WO2009064963A3 - Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use - Google Patents

Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use Download PDF

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Publication number
WO2009064963A3
WO2009064963A3 PCT/US2008/083522 US2008083522W WO2009064963A3 WO 2009064963 A3 WO2009064963 A3 WO 2009064963A3 US 2008083522 W US2008083522 W US 2008083522W WO 2009064963 A3 WO2009064963 A3 WO 2009064963A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue adhesive
cationic polysaccharide
oxidized
based polymer
polymer tissue
Prior art date
Application number
PCT/US2008/083522
Other languages
French (fr)
Other versions
WO2009064963A2 (en
Inventor
Helen S. M. Lu
Original Assignee
E. I. Du Pont De Nemours And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E. I. Du Pont De Nemours And Company filed Critical E. I. Du Pont De Nemours And Company
Priority to US12/742,457 priority Critical patent/US8426492B2/en
Priority to EP08849966.0A priority patent/EP2214731B1/en
Publication of WO2009064963A2 publication Critical patent/WO2009064963A2/en
Publication of WO2009064963A3 publication Critical patent/WO2009064963A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0031—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/043—Mixtures of macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/041—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Abstract

A tissue adhesive formed by reacting an oxidized cationic polysaccharide containing aldehyde groups and amine groups with a multi-arm amine is described. The oxidized cationic polysaccharide-based polymer tissue adhesive may be useful for medical applications including wound closure, supplementing or replacing sutures or staples in internal surgical procedures such as intestinal anastomosis and vascular anastomosis, ophthalmic procedures, drug delivery, anti-adhesive applications and as a bulking agent to treat urinary incontinence. Additionally, due to the presence of the positively charged amine groups on the oxidized polysaccharide, the polymer tissue adhesive disclosed herein may promote wound healing and blood coagulation, and may possess antimicrobial properties.
PCT/US2008/083522 2007-11-14 2008-11-14 Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use WO2009064963A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/742,457 US8426492B2 (en) 2007-11-14 2008-11-14 Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
EP08849966.0A EP2214731B1 (en) 2007-11-14 2008-11-14 Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US305907P 2007-11-14 2007-11-14
US61/003,059 2007-11-14

Publications (2)

Publication Number Publication Date
WO2009064963A2 WO2009064963A2 (en) 2009-05-22
WO2009064963A3 true WO2009064963A3 (en) 2010-03-25

Family

ID=40329354

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/083522 WO2009064963A2 (en) 2007-11-14 2008-11-14 Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use

Country Status (3)

