WO2009079389A3 - Drug-eluting endoprosthesis - Google Patents

Drug-eluting endoprosthesis Download PDF

Info

Publication number
WO2009079389A3
WO2009079389A3 PCT/US2008/086639 US2008086639W WO2009079389A3 WO 2009079389 A3 WO2009079389 A3 WO 2009079389A3 US 2008086639 W US2008086639 W US 2008086639W WO 2009079389 A3 WO2009079389 A3 WO 2009079389A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioerodible
bioerodible metal
drug
endoprosthesis
overlying
Prior art date
Application number
PCT/US2008/086639
Other languages
French (fr)
Other versions
WO2009079389A2 (en
Inventor
John T. Clarke
Tim O'connor
Yixin Xu
Barry O'brien
Ben Arcand
James Lee Shippy, Iii
Liliana Atanasoska
Aiden Flanagan
Dave Mcmorrow
Jan Weber
John Kremer
Michael Kuehling
Dominique Seidel
Original Assignee
Boston Scientific Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Limited filed Critical Boston Scientific Limited
Priority to EP08862659A priority Critical patent/EP2231216B1/en
Publication of WO2009079389A2 publication Critical patent/WO2009079389A2/en
Publication of WO2009079389A3 publication Critical patent/WO2009079389A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A61L2300/61—Coatings having two or more layers containing two or more active agents in different layers

Abstract

A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.
PCT/US2008/086639 2007-12-14 2008-12-12 Drug-eluting endoprosthesis WO2009079389A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08862659A EP2231216B1 (en) 2007-12-14 2008-12-12 Drug-eluting endoprosthesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1390507P 2007-12-14 2007-12-14
US61/013,905 2007-12-14

Publications (2)

Publication Number Publication Date
WO2009079389A2 WO2009079389A2 (en) 2009-06-25
WO2009079389A3 true WO2009079389A3 (en) 2010-04-08

Family

ID=40459707

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/086639 WO2009079389A2 (en) 2007-12-14 2008-12-12 Drug-eluting endoprosthesis

Country Status (3)

