WO2010091124A3 - Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications - Google Patents
Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications Download PDFInfo
- Publication number
- WO2010091124A3 WO2010091124A3 PCT/US2010/023108 US2010023108W WO2010091124A3 WO 2010091124 A3 WO2010091124 A3 WO 2010091124A3 US 2010023108 W US2010023108 W US 2010023108W WO 2010091124 A3 WO2010091124 A3 WO 2010091124A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compositions
- bismuth
- certain
- chronic wounds
- wounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/29—Antimony or bismuth compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (38)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2751386A CA2751386C (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
EP10739086.6A EP2393491B1 (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
EP20163101.7A EP3695835A1 (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
AU2010210620A AU2010210620B2 (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
JP2011548426A JP5674684B2 (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiol as a disinfectant for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
BRPI1007885A BRPI1007885A2 (en) | 2009-02-03 | 2010-02-03 | antiseptic bismutholols for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
CN201080009333.0A CN102341105B (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
MX2016010269A MX371047B (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses. |
KR1020127022562A KR101821833B1 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
AU2011212941A AU2011212941B2 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
KR1020207003093A KR20200015814A (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
CA2788669A CA2788669C (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
CN201710523562.8A CN107308186A (en) | 2010-02-03 | 2011-02-03 | It is used for the biomedical applications and the bismuth mercaptan of other purposes for the treatment of for including bacterial biof iotalm as antiseptic |
KR1020197009488A KR102074444B1 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
JP2012552075A JP2013518895A (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiol as a disinfectant for biomedical use, including treatment of bacterial biofilms and other uses |
KR1020177034637A KR101966867B1 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
BR112012019286A BR112012019286A2 (en) | 2010-02-03 | 2011-02-03 | bismuththiols as an antiseptic for biomedical uses, including treatment of bacterial biofilms and other uses |
EP11740333.7A EP2536406A4 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
PCT/US2011/023549 WO2011097347A2 (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
MX2012009054A MX346409B (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses. |
CN2011800153054A CN103079557A (en) | 2010-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
HK12107475.5A HK1166707A1 (en) | 2009-02-03 | 2012-07-31 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
MX2019010863A MX2019010863A (en) | 2010-02-03 | 2012-08-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses. |
US13/566,816 US9028878B2 (en) | 2009-02-03 | 2012-08-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
US13/765,514 US9408393B2 (en) | 2010-02-03 | 2013-02-12 | Bismuth-thiols as antiseptics for agricultural, industrial and other uses |
AU2013202847A AU2013202847C1 (en) | 2009-02-03 | 2013-04-08 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
US14/676,698 US20160058772A1 (en) | 2009-02-03 | 2015-04-01 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
