WO2010026116A1 - Therapeutic light source - Google Patents
Therapeutic light source Download PDFInfo
- Publication number
- WO2010026116A1 WO2010026116A1 PCT/EP2009/061174 EP2009061174W WO2010026116A1 WO 2010026116 A1 WO2010026116 A1 WO 2010026116A1 EP 2009061174 W EP2009061174 W EP 2009061174W WO 2010026116 A1 WO2010026116 A1 WO 2010026116A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- light source
- laser diodes
- wavelength
- source according
- pulses
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 26
- 239000013307 optical fiber Substances 0.000 claims abstract description 7
- 230000008878 coupling Effects 0.000 claims abstract description 3
- 238000010168 coupling process Methods 0.000 claims abstract description 3
- 238000005859 coupling reaction Methods 0.000 claims abstract description 3
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 238000002428 photodynamic therapy Methods 0.000 description 7
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 6
- 230000005669 field effect Effects 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 6
- 239000003990 capacitor Substances 0.000 description 4
- 239000003504 photosensitizing agent Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000010079 rubber tapping Methods 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 210000004881 tumor cell Anatomy 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/063—Radiation therapy using light comprising light transmitting means, e.g. optical fibres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
- A61N2005/0652—Arrays of diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0659—Radiation therapy using light characterised by the wavelength of light used infrared
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
Definitions
- the present invention relates to a therapeutic light source.
- Photochemotherapy of cancer is often referred to as photodynamic therapy (PDT).
- PDT photodynamic therapy
- a photosensitizing agent is administered to a patient and is preferentially retained in tumour cells.
- the agent is irradiated with visible or near infrared light, the wavelength of which is chosen to match the absorption wavelength of the photosensitizing agent.
- the agent becomes excited and passes its energy to oxygen molecules within the cell to generate singlet oxygen and so cause cell necrosis.
- the present invention seeks to provide an improved therapeutic light source.
- a therapeutic light source comprising at least two laser diodes, means for causing the laser diodes to emit pulses of light substantially simultaneously and having intervals between pulses of less than 1 microsecond and means for coupling light emitted by the laser diodes into an optical fibre.
- the light source can generate short pulses of light at high power which can be particular effective in therapies, such as PDT.
- the therapeutic light source may comprise at least three laser diodes.
- the therapeutic light source may comprise a first laser diode for emitting light at a first wavelength, a second laser diode for emitting light at a second wavelength and a third laser diode for emitting light at a third wavelength, wherein the first, second and third wavelengths are different.
- the therapeutic light source may comprise at least two diodes for emitting light at the first wavelength, at least two diodes for emitting light at the second wavelength; and at least two diodes for emitting light at the third wavelength.
- the first wavelength may be about 635 nm
- the second wavelength may be about 1050 nm
- the third wavelength may be about 1270 nm.
- the laser diodes may be configured to output light having a combined power of at least 500 mW.
- the combined power may be at least 1 W.
- the means for causing the laser diodes to emit pulses of light may comprise means for generating a pulse waveform and means for driving current through the laser diodes, wherein the generating means provides at least one pulse waveform to the current driving means.
- the therapeutic light source may comprises at least two current driving means, each configured to drive a respective laser diode; wherein the generating means provides at least two pulse waveforms.
- the pulse waveform generating means may be a processor and the current driving means comprises an amplifier circuit.
- the current driving means may include a means for switching current on and off and means for regulating current through a laser diode
- the means for causing the laser diodes to emit pulses of light may be configured to cause the laser diodes to emit pulses having intervals between pulses of less than or equal to 100 ns or less than or equal to 10 ns.
- At least two laser diodes a circuit arranged to cause the laser diodes to emit pulses of light substantially simultaneously and having intervals between pulses of less than 1 microsecond and a coupler for channelling light emitted by the laser diodes into an optical fibre.
- the circuit may be programmable.
- Figure 1 is schematic block diagram of a therapeutic light source in accordance with the present invention
- Figure 2 is a timing diagram illustrating simultaneous output of pulsed light from laser diodes
- Figure 3 is a more detailed view of some of the blocks shown in Figure 1 ; and Figure 4 illustrates in more detail a driver circuit shown in Figure 1.