Country Link
US (1) US20100008970A1 (en)
EP (1) EP2231216B1 (en)
WO (1) WO2009079389A2 (en)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713297B2 (en) * 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
AU2002345328A1 (en) 2001-06-27 2003-03-03 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
US7758892B1 (en) * 2004-05-20 2010-07-20 Boston Scientific Scimed, Inc. Medical devices having multiple layers
US20060127443A1 (en) * 2004-12-09 2006-06-15 Helmus Michael N Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery
US20070038176A1 (en) * 2005-07-05 2007-02-15 Jan Weber Medical devices with machined layers for controlled communications with underlying regions
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070224244A1 (en) * 2006-03-22 2007-09-27 Jan Weber Corrosion resistant coatings for biodegradable metallic implants
US20070224235A1 (en) * 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) * 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) * 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US20070264303A1 (en) * 2006-05-12 2007-11-15 Liliana Atanasoska Coating for medical devices comprising an inorganic or ceramic oxide and a therapeutic agent
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) * 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
EP2054537A2 (en) 2006-08-02 2009-05-06 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
WO2008033711A2 (en) 2006-09-14 2008-03-20 Boston Scientific Limited Medical devices with drug-eluting coating
CA2663220A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
WO2008034031A2 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
WO2008034048A2 (en) * 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprosthesis with biostable inorganic layers
JP2010503494A (en) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド Biodegradable endoprosthesis and method for producing the same
EP2073764A2 (en) * 2006-09-18 2009-07-01 Boston Scientific Limited Controlling biodegradation of a medical instrument
EP2068962B1 (en) * 2006-09-18 2013-01-30 Boston Scientific Limited Endoprostheses
US20080086195A1 (en) * 2006-10-05 2008-04-10 Boston Scientific Scimed, Inc. Polymer-Free Coatings For Medical Devices Formed By Plasma Electrolytic Deposition
US20080294236A1 (en) * 2007-05-23 2008-11-27 Boston Scientific Scimed, Inc. Endoprosthesis with Select Ceramic and Polymer Coatings
US7981150B2 (en) * 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
ES2506144T3 (en) 2006-12-28 2014-10-13 Boston Scientific Limited Bioerodible endoprosthesis and their manufacturing procedure
US8431149B2 (en) * 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) * 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US9284409B2 (en) 2007-07-19 2016-03-15 Boston Scientific Scimed, Inc. Endoprosthesis having a non-fouling surface
US8815273B2 (en) * 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
US8221822B2 (en) * 2007-07-31 2012-07-17 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
WO2009020520A1 (en) * 2007-08-03 2009-02-12 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8052745B2 (en) * 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US20090118809A1 (en) * 2007-11-02 2009-05-07 Torsten Scheuermann Endoprosthesis with porous reservoir and non-polymer diffusion layer
US8029554B2 (en) * 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US20090118821A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with porous reservoir and non-polymer diffusion layer
US20090118818A1 (en) * 2007-11-02 2009-05-07 Boston Scientific Scimed, Inc. Endoprosthesis with coating
JP5581311B2 (en) 2008-04-22 2014-08-27 ボストン サイエンティフィック サイムド，インコーポレイテッド MEDICAL DEVICE HAVING INORGANIC MATERIAL COATING AND MANUFACTURING METHOD THEREOF
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers
US7998192B2 (en) * 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
WO2009155328A2 (en) 2008-06-18 2009-12-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8114148B2 (en) * 2008-06-25 2012-02-14 Boston Scientific Scimed, Inc. Medical devices for delivery of therapeutic agent in conjunction with galvanic corrosion
US20100004733A1 (en) * 2008-07-02 2010-01-07 Boston Scientific Scimed, Inc. Implants Including Fractal Structures
EP2307070B1 (en) * 2008-07-16 2013-03-27 Boston Scientific Scimed, Inc. Medical devices having metal coatings for controlled drug release
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8231980B2 (en) * 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
US8414656B2 (en) * 2008-12-05 2013-04-09 Boston Scientific Scimed, Inc. Porous ureteral stent
WO2010101901A2 (en) 2009-03-02 2010-09-10 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) * 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) * 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US20100274352A1 (en) * 2009-04-24 2010-10-28 Boston Scientific Scrimed, Inc. Endoprosthesis with Selective Drug Coatings
EP2266638A3 (en) * 2009-06-25 2014-08-13 Biotronik VI Patent AG Biocorrodible implant having an active coating
US20110022158A1 (en) * 2009-07-22 2011-01-27 Boston Scientific Scimed, Inc. Bioerodible Medical Implants
EP2289575B1 (en) * 2009-08-06 2017-07-05 Biotronik VI Patent AG Medical implant containing an antioxidative substance
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
EP2566535A4 (en) * 2010-05-03 2013-12-18 Izhar Halahmi Releasing device for administering a bio-active agent
US20110282428A1 (en) * 2010-05-13 2011-11-17 Boston Scientific Scimed, Inc. Biodegradable composite stent
EP3038666B1 (en) * 2013-08-28 2018-04-18 Boston Scientific Scimed, Inc. Bioerodible composites for endoprostheses
US9795400B2 (en) 2013-11-13 2017-10-24 Covidien Lp Galvanically assisted attachment of medical devices to thrombus
US20150297803A1 (en) * 2014-04-22 2015-10-22 Medtronic Vascular, Inc. Bioerodible Stent
US10265515B2 (en) 2015-03-27 2019-04-23 Covidien Lp Galvanically assisted aneurysm treatment
EP3352685B1 (en) 2015-09-25 2019-08-14 Covidien LP Medical device delivery system
WO2019018628A2 (en) * 2017-07-20 2019-01-24 RDJE Technologies LLC Controlled release polymer encapsulated fragrances

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006108065A2 (en) * 2005-04-05 2006-10-12 Elixir Medical Corporation Degradable implantable medical devices
WO2008106271A2 (en) * 2007-02-26 2008-09-04 Medtronic Vascular Inc. Drug coated stent with magnesium topcoat
WO2008118606A2 (en) * 2007-03-26 2008-10-02 Medtronic Vascular Inc. Biodegradable metal barrier layer for a drug-eluting stent