JP2016003005A JP6272366B2 (en) | 2010-02-03 | 2016-01-08 | Bismuth-thiol as a disinfectant for biomedical use, including treatment of bacterial biofilms and other uses |
US15/151,130 US20160375034A1 (en) | 2009-02-03 | 2016-05-10 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
AU2016203475A AU2016203475A1 (en) | 2010-02-03 | 2016-05-26 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
US15/199,554 US20170150724A1 (en) | 2010-02-03 | 2016-06-30 | Bismuth-thiols as antiseptics for agricultural, industrial and other uses |
JP2017253007A JP6685991B2 (en) | 2010-02-03 | 2017-12-28 | Bismuth-thiol as a disinfectant for biomedical use, including treatment of bacterial biofilms and other uses |
US15/980,622 US20180303846A1 (en) | 2009-02-03 | 2018-05-15 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
AU2018204190A AU2018204190B2 (en) | 2010-02-03 | 2018-06-13 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
US16/284,723 US10960012B2 (en) | 2009-02-03 | 2019-02-25 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
US16/433,660 US20200138033A1 (en) | 2009-02-03 | 2019-06-06 | Bismuth-thiols as antiseptics for agricultural, industrial and other uses |
JP2019225544A JP2020063277A (en) | 2010-02-03 | 2019-12-13 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
US17/181,781 US20220016132A1 (en) | 2009-02-03 | 2021-02-22 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14959309P | 2009-02-03 | 2009-02-03 | |
US61/149,593 | 2009-02-03 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/699,680 Continuation-In-Part US8389021B2 (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2011/023549 Continuation-In-Part WO2011097347A2 (en) | 2009-02-03 | 2011-02-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
US13/566,816 Continuation-In-Part US9028878B2 (en) | 2009-02-03 | 2012-08-03 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010091124A2 WO2010091124A2 (en) | 2010-08-12 |
WO2010091124A3 true WO2010091124A3 (en) | 2010-12-16 |
Family
ID=42542638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2010/023108 WO2010091124A2 (en) | 2009-02-03 | 2010-02-03 | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
Country Status (9)
Country | Link |
---|---|
US (5) | US8389021B2 (en) |
EP (2) | EP3695835A1 (en) |
JP (2) | JP5674684B2 (en) |
CN (1) | CN102341105B (en) |
AU (1) | AU2010210620B2 (en) |
BR (1) | BRPI1007885A2 (en) |
CA (1) | CA2751386C (en) |
HK (1) | HK1166707A1 (en) |
WO (1) | WO2010091124A2 (en) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE112008001301T5 (en) | 2007-05-14 | 2010-04-29 | Reserach Foundation Of State University Of New York | Induction of a physiological dispersion response in bacterial cells in a biofilm |
WO2010036945A2 (en) | 2008-09-26 | 2010-04-01 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
US9408393B2 (en) | 2010-02-03 | 2016-08-09 | Microbion Corporation | Bismuth-thiols as antiseptics for agricultural, industrial and other uses |
US9028878B2 (en) * | 2009-02-03 | 2015-05-12 | Microbion Corporation | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
JP5674684B2 (en) * | 2009-02-03 | 2015-02-25 | マイクロビオン コーポレーション | Bismuth-thiol as a disinfectant for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
KR102074444B1 (en) * | 2010-02-03 | 2020-02-06 | 마이크로비온 코포레이션 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
MX346409B (en) * | 2010-02-03 | 2017-03-17 | Microbion Corp * | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses. |
PL2568987T3 (en) | 2010-05-12 | 2017-06-30 | Rempex Pharmaceuticals, Inc. | Tetracycline compositions |
