WO2010028612A1 - Device for spectral analysis of parenchyma - Google Patents

Device for spectral analysis of parenchyma Download PDF

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Publication number
WO2010028612A1
WO2010028612A1 PCT/CZ2009/000110 CZ2009000110W WO2010028612A1 WO 2010028612 A1 WO2010028612 A1 WO 2010028612A1 CZ 2009000110 W CZ2009000110 W CZ 2009000110W WO 2010028612 A1 WO2010028612 A1 WO 2010028612A1
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WO
WIPO (PCT)
Prior art keywords
spectroscopic probe
introducing
fiber
optical fiber
endoscope
Prior art date
Application number
PCT/CZ2009/000110
Other languages
French (fr)
Other versions
WO2010028612A4 (en
Inventor
Jiri Votruba
Tomas Bruha
Original Assignee
Jiri Votruba
Tomas Bruha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jiri Votruba, Tomas Bruha filed Critical Jiri Votruba
Publication of WO2010028612A1 publication Critical patent/WO2010028612A1/en
Publication of WO2010028612A4 publication Critical patent/WO2010028612A4/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6848—Needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0238—Optical sensor arrangements for performing transmission measurements on body tissue

Definitions

  • Field of the invention relates; ,to,,ai device for a detection of structural changes in a tissue of parenchymatous organs.
  • Principle of invention is based on the detection of near infrared radiation penetrating through the examinated tissue. This device enables very effective examination of the parenchymatous organs.
  • the aim of the present invention was therefore to develop a device for comparatively simple monitoring of structural changes of parenchyma while eliminating disadvantages of devices known from the prior art.
  • NIR radiation penetrating through parenchymatous tissue brings information about organ structure and this information can be obtained by proper processing of detected optical signal. Consequently, the inventors designed a device for imaging and evaluation of NIR radiation penetrating through parenchyma that is based on the principle mentioned above.
  • the device according to the invention it is possible to monitor and detect spectral changes of penetrating radiation or visual changes in the images gained by hyperspectral camera. These changes are supposed to be in strong correlation with biochemical, structural and accordingly optical characteristics of the examinated parenchyma.
  • the device for detection of structural parenchymal changes comprises spectroscope with the evaluation unit. Near infrared radiation coming from the light source and penetrating through examinated tissue is directed to the spectroscope input by a spectroscopic probe which is introduced into parenchymatous organ.
  • a spectroscopic probe which is introduced into parenchymatous organ.
  • One of the preferred embodiments of the present invention consists of substitution of the spectroscope and spectroscopic probe by a hyperspectral camera with connected flexible bronchoscope. In that way NIR radiation is detected and subsequently analogically or digitally visualized and further processed.
  • the subject-matter of the invention is therefore the device for detection of structural changes in parenchyma of various parenchymatous organs.
  • the device according to the invention consists of spectroscope with spectroscopic probe, source of near infrared (NIR) radiation with connected an optical . fiber comprising means for proper light beam directing and means for introducing the optical fiber and spectroscopic probe into the examinated organ.
  • NIR near infrared
  • distal end of the optical fiber with the means for proper light beam directing and distal end of spectroscopic probe are mutually positioned in a defined distance.
  • Preferred means for light beam directing is micromirror; more preferably it is the titan micromirror.
  • the means for introducing the optical fiber and spectroscopic probe into parenchymatous organ is a hollow needle, that is preferably equipped with a side opening.
  • the preferred means for introducing the optical fiber and spectroscopic probe into examinated organ is the flexible catheter.
  • the preferred modification of the device according to invention is the use of endoscope as the means for introducing optical fiber and spectroscopic probe, whereas the optical fiber passes through the working channel of the endoscope and spectroscope with spectroscopic probe is replaced by endoscope with connected hyperspectral camera.
  • the optical fiber is adjusted for attaching externally to the surface of the body.
  • the device according to the present invention enables entirely new possibility in correlation of spectroscopic or visual findings with histological and biological analyses in individual patients. In the future, this might eliminate ,,bloody biopsy" which will be fully substituted by ,,optical biopsy".
  • the device according to the invention enables the examination of a tissue at several points during one examination and therefore enables to specify exactly the area of structural changes of parenchyma.
  • the device as well enables improving of endoscopic navigation accuracy in parenchymatous organs in the search for correct biopsy position in endoscopically occult parenchymal lesions. Compilation of measurements database enables as well monitoring and evaluating of time dependent changes.
  • Fig.1 Basic embodiment of a device for invasive application is illustrated.
  • the device contains source of NIR light, optical fiber, spectroscope with spectroscopic probe and hollow needle for introducing optical fiber and spectroscopic probe into parenchymatous organ, as for example liver.
  • Fig. 2 Example of preferred embodiment for non-invasive application is illustrated.
  • the device contains source of NIR light, optical fiber, spectroscope with spectroscopic probe and flexible catheter for introducing optical fiber and spectroscopic probe into parenchymatous organ, as for example lung.
  • Fig. 3 Example of another embodiment of the device is illustrated.
  • NIR radiation is supplied by optical fiber to periphery of parenchymatous organ through the working channel of the endoscope connected to optical system of hyperspectral camera. .
  • Fig. 4 Further preferred embodiment of the device for non-invasive application is illustrated.
  • optical fiber is in direct contact with surface of the body (for example chest or abdominal wall) and flexible endoscope is connected to the optical system of hyperspectral camera and introduced into the cavity organ.
  • Example 1 Preferred embodiment of the device according to the invention is illustrated on Fig.1.
  • the device contains spectroscope 2 with evaluating unit (AVANTES AVS - PC 2000 Plug-in Spectrometers PC2E1260 Master, wavelength range 200-1100 nm) with spectroscopic probe 3 and optical fiber 5, which is connected to source of NIR radiation (EVEREST.VIP ELS 24 DC, mercury vacuum tube, wavelength range 300-1200 nm).
  • Optical fiber is equipped by the means 8 for adjustment of light directing, i.e. micro mirror, more preferably titan micro mirror.
  • the device contains as well the hollow needle 7 (or in another preferred embodiment the flexible hollow catheter 9, as is illustrated on Fig.2) for introducing into the parenchymal organ ⁇ Spectroscopic probe 3 and optical fiber 5 passes through needle 7 (or catheter 9), whereas optical fiber 5 (made from flexible light fibers, preferably from plastics light fibers) is adapted for introducing into parenchyma 1 through the needle 7 (or catheter 9).
  • the spectroscopic probe 3Js ejected from needle 7 (or catheter 9), particularly from side of the needle 7 into parenchyma 1.
  • Spectrometric data obtained by the device can be presented in real time on monitor of spectrometer 2 and/or can be saved to the computer memory, whereas the structure of parenchyma is evaluated on the basis of these data.
  • spectroscopic and clinical data are evaluated together using specific software.
  • the device according to the invention contains the optic fiber 5 connected to the source of NIR radiation (see example 1 ), which is adapted for introducing into a periphery of parenchymatous organ 1 by the use of working channel of the flexible endoscope 10 (bronchoscope Olympus BF 1T60, diameter of working channel 3 mm).
  • Endoscope 10 is connected to the optical system of hyperspectral camera H (Spectral camera QE V10E, wavelength range 400-1100 nm.) Visualization of penetrating NIR radiation is evaluated in real time on monitor.
  • the source of NIR radiation, or rather the optical fiber is adapted for attaching on a chest or an abdominal wall.
  • Flexible endoscope is as in previous device connected to optical system of hyperspectral camera IJ. and subsequently introduced into the cavity organ I 1
  • Device is applicable everywhere, wherein it is necessary to perform effective examination of parenchymatous organs considering defects damaging parenchyma by fibrotization, tumours, chronic infection, deposition of substances or oedema.

