WO2009100283A2 - Tooth sealant - Google Patents
Tooth sealant Download PDFInfo
- Publication number
- WO2009100283A2 WO2009100283A2 PCT/US2009/033312 US2009033312W WO2009100283A2 WO 2009100283 A2 WO2009100283 A2 WO 2009100283A2 US 2009033312 W US2009033312 W US 2009033312W WO 2009100283 A2 WO2009100283 A2 WO 2009100283A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fluoride
- composition
- recited
- dental
- sealant
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Definitions
- the present invention relates to tooth sealant compositions comprising a basic amino acid in free or salt form that may be used to help prevent demineralization of teeth, alleviate pain and/or sensitivity of a patient's teeth, and provide other benefits.
- Sealants may include polymeric coatings, varnishes and foams to coat the teeth and/or dental device for extended periods.
- Dental caries consist of demineralization of a tooth caused by bacteria. In the early stages of caries a white spot develops on the tooth and if the disease is not halted and reversed, the enamel surface breaks down to form a lesion. This can then lead to decay and eventually, a fractured tooth. It is well known that development of dental caries may be reduced by means of various factors, such as diet and oral hygiene measures, anti-microbial treatments and the provision of fluoride to the teeth.
- Tooth sensitivity is also a common problem affecting children and adults.
- tooth sensitivity may be caused by gingival recession, dentine exposure due to erosion or abrasion, or periodontal surgery that includes root planning. Such conditions leave the dentinal tubules of the tissue susceptible to irritation by chemical, bacterial, mechanical or thermal stimuli. Examples of stimuli include heat, cold, and sweet foods. It is believed that tooth sensitivity is the result of nerve endings of the dental pulp being excited by fluid flow through the exposed dentinal tubules.
- Treatments directed to alleviating pain associated with sensitive teeth have generally focused on blocking access to the dentinal tubules so as to prevent stimuli from causing pain and sensitivity.
- Many treatments have been developed which include application of inorganic or organic components designed to plug or otherwise block dentinal tubules for a limited time.
- a disadvantage of such treatments is that normal habits such as eating certain foods (e.g., foods with a high acid content) or brushing can negate the treatment.
- eating certain foods e.g., foods with a high acid content
- brushing can negate the treatment.
- Recently, testing has revealed that increased fluoride levels within the mouth may also be used as a treatment for tooth sensitivity (Toumba and Andreadis).
- Arginine and other basic amino acids have been proposed for use in oral care and are believed to have significant benefits in combating cavity formation and tooth sensitivity. Combining these basic amino acids with minerals having oral care benefits, e.g., fluoride and calcium, to form an oral care product having acceptable long term stability, however, has proven challenging. Partly because of unaddressed formulation hurdles and partly because arginine has generally been viewed in the art as a potential alternative to fluoride rather than a co-active, there has been little motivation to make oral care products comprising both arginine and fluoride. Additional hurdles are potentially posed by addition of an antimicrobial agent. Commercially available arginine-based toothpaste, such as ProClude® and DenClude®, for example, contain arginine bicarbonate and calcium carbonate, but not fluoride nor any antimicrobial agent.
- the invention provides a dental sealant composition comprising a basic amino acid in free or salt form (BAA).
- the sealant composition additionally may comprise fluoride.
- the BAA is preferably arginine, in free or orally acceptable salt form.
- the present invention relates to a method of treating sensitive teeth with a basic amino acid in free or salt form (BAA) in a sealant composition, preferably in the presence of fluoride. The method involves: (1) attaching a BAA-releasing sealant composition to a person's tooth; and (2) allowing a BAA to be slowly released over time in order to reduce chronic and/or acute tooth sensitivity.
- the sealant acts also as a fluoride releasing composition as well. Because the method relies on release of a BAA into the oral cavity, the method also prevents future pain associated with dental caries by preventing deminerahzation and maintaining strong enamel.