DE102010049113A1 (en) * | 2010-10-22 | 2012-04-26 | Schülke & Mayr GmbH | Textile fabric impregnated with an antimicrobial active ingredient preparation with a polyolefin-based carrier material |
DE102010049114A1 (en) * | 2010-10-22 | 2012-04-26 | Schülke & Mayr GmbH | Fabric impregnated with an antimicrobial agent solution for use on busy surfaces |
GB201021186D0 (en) * | 2010-12-14 | 2011-01-26 | Novabiotics Ltd | Composition |
US9572774B2 (en) | 2011-05-19 | 2017-02-21 | Savara Inc. | Dry powder vancomycin compositions and associated methods |
WO2014005107A2 (en) * | 2012-06-28 | 2014-01-03 | Ansun Biopharma, Inc. | Microparticle formulations for delivery to the upper and central respiratory tract and methods of manufacture |
EP2866792A4 (en) | 2012-06-28 | 2016-08-17 | Ansun Biopharma Inc | Microparticle formulations for delivery to the lower and central respiratory tract and methods of manufacture |
US9125892B2 (en) | 2014-02-03 | 2015-09-08 | George D. Petito | Composition for reduced scar formation of wounds |
US20150352064A1 (en) * | 2014-06-10 | 2015-12-10 | Kuwait University | Method of treating delayed healing of a wound associated with diabetes |
US9492374B2 (en) * | 2015-03-25 | 2016-11-15 | Jose Rafael Salinas Andrade | Composition and method for treatment of ulcers |
CN104982456B (en) * | 2015-07-20 | 2017-05-24 | 国家林业局泡桐研究开发中心 | Method for delaying blossoming of kernel-apricots as well as blossoming-delaying solution and preparation method of blossoming-delaying solution |
WO2017145142A1 (en) | 2016-02-25 | 2017-08-31 | Nobio Ltd. | Micro and nanoparticulate compositions comprising anti-microbially active groups |
US11740241B2 (en) * | 2016-03-30 | 2023-08-29 | Synovo Gmbh | Construct including an anchor, an enzyme recognition site and an indicator region for detecting microbial infection in wounds |
US10905660B2 (en) | 2016-06-07 | 2021-02-02 | Novabiotics Limited | Microparticles |
IL263540B2 (en) * | 2016-06-07 | 2023-07-01 | Novabiotics Ltd | Microparticles comprising a sulphur-containing compound |
GB201609940D0 (en) * | 2016-06-07 | 2016-07-20 | Novabiotics Ltd | Microparticles |
US11389396B2 (en) | 2016-10-28 | 2022-07-19 | The Regents Of The University Of California | Tumescent antibiotic injection for treatment of chronic skin and soft tissue infections |
BR112020004156A2 (en) | 2017-08-30 | 2020-09-08 | Nobio Ltd. | antimicrobial particles and methods of applying them |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
EP3829299A4 (en) | 2018-07-31 | 2022-04-13 | Microbion Corporation | Bismuth-thiol compositions and methods for treating wounds |
CN112804878A (en) | 2018-07-31 | 2021-05-14 | 微生物公司 | Bismuth-thiol compositions and methods of use |
BR112021022606A2 (en) | 2019-06-14 | 2022-01-04 | Dow Global Technologies Llc | Liquid additive for washing clothes |
CN110237255B (en) * | 2019-07-02 | 2021-10-22 | 首都医科大学 | Drug delivery system of targeting tumor cells and preparation method and application thereof |
WO2021195236A1 (en) * | 2020-03-24 | 2021-09-30 | Microbion Corporation | Bismuth thiol compounds and compositions and methods of treating microbial co-infections |
CN113969300A (en) * | 2020-07-23 | 2022-01-25 | 启迪禾美生物科技(嘉兴)有限公司 | Eucalyptus leaf composite active extract process and antibacterial application thereof |
WO2022072842A1 (en) * | 2020-10-01 | 2022-04-07 | Microbion Corporation | Methods of treating bone infections |
CN112426515A (en) * | 2020-11-30 | 2021-03-02 | 唐芳艳 | Medical mask for repairing burned skin |