Family Cites Families (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4002877A (en) * 1974-12-13 1977-01-11 United Technologies Corporation Method of cutting with laser radiation and liquid coolant
US4308868A (en) * 1980-05-27 1982-01-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Implantable electrical device
US4634502A (en) * 1984-11-02 1987-01-06 The Standard Oil Company Process for the reductive deposition of polyoxometallates
US4800882A (en) * 1987-03-13 1989-01-31 Cook Incorporated Endovascular stent and delivery system
US5079203A (en) * 1990-05-25 1992-01-07 Board Of Trustees Operating Michigan State University Polyoxometalate intercalated layered double hydroxides
DE4104359A1 (en) * 1991-02-13 1992-08-20 Implex Gmbh CHARGING SYSTEM FOR IMPLANTABLE HOERHILFEN AND TINNITUS MASKERS
JP2961287B2 (en) * 1991-10-18 1999-10-12 グンゼ株式会社 Biological duct dilator, method for producing the same, and stent
US5591224A (en) * 1992-03-19 1997-01-07 Medtronic, Inc. Bioelastomeric stent
GEP20002074B (en) * 1992-05-19 2000-05-10 Westaim Tech Inc Ca Modified Material and Method for its Production
CA2074318A1 (en) * 1992-07-22 1994-01-23 Morteza Shirkhanzadeh Prosthetic implant with self-generated current for early fixation in skeletal bone
US5385776A (en) * 1992-11-16 1995-01-31 Alliedsignal Inc. Nanocomposites of gamma phase polymers containing inorganic particulate material
US5380298A (en) * 1993-04-07 1995-01-10 The United States Of America As Represented By The Secretary Of The Navy Medical device with infection preventing feature
US20030203976A1 (en) * 1993-07-19 2003-10-30 William L. Hunter Anti-angiogenic compositions and methods of use
US6017577A (en) * 1995-02-01 2000-01-25 Schneider (Usa) Inc. Slippery, tenaciously adhering hydrophilic polyurethane hydrogel coatings, coated polymer substrate materials, and coated medical devices
US6981986B1 (en) * 1995-03-01 2006-01-03 Boston Scientific Scimed, Inc. Longitudinally flexible expandable stent
US5830217A (en) * 1996-08-09 1998-11-03 Thomas J. Fogarty Soluble fixation device and method for stent delivery catheters
US6174329B1 (en) * 1996-08-22 2001-01-16 Advanced Cardiovascular Systems, Inc. Protective coating for a stent with intermediate radiopaque coating
US6013591A (en) * 1997-01-16 2000-01-11 Massachusetts Institute Of Technology Nanocrystalline apatites and composites, prostheses incorporating them, and method for their production
US5858556A (en) * 1997-01-21 1999-01-12 Uti Corporation Multilayer composite tubular structure and method of making
DE19731021A1 (en) * 1997-07-18 1999-01-21 Meyer Joerg In vivo degradable metallic implant
US6174330B1 (en) * 1997-08-01 2001-01-16 Schneider (Usa) Inc Bioabsorbable marker having radiopaque constituents
DE19734972A1 (en) * 1997-08-13 1999-02-18 Cerdec Ag Gold-containing nanoporous alumina membranes, process for their preparation and their use
US6342507B1 (en) * 1997-09-05 2002-01-29 Isotechnika, Inc. Deuterated rapamycin compounds, method and uses thereof
DE19746735C2 (en) * 1997-10-13 2003-11-06 Simag Gmbh Systeme Und Instr F NMR imaging method for the display, position determination or functional control of a device inserted into an examination object and device for use in such a method
NO311781B1 (en) * 1997-11-13 2002-01-28 Medinol Ltd Metal multilayer stents
US6241762B1 (en) * 1998-03-30 2001-06-05 Conor Medsystems, Inc. Expandable medical device with ductile hinges
US6335029B1 (en) * 1998-08-28 2002-01-01 Scimed Life Systems, Inc. Polymeric coatings for controlled delivery of active agents
US6984404B1 (en) * 1998-11-18 2006-01-10 University Of Florida Research Foundation, Inc. Methods for preparing coated drug particles and pharmaceutical formulations thereof
KR100439444B1 (en) * 1998-11-26 2004-07-09 인피니언 테크놀로지스 아게 Complex compound of an element of sub-group iv
US6170488B1 (en) * 1999-03-24 2001-01-09 The B. F. Goodrich Company Acoustic-based remotely interrogated diagnostic implant device and system
