WO2009108760A3 - Dendritic macroporous hydrogels prepared by crystal templating - Google Patents
Dendritic macroporous hydrogels prepared by crystal templating Download PDFInfo
- Publication number
- WO2009108760A3 WO2009108760A3 PCT/US2009/035257 US2009035257W WO2009108760A3 WO 2009108760 A3 WO2009108760 A3 WO 2009108760A3 US 2009035257 W US2009035257 W US 2009035257W WO 2009108760 A3 WO2009108760 A3 WO 2009108760A3
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- WIPO (PCT)
- Prior art keywords
- polymer
- mixture
- hydrogel
- crystal structure
- hydrogels prepared
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/26—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0095—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J13/0052—Preparation of gels
- B01J13/0065—Preparation of gels containing an organic phase
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- C—CHEMISTRY; METALLURGY
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- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
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- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
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Abstract
The present invention includes a hydrogel and a method of making a porous hydrogel by preparing an aqueous mixture of an uncrosslinked polymer and a crystallizable molecule; casting the mixture into a vessel; allowing the cast mixture to dry to form an amorphous hydrogel film; seeding the cast mixture with a seed crystal of the crystallizable molecule; growing the crystallizable molecule into a crystal structure within the uncrosslinked polymer; crosslinking the polymer around the crystal structure under conditions in which the crystal structure within the crosslinked polymer is maintained; and dissolving the crystals within the crosslinked polymer to form the porous hydrogel.
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/919,667 US8668863B2 (en) | 2008-02-26 | 2009-02-26 | Dendritic macroporous hydrogels prepared by crystal templating |
US13/909,707 US8728499B2 (en) | 2008-02-26 | 2013-06-04 | Dendritic macroporous hydrogels prepared by crystal templating |
US14/277,170 US9320827B2 (en) | 2008-02-26 | 2014-05-14 | Dendritic macroporous hydrogels prepared by crystal templating |
US15/135,978 US9896561B2 (en) | 2008-02-26 | 2016-04-22 | Dendritic macroporous hydrogels prepared by crystal templating |
US15/890,719 US10442911B2 (en) | 2008-02-26 | 2018-02-07 | Dendritic macroporous hydrogels prepared by crystal templating |
US16/597,106 US10982068B2 (en) | 2008-02-26 | 2019-10-09 | Dendritic macroporous hydrogels prepared by crystal templating |
US17/231,653 US11760858B2 (en) | 2008-02-26 | 2021-04-15 | Dendritic macroporous hydrogels prepared by crystal templating |
US18/361,981 US20230383086A1 (en) | 2008-02-26 | 2023-07-31 | Dendritic Macroporous Hydrogels Prepared By Crystal Templating |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3165108P | 2008-02-26 | 2008-02-26 | |
US61/031,651 | 2008-02-26 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/919,667 A-371-Of-International US8668863B2 (en) | 2008-02-26 | 2009-02-26 | Dendritic macroporous hydrogels prepared by crystal templating |
US13/909,707 Continuation US8728499B2 (en) | 2008-02-26 | 2013-06-04 | Dendritic macroporous hydrogels prepared by crystal templating |
Publications (3)
Publication Number | Publication Date |
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WO2009108760A2 WO2009108760A2 (en) | 2009-09-03 |
WO2009108760A3 true WO2009108760A3 (en) | 2009-12-10 |
WO2009108760A8 WO2009108760A8 (en) | 2010-02-04 |
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Application Number | Title | Priority Date | Filing Date |
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PCT/US2009/035257 WO2009108760A2 (en) | 2008-02-26 | 2009-02-26 | Dendritic macroporous hydrogels prepared by crystal templating |
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US (8) | US8668863B2 (en) |
WO (1) | WO2009108760A2 (en) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
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KR101443926B1 (en) | 2006-06-15 | 2014-10-02 | 마이크로벤션, 인코포레이티드 | Embolization device constructed from expansible polymer |