Country Link
US (1) US8426492B2 (en)
EP (1) EP2214731B1 (en)
WO (1) WO2009064963A2 (en)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8431114B2 (en) 2004-10-07 2013-04-30 Actamax Surgical Materials, Llc Polysaccharide-based polymer tissue adhesive for medical use
US8426492B2 (en) 2007-11-14 2013-04-23 Actamax Surgical Materials, Llc Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
US8846095B2 (en) 2007-11-14 2014-09-30 Actamax Surgical Materials, Llc Dextran-based polymer tissue adhesive for medical use
US20100015231A1 (en) * 2008-07-17 2010-01-21 E.I. Du Pont De Nemours And Company Low swell, long-lived hydrogel sealant
US8466327B2 (en) 2008-11-19 2013-06-18 Actamax Surgical Materials, Llc Aldehyde-functionalized polyethers and method of making same
US9044529B2 (en) * 2008-11-19 2015-06-02 Actamax Surgical Materials, Llc Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether
JP5559190B2 (en) * 2008-11-19 2014-07-23 アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー Fibrous tissue sealant and method of use thereof
US20100160960A1 (en) * 2008-12-19 2010-06-24 E. I. Du Pont De Nemours And Company Hydrogel tissue adhesive having increased degradation time
CN102438666A (en) 2009-04-09 2012-05-02 阿克塔马克斯手术器材有限责任公司 Hydrogel tissue adhesive having reduced degradation time
US20120094955A1 (en) * 2009-04-09 2012-04-19 Actamax Surgical Materials Llc Method of dissolving an oxidized polysaccharide in an aqueous solution
ES2574238T3 (en) 2009-07-02 2016-06-16 Actamax Surgical Materials Llc Tissue hydrogel adhesive for medical use
US8580950B2 (en) 2009-07-02 2013-11-12 Actamax Surgical Materials, Llc Aldehyde-functionalized polysaccharides
US8796242B2 (en) 2009-07-02 2014-08-05 Actamax Surgical Materials, Llc Hydrogel tissue adhesive for medical use
WO2011002956A1 (en) 2009-07-02 2011-01-06 E. I. Du Pont De Nemours And Company Aldehyde-functionalized polysaccharides
US8211450B2 (en) 2010-05-05 2012-07-03 Senju Usa, Inc. Ophthalmic composition
KR101200392B1 (en) 2010-07-12 2012-11-13 주식회사 바이오피드 Patch for curing and/or alleviating the skin diseases accompanying the exudation of plasma proteins
US8859705B2 (en) 2012-11-19 2014-10-14 Actamax Surgical Materials Llc Hydrogel tissue adhesive having decreased gelation time and decreased degradation time
EP3027659B1 (en) 2013-07-29 2020-12-09 Actamax Surgical Materials LLC Low swell tissue adhesive and sealant formulations
KR101664444B1 (en) * 2013-12-13 2016-10-12 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 Biodegradable medical adhesive or sealant compositions
CA2934530C (en) 2013-12-23 2022-03-01 Massachusetts Institute Of Technology Adhesive for biological tissue comprising a polymer having aldehyde groups and a dendrimer wherein the polymer and/or the dendrimer is substituted with a moiety capable of photoreversible dimerization
CN107428850B (en) 2015-03-20 2019-10-11 杨达志 The poly- ammonia copolymer of polysaccharide-and its reduce blood plasma in ldl concn application
US10723809B2 (en) 2015-03-20 2020-07-28 Howard University Microcarriers, matrices and scaffolds for culturing mammalian cells and methods of manufacture
NL2019650B1 (en) * 2017-09-29 2019-04-08 Polyganics Ip B V Improved tissue-adhesive polymers
CN112807478B (en) * 2018-08-20 2022-08-02 稳得希林(杭州)生物科技有限公司 Polysaccharide-based tissue adhesive medical adhesive and application thereof
CN110680952B (en) * 2019-10-29 2021-12-14 无锡贝迪生物工程股份有限公司 Injectable medical wound dressing with antibacterial function

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5092883A (en) * 1988-12-28 1992-03-03 Eppley Barry L Method for promoting soft connective tissue growth and repair in mammals
US5502042A (en) * 1994-07-22 1996-03-26 United States Surgical Corporation Methods and compositions for treating wounds
US20020151520A1 (en) * 1999-03-25 2002-10-17 Gruskin Elliott A. Method of promoting angiogenesis
US20060078536A1 (en) * 2004-10-07 2006-04-13 Kodokian George K Polysaccharide-based polymer tissue adhesive for medical use
WO2009064977A2 (en) * 2007-11-14 2009-05-22 E.I. Du Pont De Nemours And Company Dextran-based polymer tissue adhesive for medical use

