WO2009110858A3 - Vasodilator eluting dynamic blood handling devices with a specific polyphosphazene coating and methods for their manufacture and use - Google Patents

Vasodilator eluting dynamic blood handling devices with a specific polyphosphazene coating and methods for their manufacture and use Download PDF

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Publication number
WO2009110858A3
WO2009110858A3 PCT/US2007/083192 US2007083192W WO2009110858A3 WO 2009110858 A3 WO2009110858 A3 WO 2009110858A3 US 2007083192 W US2007083192 W US 2007083192W WO 2009110858 A3 WO2009110858 A3 WO 2009110858A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood
present
products
devices
reduce
Prior art date
Application number
PCT/US2007/083192
Other languages
French (fr)
Other versions
WO2009110858A2 (en
Inventor
Olaf Fritz
Ulf Fritz
Roman Denk
Teresa Wilson
Ralph E. Gaskins
Original Assignee
Celonova Biosciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celonova Biosciences, Inc. filed Critical Celonova Biosciences, Inc.
Priority to EP07875263A priority Critical patent/EP2219701A2/en
Priority to PCT/US2007/083192 priority patent/WO2009110858A2/en
Publication of WO2009110858A2 publication Critical patent/WO2009110858A2/en
Publication of WO2009110858A3 publication Critical patent/WO2009110858A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials

Abstract

The present invention is directed to medical devices in which flow is channeled of blood and blood products for the purpose of effecting a chemical exchange to remove desired chemicals from the blood or blood products, and to impart nitric oxide, other smooth muscle relaxant compounds, or other desired chemicals to the blood or blood products to achieve vascular dilatation, reduce adverse reactions, reduce thrombosis, reduce red blood cell injuries, and improve blood handling capabilities. In the present invention, such chemical exchanges occur over semipermeable membranes associated with channeled flow of blood and blood products. Various embodiments of the present invention thus apply to the clinical settings for filters, cannulae, tubing, and blood handling components for dynamic blood handling, filtering, and processing devices including, but not limited to, cardiopulmonary bypass pumps, left ventricular assist devices, artificial hearts, ECMO devices, renal or hepatic hemodialysis systems, and hemofiltration systems.
PCT/US2007/083192 2007-10-31 2007-10-31 Vasodilator eluting dynamic blood handling devices with a specific polyphosphazene coating and methods for their manufacture and use WO2009110858A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07875263A EP2219701A2 (en) 2007-10-31 2007-10-31 Vasodilator eluting dynamic blood handling devices with a specific polyphosphazene coating and methods for their manufacture and use
PCT/US2007/083192 WO2009110858A2 (en) 2007-10-31 2007-10-31 Vasodilator eluting dynamic blood handling devices with a specific polyphosphazene coating and methods for their manufacture and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/083192 WO2009110858A2 (en) 2007-10-31 2007-10-31 Vasodilator eluting dynamic blood handling devices with a specific polyphosphazene coating and methods for their manufacture and use

Publications (2)

Publication Number Publication Date
WO2009110858A2 WO2009110858A2 (en) 2009-09-11
WO2009110858A3 true WO2009110858A3 (en) 2009-10-29

Family

ID=40937597

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/083192 WO2009110858A2 (en) 2007-10-31 2007-10-31 Vasodilator eluting dynamic blood handling devices with a specific polyphosphazene coating and methods for their manufacture and use

Country Status (2)

Country Link
EP (1) EP2219701A2 (en)
WO (1) WO2009110858A2 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035660A1 (en) * 1996-03-23 1997-10-02 White Eagle International Technologies Group, Inc. Sorbents for removing toxicants from blood or plasma, and method of producing same
WO2001070296A1 (en) * 2000-03-18 2001-09-27 Polyzenix Gmbh Polyphosphazene derivatives
US20030157142A1 (en) * 2000-08-11 2003-08-21 Stefan Nagel Implants with a phosphazene-containing coating
WO2004060283A2 (en) * 2002-12-16 2004-07-22 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
US20050025799A1 (en) * 2003-07-30 2005-02-03 Hossainy Syed F. A. Biologically absorbable coatings for implantable devices and methods for fabricating the same
US20050136093A1 (en) * 2002-07-05 2005-06-23 Polyzenix Gmbh Implant for transport and release for pharmacologically active agents as well as a process for producing the same
US20060246109A1 (en) * 2005-04-29 2006-11-02 Hossainy Syed F Concentration gradient profiles for control of agent release rates from polymer matrices

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997035660A1 (en) * 1996-03-23 1997-10-02 White Eagle International Technologies Group, Inc. Sorbents for removing toxicants from blood or plasma, and method of producing same
WO2001070296A1 (en) * 2000-03-18 2001-09-27 Polyzenix Gmbh Polyphosphazene derivatives
US20030157142A1 (en) * 2000-08-11 2003-08-21 Stefan Nagel Implants with a phosphazene-containing coating
US20050136093A1 (en) * 2002-07-05 2005-06-23 Polyzenix Gmbh Implant for transport and release for pharmacologically active agents as well as a process for producing the same
WO2004060283A2 (en) * 2002-12-16 2004-07-22 Nitromed, Inc. Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
US20050025799A1 (en) * 2003-07-30 2005-02-03 Hossainy Syed F. A. Biologically absorbable coatings for implantable devices and methods for fabricating the same
US20060246109A1 (en) * 2005-04-29 2006-11-02 Hossainy Syed F Concentration gradient profiles for control of agent release rates from polymer matrices

Also Published As

Publication number Publication date
EP2219701A2 (en) 2010-08-25
WO2009110858A2 (en) 2009-09-11

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