WO2022159881A1 (en) * | 2021-01-25 | 2022-07-28 | Microbion Corporation | Amorphous form of bismuth-1,2-ethanedithiol and methods of making |
AU2022281289A1 (en) * | 2021-05-26 | 2023-11-23 | Steven Baranowitz | Methods and compositions for radioprotection |
US20230233477A1 (en) * | 2022-01-27 | 2023-07-27 | Kent State University | Bi2O3 NANOPARTICLES PREPARED BY THE TOP-DOWN ULTRASONICATION ROUTE AS A BROAD-SPECTRUM ANTIMICROBIAL TO OVERCOME DRUG RESISTANCE IN ANTIBIOTICS |
CN116440282B (en) * | 2023-05-09 | 2023-10-20 | 中海生物制药(泰州)有限公司 | Freeze-drying protective agent for live vaccine of infectious bronchitis and preparation method thereof |
Family Cites Families (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2809971A (en) | 1955-11-22 | 1957-10-15 | Olin Mathieson | Heavy-metal derivatives of 1-hydroxy-2-pyridinethiones and method of preparing same |
USRE29409E (en) * | 1965-03-15 | 1977-09-20 | Ventron Corporation | Phenoxarsine compounds incorporated into resins with phenols |
US3523121A (en) * | 1967-03-09 | 1970-08-04 | Rohm & Haas | Certain 2-carbamoyl-3-isothiazolenes |
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
EP0046354B1 (en) * | 1980-08-15 | 1983-10-05 | Scott Bader Company Limited | Coating compositions |
US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
US4596724A (en) * | 1984-05-15 | 1986-06-24 | Marine Shield Corp. | Anti-fouling coating composition, process for applying same and coating thereby obtained |
US4568343A (en) | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
US4788302A (en) * | 1985-06-14 | 1988-11-29 | Duke University | Anti-fouling compound and method of use |
US4783450A (en) | 1987-04-13 | 1988-11-08 | Warner-Lambert Company | Use of commercial lecithin as skin penetration enhancer |
JPH0653735B2 (en) * | 1987-08-03 | 1994-07-20 | 明治製菓株式会社 | N-alkylbenzenesulfonylcarbamoyl-5-chloroisothiazole derivatives and microbicides |
ES2077023T3 (en) * | 1989-03-10 | 1995-11-16 | Yamanouchi Pharma Co Ltd | COATING MATERIAL THAT CONTROLS THE RELEASE OF A MEDICINAL PRODUCT FOR FORMULATIONS OF PROLONGED ACTIVITY. |
US5229124A (en) * | 1990-04-02 | 1993-07-20 | Morton International, Inc. | Microbicides immobilized in water soluble thermoplastic resins and aqueous dispersions of microbicides prepared therefrom |
US5194248A (en) * | 1990-06-21 | 1993-03-16 | Trustees Of Boston University | Compositions comprising vitamin D analog precursors and the use thereof |
JPH04325569A (en) | 1991-04-24 | 1992-11-13 | Ishihara Sangyo Kaisha Ltd | Antifouling coating composition |
DE4221268C2 (en) | 1992-06-26 | 1997-06-12 | Lancaster Group Ag | Use of a dermatological to support the oxygen transport in the skin |
DE4221255C2 (en) | 1992-06-26 | 1994-09-15 | Lancaster Group Ag | Cosmetolipid-containing cosmetic |
US6488912B1 (en) * | 1992-07-30 | 2002-12-03 | Ed. Geistlich Soehne Ag Fuer Chemische Industrie | Treatment of dentoalveolar infections with taurolidine and/or taurultam |
US5334389A (en) * | 1992-10-15 | 1994-08-02 | Duke University | Antifouling coating and method for using same |
US5384176A (en) * | 1992-12-11 | 1995-01-24 | Zimmerman; Richard C. | Phenolic acid sulfate esters for prevention of marine biofouling |
US5928671A (en) * | 1995-04-25 | 1999-07-27 | Winthrop University Hospital | Method and composition for inhibiting bacteria |
US6086921A (en) * | 1995-04-25 | 2000-07-11 | Wintrop-University Hospital | Metal/thiol biocides |
US6558686B1 (en) * | 1995-11-08 | 2003-05-06 | Baylor College Of Medicine | Method of coating medical devices with a combination of antiseptics and antiseptic coating therefor |
