WO2010027113A3 - Process for preparing (s)-(-)-felodipine - Google Patents

Process for preparing (s)-(-)-felodipine Download PDF

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Publication number
WO2010027113A3
WO2010027113A3 PCT/KR2008/005239 KR2008005239W WO2010027113A3 WO 2010027113 A3 WO2010027113 A3 WO 2010027113A3 KR 2008005239 W KR2008005239 W KR 2008005239W WO 2010027113 A3 WO2010027113 A3 WO 2010027113A3
Authority
WO
WIPO (PCT)
Prior art keywords
felodipine
preparing
glycidol
chiral separation
separation compound
Prior art date
Application number
PCT/KR2008/005239
Other languages
French (fr)
Other versions
WO2010027113A2 (en
Inventor
Jin Auh
Duk Kwon Won
Byung Hyun Moon
O Zoon Kwon
Chang Woo Jong
Kyung Yong Jin
Kyoung Ho Bae
Hee Yoon Lee
Jung Ah Shin
Original Assignee
Ahn-Gook Pharmaceutical Co., Ltd
Korea Advanced Institute Of Science And Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ahn-Gook Pharmaceutical Co., Ltd, Korea Advanced Institute Of Science And Technology filed Critical Ahn-Gook Pharmaceutical Co., Ltd
Priority to PCT/KR2008/005239 priority Critical patent/WO2010027113A2/en
Priority to CN200880130953.2A priority patent/CN102143948B/en
Publication of WO2010027113A2 publication Critical patent/WO2010027113A2/en
Publication of WO2010027113A3 publication Critical patent/WO2010027113A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

The embodiment proposes a method for preparing (S)-(-)- ethyl methyl 4-(2,3-dichlorophenyl)- 1,4-dihydro-2,6-dimethyl-3,5-pyridine- dicarboxylate (hereinafter, referring to as "(S)-(-)-felodipine", and more particularly, a method for effectively preparing the (S)-(-)-felodipine through a selective transesterification of -hydroxy ester after synthesizing a felodipine derivate including a chiral separation compound and isolating (S)-isomers. The chiral separation compound is synthesized from (R)-glycidol or (S)-glycidol through reaction with various nucleophiles and epoxide.
PCT/KR2008/005239 2008-09-04 2008-09-04 Process for preparing (s)-(-)-felodipine WO2010027113A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/KR2008/005239 WO2010027113A2 (en) 2008-09-04 2008-09-04 Process for preparing (s)-(-)-felodipine
CN200880130953.2A CN102143948B (en) 2008-09-04 2008-09-04 Process for preparing (s)-(-)-felodipine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2008/005239 WO2010027113A2 (en) 2008-09-04 2008-09-04 Process for preparing (s)-(-)-felodipine

Publications (2)

Publication Number Publication Date
WO2010027113A2 WO2010027113A2 (en) 2010-03-11
WO2010027113A3 true WO2010027113A3 (en) 2010-07-15

Family

ID=41797605

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/005239 WO2010027113A2 (en) 2008-09-04 2008-09-04 Process for preparing (s)-(-)-felodipine

Country Status (2)

Country Link
CN (1) CN102143948B (en)
WO (1) WO2010027113A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111518024A (en) * 2020-04-26 2020-08-11 山东省药学科学院 Preparation method of two high-purity felodipine impurities

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310917A (en) * 1991-09-13 1994-05-10 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropydrines
US5942624A (en) * 1996-01-10 1999-08-24 Astra Aktiebolag Manufacturing process for felodipine
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
US20040204604A1 (en) * 2003-04-14 2004-10-14 Daqing Che Process to prepare 1,4-dihydropyridine intermediates and derivatives thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310917A (en) * 1991-09-13 1994-05-10 Merck & Co., Inc. Process for the preparation of 4-substituted-1,4-dihydropydrines
US5977369A (en) * 1995-12-28 1999-11-02 Napp Technologies, Inc. Process to prepare dihydropyridine and derivatives thereof
US5942624A (en) * 1996-01-10 1999-08-24 Astra Aktiebolag Manufacturing process for felodipine
US20040204604A1 (en) * 2003-04-14 2004-10-14 Daqing Che Process to prepare 1,4-dihydropyridine intermediates and derivatives thereof

Also Published As

Publication number Publication date
WO2010027113A2 (en) 2010-03-11
CN102143948A (en) 2011-08-03
CN102143948B (en) 2013-07-31

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