- the invention further provides methods to improve oral health comprising use of a dental sealant composition comprising a BAA, e.g., by a subject in need thereof, to a. reduce or inhibit formation of dental caries, b. reduce, repair or inhibit early enamel lesions, c. reduce or inhibit demineraiization and promote reminera ⁇ zation of the teeth, d. reduce hypersensitivity of the teeth, e. reduce or inhibit gingivitis, f promote healing of sores or cuts in the mouth, g. reduce levels of acid producing bacteria, h. to increase relative levels of arginolytic bacteria. i. inhibit microbial biofilm formation in the oral cavity, j. raise and/or maintain plaque pH at levels of at least pH 5.5 following sugar challenge, k. reduce plaque accumulation,
- the invention further provides the use of a BAA in the manufacture of a dental sealant, e.g., for use in a method of treating sensitive teeth, or in any of the methods set forth above.
- the sealant compositions may be used for alleviating pain and/or sensitivity of teeth in addition to any effect that the BAA releasing sealant compositions may have in preventing dental caries.
- the compositions may be attached to a tooth to provide slow-BAA releasing devices for releasing a BAA into the saliva of an individual.
- the daily dissolution rate (DDR) of the composition under conditions in the mouth may range from about O.I to about 100 % per day.
- the required DDR of the sealant composition will depend upon the duration of BAA release required. For example, if the composition is required to release a BAA over a long period, such as 1-2 years, the DDR is preferably about 0.1 to about 0.5 %. However, if a BAA need only be released for a shorter period, such as a few hours, days, weeks, or months, a faster releasing sealant may be used, for example having a DDR of up to about 100 %.
- compositions which attaches to the teeth.
- the compositions may be applied as a spray, for example using a hydrocarbon propellant.
- the compositions comprise a polymer or vamish suitable for painting onto teeth,
- the compositions may be incorporated into dental cement or filling materials.
- the compositions may be attached to a tooth, for example being attached to rear molar using standard dental cement or as a powder for adding to dental materials, such as dental amalgams, thereby providing means to supplement a BAA release into saliva to assist in the prevention or reduction of dental caries.
- the powder may be included in a number of other dental materials, such as fissure sealant resins or composite bonding materials to cement bonds and brackets in orthodontic appliances. Powder applications may use sealant compositions that have a lower DDR than those that are attached directly to a tooth, for example having a DDR of about 0.1 to about 1 %.
- the inventive method involves attaching a BAA releasing sealant composition to a person's tooth, or a dental appliance, such as a denture, and then allowing a BAA to be slowly released over time in order to reduce chronic and/or acute tooth sensitivity.
- the BAA releasing sealant composition comprises about 5 to about 75 weight percent BAA and about 5 to about 30 weight percent fluorine.
- the basic amino acids which can be used in the compositions and methods of the invention include not only naturally occurring basic amino acids, such as arginine, lysine, and histidine, but also any basic amino acids having a carboxyl group and an amino group in the molecule, which are water-soluble and provide an aqueous solution with a pH of 7 or greater.
- basic amino acids include, but are not limited to, arginine, lysine, citrullene, ornithine, creatine, histidine, diaminobutanoic acid, diaminoproprionic acid, salts thereof or combinations thereof.
- the basic amino acids are selected from arginine, citrullene, and ornithine.
- the basic amino acid is arginine, for example, 1-arginine, or a salt thereof, for example arginine bicarbonate, arginine phosphate, or arginine hydrochloride.
- compositions of the invention are intended for consumption and so salts for use in the present invention should be safe for such use, in the amounts and concentrations provided.
- Suitable salts include salts known in the art to be pharmaceutically acceptable salts are generally considered to be physiologically acceptable in the amounts and concentrations provided.
- Physiologically acceptable salts include those derived from pharmaceutically acceptable inorganic or organic acids or bases, for example acid addition salts formed by acids which form a physiological acceptable anion, e.g., hydrochloride or bromide salt, and base addition salts formed by bases which form a physiologically acceptable cation, for example those derived from alkali metals such as potassium and sodium or alkaline earth metals such as calcium and magnesium.