US6022498A (en) * | 1996-04-19 | 2000-02-08 | Q2100, Inc. | Methods for eyeglass lens curing using ultraviolet light |
US6071528A (en) | 1997-02-19 | 2000-06-06 | Ultradent Products, Inc. | Adhesive antimicrobial and/or reparative dentin stimulating dental compositions and methods for forming and using such compositions |
US6017936A (en) * | 1997-03-14 | 2000-01-25 | Arch Chemicals, Inc. | Method for producing particles of pyrithione salts and particles so produced |
US5999828A (en) | 1997-03-19 | 1999-12-07 | Qualcomm Incorporated | Multi-user wireless telephone having dual echo cancellers |
US6455031B1 (en) * | 1997-06-18 | 2002-09-24 | David G Davies | Methods and compositions for controlling biofilm development |
AU2003204105B2 (en) | 1997-10-28 | 2005-11-17 | Winthrop-University Hospital | Metal/Thiol Biocides |
JPH11158328A (en) | 1997-11-27 | 1999-06-15 | Fujikura Rubber Ltd | Antibacterial rubber part |
GB9802355D0 (en) * | 1998-02-04 | 1998-04-01 | Ciba Geigy Ag | Organic compounds |
WO1999039707A1 (en) | 1998-02-04 | 1999-08-12 | Winthrop-University Hospital | Metal-thiols as immunomodulating agents |
US6465015B1 (en) | 1998-02-24 | 2002-10-15 | Arch Chemicals, Inc. | Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles |
TWI245763B (en) | 1998-04-02 | 2005-12-21 | Janssen Pharmaceutica Nv | Biocidal benzylbiphenyl derivatives |
EP1115289A2 (en) | 1998-09-23 | 2001-07-18 | Phycogen, Inc. | Environmentally benign crop protection agents |
US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
US6261539B1 (en) * | 1998-12-10 | 2001-07-17 | Akwete Adjei | Medicinal aerosol formulation |
US6682724B2 (en) * | 1999-02-23 | 2004-01-27 | Arch Chemcials, Inc. | Sonic method of enhancing chemical reactions to provide uniform, non-agglomerated particles |
JP2000336080A (en) * | 1999-05-28 | 2000-12-05 | Nippon Bayer Agrochem Co Ltd | Isothiazolecarboxamides |
AU5464901A (en) | 2000-03-01 | 2001-09-12 | Nihon Bayer Agrochem K.K. | Dichloropyridyl- and dichloroisothiazolyl-thiocarboxamides and their use as microbicides |
MXPA03003486A (en) * | 2000-10-16 | 2004-09-10 | Biocosmetics Sl | Use of olive oil in the preparation of a product for oral hygiene for eliminating or reducing bacterial plaque and/or bacteria in the mouth. |
US6726898B2 (en) * | 2000-11-17 | 2004-04-27 | Gary R. Jernberg | Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease |
US6630172B2 (en) | 2001-01-22 | 2003-10-07 | Kareem I. Batarseh | Microbicidal composition containing potassium sodium tartrate |
US6582719B2 (en) | 2001-02-02 | 2003-06-24 | The Trustees Of Columbia University In The City Of New York | Combinations of antiseptic and antibiotic agents that inhibit the development of resistant microorganisms |
EP1363600B1 (en) * | 2001-02-15 | 2008-10-01 | Access Pharmaceuticals, Inc. | Liquid formulations for the prevention and treatment of mucosal diseases and disorders |
US6555599B2 (en) * | 2001-03-26 | 2003-04-29 | Milliken & Company | Antimicrobial vulcanized EPDM rubber articles |
US6448306B1 (en) * | 2001-03-23 | 2002-09-10 | Milliken & Company | Antimicrobial articles made from nitrile or natural rubber |
CN1303142C (en) | 2001-03-23 | 2007-03-07 | 美利肯公司 | Antimicrobial rubber compositions |
US6730324B2 (en) * | 2001-04-20 | 2004-05-04 | The University Of British Columbia | Biofunctional hydroxyapatite coatings and microspheres for in-situ drug encapsulation |
US20030059450A1 (en) | 2001-09-24 | 2003-03-27 | Maibach Howard I. | Method and topical formulation for treating skin conditions associated with aging |