- a light source 1 for use in therapy such as PDT, in accordance with the present invention is shown.
- the power output of the light source 1 can exceed 500 mW and operate in pulse mode producing pulses of light having pulse intervals and/or pulse duration less than 1 microsecond.
- pulses of light at such high power can stimulate singlet oxygen production in tumour cells more efficiently.
- the light source 1 includes a microprocessor 2 which provides a programmable signal generator 3.
- the microprocessor 2 is coupled to circuits 4 (or “drivers") for driving respective semiconductor laser diodes 5.
- the microprocessor 2 and the drivers 4 are supported on a motherboard (not shown).
- the laser diodes 5 There may be two or more laser diodes 5. For example, there may be up to about 20 laser diodes. Some or all of the laser diodes 5 may emit light at the same wavelength. In this and some embodiments of the invention, the laser diodes 5 include at least two sets of laser diodes, preferably three sets of diodes, each set of laser diodes 5 emitting light at a different wavelength. A set of laser diodes 5 may include one or more than one laser diode.
- the laser diodes 5 include a first set of diodes 5j which emit light at a first wavelength X 1 , in this case 635 nm, a second set of laser diodes 5 2 which emit light at a second, different wavelength X 2 (X 2 ⁇ X 1 ), in this example 1050 nm, and a third set of laser diodes 5 3 which emit light at a third, different wavelength ⁇ 3 ( ⁇ 3 ⁇ X 2 ⁇ X 1 ), in this case 1270 nm.
- Suitable laser diodes 5 can be obtained from LDX Optronics, Inc., 1729 Triangle Park Drive, Maryville, TN 37801, USA.
- the laser diodes 5 form part of an optical system 6.
- the laser diodes 5 are attached via respective optical fibres 7 to an optical junction 8 (or "node” or “coupler") which is attached to one end of an optical fibre 9 having a diameter, in this example, of about 200 to 400 ⁇ m.
- the optical junction 8 focuses light into the fibre 9.
- the optical junction 8 includes a dense, polished semicylindrical prism (not shown) and a gradient lens (not shown) which gathers scattered photons and focuses them into the optical fibre 7.
- the light source 1 is housed in a casing (not shown).
- the light source 1 is cheap to produce, compared with conventional dedicated high-power lasers since laser diodes 5 are inexpensive.
- the laser diodes 5 are mounted and rigidly fixed onto the motherboard (not shown) which includes a cooling system (not shown) comprising fans and/or heat sinks.
- the light source 1 also includes a power supply unit 11, control panel 12, display 13 and memory 14.
- control panel 12 and display 13 are combined in the form of a touch screen display.
- the control panel 12 includes actuators, e.g. push buttons, switches or selectable regions on a touch display, for switching power on and off, starting and stopping light output, setting output power, resetting, switching between pulse and continuous modes, setting the duration of flashes and/or pauses and setting the brightness of an aiming beam.
- Power output can be selected, for example, in a range 100 mW to 1 W, in increments of 100 mW. If multiple wavelengths are used, the control panel 12 may include an actuator for switching between wavelengths.
- the display 13 indicates operation and other settings, such as whether power is one or off, output power (W), pulse/continuous mode, indicator 'ready', flash duration (in nanoseconds), duration of pause (in nanoseconds) and flash counter.
- the total output power of the laser diodes is about IW.
- the total power can be lower or higher.
- the light source 1 can be operated in continuous or pulse mode.
- the light source 1 in pulse mode, can generate pulses of light having duration, T w , of the order of 1 or 10 nanoseconds, e.g. about 5 - 10 nanoseconds, and/or separated by intervals, T 1 , of the order of 1 or 10 nanoseconds, e.g. about 5 - 10 nanoseconds.
- T w duration of 1 or 10 nanoseconds
- T 1 intervals of the order of 1 or 10 nanoseconds
- the laser diodes 5 are arranged to emit pulses of light substantially simultaneously. However, the laser diodes 5 can work with a delay.
- microprocessor 2 and drivers 4 can be used instead of a conventional (dedicated) high-frequency driver which is complex and costly. This can help reduce power consumption and heat production.