- Physiologically acceptable sails may be obtained using standard procedures known in the art, for example, by reacting a sufficiently basic compound such as an amine with a suitable acid affording a physiologically acceptable anion.
- the concentration of BAA will vary depending on the formulation.
- the BAA (amount of salt expressed as weight of the free base) is 1 - 40 % by weight of the formulation, e.g. 5 - 20%, for example about 10%.
- compositions of the invention may additionally comprise tluoride.
- Representative fluoride ion sources include, but are not limited to, stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate. amine fluoride, ammonium fluoride, and combinations thereof.
- the fluoride ion source includes stannous fluoride, sodium fluoride, sodium monofluorophosphate as well as mixtures thereof.
- the fluoride source is sodium fluoride or sodium monofluorophosphate.
- the fluoride may be present in the formulation in effective amounts, as used i ⁇ conventional dental sealants, e.g.
- the composition may, for example be present, e.g., in an amount of about 2,500 ppm to about 250,000 ppm, expressed as level of fluoride ion, or in an amount of 2 - 25%, for example, at least 12%, e.g., 15 - 25% by weight of the composition.
- compositions may additionally comprise an antibacterial agent, such as iriclosan, or an agent which inhibits attachment of bacteria.
- an antibacterial agent such as iriclosan, or an agent which inhibits attachment of bacteria.
- J0027J Formulations comprising 30 wt % arginine bicarbonate are prepared as follows: TABLE 1
- Varnish formulation comprising 10 wt % arginine hydrochloride is prepared as follows:
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09708758.9A EP2249764B1 (en) | 2008-02-08 | 2009-02-06 | Tooth sealant |
JP2010544489A JP2011510095A (en) | 2008-02-08 | 2009-02-06 | Dental Sealant [0001] This application claims the benefit of US Serial No. 61 / 027,425, filed February 8, 2008, the contents of which are incorporated herein by reference. |
BRPI0907103A BRPI0907103A2 (en) | 2008-02-08 | 2009-02-06 | A method for treating sensitive teeth, making dental sealants, and using a basic free-form or salt-based amino acid. |
CA2711262A CA2711262C (en) | 2008-02-08 | 2009-02-06 | Dental composition comprising a basic amino acid for alleviating tooth sensitivity |
CN2009801045327A CN101938970A (en) | 2008-02-08 | 2009-02-06 | Tooth sealant |
US12/866,766 US10391038B2 (en) | 2008-02-08 | 2009-02-06 | Tooth sealant |
RU2010137322/15A RU2493812C2 (en) | 2008-02-08 | 2009-02-06 | Dental seal |
AU2009212339A AU2009212339B2 (en) | 2008-02-08 | 2009-02-06 | Tooth sealant |
MX2010007738A MX2010007738A (en) | 2008-02-08 | 2009-02-06 | Tooth sealant. |
ZA2010/03694A ZA201003694B (en) | 2008-02-08 | 2010-05-24 | Tooth sealant |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2742508P | 2008-02-08 | 2008-02-08 | |
US61/027,425 | 2008-02-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009100283A2 true WO2009100283A2 (en) | 2009-08-13 |
WO2009100283A3 WO2009100283A3 (en) | 2009-11-12 |
Family
ID=40952706
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/033312 WO2009100283A2 (en) | 2008-02-08 | 2009-02-06 | Tooth sealant |
Country Status (14)
Country | Link |
---|---|
US (1) | US10391038B2 (en) |
EP (1) | EP2249764B1 (en) |
JP (2) | JP2011510095A (en) |
CN (1) | CN101938970A (en) |
AR (1) | AR070589A1 (en) |
AU (1) | AU2009212339B2 (en) |
BR (1) | BRPI0907103A2 (en) |
CA (1) | CA2711262C (en) |
CO (1) | CO6241091A2 (en) |
MX (1) | MX2010007738A (en) |
RU (1) | RU2493812C2 (en) |
TW (1) | TWI376237B (en) |
WO (1) | WO2009100283A2 (en) |