Abstract

A device for detection of changes in the tissue of various parenchymatous organs (1 ) comprising a spectroscope (2) with the spectroscopic probe (3), source (6) of near infrared radiation with connected light fiber (5) which contains on its other end the means (8) for directing light beam and than the means (7) for introducing the light fiber (5) and spectroscopic probe (3) into the examined organ (1). The device is applicable for effective and precise examination of the parenchyma.

Description

DEVICE FOR SPECTRAL ANALYSIS OF PARENCHYMA
Field of the invention Present invention relates; ,to,,ai device for a detection of structural changes in a tissue of parenchymatous organs. Principle of invention is based on the detection of near infrared radiation penetrating through the examinated tissue. This device enables very effective examination of the parenchymatous organs.
Background of the invention
Diseases of parenchymatous "'organs represent, very heterogeneous group of illnesses. Diagnosis of tumorous, fibrotising, inflammatory or oedematous processes in the parenchyma ,is usually very difficult. Nowadays, there are several methods used for the diagnosis of structural abnormalities - computer tomography (CT), nuclear magnetic resonance (MRI) and sonography. These methods are often supplemented by cytological or histological evaluation of parenchyma. All these methods are encumbered by subjective variability in the evaluation of results and they are often very demanding for patients (opened pulmonary biopsy, transbronchial biopsy, liver biopsy or biopsy of other organs). In addition, all these techniques are very complex and expensive. Considering great heterogeneity of parenchymatous diseases and the fact that many of them are still not elucidated, any new descriptor on the disease would be very valuable for the clinical and research purposes. The aim of the present invention was therefore to develop a device for comparatively simple monitoring of structural changes of parenchyma while eliminating disadvantages of devices known from the prior art.
Description of the invention
In their previous experiments, the inventors found and repeatedly verified that near infrared (NIR) radiation penetrating through parenchymatous tissue brings information about organ structure and this information can be obtained by proper processing of detected optical signal. Consequently, the inventors designed a device for imaging and evaluation of NIR radiation penetrating through parenchyma that is based on the principle mentioned above. By using the device according to the invention it is possible to monitor and detect spectral changes of penetrating radiation or visual changes in the images gained by hyperspectral camera. These changes are supposed to be in strong correlation with biochemical, structural and accordingly optical characteristics of the examinated parenchyma.
The device for detection of structural parenchymal changes comprises spectroscope with the evaluation unit. Near infrared radiation coming from the light source and penetrating through examinated tissue is directed to the spectroscope input by a spectroscopic probe which is introduced into parenchymatous organ. One of the preferred embodiments of the present invention consists of substitution of the spectroscope and spectroscopic probe by a hyperspectral camera with connected flexible bronchoscope. In that way NIR radiation is detected and subsequently analogically or digitally visualized and further processed.
The subject-matter of the invention is therefore the device for detection of structural changes in parenchyma of various parenchymatous organs. In its basic embodiment the device according to the invention consists of spectroscope with spectroscopic probe, source of near infrared (NIR) radiation with connected an optical . fiber comprising means for proper light beam directing and means for introducing the optical fiber and spectroscopic probe into the examinated organ.
In a preferred embodiment, distal end of the optical fiber with the means for proper light beam directing and distal end of spectroscopic probe are mutually positioned in a defined distance. Preferred means for light beam directing is micromirror; more preferably it is the titan micromirror.
The means for introducing the optical fiber and spectroscopic probe into parenchymatous organ is a hollow needle, that is preferably equipped with a side opening. For the use in a non-invasive method, the preferred means for introducing the optical fiber and spectroscopic probe into examinated organ is the flexible catheter.
The preferred modification of the device according to invention is the use of endoscope as the means for introducing optical fiber and spectroscopic probe, whereas the optical fiber passes through the working channel of the endoscope and spectroscope with spectroscopic probe is replaced by endoscope with connected hyperspectral camera.
In another modification of the device according to the invention the optical fiber is adjusted for attaching externally to the surface of the body.