EP2231215B1 (en) | 2007-12-21 | 2019-01-30 | MicroVention, Inc. | Hydrogel filaments for biomedical uses |
US8668863B2 (en) | 2008-02-26 | 2014-03-11 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
US9993252B2 (en) | 2009-10-26 | 2018-06-12 | Microvention, Inc. | Embolization device constructed from expansile polymer |
WO2012048283A1 (en) * | 2010-10-08 | 2012-04-12 | Board Of Regents, The University Of Texas System | One-step processing of hydrogels for mechanically robust and chemically desired features |
EP2624874A4 (en) | 2010-10-08 | 2014-04-02 | Univ Texas | Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications |
WO2012145431A2 (en) | 2011-04-18 | 2012-10-26 | Microvention, Inc. | Embolic devices |
WO2013158781A1 (en) | 2012-04-18 | 2013-10-24 | Microvention, Inc. | Embolic devices |
EP3984556A1 (en) | 2012-06-14 | 2022-04-20 | Microvention, Inc. | Polymeric treatment compositions |
CN104717983B (en) | 2012-10-15 | 2018-09-18 | 微仙美国有限公司 | It polymerize therapeutic combination |
US11565027B2 (en) | 2012-12-11 | 2023-01-31 | Board Of Regents, The University Of Texas System | Hydrogel membrane for adhesion prevention |
US9662424B2 (en) | 2012-12-11 | 2017-05-30 | Board Of Regents, The University Of Texas System | Hydrogel membrane for adhesion prevention |
TWI485189B (en) | 2012-12-28 | 2015-05-21 | Ind Tech Res Inst | Solid form and method for preparing the same |
US10124090B2 (en) | 2014-04-03 | 2018-11-13 | Terumo Corporation | Embolic devices |
US10092663B2 (en) | 2014-04-29 | 2018-10-09 | Terumo Corporation | Polymers |
WO2015167752A1 (en) | 2014-04-29 | 2015-11-05 | Microvention, Inc. | Polymers including active agents |
WO2016201250A1 (en) | 2015-06-11 | 2016-12-15 | Microvention, Inc. | Expansile device for implantation |
US10624987B2 (en) | 2015-09-03 | 2020-04-21 | The Texas A&M University System | Implant-based repair of osteochondral defects |
EP3362266B1 (en) | 2015-10-15 | 2021-09-01 | The Regents of the University of California | Apparatus and method for cryogenic 3d printing |
US10449272B2 (en) | 2015-10-16 | 2019-10-22 | Industrial Technology Research Institute | Hydrogel composition and method for using the same |
EP3181700A1 (en) * | 2015-12-18 | 2017-06-21 | Safeguard Biosystems Holdings Ltd. | Three-dimensional polymer networks with channels situated therein |
US10368874B2 (en) | 2016-08-26 | 2019-08-06 | Microvention, Inc. | Embolic compositions |
WO2018073235A1 (en) * | 2016-10-18 | 2018-04-26 | Aarhus Universitet | Printed hyaluronic acid scaffolds |
US20200054875A1 (en) | 2017-02-13 | 2020-02-20 | University Of Florida Research Foundation, Incorporated | Sharklet topographies to control neutral cell interactions with implanted electrodes |
US11376005B2 (en) | 2017-05-24 | 2022-07-05 | University Of Florida Research Foundation, Incorporated | Tissue-engineered electronic peripheral nerve interface |
EP3418741A1 (en) * | 2017-06-19 | 2018-12-26 | Safeguard Biosystems Holdings Ltd. | Three-dimensional polymer networks and their use |
CN108187130B (en) * | 2017-09-15 | 2020-08-18 | 海宁侏罗纪生物科技有限公司 | Reagent for repairing biological injury or stopping bleeding and application thereof |
CN111200976B (en) | 2017-10-09 | 2023-07-07 | 微仙美国有限公司 | Radioactive liquid embolism |
WO2020051133A1 (en) * | 2018-09-04 | 2020-03-12 | Massachusetts Eye And Ear Infirmary | Light activated adhesive scaffold |
WO2020051920A1 (en) * | 2018-09-15 | 2020-03-19 | 深圳先进技术研究院 | Controlled bidirectional three-dimensional deformation hydrogel thin film, preparation method therefor, and flexible microelectrode array |
CN109294002B (en) * | 2018-09-15 | 2021-05-04 | 深圳先进技术研究院 | Controllable bidirectional three-dimensional deformation hydrogel film, preparation method thereof and flexible microelectrode array |
CN110698701B (en) * | 2019-11-04 | 2023-01-13 | 武汉轻工大学 | Low-temperature induced collagen self-assembly gel and preparation method thereof |
WO2022149070A1 (en) | 2021-01-05 | 2022-07-14 | C-Care, Llc | Unit dose article for adding a cosmetic function to a cosmetic base product |
CN113788971A (en) * | 2021-10-22 | 2021-12-14 | 华东理工大学 | Deproteinized natural rubber/chitosan composite membrane and preparation method thereof |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991004732A1 (en) * | 1989-10-03 | 1991-04-18 | Advanced Polymer Systems, Inc. | Erodible macroporous hydrogel particles and preparation thereof |