US6503556B2 (en) * 2000-12-28 2003-01-07 Advanced Cardiovascular Systems, Inc. Methods of forming a coating for a prosthesis
US6337076B1 (en) * 1999-11-17 2002-01-08 Sg Licensing Corporation Method and composition for the treatment of scars
US6936066B2 (en) * 1999-11-19 2005-08-30 Advanced Bio Prosthetic Surfaces, Ltd. Complaint implantable medical devices and methods of making same
US6458153B1 (en) * 1999-12-31 2002-10-01 Abps Venture One, Ltd. Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof
US20060013850A1 (en) * 1999-12-03 2006-01-19 Domb Abraham J Electropolymerizable monomers and polymeric coatings on implantable devices prepared therefrom
US6338739B1 (en) * 1999-12-22 2002-01-15 Ethicon, Inc. Biodegradable stent
US6451177B1 (en) * 2000-01-21 2002-09-17 Applied Materials, Inc. Vault shaped target and magnetron operable in two sputtering modes
AU2001229351A1 (en) * 2000-01-25 2001-08-07 Boston Scientific Limited Manufacturing medical devices by vapor deposition
EP1132058A1 (en) * 2000-03-06 2001-09-12 Advanced Laser Applications Holding S.A. Intravascular prothesis
US6315708B1 (en) * 2000-03-31 2001-11-13 Cordis Corporation Stent with self-expanding end sections
US6395326B1 (en) * 2000-05-31 2002-05-28 Advanced Cardiovascular Systems, Inc. Apparatus and method for depositing a coating onto a surface of a prosthesis
US6673385B1 (en) * 2000-05-31 2004-01-06 Advanced Cardiovascular Systems, Inc. Methods for polymeric coatings stents
JP4545888B2 (en) * 2000-06-08 2010-09-15 株式会社泉精器製作所 Solid-liquid separator
US20030018380A1 (en) * 2000-07-07 2003-01-23 Craig Charles H. Platinum enhanced alloy and intravascular or implantable medical devices manufactured therefrom
AU2001273276A1 (en) * 2000-07-10 2002-01-21 Epion Corporation Improving effectiveness of medical stents by gcib
US6451373B1 (en) * 2000-08-04 2002-09-17 Advanced Cardiovascular Systems, Inc. Method of forming a therapeutic coating onto a surface of an implantable prosthesis
US6506437B1 (en) * 2000-10-17 2003-01-14 Advanced Cardiovascular Systems, Inc. Methods of coating an implantable device having depots formed in a surface thereof
GB0100760D0 (en) * 2001-01-11 2001-02-21 Biocompatibles Ltd Drug delivery from stents
US6673105B1 (en) * 2001-04-02 2004-01-06 Advanced Cardiovascular Systems, Inc. Metal prosthesis coated with expandable ePTFE
US7056339B2 (en) * 2001-04-20 2006-06-06 The Board Of Trustees Of The Leland Stanford Junior University Drug delivery platform
WO2002085386A2 (en) * 2001-04-23 2002-10-31 Nucryst Pharmaceuticals Corp. Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use to induce apoptosis in cancerous tissue
US6613083B2 (en) * 2001-05-02 2003-09-02 Eckhard Alt Stent device and method
US7201940B1 (en) * 2001-06-12 2007-04-10 Advanced Cardiovascular Systems, Inc. Method and apparatus for thermal spray processing of medical devices
US20030003127A1 (en) * 2001-06-27 2003-01-02 Ethicon, Inc. Porous ceramic/porous polymer layered scaffolds for the repair and regeneration of tissue
US6656216B1 (en) * 2001-06-29 2003-12-02 Advanced Cardiovascular Systems, Inc. Composite stent with regioselective material
US6585755B2 (en) * 2001-06-29 2003-07-01 Advanced Cardiovascular Polymeric stent suitable for imaging by MRI and fluoroscopy
US6676987B2 (en) * 2001-07-02 2004-01-13 Scimed Life Systems, Inc. Coating a medical appliance with a bubble jet printing head
US7157096B2 (en) * 2001-10-12 2007-01-02 Inframat Corporation Coatings, coated articles and methods of manufacture thereof
US20030077310A1 (en) * 2001-10-22 2003-04-24 Chandrashekhar Pathak Stent coatings containing HMG-CoA reductase inhibitors
US6506972B1 (en) * 2002-01-22 2003-01-14 Nanoset, Llc Magnetically shielded conductor
DE60220319T3 (en) * 2002-01-31 2011-03-17 Radi Medical Systems Ab RESOLVING STENT
ES2276084T3 (en) * 2002-02-15 2007-06-16 Cv Therapeutics, Inc. POLYMER COATING FOR MEDICAL DEVICES.
EP1348402A1 (en) * 2002-03-29 2003-10-01 Advanced Laser Applications Holding S.A. Intraluminal endoprosthesis, radially expandable, perforated for drug delivery