The device according to the present invention enables entirely new possibility in correlation of spectroscopic or visual findings with histological and biological analyses in individual patients. In the future, this might eliminate ,,bloody biopsy" which will be fully substituted by ,,optical biopsy". The device according to the invention enables the examination of a tissue at several points during one examination and therefore enables to specify exactly the area of structural changes of parenchyma. The device as well enables improving of endoscopic navigation accuracy in parenchymatous organs in the search for correct biopsy position in endoscopically occult parenchymal lesions. Compilation of measurements database enables as well monitoring and evaluating of time dependent changes.
Brief description of the drawings
Fig.1 : Basic embodiment of a device for invasive application is illustrated. In this case the device contains source of NIR light, optical fiber, spectroscope with spectroscopic probe and hollow needle for introducing optical fiber and spectroscopic probe into parenchymatous organ, as for example liver.
Fig. 2: Example of preferred embodiment for non-invasive application is illustrated. In this case, the device contains source of NIR light, optical fiber, spectroscope with spectroscopic probe and flexible catheter for introducing optical fiber and spectroscopic probe into parenchymatous organ, as for example lung.
Fig. 3: Example of another embodiment of the device is illustrated. In this case NIR radiation is supplied by optical fiber to periphery of parenchymatous organ through the working channel of the endoscope connected to optical system of hyperspectral camera. .
Fig. 4: Further preferred embodiment of the device for non-invasive application is illustrated. In this case, optical fiber is in direct contact with surface of the body (for example chest or abdominal wall) and flexible endoscope is connected to the optical system of hyperspectral camera and introduced into the cavity organ.
Examples of the preferred embodiments
Example 1 Preferred embodiment of the device according to the invention is illustrated on Fig.1. The device contains spectroscope 2 with evaluating unit (AVANTES AVS - PC 2000 Plug-in Spectrometers PC2E1260 Master, wavelength range 200-1100 nm) with spectroscopic probe 3 and optical fiber 5, which is connected to source of NIR radiation (EVEREST.VIP ELS 24 DC, mercury vacuum tube, wavelength range 300-1200 nm). Optical fiber is equipped by the means 8 for adjustment of light directing, i.e. micro mirror, more preferably titan micro mirror. The device contains as well the hollow needle 7 (or in another preferred embodiment the flexible hollow catheter 9, as is illustrated on Fig.2) for introducing into the parenchymal organ ^Spectroscopic probe 3 and optical fiber 5 passes through needle 7 (or catheter 9), whereas optical fiber 5 (made from flexible light fibers, preferably from plastics light fibers) is adapted for introducing into parenchyma 1 through the needle 7 (or catheter 9). After penetrating needle through skin cover (or catheter 9_through preformed ways) to parenchymal organ 1, the spectroscopic probe 3Js ejected from needle 7 (or catheter 9), particularly from side of the needle 7 into parenchyma 1. The mutual distance between end of the needle 7 (or catheter 9), more specifically between distal end of optical fiber 5 with micromirror 8 and distal end of the spectroscopic probe 3 is exactly defined. Spectrometric data obtained by the device can be presented in real time on monitor of spectrometer 2 and/or can be saved to the computer memory, whereas the structure of parenchyma is evaluated on the basis of these data. Preferably spectroscopic and clinical data are evaluated together using specific software.
Example 2
In this embodiment illustrated on Fig. 3 the device according to the invention contains the optic fiber 5 connected to the source of NIR radiation (see example 1 ), which is adapted for introducing into a periphery of parenchymatous organ 1 by the use of working channel of the flexible endoscope 10 (bronchoscope Olympus BF 1T60, diameter of working channel 3 mm). Endoscope 10 is connected to the optical system of hyperspectral camera H (Spectral camera QE V10E, wavelength range 400-1100 nm.) Visualization of penetrating NIR radiation is evaluated in real time on monitor.
In another preferred modification of the device which is illustrated on Fig. 4 the source of NIR radiation, or rather the optical fiber, is adapted for attaching on a chest or an abdominal wall. Flexible endoscope is as in previous device connected to optical system of hyperspectral camera IJ. and subsequently introduced into the cavity organ I1
Industrial applicability
Device according to the invention is applicable everywhere, wherein it is necessary to perform effective examination of parenchymatous organs considering defects damaging parenchyma by fibrotization, tumours, chronic infection, deposition of substances or oedema.