US6414043B1 (en) * | 1998-06-26 | 2002-07-02 | University Of Pittsburgh | Hydrogel materials with crystalline colloidal array of watervoids for detection and macromolecule separations |
US6608117B1 (en) * | 2001-05-11 | 2003-08-19 | Nanosystems Research Inc. | Methods for the preparation of cellular hydrogels |
US6653420B2 (en) * | 2000-01-05 | 2003-11-25 | Novartis Ag | Porous hydrogels |
WO2005020849A2 (en) * | 2003-08-29 | 2005-03-10 | Mayo Foundation For Medical Education And Research | Hydrogel porogens for fabricating biodegradable scaffolds |
Family Cites Families (176)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2008026A (en) | 1933-10-06 | 1935-07-16 | B F Gladding & Co Inc | Package for fishing lines and the like |
US4141973A (en) | 1975-10-17 | 1979-02-27 | Biotrics, Inc. | Ultrapure hyaluronic acid and the use thereof |
US4196070A (en) * | 1977-12-12 | 1980-04-01 | Nuclepore Corporation | Method for forming microporous fluorocarbon polymer sheet and product |
US4818542A (en) | 1983-11-14 | 1989-04-04 | The University Of Kentucky Research Foundation | Porous microspheres for drug delivery and methods for making same |
JPS61468A (en) | 1984-06-14 | 1986-01-06 | Fuji Electric Co Ltd | Intermittent charge controlling system of electric precipitator |
JPH06100468B2 (en) | 1986-05-13 | 1994-12-12 | 大成建設株式会社 | Measuring method of oblique hole displacement |
US5017229A (en) | 1990-06-25 | 1991-05-21 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
US6235726B1 (en) | 1987-09-18 | 2001-05-22 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
US6174999B1 (en) | 1987-09-18 | 2001-01-16 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
US6030958A (en) | 1987-09-18 | 2000-02-29 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
US4937270A (en) | 1987-09-18 | 1990-06-26 | Genzyme Corporation | Water insoluble derivatives of hyaluronic acid |
US6610669B1 (en) | 1987-09-18 | 2003-08-26 | Genzyme Corporation | Water insoluble derivatives of polyanionic polysaccharides |
IT1248666B (en) | 1990-05-30 | 1995-01-26 | Fidia Spa | GEL IN THE FORM OF HIGHLY HYDRATED SELF-SUPPORTING FILMS, PROCESS FOR THEIR PREPARATION AND USE IN THE THERAPY OF INJURIES AND / OR SKIN PATHOLOGIES |
US5563188A (en) | 1990-06-05 | 1996-10-08 | Stankiewicz Gmbh | Impact resistant coating composition |
JPH04236124A (en) | 1991-01-11 | 1992-08-25 | Meidensha Corp | Method for detecting small ground fault of high-voltage distribution line |
US5443459A (en) | 1991-01-30 | 1995-08-22 | Alza Corporation | Osmotic device for delayed delivery of agent |
GR920100122A (en) | 1991-04-05 | 1993-03-16 | Ethicon Inc | Ionically crosslinked carboxyl-containing polysaccharides for adhension prevention. |
US5605938A (en) | 1991-05-31 | 1997-02-25 | Gliatech, Inc. | Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate |
CA2120230A1 (en) * | 1991-10-15 | 1993-04-29 | Donald W. Renn | .beta.-1,3-glucan polysaccharides, compositions, and their preparation and uses |
AU662357B2 (en) | 1991-10-18 | 1995-08-31 | Ethicon Inc. | Adhesion barrier applicator |
IT1254170B (en) | 1991-12-18 | 1995-09-11 | Mini Ricerca Scient Tecnolog | COMPOSITE MEMBRANES FOR GUIDED REGENERATION OF FABRICS |
US7968110B2 (en) | 1992-02-11 | 2011-06-28 | Merz Aesthetics, Inc. | Tissue augmentation material and method |
US7060287B1 (en) | 1992-02-11 | 2006-06-13 | Bioform Inc. | Tissue augmentation material and method |
US5312333A (en) | 1992-04-03 | 1994-05-17 | United States Surgical Corporation | Endoscopic material delivery device |
US20040138329A1 (en) | 1992-04-20 | 2004-07-15 | Board Of Regents Of The University Of Texas System | Gels for encapsulation of biological materials |
US5266326A (en) | 1992-06-30 | 1993-11-30 | Pfizer Hospital Products Group, Inc. | In situ modification of alginate |
JPH06100468A (en) | 1992-09-25 | 1994-04-12 | Kibun Food Chemifa Co Ltd | Sustained release composition |
CA2114290C (en) | 1993-01-27 | 2006-01-10 | Nagabushanam Totakura | Post-surgical anti-adhesion device |
US5531716A (en) | 1993-09-29 | 1996-07-02 | Hercules Incorporated | Medical devices subject to triggered disintegration |