US20040000540A1 (en) * 2002-05-23 2004-01-01 Soboyejo Winston O. Laser texturing of surfaces for biomedical implants
US6865810B2 (en) * 2002-06-27 2005-03-15 Scimed Life Systems, Inc. Methods of making medical devices
US20040004063A1 (en) * 2002-07-08 2004-01-08 Merdan Kenneth M. Vertical stent cutting process
AU2003277332B2 (en) * 2002-10-11 2009-03-12 University Of Connecticut Shape memory polymers based on semicrystalline thermoplastic polyurethanes bearing nanostructured hard segments
US7169178B1 (en) * 2002-11-12 2007-01-30 Advanced Cardiovascular Systems, Inc. Stent with drug coating
US8281737B2 (en) * 2003-03-10 2012-10-09 Boston Scientific Scimed, Inc. Coated medical device and method for manufacturing the same
DE10311729A1 (en) * 2003-03-18 2004-09-30 Schultheiss, Heinz-Peter, Prof. Dr. Endovascular implant with an at least sectionally active coating of ratjadon and / or a ratjadon derivative
EP1633320A2 (en) * 2003-05-02 2006-03-15 SurModics, Inc. Implantable controlled release bioactive agent delivery device
US6846323B2 (en) * 2003-05-15 2005-01-25 Advanced Cardiovascular Systems, Inc. Intravascular stent
FI20045223A (en) * 2004-06-15 2005-12-16 Bioretec Oy A multifunctional biodegradable composite and a surgical implant comprising said composite
US20050021127A1 (en) * 2003-07-21 2005-01-27 Kawula Paul John Porous glass fused onto stent for drug retention
US20050021128A1 (en) * 2003-07-24 2005-01-27 Medtronic Vascular, Inc. Compliant, porous, rolled stent
US7682603B2 (en) * 2003-07-25 2010-03-23 The Trustees Of The University Of Pennsylvania Polymersomes incorporating highly emissive probes
US8435287B2 (en) * 2004-03-30 2013-05-07 Toyo Advanced Technologies Co., Ltd. Stent and method for fabricating the same
US8512734B2 (en) * 2004-07-05 2013-08-20 Katholieke Universiteit Leuven, K.U.Leuven R&D Biocompatible coating of medical devices
US20060009839A1 (en) * 2004-07-12 2006-01-12 Scimed Life Systems, Inc. Composite vascular graft including bioactive agent coating and biodegradable sheath
US7078108B2 (en) * 2004-07-14 2006-07-18 The Regents Of The University Of California Preparation of high-strength nanometer scale twinned coating and foil
US20060015361A1 (en) * 2004-07-16 2006-01-19 Jurgen Sattler Method and system for customer contact reporting
US7269700B2 (en) * 2004-07-26 2007-09-11 Integrated Device Technology, Inc. Status bus accessing only available quadrants during loop mode operation in a multi-queue first-in first-out memory system
US20080003431A1 (en) * 2006-06-20 2008-01-03 Thomas John Fellinger Coated fibrous nodules and insulation product
US20070003589A1 (en) * 2005-02-17 2007-01-04 Irina Astafieva Coatings for implantable medical devices containing attractants for endothelial cells
GB2424223C (en) * 2005-03-07 2011-02-02 Massachusetts Inst Technology Biomaterial.
DE102005031868A1 (en) * 2005-07-04 2007-01-18 Biotronik Vi Patent Ag Drug depot for parenteral, especially intravascular drug release
US8815275B2 (en) * 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
US8771343B2 (en) * 2006-06-29 2014-07-08 Boston Scientific Scimed, Inc. Medical devices with selective titanium oxide coatings
US7632305B2 (en) * 2007-07-06 2009-12-15 Boston Scientific Scimed, Inc. Biodegradable connectors
US8002823B2 (en) * 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) * 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
DE102007032686A1 (en) * 2007-07-13 2009-01-15 Biotronik Vi Patent Ag Stent with a coating
US8205317B2 (en) * 2007-07-16 2012-06-26 Medtronic Vascular, Inc. Method of manufacturing a controlled porosity stent
US20090024209A1 (en) * 2007-07-20 2009-01-22 Medtronic Vascular, Inc. Hypotubes for Intravascular Drug Delivery
DE102007034041A1 (en) * 2007-07-20 2009-01-22 Biotronik Vi Patent Ag Medication depots for medical implants
DE102007034019A1 (en) * 2007-07-20 2009-01-22 Biotronik Vi Patent Ag Stent with a coating or filling of a cavity