- the light source 1 can also be used as part of an integrated unit (or "array") (not shown).
- the array (not shown) includes the light source 1 and a fluoroscopy camera (not shown) for monitoring the quantity of singlet oxygen produced during therapy (usually referred to as the "yield of singlet oxygen").
- the life time of singlet oxygen is short and usually lasts no more than 50 nanoseconds.
- circuitry 15 of the light source 1 shown in more detail.
- the microprocessor 2 is operatively connected to the drivers 4 using digital-to- analogue converters (DACs) 16 l 5 16 2 , 16 3 .
- DACs digital-to- analogue converters
- the digital-to-analogue converters 1O 1 , 16 2 , 16 3 may be provided internally by the microprocessor 2 and/or externally as separate units.
- the microprocessor 2 can provide signals to an external digital-to-analogue converter via a bus 17, such as Inter-Integrated Circuit (I2C) bus having serial data (SDA) and serial clock (SCL) lines 17 l 5 17 2 .
- I2C Inter-Integrated Circuit
- SDA serial data
- SCL serial clock
- the microprocessor 2 is provided with RAM 14 ⁇ and with flash memory 14 2 for storing BIOS and control software.
- a foot-operated treadle 18 can also be used to control operation of the light source 1.
- the microprocessor 2 generates a programmable waveform using its internal clock (not shown).
- the driver 4 is configured to drive the laser diode 5 using a constant current source.
- the laser diode 4 is connected in series between positive supply 19 and ground 20 via a Darlington transistor 21, power field-effect transistor 22 and sensing resistance 23.
- a signal from the DAC 16 is fed into a first input 24 of a differential amplifier 25.
- the first input 24 is a non-inverting input.
- the output 26 of the differential amplifier 25 is connected to a first resistor 27 (in this example, R 1 is about 2k ⁇ ) which in turn is connected to the base 28 of the Darlington transistor 21.
- the laser diode 5 is connected between the supply 19 and the collector 29 of the Darlington transistor 21.
- the emitter 30 of the Darlington transistor 21 is connected to the drain 31 of the power field-effect transistor 22.
- the differential amplifier 25 is arranged to provide full gain swing between the supply rails.
- a signal from the DAC 16 provides control (e.g. 'high' and 'low' signal) for switching the diode 5 on and off.
- the differential amplifier 25 provides a high gain signal for switching the Darlington transistor 21 on and off, which in turn switches the laser diode 5 on and off.
- the sensing point 33 is connected to a second resistor 35 (in this example, R 2 is about 10 k ⁇ ) which is connected in series to a first variable resistor 36 (in this example, R ⁇ 1 is about 10 k ⁇ ) which in turn is connected to ground 37 thereby forming a potential divider.
- a tapping point 38 (also often refereed to as a "wiper") of the first variable resistor 36 is connected into a first input 39 of the voltage comparator 32.
- the first input 39 is a non-inverting input.
- a reference voltage is applied to a second input 40 of the voltage comparator 32.
- the output 41 of the voltage comparator 32 is fed back to the first input 39 of the voltage comparator 32 via third resistor 42 (in this example, R 3 is about 1 M ⁇ ).
- the output 41 is also connected to the gate 43 of the power field-effect transistor 22.
- the gate 43 is also connected to positive supply 44 via a fourth resistor 45 (in this example, R 4 is about 4.7k ⁇ ).
- the reference voltage is provided using a positive voltage 46 (e.g. +5V), regulated by a fifth resistor 47 (in this example, R 5 is about 510 ⁇ ) and a Zener diode 48, and set using a sixth resistor 49 (in this example, R 6 is about 10 k ⁇ ), a second variable resistor 50 and first capacitor 51 (in this example, C 1 is about 0.1 ⁇ F).
- the sixth resistor 49 is arranged in series with a parallel arrangement of the second variable resistor 50 (in this example, R ⁇ 2 is about 10 k ⁇ ) and first capacitor 51. However, one terminal 52 of the first capacitor 51 is connected to both an end terminal 53 and a tapping terminal 54 of the second variable resistor 50.
- the sensing node 33 is also connected to a second capacitor 55 (in this example, C 2 is about 0.1 (IF) which is connected to ground 56.
