WO2010051383A4 - A device and method for delivery of a drug depot - Google Patents

A device and method for delivery of a drug depot Download PDF

Info

Publication number
WO2010051383A4
WO2010051383A4 PCT/US2009/062612 US2009062612W WO2010051383A4 WO 2010051383 A4 WO2010051383 A4 WO 2010051383A4 US 2009062612 W US2009062612 W US 2009062612W WO 2010051383 A4 WO2010051383 A4 WO 2010051383A4
Authority
WO
WIPO (PCT)
Prior art keywords
drug depot
cannula
nerve
skin
patient
Prior art date
Application number
PCT/US2009/062612
Other languages
French (fr)
Other versions
WO2010051383A2 (en
WO2010051383A3 (en
Inventor
Thomas A. Simonton
William F. Mckay
Sean M. Haddock
John Myers Zanella
Original Assignee
Warsaw Orthopedic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warsaw Orthopedic, Inc. filed Critical Warsaw Orthopedic, Inc.
Priority to EP09824140A priority Critical patent/EP2349409A4/en
Publication of WO2010051383A2 publication Critical patent/WO2010051383A2/en
Publication of WO2010051383A3 publication Critical patent/WO2010051383A3/en
Publication of WO2010051383A4 publication Critical patent/WO2010051383A4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/4893—Nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0068—Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
    • A61M25/007—Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles

Abstract

Drug depot delivery devices and methods are provided for delivering one or more drug depots to one or more sites beneath the skin of a patient with or without repositioning the cannula. The device has a cannula capable of insertion to the site beneath the skin of the patient and one or more side port openings for delivering a drug depot. The side port openings are spaced a distance from the blunt tip, which will allow the user to implant at a set distance from a nerve. The device may also include an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot at or near the nerve.

Claims

AMENDED CLAIMS received by the International Bureau on 08 August 2010WHAT IS CLAIMED IS:
1. A device for directional placement of a drug depot at a delivery site beneath the skin of a patient, the device comprising: a cannula having a proximal end and a distal end, the proximal end of the cannula having an opening to receive the drug depot, the distal end of the cannula capable of insertion to the delivery site beneath the skin of the patient and having a side port opening for passage of the drug depot, wherein the proximal end further comprises an index marker to provide a visual indicator to a user of a location of the side port opening; a housing having a coupling, means for coupling the proximal end of the cannula to the housing and a storage component configured for storing the drug depot; and a plunger having a handle and a tip adapted for dispensing the drug depot, wherein the tip of the plunger is slidably receivable within each of the housing, storage component and the cannula to deliver the drug depot out the side port opening to the delivery site beneath the skin of the patient.
2. ' A device for directional placement of a drug depot according to claim 1, wherein the housing comprises a nerve sensing unit comprising an electrical contact and an alarm coupled to the nerve sensing unit such that when the distal end of the cannula is in close proximity to a nerve or contacts a nerve, the alarm is activated.
3. A device for directional placement of a drug depot according to claim 2, wherein the alarm is audible or visible or audible and visible.
4. A device for directional placement of a drug depot according to claim 1, wherein the cannula comprises two or more side port openings disposed at the distal end for dispensing two or more drug depots to two or more different delivery sites beneath the skin of the patient.
5. A device for directional placement of a drug depot according to claim 4, wherein the plunger comprises two or more plunger tips that align with the two or more side port
37 openings for delivery of the two or more drug depots to the two or more different delivery sites beneath the skin of the patient.
6. A device for directional placement of a drug depot according to claim 5, wherein the proximal end of the cannula has two or more openings, each opening capable of receiving a drug depot and two or more side port openings on the distal end of the cannula, each of the side port openings capable of dispensing a drug depot to the two or more different delivery sites beneath the skin of the patient
7. A device for directional placement of a drug depot according to claim 60, wherein the drug depots may be simultaneously delivered to the drug delivery sites.
8. A device for directional placement of a drug depot at a delivery site beneath the skin of a patient, the device comprising: a cannula having a proximal end and a distal end, the proximal end of the cannula having an opening to receive the drag depot and a nerve sensing unit comprising an electrical contact and an alarm coupled to the nerve sensing unit, the distal end of the cannula capable of insertion to the delivery site beneath the skin of the patient and having a side port opening for passage of the drug depot, wherein when the distal end of the cannula is in close proximity to a nerve or contacts a nerve, the alarm is activated; and a plunger having a handle and a tip adapted for dispensing the drug depot, wherein the tip of the plunger is slidably receivable within the cannula to deliver the drug depot out the side port opening to the delivery site beneath the skin of the patient.
9. A device for directional placement of a drug depot according to claim 8, wherein the proximal end of the cannula further comprises an index marker to provide a visual indicator to a user of a location of the side port opening.
10. A device for directional placement of a drug depot according to claim 8, wherein the cannula comprises two or more side port openings for dispensing two or more drug depots to two or more different delivery sites beneath the skin of the patient.
38
11. A device for directional placement of a drug depot according to claim 10, wherein the plunger comprises two or more plunger tips that align with the two or more side port openings for delivery of the two or more drug depots to the two or more different delivery sites beneath the skin of the patient.
12. A device for delivery a drug depot at or near a nerve site beneath the skin of a patient, the device comprising: a cannula having a proximal end and a distal end, the proximal end of the cannula having an opening to receive the drug depot, the distal end of the cannula capable of insertion to the nerve site beneath the skin of the patient and having an opening for passage of the drug depot; a plunger being slidably receivable within the opening of the proximal end of the cannula, the plunger having a first end and a tip at a second end, the first end being capable of moving the tip of the plunger to an extended position; a nerve sensing unit disposed on or within the device, the nerve sensing unit comprising an electrical contact material configured to receive electrical impulses from the nerve site so as to detect the nerve.
13. A device for delivering a drug depot according to claim 12, wherein the electrical contact material is disposed at or in a tip of the distal end of the cannula.
14. A device for delivering a drug depot according to claim 12, wherein the device further comprises a housing, wherein the housing has the nerve sensing unit disposed on or in the housing.
15. A device for delivering a drug depot according to claim 12, wherein (he nerve site comprises the sciatic nerve,
PCT/US2009/062612 2008-10-31 2009-10-29 A device and method for delivery of a drug depot WO2010051383A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP09824140A EP2349409A4 (en) 2008-10-31 2009-10-29 A device and method for delivery of a drug depot