Claims

1. A device for monitoring of structural changes in the parenchyma tissue of various parenchymatous organs (1 ) characterized in that it comprises spectroscope (2) with spectroscopic probe (3), the source (6) of near infrared radiation with connected optical fiber (5), the fiber (5) containing on its other ending the means (8) for directing the light beam and also the means (7, 9) for introducing optical fiber (5) and spectroscopic probe (3) into the examined organ (1 ).
2. The device according to claim 1 characterized in that the optical fiber (5) ending equipped with the means (8) for directing light beam and the end of the spectroscopic probe are mutually positioned in a defined distance.
3. The device according claim 1 or 2 characterized in that the means (8) for light beam directing is a mirror.
4. The device according to any one of the claims 1 to 3 characterized in that the means for introducing the light fiber (5) and spectroscopic probe (3) into the organ is a hollow needle (7).
5. The device according to claim 4 characterized in that the hollow needle (7) comprises a side opening.
6. The device according to any one of the claims 1 to 3 characterized in that the means for introducing light fiber (5) and spectroscopic probe (3) into the organ is a flexible catheter (9).
7. The device according to claim 1 characterized in that the means for introducing light fiber (5) and spectroscopic probe (3) is the flexible endoscope (10), wherein the light fiber (5) passes through the working channel of the endoscope (10) and the spectroscope (2) together with spectroscopic probe (3) is replaced by the endoscope (10) with connected hyperspectral camera (11 ).
8. The device according to claim 1 characterized in that the means for introducing the light fiber (5) and the spectroscopic probe (3) is the flexible endoscope (10), wherein the spectroscope (2) together with spectroscopic probe (3) is replaced by the endoscope (10) with connected hyperspectral camera (11 ) and the light fiber (5) is adapted for attaching externally to the surface of the body.
PCT/CZ2009/000110 2008-09-11 2009-09-11 Device for spectral analysis of parenchyma WO2010028612A1 (en)

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CZPV2008-556 2008-09-11

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US9560953B2 (en) 2010-09-20 2017-02-07 Endochoice, Inc. Operational interface in a multi-viewing element endoscope
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