US6638993B2 (en) * | 2001-12-12 | 2003-10-28 | Milliken & Company | Colored antimicrobial vulcanized rubber articles |
US6579513B1 (en) * | 2002-01-03 | 2003-06-17 | Playtex Products, Inc. | Hygiene mouthspray composition |
US7438925B2 (en) * | 2002-08-26 | 2008-10-21 | Biovention Holdings Ltd. | Drug eluting coatings for medical implants |
JP4357166B2 (en) * | 2002-10-21 | 2009-11-04 | 日揮触媒化成株式会社 | Antibacterial / antifungal / algae-proof composition |
US6861049B2 (en) * | 2002-11-12 | 2005-03-01 | Douglas B. Harwood | Aqueous slurries useful for cleaning the tongue and throat |
US6848871B1 (en) * | 2002-12-19 | 2005-02-01 | Cottrell, Inc. | Strap tie-down system |
WO2008043175A1 (en) | 2006-10-13 | 2008-04-17 | Kane Biotech Inc. | SOLUBLE β-N-ACETYLGLUCOSAMINIDASE BASED ANTIBIOFILM COMPOSITIONS AND USES THEREOF |
JP2004307483A (en) | 2003-04-07 | 2004-11-04 | Rohm & Haas Co | Microbicidal composition |
US6852782B2 (en) * | 2003-04-25 | 2005-02-08 | Milliken & Company | Antimicrobial articles and compositions made from non-silicone vulcanized rubber |
US6943205B2 (en) * | 2003-04-25 | 2005-09-13 | Milliken & Company | Antimicrobial articles and compositions made from styrene butadiene rubber |
US7060739B2 (en) * | 2003-04-25 | 2006-06-13 | Milliken & Company | Antimicrobial fluoroelastomer rubber articles and compositions |
US6875453B2 (en) * | 2003-07-18 | 2005-04-05 | Manuel Viamonte, Jr. | Non-toxic disinfectant containing a isopropyl alcohol and sesame oil composition with lemon oil and menthol |
US7381751B2 (en) * | 2003-08-26 | 2008-06-03 | Shantha Sarangapani | Antimicrobial composition for medical articles |
JP5209963B2 (en) * | 2004-07-02 | 2013-06-12 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Aerosol suspension formulation containing TG227EA or TG134A as propellant |
AU2005298344B2 (en) | 2004-10-25 | 2011-02-10 | Varian Medical Systems, Inc. | Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
US7419681B2 (en) * | 2004-12-02 | 2008-09-02 | Bioretec, Ltd. | Method to enhance drug release from a drug-releasing material |
US20060205838A1 (en) * | 2005-03-10 | 2006-09-14 | Velamakanni Bhaskar V | Hardenable antimicrobial dental compositions and methods |
US7507281B2 (en) * | 2005-09-02 | 2009-03-24 | Microban Products Company | Antimicrobial cementitious composition, method and article |
CA2630147C (en) | 2005-11-18 | 2015-08-11 | Glanbia Nutritionals (Ireland) Limited | Compositions for disrupting and inhibiting reconstitution of wound biofilm |
US8268395B2 (en) * | 2005-12-05 | 2012-09-18 | E. I. Du Pont De Nemours And Company | Method for providing resistance to biofouling in a porous support |
JP4568232B2 (en) | 2006-01-06 | 2010-10-27 | 秀和 西松 | Artificial bone head holder |
JP2007332040A (en) | 2006-06-12 | 2007-12-27 | Shinshu Univ | Microbicide containing carbon nanotube and material and pharmaceutical preparation using the same |
GB0618697D0 (en) * | 2006-09-22 | 2006-11-01 | Syntopix Ltd | Formulations |
EP2117611B1 (en) * | 2007-01-24 | 2014-07-30 | Cook Medical Technologies LLC | Biofilm-inhibiting medical products |
US8343536B2 (en) * | 2007-01-25 | 2013-01-01 | Cook Biotech Incorporated | Biofilm-inhibiting medical products |
US8895044B2 (en) | 2007-05-18 | 2014-11-25 | Sciessent, Llc | Food preservation compositions and methods |
WO2008150375A1 (en) | 2007-06-01 | 2008-12-11 | Arrow International, Inc. | Combined fibrinolytic and antimicrobial catheter and uses thereof |
AU2007356895B2 (en) | 2007-07-25 | 2012-11-15 | Varian Medical Systems, Inc. | Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same |
