WO2009102967A3 - Molecular enhancement of extracellular matrix and methods of use - Google Patents

Molecular enhancement of extracellular matrix and methods of use Download PDF

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Publication number
WO2009102967A3
WO2009102967A3 PCT/US2009/034071 US2009034071W WO2009102967A3 WO 2009102967 A3 WO2009102967 A3 WO 2009102967A3 US 2009034071 W US2009034071 W US 2009034071W WO 2009102967 A3 WO2009102967 A3 WO 2009102967A3
Authority
WO
WIPO (PCT)
Prior art keywords
extracellular matrix
repair
methods
tissue
animal
Prior art date
Application number
PCT/US2009/034071
Other languages
French (fr)
Other versions
WO2009102967A2 (en
Inventor
Kathleen Anne Derwin
Joseph Patrick Iannotti
Likang Chin
Anthony Calabro
Original Assignee
The Cleveland Clinic Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Cleveland Clinic Foundation filed Critical The Cleveland Clinic Foundation
Priority to ES09710120.8T priority Critical patent/ES2585483T3/en
Priority to EP09710120.8A priority patent/EP2249891B1/en
Publication of WO2009102967A2 publication Critical patent/WO2009102967A2/en
Publication of WO2009102967A3 publication Critical patent/WO2009102967A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/08—Muscles; Tendons; Ligaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3633—Extracellular matrix [ECM]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/11—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis
    • A61B17/1146—Surgical instruments, devices or methods, e.g. tourniquets for performing anastomosis; Buttons for anastomosis of tendons

Abstract

A composition comprising a human- or animal-derived extracellular matrix and a macromolecular network which is prepared ex vivo is provided that is useful in the repair of a tissue injury, particularly in repair of tears or gaps between a tendon and a bone, such as in a rotator cuff tear. In an embodiment, the composition comprises a human- or animal-derived extracellular matrix having impregnated therein a macromolecular network of hyaluronan macromolecules that have been cross-linked via dihydroxyphenyl linkages, so that the cross-linked network is interlocked within the extracellular matrix. The resulting HA-incorporated extracellular matrix can be supplied in the form of a patch to reinforce a tissue repair or cover a tissue defect.
PCT/US2009/034071 2008-02-13 2009-02-13 Molecular enhancement of extracellular matrix and methods of use WO2009102967A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES09710120.8T ES2585483T3 (en) 2008-02-13 2009-02-13 Molecular improvement of the extracellular matrix and methods of use
EP09710120.8A EP2249891B1 (en) 2008-02-13 2009-02-13 Molecular enhancement of extracellular matrix and methods of use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6552708P 2008-02-13 2008-02-13
US61/065,527 2008-02-13

Publications (2)

Publication Number Publication Date
WO2009102967A2 WO2009102967A2 (en) 2009-08-20
WO2009102967A3 true WO2009102967A3 (en) 2009-10-15

Family

ID=40939573

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/034071 WO2009102967A2 (en) 2008-02-13 2009-02-13 Molecular enhancement of extracellular matrix and methods of use

Country Status (4)

Country Link
US (1) US8080260B2 (en)
EP (1) EP2249891B1 (en)
ES (1) ES2585483T3 (en)
WO (1) WO2009102967A2 (en)

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US9034002B2 (en) 2008-02-18 2015-05-19 Covidien Lp Lock bar spring and clip for implant deployment device
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Also Published As

Publication number Publication date
US8080260B2 (en) 2011-12-20
EP2249891A2 (en) 2010-11-17
WO2009102967A2 (en) 2009-08-20
EP2249891B1 (en) 2016-05-25
ES2585483T3 (en) 2016-10-06
US20090204227A1 (en) 2009-08-13
EP2249891A4 (en) 2012-11-28

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