PL181064B1 (en) | 1994-03-07 | 2001-05-31 | Dendritech Inc | Biologically active and/or oriented conjugates of dendrimers |
US5981825A (en) | 1994-05-13 | 1999-11-09 | Thm Biomedical, Inc. | Device and methods for in vivo culturing of diverse tissue cells |
GB9413931D0 (en) | 1994-07-11 | 1994-08-31 | C V Lab Ltd | Alginate fabric, method of preparation and use |
GB9414304D0 (en) | 1994-07-15 | 1994-09-07 | C V Lab Ltd | Fibres, manufacture and use |
US5834029A (en) | 1994-07-20 | 1998-11-10 | Cytotherapeutics, Inc. | Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment |
US5531735A (en) | 1994-09-27 | 1996-07-02 | Hercules Incorporated | Medical devices containing triggerable disintegration agents |
JP2891640B2 (en) | 1994-09-30 | 1999-05-17 | ナショナル住宅産業株式会社 | Panel opening connection structure |
US6294202B1 (en) | 1994-10-06 | 2001-09-25 | Genzyme Corporation | Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers |
US5563186A (en) | 1994-11-21 | 1996-10-08 | Thompson; Ronald G. | Crosslinked alginate-based gels for matrix conformance |
US20020131933A1 (en) | 1996-01-16 | 2002-09-19 | Yves Delmotte | Biopolymer membrane and methods for its preparation |
US5750585A (en) | 1995-04-04 | 1998-05-12 | Purdue Research Foundation | Super absorbent hydrogel foams |
US6150581A (en) | 1995-06-07 | 2000-11-21 | United States Surgical Corporation | Chitosan/alginate anti-adhesion barrier |
WO1996041818A1 (en) | 1995-06-09 | 1996-12-27 | Drohan William N | Chitin hydrogels, methods of their production and use |
EP0844891A4 (en) | 1995-08-11 | 2004-05-06 | Dow Chemical Co | Hyper comb-branched polymer conjugates |
NZ316944A (en) | 1995-08-29 | 1999-08-30 | Fidia Advanced Biopolymers Srl | Composite biomaterial for preventing surgical adhesions of tissue containing hyaluronic acid derivative |
US5855613A (en) | 1995-10-13 | 1999-01-05 | Islet Sheet Medical, Inc. | Retrievable bioartificial implants having dimensions allowing rapid diffusion of oxygen and rapid biological response to physiological change |
US5684051A (en) | 1996-04-24 | 1997-11-04 | Hercules Incorporated | Medical devices with improved elastic response |
IL118376A0 (en) | 1996-05-22 | 1996-09-12 | Univ Ben Gurion | Polysaccharide sponges for cell culture and transplantation |
WO1997045532A1 (en) | 1996-05-28 | 1997-12-04 | Brown University Research Foundation | Hyaluronan based biodegradable scaffolds for tissue repair |
US6500777B1 (en) | 1996-06-28 | 2002-12-31 | Ethicon, Inc. | Bioresorbable oxidized cellulose composite material for prevention of postsurgical adhesions |
US6060534A (en) | 1996-07-11 | 2000-05-09 | Scimed Life Systems, Inc. | Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties |
US6368356B1 (en) | 1996-07-11 | 2002-04-09 | Scimed Life Systems, Inc. | Medical devices comprising hydrogel polymers having improved mechanical properties |
US5866554A (en) | 1996-07-19 | 1999-02-02 | Shalaby; Shalaby W. | Compositions for prevention of inflammation and adhesion formation and uses thereof |
DE69739085D1 (en) | 1996-09-19 | 2008-12-18 | Univ Michigan | POLYMERS CONTAIN POLYSACCHARIDES SUCH AS ALGINATES OR MODIFIED ALGINATES |
EP1806367A3 (en) | 1996-09-19 | 2007-11-28 | The Regents Of The University Of Michigan | Polymers containing polysaccharides such as alginates or modified alginates |
US7009034B2 (en) | 1996-09-23 | 2006-03-07 | Incept, Llc | Biocompatible crosslinked polymers |
US5863551A (en) | 1996-10-16 | 1999-01-26 | Organogel Canada Ltee | Implantable polymer hydrogel for therapeutic uses |
US5993661A (en) * | 1997-04-14 | 1999-11-30 | The Research Foundation Of State University Of New York | Macroporous or microporous filtration membrane, method of preparation and use |
US5984948A (en) | 1997-04-14 | 1999-11-16 | Hasson; Harrith M. | Device for closing an opening in tissue and method of closing a tissue opening using the device |
US6271278B1 (en) | 1997-05-13 | 2001-08-07 | Purdue Research Foundation | Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties |
US6869938B1 (en) | 1997-06-17 | 2005-03-22 | Fziomed, Inc. | Compositions of polyacids and polyethers and methods for their use in reducing adhesions |
US5906997A (en) | 1997-06-17 | 1999-05-25 | Fzio Med, Inc. | Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions |
US6184206B1 (en) | 1997-09-03 | 2001-02-06 | The Burnham Institute | Integrin ligand dissociators |
US6236726B1 (en) | 1998-02-27 | 2001-05-22 | Nortel Networks Limited | Transmit power scaling for far-end crosstalk reduction |
US6410044B1 (en) | 1998-03-19 | 2002-06-25 | Surmodics, Inc. | Crosslinkable macromers |
US6007833A (en) | 1998-03-19 | 1999-12-28 | Surmodics, Inc. | Crosslinkable macromers bearing initiator groups |
DE19825884A1 (en) | 1998-06-10 | 1999-12-16 | Hilti Ag | Undercut dowels |
US6514534B1 (en) | 1998-08-14 | 2003-02-04 | Incept Llc | Methods for forming regional tissue adherent barriers and drug delivery systems |
US7347850B2 (en) | 1998-08-14 | 2008-03-25 | Incept Llc | Adhesion barriers applicable by minimally invasive surgery and methods of use thereof |
DE69943297D1 (en) | 1998-08-14 | 2011-05-05 | Incept Llc | APPARATUS FOR IN-SITU-EDUCATION OF HYDROGELS |
US6818018B1 (en) | 1998-08-14 | 2004-11-16 | Incept Llc | In situ polymerizable hydrogels |
US6630457B1 (en) | 1998-09-18 | 2003-10-07 | Orthogene Llc | Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same |
US6841153B1 (en) | 1998-10-02 | 2005-01-11 | University Of Florida | Prevention of adhesions |
EP1022031B1 (en) | 1999-01-21 | 2005-03-23 | Nipro Corporation | Suturable adhesion-preventing membrane |
EP1146861B1 (en) | 1999-02-03 | 2005-06-29 | PowderJect Research Limited | Hydrogel particle formulations |
DE19909214A1 (en) | 1999-03-03 | 2000-09-07 | Basf Ag | Water-absorbent, foam-like, crosslinked polymers with improved distribution effect, process for their preparation and their use |
US6869936B1 (en) | 1999-03-04 | 2005-03-22 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
US6767928B1 (en) | 1999-03-19 | 2004-07-27 | The Regents Of The University Of Michigan | Mineralization and biological modification of biomaterial surfaces |
CA2364570A1 (en) | 1999-04-09 | 2000-10-19 | The Regents Of The University Of Michigan | Preparing porous hydrogel products |
DE60014400T2 (en) | 1999-07-28 | 2005-10-06 | United States Surgical Corp., Norwalk | ANTI-ADHESION LAYER OF HYALURONIC ACID |
US6566345B2 (en) | 2000-04-28 | 2003-05-20 | Fziomed, Inc. | Polyacid/polyalkylene oxide foams and gels and methods for their delivery |
JP2001212224A (en) | 2000-02-04 | 2001-08-07 | Toyobo Co Ltd | Wound coating material |
US6521223B1 (en) | 2000-02-14 | 2003-02-18 | Genzyme Corporation | Single phase gels for the prevention of adhesions |
US6638917B1 (en) | 2000-02-25 | 2003-10-28 | Scimed Life Systems, Inc. | Reducing adhesion |
JP2001259212A (en) | 2000-03-15 | 2001-09-25 | Sankyo Kk | Apparatus for game |
JP2001269212A (en) | 2000-03-24 | 2001-10-02 | Chikuma & Co Ltd | Satchel |
US6991652B2 (en) | 2000-06-13 | 2006-01-31 | Burg Karen J L | Tissue engineering composite |
WO2002009792A1 (en) | 2000-07-28 | 2002-02-07 | Anika Therapeutics, Inc. | Bioabsorbable composites of derivatized hyaluronic acid |
US6599526B2 (en) | 2000-08-18 | 2003-07-29 | The University Of North Texas Health Science Center At Fort Worth | Pericardial anti-adhesion patch |
KR100451910B1 (en) | 2000-10-05 | 2004-10-08 | 주식회사 바이오폴리테크 | A water soluble and biodegradable polymer gel, and a process of preparing for the same |
JP3418373B2 (en) | 2000-10-24 | 2003-06-23 | エヌ・アール・エス・テクノロジー株式会社 | Surface acoustic wave device and method of manufacturing the same |
US6660225B2 (en) | 2000-12-11 | 2003-12-09 | Advanced Materials Technologies Pte, Ltd. | Method to form multi-material components |
US6653240B2 (en) | 2001-01-12 | 2003-11-25 | International Business Machines Corporation | FIB/RIE method for in-line circuit modification of microelectronic chips containing organic dielectric |
GB0103330D0 (en) | 2001-02-10 | 2001-03-28 | Surgical Innovations Ltd | Laparoscopic gel applicator |
US6878384B2 (en) * | 2001-03-13 | 2005-04-12 | Microvention, Inc. | Hydrogels that undergo volumetric expansion in response to changes in their environment and their methods of manufacture and use |
US6913765B2 (en) | 2001-03-21 | 2005-07-05 | Scimed Life Systems, Inc. | Controlling resorption of bioresorbable medical implant material |
US7615593B2 (en) | 2001-04-23 | 2009-11-10 | Wisconsin Alumni Research Foundation | Bifunctional-modified hydrogels |