ZA (1) | ZA201003694B (en) |
Cited By (2)
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WO2016101158A1 (en) * | 2014-12-24 | 2016-06-30 | Colgate-Palmolive Company | Oral care composition |
US11260103B2 (en) | 2014-12-29 | 2022-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for delivering lypophilic agents to dental pulp and for enhancing dentin production |
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US9107838B2 (en) | 2012-04-25 | 2015-08-18 | Therametrics Technologies, Inc. | Fluoride varnish |
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WO2014127178A1 (en) * | 2013-02-15 | 2014-08-21 | Dentsply International Inc. | Dental varnish compositions |
CN104758311A (en) * | 2015-04-24 | 2015-07-08 | 杭州维瓦科技有限公司 | Compound for treating hemodia and preparation method thereof |
US20180243175A1 (en) * | 2015-09-10 | 2018-08-30 | The University Of Florida Research Foundation, Inc. | Arginine-containing restorative dental materials and methods of preventing and controlling caries associated with dental work |
CN106361579A (en) * | 2016-11-10 | 2017-02-01 | 李雨阳 | Production method of tooth surface self-cleaning anti-adhesion coating |
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- 2009-02-06 RU RU2010137322/15A patent/RU2493812C2/en not_active IP Right Cessation
- 2009-02-06 AR ARP090100435 patent/AR070589A1/en not_active Application Discontinuation
- 2009-02-06 JP JP2010544489A patent/JP2011510095A/en active Pending
- 2009-02-06 BR BRPI0907103A patent/BRPI0907103A2/en not_active IP Right Cessation
- 2009-02-06 US US12/866,766 patent/US10391038B2/en active Active
- 2009-02-06 AU AU2009212339A patent/AU2009212339B2/en not_active Ceased
- 2009-02-06 TW TW98103776A patent/TWI376237B/en not_active IP Right Cessation
- 2009-02-06 CA CA2711262A patent/CA2711262C/en not_active Expired - Fee Related
- 2009-02-06 EP EP09708758.9A patent/EP2249764B1/en active Active
- 2009-02-06 WO PCT/US2009/033312 patent/WO2009100283A2/en active Application Filing
- 2009-02-06 MX MX2010007738A patent/MX2010007738A/en active IP Right Grant
- 2009-02-06 CN CN2009801045327A patent/CN101938970A/en active Pending
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2010
- 2010-05-24 ZA ZA2010/03694A patent/ZA201003694B/en unknown
- 2010-09-03 CO CO10109377A patent/CO6241091A2/en not_active Application Discontinuation
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2014
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2016101158A1 (en) * | 2014-12-24 | 2016-06-30 | Colgate-Palmolive Company | Oral care composition |
US11260103B2 (en) | 2014-12-29 | 2022-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for delivering lypophilic agents to dental pulp and for enhancing dentin production |
Also Published As
Publication number | Publication date |
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BRPI0907103A2 (en) | 2016-05-03 |
AU2009212339B2 (en) | 2011-12-22 |
RU2493812C2 (en) | 2013-09-27 |
AR070589A1 (en) | 2010-04-21 |
MX2010007738A (en) | 2010-08-10 |
EP2249764A4 (en) | 2012-02-22 |
CN101938970A (en) | 2011-01-05 |
TW201000143A (en) | 2010-01-01 |
CA2711262A1 (en) | 2009-08-13 |
RU2010137322A (en) | 2012-03-20 |
ZA201003694B (en) | 2014-11-26 |
US20100316726A1 (en) | 2010-12-16 |
US10391038B2 (en) | 2019-08-27 |
JP2011510095A (en) | 2011-03-31 |
EP2249764B1 (en) | 2019-07-31 |
CO6241091A2 (en) | 2011-01-20 |
TWI376237B (en) | 2012-11-11 |
EP2249764A2 (en) | 2010-11-17 |
JP2014088419A (en) | 2014-05-15 |
CA2711262C (en) | 2015-06-23 |
WO2009100283A3 (en) | 2009-11-12 |
AU2009212339A1 (en) | 2009-08-13 |
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