- the sensing node 33 is also connected to a seventh resistor 57 (in this example, R 6 is about 10 k ⁇ ) which is connected to a first end terminal 58 and a tap terminal 59 of a third variable resistor 60 (in this example, R v3 is about 15 k ⁇ ).
- a second end terminal 61 of the third variable resistor 60 is connected to a second input 62 of the differential amplifier 25 and to an eighth resistor 63 (in this example, R 8 is about 10 k ⁇ ) which, in turn, is connected to ground 64.
- the first input 24 of the differential amplifier 25 is connected to the DAC 16 ( Figure 3) and also to a ninth resistor 65 (in this example, R 9 is about 10 k ⁇ ) connected to ground 66.
- the sensing resistance 23 is formed by a parallel arrangement of tenth and eleventh resistors 67, 68 (in this example, R 10 is about 3.9 ⁇ and R n is about 0.56 ⁇ ).
- the differential amplifier 25 is an AD 626 (Analogue Devices)
- the Darlington transistor 21 is a KT 829
- the voltage comparator32 is an LM211 (National Semiconductor)
- the Zener diode is KC 107
- the power field-effect transistor is an IRFZ44N (International Rectifier).
- Other components having similar parameters may be used. Values of resistances and capacitances may vary.
- the driver 4 illustrated in Figure 4 can allow the laser diode 5 to be switched quickly, e.g. having pulse durations and/or pulse widths of the order of 1, 10 or 100 ns, while also delivering high currents, e.g. currents of the order of IA.
- the microcontroller 2 ( Figure 3) can select which drivers 4 to use, thereby selecting wavelength and power.
- the microcontroller 2 supplies the same waveform or synchronised waveforms to the selected drivers 4, thereby allowing high power pulses of light to be generated.
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2009289311A AU2009289311A1 (en) | 2008-09-02 | 2009-08-28 | Therapeutic light source |
CN2009901004464U CN202263304U (en) | 2008-09-02 | 2009-08-28 | Optical therapeutic apparatus |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0815950A GB2463075A (en) | 2008-09-02 | 2008-09-02 | Therapeutic light source |
GB0815950.1 | 2008-09-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010026116A1 true WO2010026116A1 (en) | 2010-03-11 |
Family
ID=39866106
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2009/061174 WO2010026116A1 (en) | 2008-09-02 | 2009-08-28 | Therapeutic light source |
Country Status (4)
Country | Link |
---|---|
CN (1) | CN202263304U (en) |
AU (1) | AU2009289311A1 (en) |
GB (1) | GB2463075A (en) |
WO (1) | WO2010026116A1 (en) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030167080A1 (en) * | 2002-03-04 | 2003-09-04 | Hart Barry Michael | Joint / tissue inflammation therapy and monitoring device(s) JITMon device |
WO2003086215A1 (en) * | 2002-04-11 | 2003-10-23 | Light Bioscience, Inc. | Low intensity light therapy for the manipulation of fibroblast-derived mammalian cells and collagen |
US20060047336A1 (en) * | 2004-08-25 | 2006-03-02 | Gale David C | Stent-catheter assembly with a releasable connection for stent retention |
US20060212025A1 (en) * | 1998-11-30 | 2006-09-21 | Light Bioscience, Llc | Method and apparatus for acne treatment |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5658323A (en) * | 1995-07-12 | 1997-08-19 | Miller; Iain D. | Method and apparatus for dermatology treatment |
US6385221B1 (en) * | 1999-06-25 | 2002-05-07 | Ceramoptec Industries, Inc. | Multiplexed medical diode laser system |
DE10108655A1 (en) * | 2001-02-22 | 2002-09-26 | W & H Dentalwerk Buermoos Ges | Medical laser treatment device |
US20050131499A1 (en) * | 2001-03-02 | 2005-06-16 | Shanks Steven C. | Laser device to treat sympathetic and parasympathetic nervous systems |
US7762965B2 (en) * | 2001-12-10 | 2010-07-27 | Candela Corporation | Method and apparatus for vacuum-assisted light-based treatments of the skin |
EP1627662B1 (en) * | 2004-06-10 | 2011-03-02 | Candela Corporation | Apparatus for vacuum-assisted light-based treatments of the skin |
