struts somewhat larger in cross-section; and for the stent to be made of cobalt-chrome (MP25N).
- MP25N cobalt-chrome
- the invention further provides a tool for use in stitching a valve member to a stent comprising a pair of elongate jaws each having a slot extending partway along its length.
- Figure 1 is a perspective view of a heart valve
- Figure 2 is a side elevation of the heart valve in Figure 1 ;
- Figure 3 is a perspective view of a stent used in the heart valve of Figure 1 ;
- Figure 4 is a perspective view of a valve member used in the heart valve illustrated in Figure 1 ;
- Figure 5 is a side elevation of a valve leaflet for the valve member illustrated in Figure 4.
- Figure 6 is a side elevation of a second embodiment of a stent for a heart valve.
- a heart valve (1 ) is shown in Figures 1 and 2 and includes a tubular stent (2) having a valve member (4) secured internally thereof and an external sleeve (6).
- the stent (2) is cylindrical and is formed by laser cutting a plurality of concentric diamond-shaped holes in a length of cobalt-chrome (MP35N) tubing.
- MP35N cobalt-chrome
- the stent (2) is shown in its expanded condition in which it has a length of between 20 and 22mm and a diameter of between 23 and 26mm. However, in the manufacture of the stent (2) a cobalt-chrome tube of 10mm diameter is used. The tube is expanded after cutting and the valve member (4) and sleeve (6) secured thereto. The assembled heart valve (1 ) is then crimped over a balloon catheter (not shown) in conventional manner.
- the valve member is formed from three valve leaflets, each cut from a sheet of kangaroo tissue which has been treated using the ADAPTTM technology of Celxcel Pty Limited.
- Each leaflet (12) has a straight outlet side (14) with normally extending sides (16) at each end, each approximately a third of the length of the outlet side (14).
- An arcuate inlet side (18) extends between the sides (16) opposite the outlet side (14).
- the inlet side (18) has a parabolic shape.
- the leaflets (12) are secured together along their sides (16) to form a triangular shape by a row of stitching (20) which tapers slightly inwardly from the start of the abutting inlet sides (18) towards the outlet sides (14).
- valve member (4) is subsequently secured within the stent (2) by stitching along the sides (16, 18) as indicated in Figure 5 by the dots (22). It will be appreciated that the parabolic shape of the inlet side (18) of each leaflet (12) corresponds to the shape of an inclined section through the stent (2) along which each leaflet (12) is secured thereto.
- the use of the treated kangaroo tissue has a number of advantages. Firstly, the tissue is flexible and resistant to wear. Secondly, it resists calcification and thus retains its flexibility for extended periods. Thirdly, it is relatively tough and can consequently be thinner than many other materials used in this application. In this embodiment, the leaflets each have a maximum thickness of 0.22mm. This characteristic of treated kangaroo tissue is especially important as it enables the entire heart valve in its crimped state in which it is ready for introduction into the human body to be appreciably smaller in diameter than in the instance of other heart valves presently used.
- kangaroo tissue enables the crimped heart valve to have a diameter of 6.7 mm [20 French] whereas the conventional prior art crimped heart valve has a diameter of 8.0 mm [24 French]. This is a significant reduction in size and it is envisaged that it will greatly facilitate initial placement of the crimped heart valve.
- the sleeve (6) is provided about the outer surface of the stent (2).
- the sleeve is made of a porous, biocompatible material, in this embodiment ultra-thin porous polyester having a thickness of 0.2 mm.
- the ends of the sleeve (6) conform to those (8, 9) of the stent (2) and stitching (24, 26) along each of the ends (8, 9)- secures the sleeve (6) to the stent (2).
- the sleeve (6) is further secured in position by the stitching securing the valve member (4) to the stent, the stitching extending about both the stent and the corresponding portion of the sleeve (6).
- the sleeve (6) has two major functions. The first is to provide a porous surface for tissue in-growth which assists in securing the heart valve (1 ) in position after implantation. The second function is to provide increased resistance between the heart valve and the arterial wall and to so prevent migration of the device after implantation. Critically, the sleeve also assists in preventing blood leakage between the heart valve (1 ) and arterial wall. This greatly increases the effectiveness of the heart valve.
- any suitable material can be used for the sleeve including expanded PTFE.
- Corex sutures are used for all the stitching, but any other suitable material can be used.
- the valve member can have any suitable shape.
- the stent too can be made of any suitable material and can have any suitable shape.
- the stent could be made so that the material at the ends (8, 9) is thinner than that at the centre (30). This will result in the end regions expanding initially during inflation to give the stent a waisted shape as illustrated by the broken lines. This shape will ensure that the heart valve becomes easily centralised within the valve annulus where it can be secured in position before inflating the balloon further to give the stent a more uniform cylindrical shape. This can easily be achieved by making the central bands of struts defining the mesh structure approximately 10% thicker than those at the ends.
- the tool (40) includes a pair of narrow elongated jaws (42) each extending from a handle (44), the handles being secured together at one end (46).
- the jaws (42) and handles (44) are made of a stainless steel and are shaped to be biased apart at the end (46).