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US527838A (en) * 1894-10-23 Automatic air-brake coupling
JPS57102932A (en) 1980-12-19 1982-06-26 Japan Synthetic Rubber Co Ltd Water-containing molding
DK260782A (en) * 1981-06-12 1982-12-13 Nat Res Dev HYDROGELS
US4703116A (en) * 1984-08-17 1987-10-27 National Starch And Chemical Corporation Polysaccharide derivatives containing aldehyde groups, their preparation from the corresponding acetals and use as paper additives
US4731162A (en) * 1984-08-17 1988-03-15 National Starch And Chemical Corporation Polysaccharide derivatives containing aldehyde groups for use as paper additives
US4741804A (en) * 1984-08-17 1988-05-03 National Starch And Chemical Corporation Polysaccharide derivatives containing aldehyde groups, their preparation from the corresponding acetals and use as paper additives
US4766245A (en) * 1985-03-01 1988-08-23 Texaco Inc. Process for the preparation of polyoxyalkylene polyamines
JPS61253065A (en) * 1985-05-02 1986-11-10 片倉チツカリン株式会社 Medical composite material of chitosan derivative and collagen and its production
WO1987000836A1 (en) 1985-08-06 1987-02-12 Boehringer Biochemia Robin S.P.A. Pharmaceutically active 2-thiomethyl-substituted-1,4-dihydropyridines
JPS6311167A (en) 1986-01-31 1988-01-18 宇部興産株式会社 Non-biological adsorbent and removal of unnecessary factor in plasma using the same
US4749800A (en) * 1987-03-09 1988-06-07 National Starch And Chemical Corporation Polysaccharide esters containing acetal and aldehyde groups
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
EP0839529A3 (en) 1989-03-13 2000-03-22 Cellegy Pharmaceuticals, Inc. Compositions containing aliphatic monocarboxylic acid esters or amides for the treatment of skin diseases
US5451398A (en) * 1990-01-05 1995-09-19 Allergan, Inc. Ophthalmic and disinfecting compositions and methods for preserving and using same
US5275838A (en) 1990-02-28 1994-01-04 Massachusetts Institute Of Technology Immobilized polyethylene oxide star molecules for bioapplications
AU660924B2 (en) 1990-04-02 1995-07-13 Procter & Gamble Company, The Particulate, absorbent, polymeric compositions containing interparticle crosslinked aggregates
EP0465420B1 (en) * 1990-07-02 1996-10-30 Ciba-Geigy Ag Azo dyestuffs
DE4033415A1 (en) * 1990-10-20 1992-04-23 Bayer Ag ANTIMICROBIAL AGENTS AND SUBSTITUTED 2-CYCLOHEXAN-1-YL-AMINE DERIVATIVES AND THE PRODUCTION THEREOF
US5639620A (en) * 1990-10-31 1997-06-17 Coulter Corporation Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US5643575A (en) * 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
DK0705298T3 (en) * 1993-12-01 2002-07-08 Bioartificial Gel Technologies Inc Albumin-based hydrogel
US5505952A (en) * 1994-04-19 1996-04-09 United States Surgical Corporation Modified synthetic cross-linked amino acid polymers and medical devices formed therefrom
US5567685A (en) * 1994-08-16 1996-10-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Water-Soluble polyene conjugate
US5840698A (en) * 1994-10-27 1998-11-24 Affymax Technologies N.V. Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use
US6833408B2 (en) * 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
EP0876165B1 (en) 1995-12-18 2006-06-21 Angiotech BioMaterials Corp. Crosslinked polymer compositions and methods for their use
US6150472A (en) * 1995-12-22 2000-11-21 Holland Biomaterials Group B.V. Multi-functional site containing polymers, and applications thereof
ES2166066T3 (en) * 1996-02-07 2002-04-01 Buckman Labor Inc SYNERGIC ANTIMICROBIAL COMPOSITIONS CONTAINING AN IONENE POLYMER AND A DODECILAMINE SALT AND ITS METHODS OF USE.
WO1997030103A2 (en) 1996-02-15 1997-08-21 The Dow Chemical Company Preparation of polyetheramines and polyetheramine derivatives