DE10123604A1 (en) | 2001-05-16 | 2002-11-21 | Solvay Fluor & Derivate | Non-flammable premix for the production of polyurethane foam products comprises binary propellant mixture and phosphorous compound |
US7201917B2 (en) | 2001-07-16 | 2007-04-10 | Depuy Products, Inc. | Porous delivery scaffold and method |
JP3805654B2 (en) | 2001-08-29 | 2006-08-02 | 株式会社ネクスト | Fine particles of biopolymers that prevent hemostasis and adhesion |
US6600011B2 (en) | 2001-10-09 | 2003-07-29 | Genzyme Corporation | Process for purification and drying of polymer hydrogels |
US7347988B2 (en) | 2001-11-15 | 2008-03-25 | University Of North Texas | Synthesis, uses and compositions of crystal hydrogels |
US7629388B2 (en) | 2001-11-20 | 2009-12-08 | William Marsh Rice University | Synthesis and characterization of biodegradable cationic poly(propylene fumarate-co-ethylene glycol) copolymer hydrogels modified with agmatine for enhanced cell adhesion |
KR20020011955A (en) | 2001-12-26 | 2002-02-09 | 김정식 | A conglutination inhibitor |
AR038269A1 (en) | 2002-01-09 | 2005-01-12 | Novartis Ag | POLYMERIC ITEMS THAT HAVE A LUBRIC COATING, AND METHOD FOR MANUFACTURING THEM |
US7235296B2 (en) | 2002-03-05 | 2007-06-26 | 3M Innovative Properties Co. | Formulations for coated diamond abrasive slurries |
US6991852B2 (en) | 2002-03-13 | 2006-01-31 | Regents Of The University Of Minnesota | Silica-based materials and methods |
US20050107868A1 (en) | 2002-03-28 | 2005-05-19 | JAPAN as represented by President of NATIONAL & CARDIOVASCULAR CENTER | Scaffold for tissue engineering, artificial blood vessel, cuff, and biological implant covering member |
WO2003089506A1 (en) | 2002-04-22 | 2003-10-30 | Purdue Research Foundation | Hydrogels having enhanced elasticity and mechanical strength properties |
DE10223310A1 (en) * | 2002-05-24 | 2003-12-11 | Biotronik Mess & Therapieg | Process for coating implants with a polysaccharide layer |
US7572894B2 (en) | 2002-11-01 | 2009-08-11 | Trustees Of Tufts College | Templated native silk smectic gels |
WO2004044281A2 (en) * | 2002-11-12 | 2004-05-27 | The Regents Of The University Of California | Nano-porous fibers and protein membranes |
US7083697B2 (en) | 2002-12-30 | 2006-08-01 | Boston Scientific Scimed, Inc. | Porous spun polymeric structures and method of making same |
FR2850380B1 (en) | 2003-01-23 | 2006-07-07 | Sanofi Synthelabo | ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THERAPEUTICS |
FR2861734B1 (en) | 2003-04-10 | 2006-04-14 | Corneal Ind | CROSSLINKING OF LOW AND HIGH MOLECULAR MASS POLYSACCHARIDES; PREPARATION OF INJECTABLE SINGLE PHASE HYDROGELS; POLYSACCHARIDES AND HYDROGELS OBTAINED |
CN101137388A (en) | 2003-05-15 | 2008-03-05 | 犹他卅大学研究基金会 | Anti-adhesion composites and methods os use thereof |
SE0301592D0 (en) | 2003-05-28 | 2003-05-28 | Amersham Biosciences Ab | Electrophoretic support |
US20080264793A1 (en) | 2003-08-15 | 2008-10-30 | Gyula Vigh | Hydrolytically Stable Isoelectric Hydrogel Compositions |
AU2004269196B2 (en) | 2003-09-03 | 2010-03-04 | Shmuel Bukshpan | Methods and apparatus for rapid crystallization of biomolecules |
US7235295B2 (en) | 2003-09-10 | 2007-06-26 | Laurencin Cato T | Polymeric nanofibers for tissue engineering and drug delivery |
US20130211320A1 (en) | 2003-10-07 | 2013-08-15 | Nawar Alkhamesi | System and method for delivering an anti-adhesive substance to a body cavity |
WO2005061014A1 (en) | 2003-12-19 | 2005-07-07 | Basf Aktiengesellschaft | Swellable hydrogel-forming polymers having a low fine dust concentration |
WO2005077013A2 (en) | 2004-02-06 | 2005-08-25 | Georgia Tech Research Corporation | Surface directed cellular attachment |
CA2559520A1 (en) | 2004-03-17 | 2005-09-29 | Genzyme Corporation | Anti-adhesion spraying |
BRPI0510042B8 (en) | 2004-04-20 | 2021-06-22 | Genzyme Corp | implant similar to surgical mesh |
US7855074B2 (en) * | 2004-04-28 | 2010-12-21 | Vaxdesign Corp. | Artificial immune system: methods for making and use |
US8030070B2 (en) * | 2004-04-28 | 2011-10-04 | Sanofi Pasteur Vaxdesign Corp. | Artificial lymphoid tissue equivalent |
US7758654B2 (en) | 2004-05-20 | 2010-07-20 | Kensey Nash Corporation | Anti-adhesion device |
EP1773485B1 (en) | 2004-06-07 | 2015-09-16 | Natrix Separations Inc. | Stable composite material comprising supported porous gels |
