WO2009094554A3 - Histotripsy for thrombolysis - Google Patents

Histotripsy for thrombolysis Download PDF

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Publication number
WO2009094554A3
WO2009094554A3 PCT/US2009/031857 US2009031857W WO2009094554A3 WO 2009094554 A3 WO2009094554 A3 WO 2009094554A3 US 2009031857 W US2009031857 W US 2009031857W WO 2009094554 A3 WO2009094554 A3 WO 2009094554A3
Authority
WO
WIPO (PCT)
Prior art keywords
ultrasound
thrombolysis
thrombosis
vein thrombosis
clot
Prior art date
Application number
PCT/US2009/031857
Other languages
French (fr)
Other versions
WO2009094554A2 (en
Inventor
Adam Maxwell
Zhen Xu
Hitinder S. Gurm
Charles A. Cain
Original Assignee
The Regents Of The University Of Michigan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US12/121,001 external-priority patent/US8057408B2/en
Application filed by The Regents Of The University Of Michigan filed Critical The Regents Of The University Of Michigan
Publication of WO2009094554A2 publication Critical patent/WO2009094554A2/en
Publication of WO2009094554A3 publication Critical patent/WO2009094554A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22001—Angioplasty, e.g. PCTA

Abstract

Methods for performing non-invasive thrombolysis with ultrasound using, in some embodiments, one or more ultrasound transducers to focus or place a high intensity ultrasound beam onto a blood clot (thrombus) or other vascular inclusion or occlusion (e.g., clot in the dialysis graft, deep vein thrombosis, superficial vein thrombosis, arterial embolus, bypass graft thrombosis or embolization, pulmonary embolus) which would be ablated (eroded, mechanically fractionated, liquefied, or dissolved) by ultrasound energy. The process can employ one or more mechanisms, such as of cavitational, sonochemical, mechanical fractionation, or thermal processes depending on the acoustic parameters selected. This general process, including the examples of application set forth herein, is henceforth referred to as 'Thrombolysis.'
PCT/US2009/031857 2008-01-25 2009-01-23 Histotripsy for thrombolysis WO2009094554A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2355408P 2008-01-25 2008-01-25
US61/023,554 2008-01-25
US12/121,001 2008-05-15
US12/121,001 US8057408B2 (en) 2005-09-22 2008-05-15 Pulsed cavitational ultrasound therapy

Publications (2)

Publication Number Publication Date
WO2009094554A2 WO2009094554A2 (en) 2009-07-30
WO2009094554A3 true WO2009094554A3 (en) 2009-10-15

Family

ID=40901637

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/031857 WO2009094554A2 (en) 2008-01-25 2009-01-23 Histotripsy for thrombolysis

Country Status (1)

Country Link
WO (1) WO2009094554A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102232857A (en) * 2010-05-06 2011-11-09 高春平 Nondestructive focused ultrasound coronary artery in-vitro thrombus dissolving system

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6618620B1 (en) 2000-11-28 2003-09-09 Txsonics Ltd. Apparatus for controlling thermal dosing in an thermal treatment system
US8425424B2 (en) * 2008-11-19 2013-04-23 Inightee Ltd. Closed-loop clot lysis
US9623266B2 (en) 2009-08-04 2017-04-18 Insightec Ltd. Estimation of alignment parameters in magnetic-resonance-guided ultrasound focusing
EP2470267B1 (en) * 2009-08-26 2015-11-11 The Regents Of The University Of Michigan Micromanipulator control arm for therapeutic and imaging ultrasound transducers
WO2011024074A2 (en) 2009-08-26 2011-03-03 Insightec Ltd. Asymmetric phased-array ultrasound transducer
GB0916635D0 (en) 2009-09-22 2009-11-04 Isis Innovation Ultrasound systems
GB0916634D0 (en) 2009-09-22 2009-11-04 Isis Innovation Ultrasound systems
US9852727B2 (en) 2010-04-28 2017-12-26 Insightec, Ltd. Multi-segment ultrasound transducers
US8932237B2 (en) 2010-04-28 2015-01-13 Insightec, Ltd. Efficient ultrasound focusing
CN102232856A (en) * 2010-05-06 2011-11-09 高春平 Double-frequency ultrasonic multi-dimensional focused cerebrovascular thrombolytic system
US9433459B2 (en) 2010-07-13 2016-09-06 Zoll Medical Corporation Deposit ablation within and external to circulatory systems
US9981148B2 (en) 2010-10-22 2018-05-29 Insightec, Ltd. Adaptive active cooling during focused ultrasound treatment
EP2903688A4 (en) * 2012-10-05 2016-06-15 Univ Michigan Bubble-induced color doppler feedback during histotripsy
US20170072228A1 (en) 2014-03-31 2017-03-16 University Of Washington Methods and systems for selectively disrupting tissue with high intensity focused ultrasound
CN104856740A (en) * 2015-04-30 2015-08-26 江苏汉美科技有限公司 Combined device for tumor blood capillary embolism with ultrasound micro-bubble contrast agents
US11806553B2 (en) 2017-09-01 2023-11-07 Dalhousie University Transducer assembly for generating focused ultrasound
FR3072577B1 (en) 2017-10-23 2019-09-27 Cardiawave Sa APPARATUS FOR TREATING VASCULAR THROMBOSIS BY ULTRASOUND
US11813485B2 (en) * 2020-01-28 2023-11-14 The Regents Of The University Of Michigan Systems and methods for histotripsy immunosensitization

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020045890A1 (en) * 1996-04-24 2002-04-18 The Regents Of The University O F California Opto-acoustic thrombolysis
US20030157025A1 (en) * 1995-06-07 2003-08-21 Unger Evan C. Novel methods of imaging and treatment with targeted compositions
US20040138563A1 (en) * 2000-02-09 2004-07-15 Moehring Mark A Method and apparatus combining diagnostic ultrasound with therapeutic ultrasound to enhance thrombolysis
US20070083120A1 (en) * 2005-09-22 2007-04-12 Cain Charles A Pulsed cavitational ultrasound therapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030157025A1 (en) * 1995-06-07 2003-08-21 Unger Evan C. Novel methods of imaging and treatment with targeted compositions
US20020045890A1 (en) * 1996-04-24 2002-04-18 The Regents Of The University O F California Opto-acoustic thrombolysis
US20040138563A1 (en) * 2000-02-09 2004-07-15 Moehring Mark A Method and apparatus combining diagnostic ultrasound with therapeutic ultrasound to enhance thrombolysis
US20070083120A1 (en) * 2005-09-22 2007-04-12 Cain Charles A Pulsed cavitational ultrasound therapy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102232857A (en) * 2010-05-06 2011-11-09 高春平 Nondestructive focused ultrasound coronary artery in-vitro thrombus dissolving system

Also Published As

Publication number Publication date
WO2009094554A2 (en) 2009-07-30

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