FR2754268B1 (en) * 1996-10-07 1998-12-24 Dev Des Utilisations Du Collag ADHESIVE COMPOSITION BASED ON MACROMOLECULAR POLYALDEHYDE AND METHOD FOR CROSSLINKING COLLAGEN OR GELATIN
US5830986A (en) * 1996-10-28 1998-11-03 Massachusetts Institute Of Technology Methods for the synthesis of functionalizable poly(ethylene oxide) star macromolecules
US6800278B1 (en) * 1996-10-28 2004-10-05 Ballard Medical Products, Inc. Inherently antimicrobial quaternary amine hydrogel wound dressings
FR2759084B1 (en) * 1997-02-06 1999-10-29 Dev Des Utilisations Du Collag COLLAGENIC MATERIAL USEFUL IN PARTICULAR FOR THE PREVENTION OF POST-OPERATIVE ADHESIONS
CA2286590C (en) 1997-04-18 2005-08-02 California Institute Of Technology Multifunctional polymeric tissue coatings
US6303585B1 (en) 1997-07-03 2001-10-16 Orquest, Inc. Cross-linked polysaccharide drug carrier
JP4182269B2 (en) 1997-08-08 2008-11-19 ベーリングウエルケ、アクティエンゲゼルシャフト Polysaccharide conjugates of biomolecules
US5929049A (en) 1997-08-08 1999-07-27 Dade Behring Marburg Gmbh Polysaccharide conjugates of biomolecules
US6514534B1 (en) * 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6703047B2 (en) * 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US7347850B2 (en) 1998-08-14 2008-03-25 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
US6458147B1 (en) * 1998-11-06 2002-10-01 Neomend, Inc. Compositions, systems, and methods for arresting or controlling bleeding or fluid leakage in body tissue
US6696089B2 (en) * 1998-09-03 2004-02-24 Board Of Regents Of The University Of Nebraska Nanogel networks including polyion polymer fragments and biological agent compositions thereof
US6465694B1 (en) * 1998-10-26 2002-10-15 University Of Utah Research Foundation Method for preparation of polyethylene glycol aldehyde derivatives
US6121375A (en) * 1999-02-11 2000-09-19 Hydromer, Inc. Gels formed by the interaction of poly(aldehyde) with various substances
WO2000051566A1 (en) * 1999-03-04 2000-09-08 United States Surgical Corporation Scar reduction
ATA49899A (en) * 1999-03-19 2002-06-15 Immuno Ag METHOD AND DEVICE FOR MIXING COMPONENTS
DE19921898A1 (en) 1999-05-12 2000-11-16 Creavis Tech & Innovation Gmbh Preparation of antimicrobial polymer for medical and hygiene articles, varnishes, paints and coatings comprises polymerizing monomers that have been functionalized by a tert. amino group
JP2003503367A (en) * 1999-06-11 2003-01-28 シアウォーター・コーポレイション Hydrogels derived from chitosan and poly (ethylene glycol) or related polymers
JP2003520210A (en) 2000-01-05 2003-07-02 イマレックス セラピューティクス， インコーポレイテッド Pharmaceutical formulations for delivery of drugs with low water solubility
WO2001072280A2 (en) 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for gene therapy
US6387689B1 (en) 2000-03-31 2002-05-14 The United States Of America As Represented By The Secretary Of Agriculture Fungal degradation and bioremediation system for creosote-treated wood
NL1015159C2 (en) 2000-05-11 2001-11-13 Inst Agrotechnologisch Onderzoek Ato Dlo Functionalized polysaccharide.
JP2004523624A (en) 2001-02-26 2004-08-05 デューク ユニバーシティ Novel dendritic polymer and its biomedical use
US6844028B2 (en) 2001-06-26 2005-01-18 Accelr8 Technology Corporation Functional surface coating
US6710175B2 (en) 2001-08-31 2004-03-23 Kevin Ray Anderson Compositions suitable as additives in the paper industry, preparation; use; and, paper comprising such
DE10152407A1 (en) 2001-10-24 2003-05-08 Aesculap Ag & Co Kg Composition of at least two biocompatible chemically crosslinkable components
EP1364663A1 (en) 2002-05-21 2003-11-26 Commonwealth Scientific And Industrial Research Organisation Ocular devices with functionalized surface with adhesive properties
KR20040040782A (en) * 2002-11-08 2004-05-13 선바이오(주) Novel hexa-arm polyethylene glycol and its derivatives and the methods of preparation thereof