AU2003292591A1 (en) * | 2003-06-20 | 2005-01-04 | Keio University | Photodynamic therapy apparatus, method for controlling photodynamic therapy apparatus, and photodynamic therapy method |
DE102006019127A1 (en) * | 2006-04-25 | 2007-10-31 | Carl Zeiss Meditec Ag | Multi-wavelength laser system and method for ophthalmic applications |
-
2008
- 2008-09-02 GB GB0815950A patent/GB2463075A/en not_active Withdrawn
-
2009
- 2009-08-28 AU AU2009289311A patent/AU2009289311A1/en not_active Abandoned
- 2009-08-28 CN CN2009901004464U patent/CN202263304U/en not_active Expired - Fee Related
- 2009-08-28 WO PCT/EP2009/061174 patent/WO2010026116A1/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060212025A1 (en) * | 1998-11-30 | 2006-09-21 | Light Bioscience, Llc | Method and apparatus for acne treatment |
US20030167080A1 (en) * | 2002-03-04 | 2003-09-04 | Hart Barry Michael | Joint / tissue inflammation therapy and monitoring device(s) JITMon device |
WO2003086215A1 (en) * | 2002-04-11 | 2003-10-23 | Light Bioscience, Inc. | Low intensity light therapy for the manipulation of fibroblast-derived mammalian cells and collagen |
US20060047336A1 (en) * | 2004-08-25 | 2006-03-02 | Gale David C | Stent-catheter assembly with a releasable connection for stent retention |
Also Published As
Publication number | Publication date |
---|---|
CN202263304U (en) | 2012-06-06 |
AU2009289311A1 (en) | 2010-03-11 |
GB0815950D0 (en) | 2008-10-08 |
GB2463075A (en) | 2010-03-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7957440B2 (en) | Dual pulse-width medical laser | |
US8575840B2 (en) | Light source turn-on/off controller | |
CA1133348A (en) | Device for the local treatment of a patient and more particularly applicable in acupuncture and auriculotherapy | |
US20170070029A1 (en) | Optical pulse emitter | |
US20070106347A1 (en) | Portable medical and cosmetic photon emission adjustment device and method using the same | |
US8970125B2 (en) | UV irradiation apparatus | |
US20140214136A1 (en) | Pulse Width Modulation Control for Battery-Powered Laser Device | |
US20140314112A1 (en) | Bias Current Control Of Laser Diode Instrument To Reduce Power Consumption Of The Instrument | |
EP2556723B1 (en) | Driver system for driving a plurality of leds | |
JP2007042731A (en) | Pulse power supply device | |
US9282620B2 (en) | Apparatus and method for generating constant current pulse wave, medical operation method using same, and light generating apparatus | |
US20230134679A1 (en) | Managing optical power in laser system | |
ATE536804T1 (en) | HIGH VOLTAGE GENERATING CIRCUIT, PUNCTURE DEVICE AND BLOOD TEST DEVICE | |
WO2010026116A1 (en) | Therapeutic light source | |
JP2014531755A (en) | LED driver | |
JP2013530763A (en) | Spectral sweep type photocrosslinking device | |
US20220273399A1 (en) | Systems combining therapeutic lasers and curing lights | |
KR101510846B1 (en) | Apparatus for controling consumption of electrical power and method for controling the same | |
RU2687568C1 (en) | Universal laser diode medical device | |
KR200225764Y1 (en) | Integrated therapeutic device using a visible light and ultrasound | |
KR200302173Y1 (en) | Electric matt using low power laser diodes with reliable and stable laser beam | |
WO2008105093A1 (en) | Toning circuit for liquid crystal back light | |
JPH09225049A (en) | Phototherapeutic apparatus with low-frequency therapy | |
JPH11151307A (en) | Laser therapy device | |
CN216291510U (en) | Pulse steady-state semiconductor light source |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200990100446.4 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 09782365 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 592004 Country of ref document: NZ Ref document number: 2009289311 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2009289311 Country of ref document: AU Date of ref document: 20090828 Kind code of ref document: A |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 09782365 Country of ref document: EP Kind code of ref document: A1 |