ITRM20040318A1 (en) | 2004-06-28 | 2004-09-28 | Univ Palermo | HYALURONIC AND ALPHA HYDROGEL, BETA-POLYASPARTYL HYDRAZIDE AND THEIR BIOMEDICAL AND PHARMACEUTICAL APPLICATIONS. |
JP4934036B2 (en) | 2004-08-17 | 2012-05-16 | タイコ ヘルスケア グループ リミテッド パートナーシップ | Anti-adhesion barrier |
US8663625B2 (en) * | 2004-10-15 | 2014-03-04 | Cornell Research Foundation | Diffusively permeable monolithic biomaterial with embedded microfluidic channels |
US7252832B1 (en) | 2004-12-13 | 2007-08-07 | Biomet Sports Medicine, Inc. | Composite collagen material and method of forming same |
AU2006244714A1 (en) | 2005-05-13 | 2006-11-16 | Protista Biotechnology Ab | Macroporous hydrogels, their preparation and their use |
WO2007016622A2 (en) | 2005-08-02 | 2007-02-08 | Wright Medical Technolody, Inc. | Gel composition for inhibiting cellular adhesion |
KR100785378B1 (en) | 2005-09-05 | 2007-12-14 | 주식회사 바이오레인 | Multi-layered antiadhesion barrier |
WO2007038219A2 (en) | 2005-09-23 | 2007-04-05 | University Of North Texas | Synthesis of columnar hydrogel colloidal crystals in water-organic solvent mixture |
EP1806387B1 (en) | 2005-12-07 | 2012-07-04 | Seiko Epson Corporation | Photocurable ink composition and photocurable ink set |
EP1968499A1 (en) | 2005-12-14 | 2008-09-17 | Anika Therapeutics Inc. | Bioabsorbable implant of hyaluronic acid derivative for treatment of osteochondral and chondral defects |
US20100273667A1 (en) | 2006-02-10 | 2010-10-28 | The Regents Of The University Of Michigan | Cell culture well-plates having inverted colloidal crystal scaffolds |
US8110242B2 (en) | 2006-03-24 | 2012-02-07 | Zimmer, Inc. | Methods of preparing hydrogel coatings |
WO2007120818A2 (en) | 2006-04-12 | 2007-10-25 | Massachusetts Institute Of Technology | Compositions and methods for inhibiting adhesions |
US7833284B2 (en) | 2006-06-28 | 2010-11-16 | The Cleveland Clinic Foundation | Anti-adhesion membrane |
EP2073792A2 (en) | 2006-07-06 | 2009-07-01 | Abbott Laboratories | Superporous hydrogels |
WO2008076339A2 (en) | 2006-12-15 | 2008-06-26 | Drexel University | Multilayer films |
US20080182012A1 (en) | 2007-01-31 | 2008-07-31 | Motorola, Inc. | Micro fuel cell having macroporous metal current collectors |
CN101605817B (en) | 2007-02-06 | 2013-03-27 | 帝人株式会社 | Cellulose derivative and method for production thereof |
US8741316B2 (en) | 2007-03-12 | 2014-06-03 | Board Of Regents, The University Of Texas System | Highly porous, recognitive polymer systems |
US7504286B2 (en) | 2007-03-28 | 2009-03-17 | Advanced Micro Devices, Inc. | Semiconductor memory devices and methods for fabricating the same |
US7998380B2 (en) | 2007-07-13 | 2011-08-16 | Wisconsin Alumni Research Foundation | Method of fabricating a tissue engineering scaffold |
US20090062233A1 (en) | 2007-08-09 | 2009-03-05 | Xin Ji | Modified starch material of biocompatible hemostasis |
US20120070473A1 (en) | 2007-08-17 | 2012-03-22 | Anhese Llc | Apparatus and Method for Reducing the Occurrence of Post-Surgical Adhesions |
US8075908B2 (en) | 2007-08-17 | 2011-12-13 | Anhese Llc | Apparatus and method for reducing the occurrence of post-surgical adhesions |
CN101848739A (en) | 2007-08-28 | 2010-09-29 | T·阿萨纳夏季斯 | Surgical hydrogel |
US7919542B2 (en) | 2007-11-12 | 2011-04-05 | Zimmer Spine, Inc. | Phase separated, branched, copolymer hydrogel |
BRPI0821424A2 (en) | 2007-12-31 | 2019-09-24 | Acclarent Inc | mucosal tissue dressing and method of use |
US8668863B2 (en) | 2008-02-26 | 2014-03-11 | Board Of Regents, The University Of Texas System | Dendritic macroporous hydrogels prepared by crystal templating |
US20090294049A1 (en) | 2008-06-02 | 2009-12-03 | Medtronic Vascular, Inc. | Biodegradable Adhesive Hydrogels |
US8551136B2 (en) | 2008-07-17 | 2013-10-08 | Actamax Surgical Materials, Llc | High swell, long-lived hydrogel sealant |
US20100015231A1 (en) | 2008-07-17 | 2010-01-21 | E.I. Du Pont De Nemours And Company | Low swell, long-lived hydrogel sealant |
FR2937857B1 (en) | 2008-10-30 | 2015-04-03 | Brothier Lab | SURGICAL MEMBRANE ANTIADHERENCE |
US8927521B2 (en) | 2008-11-10 | 2015-01-06 | University of Pittsburgh—of the Commonwealth System of Higher Education | Cyclic adenosine monophosphates for reducing the formation of adhesions |