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/262,823 US8702677B2 (en) 2008-10-31 2008-10-31 Device and method for directional delivery of a drug depot
US12/262,823 2008-10-31

Publications (3)

Publication Number Publication Date
WO2010051383A2 WO2010051383A2 (en) 2010-05-06
WO2010051383A3 WO2010051383A3 (en) 2010-08-26
WO2010051383A4 true WO2010051383A4 (en) 2010-10-14

Family

ID=42129553

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/062612 WO2010051383A2 (en) 2008-10-31 2009-10-29 A device and method for delivery of a drug depot

Country Status (3)

Country Link
US (1) US8702677B2 (en)
EP (1) EP2349409A4 (en)
WO (1) WO2010051383A2 (en)

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US9888859B1 (en) * 2013-03-14 2018-02-13 Nuvasive, Inc. Directional dilator for intraoperative monitoring
US9764122B2 (en) 2014-07-25 2017-09-19 Warsaw Orthopedic, Inc. Drug delivery device and methods having an occluding member
US9775978B2 (en) 2014-07-25 2017-10-03 Warsaw Orthopedic, Inc. Drug delivery device and methods having a retaining member
US10076650B2 (en) 2015-11-23 2018-09-18 Warsaw Orthopedic, Inc. Enhanced stylet for drug depot injector
DE102016110379A1 (en) * 2016-06-06 2017-12-07 Pajunk GmbH Medizintechnologie Unipolar cannula
USD802755S1 (en) 2016-06-23 2017-11-14 Warsaw Orthopedic, Inc. Drug pellet cartridge
US10434261B2 (en) 2016-11-08 2019-10-08 Warsaw Orthopedic, Inc. Drug pellet delivery system and method
TWI679040B (en) * 2017-01-30 2019-12-11 喜樂醫療器材股份有限公司 Particulate material delivery system and method

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Also Published As

Publication number Publication date
US20100114075A1 (en) 2010-05-06
US8702677B2 (en) 2014-04-22
WO2010051383A2 (en) 2010-05-06
EP2349409A4 (en) 2012-05-23
EP2349409A2 (en) 2011-08-03
WO2010051383A3 (en) 2010-08-26

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