US7217845B2 (en) * 2002-11-25 2007-05-15 Sun Bio, Inc. Bifunctional polyethylene glycol derivatives
US7323539B2 (en) 2003-05-06 2008-01-29 E. I. Du Pont De Nemours And Company Polytrimethylene ether glycol and polytrimethylene ether ester with excellent quality
KR100512483B1 (en) 2003-05-07 2005-09-05 선바이오(주) Novel Preparation method of PEG-maleimide PEG derivatives
US20060004400A1 (en) 2004-06-16 2006-01-05 Mcgurk Erin Method of treating a lung
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
EP1647937A1 (en) * 2004-10-15 2006-04-19 Sony Deutschland GmbH Method for motion estimation
US7837986B2 (en) 2004-12-01 2010-11-23 E. I. Du Pont De Nemours And Company Protein-based polymer tissue adhesives for medical use
KR101201056B1 (en) 2005-01-31 2012-11-14 가부시끼가이샤 비엠지 Self-degradable two-component reactive adhesive for medical use and resin for medical use
US7834065B2 (en) 2005-01-31 2010-11-16 Bmg Incorporated Medical-use two part reactive adhesive and medical-use resin having self-degradation property
EP1846505B1 (en) 2005-02-09 2015-11-11 Covidien LP Synthetic sealants
DE102005030011A1 (en) 2005-06-17 2006-12-21 Aesculap Ag & Co. Kg Process for the preparation of sterile polysaccharide solutions
US20070031467A1 (en) 2005-08-04 2007-02-08 Abrahams John M Composition and method for vascular embolization
US8679537B2 (en) 2005-08-24 2014-03-25 Actamaz Surgical Materials, LLC Methods for sealing an orifice in tissue using an aldol-crosslinked polymeric hydrogel adhesive
US7868132B2 (en) 2006-04-25 2011-01-11 E. I. Du Pont De Nemours And Company Method for preparing multi-arm poly (ethylene glycol) amines
US7960498B2 (en) 2006-06-30 2011-06-14 Actamax Surgical Materials, Llc Tissue adhesives with modified elasticity
CN101541857B (en) 2006-11-27 2012-12-12 阿克塔马克斯手术器材有限责任公司 Multi-functional polyalkylene oxide, hydrogel tissue adhesives
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
US20100112063A1 (en) * 2007-06-28 2010-05-06 Figuly Garret D Method for preparing a hydrogel adhesive having extended gelation time and decreased degradation time
US20090035249A1 (en) 2007-08-02 2009-02-05 Bhatia Sujata K Method of inhibiting proliferation of Escherichia coli
US8241609B2 (en) * 2007-08-24 2012-08-14 E I Du Pont De Nemours And Company Method for embolization using liquid embolic materials
US8426492B2 (en) 2007-11-14 2013-04-23 Actamax Surgical Materials, Llc Oxidized cationic polysaccharide-based polymer tissue adhesive for medical use
JP5559190B2 (en) 2008-11-19 2014-07-23 アクタマックス サージカル マテリアルズ リミテッド ライアビリティ カンパニー Fibrous tissue sealant and method of use thereof
US9044529B2 (en) 2008-11-19 2015-06-02 Actamax Surgical Materials, Llc Hydrogel tissue adhesive formed from aminated polysaccharide and aldehyde-functionalized multi-arm polyether

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5092883A (en) * 1988-12-28 1992-03-03 Eppley Barry L Method for promoting soft connective tissue growth and repair in mammals
US5502042A (en) * 1994-07-22 1996-03-26 United States Surgical Corporation Methods and compositions for treating wounds
US20020151520A1 (en) * 1999-03-25 2002-10-17 Gruskin Elliott A. Method of promoting angiogenesis
US20060078536A1 (en) * 2004-10-07 2006-04-13 Kodokian George K Polysaccharide-based polymer tissue adhesive for medical use
WO2009064977A2 (en) * 2007-11-14 2009-05-22 E.I. Du Pont De Nemours And Company Dextran-based polymer tissue adhesive for medical use

Also Published As

Publication number Publication date
US8426492B2 (en) 2013-04-23
EP2214731B1 (en) 2014-05-14
US20100272804A1 (en) 2010-10-28
WO2009064963A2 (en) 2009-05-22
EP2214731A2 (en) 2010-08-11

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