WO2009086470A2 (en) * | 2007-12-27 | 2009-07-09 | Aires Pharmaceuticals, Inc. | Aerosolized nitrite and nitric oxide - donating compounds and uses thereof |
US20090197003A1 (en) * | 2008-02-01 | 2009-08-06 | Thomas Van Zandt | Anti-fouling coatings, Compounds, and methods |
WO2009102787A2 (en) * | 2008-02-12 | 2009-08-20 | Boston Scientific Scimed, Inc. | Medical implants with polysaccharide drug eluting coatings |
US20110092589A1 (en) | 2008-03-10 | 2011-04-21 | The Charlotte-Mecklenburg Hospotal Authority | Treatment of Inflammatory Conditions and Diseases with Metal-Thiols |
JP5674684B2 (en) | 2009-02-03 | 2015-02-25 | マイクロビオン コーポレーション | Bismuth-thiol as a disinfectant for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications |
US9028878B2 (en) * | 2009-02-03 | 2015-05-12 | Microbion Corporation | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
US9408393B2 (en) | 2010-02-03 | 2016-08-09 | Microbion Corporation | Bismuth-thiols as antiseptics for agricultural, industrial and other uses |
KR102074444B1 (en) | 2010-02-03 | 2020-02-06 | 마이크로비온 코포레이션 | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses |
-
2010
- 2010-02-03 JP JP2011548426A patent/JP5674684B2/en active Active
- 2010-02-03 EP EP20163101.7A patent/EP3695835A1/en active Pending
- 2010-02-03 BR BRPI1007885A patent/BRPI1007885A2/en not_active Application Discontinuation
- 2010-02-03 US US12/699,680 patent/US8389021B2/en active Active
- 2010-02-03 AU AU2010210620A patent/AU2010210620B2/en active Active
- 2010-02-03 CN CN201080009333.0A patent/CN102341105B/en active Active
- 2010-02-03 WO PCT/US2010/023108 patent/WO2010091124A2/en active Application Filing
- 2010-02-03 CA CA2751386A patent/CA2751386C/en active Active
- 2010-02-03 EP EP10739086.6A patent/EP2393491B1/en active Active
-
2012
- 2012-07-31 HK HK12107475.5A patent/HK1166707A1/en unknown
-
2013
- 2013-03-01 US US13/782,963 patent/US20130171210A1/en not_active Abandoned
-
2014
- 2014-09-08 JP JP2014182123A patent/JP2015007113A/en active Pending
-
2018
- 2018-07-31 US US16/050,038 patent/US10835510B2/en active Active
-
2020
- 2020-10-05 US US17/063,491 patent/US11564903B2/en active Active
-
2023
- 2023-01-18 US US18/098,466 patent/US20230149340A1/en active Pending
Non-Patent Citations (4)
Title |
---|
LISA AGOCS ET AL.: "The Structurally Flexible Bicyclic Bis(2-hydroxyethaneth iolato)bismuth(III) Complex: A Model for Asymmetric Monoanionic Chelation of Bismuth(III)", INORGANIC CHEMISTRY, vol. 36, 1997, pages 2855 - 2860, XP008154591 * |
PHILIP DOMENICO ET AL.: "Activities of Bismuth Thiols against Staphylococci and Staphylococcal Biofilms", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, May 2001 (2001-05-01), pages 1417 - 1421, XP008154597 * |
WILFREDO G. VELOIRA ET AL.: "In vitro Activity and Synergy of bismuth thiols and tobramycin against Burkholderia Cpacia complex", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 52, 2003, pages 915 - 819, XP008154593 * |
ZHANG H. J. ET AL.: "Inhibition of Bacterial Adherence on the surface of Stents and Bacterial Growth in Bile by Bismuth Dimercaprol", DIGESTIVE DISEASE AND SCIENCES, vol. 50, no. 6, June 2005 (2005-06-01), pages 1046 - 1051, XP019237369 * |
Also Published As
Publication number | Publication date |
---|---|
CN102341105B (en) | 2014-09-17 |
CA2751386A1 (en) | 2010-08-12 |
US20110003001A1 (en) | 2011-01-06 |
US11564903B2 (en) | 2023-01-31 |
AU2010210620A1 (en) | 2011-09-22 |
JP5674684B2 (en) | 2015-02-25 |
US20130171210A1 (en) | 2013-07-04 |
US8389021B2 (en) | 2013-03-05 |
US20190201371A1 (en) | 2019-07-04 |
EP3695835A1 (en) | 2020-08-19 |