US9622481B2 (en) | 2009-01-23 | 2017-04-18 | Kane Biotech Inc. | Biofilm-removing antimicrobial compositions and uses thereof |
US9592108B2 (en) | 2009-07-29 | 2017-03-14 | Covidien Lp | System and method of laparoscopic use of hemostatic patch |
AU2010310208A1 (en) | 2009-10-21 | 2012-05-10 | Bayer Materialscience Ag | Biodegradable hydrogel |
KR20090130277A (en) | 2009-11-29 | 2009-12-22 | 이정삼 | The special mesh used in one port laparoscopic hernia operation |
US10226480B2 (en) | 2010-03-30 | 2019-03-12 | Histocell, S.L. | Biomaterial from Wharton's jelly umbilical cord |
AU2011243517B2 (en) | 2010-04-22 | 2014-02-13 | Teijin Limited | Hydrogel |
CN103189035A (en) | 2010-08-16 | 2013-07-03 | 瑞士商麦斯特医疗股份有限公司 | Anti-adhesion alginate barrier of variable absorbance |
EP2624874A4 (en) | 2010-10-08 | 2014-04-02 | Univ Texas | Anti-adhesive barrier membrane using alginate and hyaluronic acid for biomedical applications |
CN103189078A (en) | 2010-10-29 | 2013-07-03 | 汇美迪斯有限公司 | Adhesion barrier containing hyaluronic acids and L-arginine |
US8404256B2 (en) | 2011-05-06 | 2013-03-26 | The University Of Memphis Research Foundation | Biomaterial composite composition and method of use |
EP2716662A4 (en) | 2011-05-31 | 2014-11-19 | Univ Tokyo | Hydrogel and method for producing same |
KR101330652B1 (en) | 2012-02-28 | 2013-11-18 | (주)시지바이오 | Anti―adhesion polymer composition able to load growth factors |
DE102012104530A1 (en) | 2012-05-25 | 2013-11-28 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Use of a biocompatible composition |
US9662424B2 (en) | 2012-12-11 | 2017-05-30 | Board Of Regents, The University Of Texas System | Hydrogel membrane for adhesion prevention |
US9990917B2 (en) | 2015-04-13 | 2018-06-05 | Intel Corporation | Method and system of random access compression of transducer data for automatic speech recognition decoding |
-
2009
- 2009-02-26 US US12/919,667 patent/US8668863B2/en active Active
- 2009-02-26 WO PCT/US2009/035257 patent/WO2009108760A2/en active Application Filing
-
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- 2013-06-04 US US13/909,707 patent/US8728499B2/en active Active
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- 2014-05-14 US US14/277,170 patent/US9320827B2/en active Active
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- 2016-04-22 US US15/135,978 patent/US9896561B2/en active Active
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- 2018-02-07 US US15/890,719 patent/US10442911B2/en active Active
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- 2023-07-31 US US18/361,981 patent/US20230383086A1/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1991004732A1 (en) * | 1989-10-03 | 1991-04-18 | Advanced Polymer Systems, Inc. | Erodible macroporous hydrogel particles and preparation thereof |
US6414043B1 (en) * | 1998-06-26 | 2002-07-02 | University Of Pittsburgh | Hydrogel materials with crystalline colloidal array of watervoids for detection and macromolecule separations |
US6653420B2 (en) * | 2000-01-05 | 2003-11-25 | Novartis Ag | Porous hydrogels |
US6608117B1 (en) * | 2001-05-11 | 2003-08-19 | Nanosystems Research Inc. | Methods for the preparation of cellular hydrogels |
WO2005020849A2 (en) * | 2003-08-29 | 2005-03-10 | Mayo Foundation For Medical Education And Research | Hydrogel porogens for fabricating biodegradable scaffolds |
Non-Patent Citations (1)
Title |
---|
JULIANA MATOS SEIDEL ET AL.: "Synthesis of polyHEMA hydrogels for using as biomaterials. Bulk and solution radical- initiated polymerization techniques.", MATERIALS RESEARCH., vol. 3, no. 3, July 2000 (2000-07-01) * |
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WO2009108760A8 (en) | 2010-02-04 |
US20110008442A1 (en) | 2011-01-13 |
US11760858B2 (en) | 2023-09-19 |
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US20160237235A1 (en) | 2016-08-18 |
US20230383086A1 (en) | 2023-11-30 |
US10982068B2 (en) | 2021-04-20 |
US20140242126A1 (en) | 2014-08-28 |
US20180163012A1 (en) | 2018-06-14 |
US20130266618A1 (en) | 2013-10-10 |
US20200062919A1 (en) | 2020-02-27 |
US8668863B2 (en) | 2014-03-11 |
US20210238379A1 (en) | 2021-08-05 |
US10442911B2 (en) | 2019-10-15 |
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US9320827B2 (en) | 2016-04-26 |
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