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006108065A2 (en) * 2005-04-05 2006-10-12 Elixir Medical Corporation Degradable implantable medical devices
WO2008106271A2 (en) * 2007-02-26 2008-09-04 Medtronic Vascular Inc. Drug coated stent with magnesium topcoat
WO2008118606A2 (en) * 2007-03-26 2008-10-02 Medtronic Vascular Inc. Biodegradable metal barrier layer for a drug-eluting stent

Also Published As

Publication number Publication date
WO2009079389A2 (en) 2009-06-25
US20100008970A1 (en) 2010-01-14
EP2231216B1 (en) 2012-08-08
EP2231216A2 (en) 2010-09-29

Similar Documents

Publication Publication Date Title
WO2009079389A3 (en) Drug-eluting endoprosthesis
NZ588549A (en) Stents having bioabsorbable layers
WO2008138611A3 (en) Vessel stent
WO2008118606A3 (en) Biodegradable metal barrier layer for a drug-eluting stent
WO2008051680A3 (en) Medical device hydrogen surface treatment by electrochemical reduction
WO2008034048A3 (en) Bioerodible endoprosthesis with biostable inorganic layers
WO2007109756A3 (en) Medical devices having electrical circuits with multilayer regions
WO2010014612A3 (en) Bioerodible endoprosthesis
WO2007126606A3 (en) Controlled degradation and drug release in stents
EP1721997A4 (en) Ni-Pt ALLOY AND TARGET COMPRISING THE ALLOY
WO2008016696A3 (en) Composite polymeric and metallic stent with radiopacity
TW200614279A (en) Transparent conductive multilayer body and transparent touch panel
WO2005089825A3 (en) Medical articles with polyelectrolyte multilayer coatings
WO2008083190A3 (en) Bioerodible endoprostheses and methods of making same
SI2077976T1 (en) Bioactive, ruthenium-containing coating and device
CA123055S (en) Shoe
WO2009059129A3 (en) Endoprosthesis with porous reservoir and non-polymer diffusion layer
WO2008036357A3 (en) Medical devices having biodegradable polymeric regions with overlying hard, thin layers
WO2008002632A3 (en) Carbon coating on an implantable device
HUE049307T2 (en) Enterically coated cysteamine bitartrate and cystamine
SG131043A1 (en) Metal duplex and method
TW200700897A (en) Plating treatment method, thansparency conductity film and electro-magnetic wave sheliding film
CA120928S (en) Sprayer
CA120929S (en) Container
GB201115975D0 (en) Slide member

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08862659

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008862659

Country of ref document: EP