- Corresponding slots (48) extend centrally along each jaw (42) from the free end (50) thereof, with the slots (48) each having a series of spaced apart arcuate notches (52) therein.
- the notches (52) are shaped to receive a sewing needle.
- the joined sides (16) of leaflets (12) are held against the side of the stent by between the jaws (42) whereafter they are stitched in position, the notches (52) acting as a template to ensure uniformity.
- the tool is fairly simple to make but greatly facilitates manufacture of the stent as it permits both the valve member to be held in position and to be secured by a stitching whilst being so held. It will be appreciated that other embodiments of a tool exist which fall within the scope of the invention especially as regards the shape of the jaws and the slot therein.
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010800097454A CN102395330A (en) | 2009-02-28 | 2010-02-26 | A heart valve |
AU2010217291A AU2010217291B2 (en) | 2009-02-28 | 2010-02-26 | A heart valve |
ZA2011/06839A ZA201106839B (en) | 2009-02-28 | 2011-09-20 | A heart valve |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ZA200809338 | 2009-02-28 | ||
ZA2008/09338 | 2009-02-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010097694A1 true WO2010097694A1 (en) | 2010-09-02 |
Family
ID=42665051
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2010/000398 WO2010097694A1 (en) | 2009-02-28 | 2010-02-26 | A heart valve |
Country Status (4)
Country | Link |
---|---|
CN (1) | CN102395330A (en) |
AU (1) | AU2010217291B2 (en) |
WO (1) | WO2010097694A1 (en) |
ZA (1) | ZA201106839B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20220104302A (en) * | 2013-03-15 | 2022-07-26 | 네비게이트 카디악 스트럭쳐스, 인크. | Catheter-guided replacement valves apparatus and methods |
CN104799975B (en) * | 2015-04-20 | 2017-05-24 | 杭州嘉和众邦生物科技有限公司 | Artificial bioprosthetic heart valve and production method thereof |
CN110731836B (en) * | 2018-07-20 | 2021-10-12 | 先健科技(深圳)有限公司 | Heart valve |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5489297A (en) * | 1992-01-27 | 1996-02-06 | Duran; Carlos M. G. | Bioprosthetic heart valve with absorbable stent |
US5562729A (en) * | 1994-11-01 | 1996-10-08 | Biocontrol Technology, Inc. | Heart valve |
US20030212454A1 (en) * | 2002-05-08 | 2003-11-13 | Scott Michael J. | Compressed tissue for heart valve leaflets |
US20040148018A1 (en) * | 1999-01-26 | 2004-07-29 | Carpentier Alain F. | Flexible heart valve and associated connecting band |
US20070239269A1 (en) * | 2006-04-07 | 2007-10-11 | Medtronic Vascular, Inc. | Stented Valve Having Dull Struts |
WO2009111241A2 (en) * | 2008-02-29 | 2009-09-11 | The Florida International University Board Of Trustees | Catheter deliverable artificial multi-leaflet heart valve prosthesis and intravascular delivery system for a catheter deliverable heart valve prosthesis |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE8327414U1 (en) * | 1983-09-23 | 1984-02-02 | Reichart, Bruno, Prof. Dr. | HEART VALVE PROSTHESIS |
US7632738B2 (en) * | 2003-06-24 | 2009-12-15 | Sang-Yun Lee | Wafer bonding method |
US7542859B2 (en) * | 2006-03-31 | 2009-06-02 | Tokyo Electron Ltd. | Creating a virtual profile library |
-
2010
- 2010-02-26 CN CN2010800097454A patent/CN102395330A/en active Pending
- 2010-02-26 WO PCT/IB2010/000398 patent/WO2010097694A1/en active Application Filing
- 2010-02-26 AU AU2010217291A patent/AU2010217291B2/en active Active
-
2011
- 2011-09-20 ZA ZA2011/06839A patent/ZA201106839B/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5489297A (en) * | 1992-01-27 | 1996-02-06 | Duran; Carlos M. G. | Bioprosthetic heart valve with absorbable stent |
US5562729A (en) * | 1994-11-01 | 1996-10-08 | Biocontrol Technology, Inc. | Heart valve |
US20040148018A1 (en) * | 1999-01-26 | 2004-07-29 | Carpentier Alain F. | Flexible heart valve and associated connecting band |
US20030212454A1 (en) * | 2002-05-08 | 2003-11-13 | Scott Michael J. | Compressed tissue for heart valve leaflets |
US20070239269A1 (en) * | 2006-04-07 | 2007-10-11 | Medtronic Vascular, Inc. | Stented Valve Having Dull Struts |
WO2009111241A2 (en) * | 2008-02-29 | 2009-09-11 | The Florida International University Board Of Trustees | Catheter deliverable artificial multi-leaflet heart valve prosthesis and intravascular delivery system for a catheter deliverable heart valve prosthesis |
Also Published As
Publication number | Publication date |
---|---|
ZA201106839B (en) | 2012-07-25 |
AU2010217291A1 (en) | 2011-10-20 |
AU2010217291B2 (en) | 2015-03-26 |
CN102395330A (en) | 2012-03-28 |
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