JP2015007113A (en) | 2015-01-15 |
EP2393491A2 (en) | 2011-12-14 |
CN102341105A (en) | 2012-02-01 |
EP2393491A4 (en) | 2012-08-08 |
US10835510B2 (en) | 2020-11-17 |
EP2393491B1 (en) | 2020-04-22 |
CA2751386C (en) | 2018-03-06 |
US20230149340A1 (en) | 2023-05-18 |
JP2012516855A (en) | 2012-07-26 |
WO2010091124A2 (en) | 2010-08-12 |
BRPI1007885A2 (en) | 2016-02-16 |
AU2010210620B2 (en) | 2016-02-25 |
US20210260017A1 (en) | 2021-08-26 |
HK1166707A1 (en) | 2012-11-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2010091124A3 (en) | Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications | |
WO2011097347A3 (en) | Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses | |
PH12016502498A1 (en) | Bismuth-thiols as antiseptics for agricultural, industrial and other uses | |
NZ592091A (en) | Antimicrobial compositions | |
WO2011089379A3 (en) | Treatment of biofilms | |
EP2529723A3 (en) | Compositions and Methods for Treating Vaginal Infections and Pathogenic Vaginal Biofilms | |
MX352822B (en) | Biocidal compositions and methods of using the same. | |
EA033311B1 (en) | Benzoxaborole derivatives as antibacterial agents | |
MX2015011613A (en) | Antimicrobial-antibiofilm compositions and methods of use thereof. | |
WO2010004433A3 (en) | Hydrophobically enhanced aminoglycosides | |
IL211120A (en) | C7-fluoro substituted tetracycline compound, pharmaceutical composition comprising it and its use in the manufacture of medicaments for treating infection caused by bacteria | |
MX2011008043A (en) | Actagardine derivatives. | |
WO2008085578A3 (en) | Anti-microbial compositions and devices and methods of using the same | |
MX2012000136A (en) | Compositions comprising finafloxacin and methods for treating ophthalmic, otic, or nasal infections. | |
WO2008011164A3 (en) | Methods and compositions for the treatment and prevention of infections | |
WO2011102724A3 (en) | Disinfectant composition and its use in dental treatment | |
WO2011012855A3 (en) | Antibacterial combinations comprising a garlic extract or s -allyl cysteine | |
WO2009083521A3 (en) | Antibacterial compositions comprising an antiseptic in combination with an antibiotic | |
WO2008071961A8 (en) | 2-quinolinone and 2-quinoxalinone- derivatives and their use as antibacterial agents | |
WO2009013480A3 (en) | Antibacterial combination therapy | |
WO2010065110A3 (en) | Antimicrobials | |
FR2966698B1 (en) | ANTI-MICROBIAL DERMO-COSMETIC COMPOSITION FOR ANIMALS | |
EP4017520A4 (en) | Croton lechleri compositions for use in treating bleeding, wounds and infections | |
WO2010055474A3 (en) | Antimicrobial compounds and compositions | |
EP4165039A4 (en) | Novel monobactam compounds, their preparation and use as antibacterial agents |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 201080009333.0 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 10739086 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2011548426 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2751386 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 6341/DELNP/2011 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010210620 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010739086 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2010210620 Country of ref document: AU Date of ref document: 20100203 Kind code of ref document: A |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01A Ref document number: PI1007885 Country of ref document: BR |
|
ENP | Entry into the national phase |
Ref document number: PI1007885 Country of ref document: BR Kind code of ref document: A2 Effective date: 20110803 |