WO2009061916A3 - Benzodiazepinone compounds useful in the treatment of skin conditions - Google Patents

Benzodiazepinone compounds useful in the treatment of skin conditions Download PDF

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Publication number
WO2009061916A3
WO2009061916A3 PCT/US2008/082629 US2008082629W WO2009061916A3 WO 2009061916 A3 WO2009061916 A3 WO 2009061916A3 US 2008082629 W US2008082629 W US 2008082629W WO 2009061916 A3 WO2009061916 A3 WO 2009061916A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzodiazepinone
skin conditions
treatment
compounds useful
benzodiazepinone compounds
Prior art date
Application number
PCT/US2008/082629
Other languages
French (fr)
Other versions
WO2009061916A2 (en
Inventor
Gary D Glick
Original Assignee
Univ Michigan
Gary D Glick
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN2008801190839A priority Critical patent/CN101918375A/en
Priority to EP08847030.7A priority patent/EP2217576B1/en
Priority to AU2008323945A priority patent/AU2008323945B2/en
Priority to CA2703005A priority patent/CA2703005A1/en
Priority to NZ584842A priority patent/NZ584842A/en
Priority to MX2010004857A priority patent/MX2010004857A/en
Application filed by Univ Michigan, Gary D Glick filed Critical Univ Michigan
Priority to JP2010532341A priority patent/JP5539212B2/en
Priority to BRPI0820477-2A priority patent/BRPI0820477A2/en
Publication of WO2009061916A2 publication Critical patent/WO2009061916A2/en
Publication of WO2009061916A3 publication Critical patent/WO2009061916A3/en
Priority to ZA2010/02764A priority patent/ZA201002764B/en
Priority to IL205562A priority patent/IL205562A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a benzodiazepinone.
PCT/US2008/082629 2007-11-06 2008-11-06 Benzodiazepinone compounds useful in the treatment of skin conditions WO2009061916A2 (en)

Priority Applications (10)

Application Number Priority Date Filing Date Title
EP08847030.7A EP2217576B1 (en) 2007-11-06 2008-11-06 Benzodiazepinone compounds useful in the treatment of skin conditions
AU2008323945A AU2008323945B2 (en) 2007-11-06 2008-11-06 Benzodiazepinone compounds useful in the treatment of skin conditions
CA2703005A CA2703005A1 (en) 2007-11-06 2008-11-06 Benzodiazepinone compounds useful in the treatment of skin conditions
NZ584842A NZ584842A (en) 2007-11-06 2008-11-06 Benzodiazepinone compounds useful in the treatment of skin conditions, in particular, psoriasis
MX2010004857A MX2010004857A (en) 2007-11-06 2008-11-06 Benzodiazepinone compounds useful in the treatment of skin conditions.
CN2008801190839A CN101918375A (en) 2007-11-06 2008-11-06 Benzodiazepinone compounds useful in the treatment of skin conditions
JP2010532341A JP5539212B2 (en) 2007-11-06 2008-11-06 Benzodiazepinone compounds useful for the treatment of skin conditions
BRPI0820477-2A BRPI0820477A2 (en) 2007-11-06 2008-11-06 Benzodiazepinone compounds useful in the treatment of skin disorders
ZA2010/02764A ZA201002764B (en) 2007-11-06 2010-04-20 Benzodiazepinone compounds useful in the treatment of skin conditions
IL205562A IL205562A0 (en) 2007-11-06 2010-05-05 Benzodiazepinone compounds useful in the treatment of skin conditions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98589807P 2007-11-06 2007-11-06
US60/985,898 2007-11-06

Publications (2)

Publication Number Publication Date
WO2009061916A2 WO2009061916A2 (en) 2009-05-14
WO2009061916A3 true WO2009061916A3 (en) 2009-07-16

Family

ID=40588763

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/082629 WO2009061916A2 (en) 2007-11-06 2008-11-06 Benzodiazepinone compounds useful in the treatment of skin conditions

Country Status (15)

Country Link
US (3) US8188072B2 (en)
EP (1) EP2217576B1 (en)
JP (1) JP5539212B2 (en)
KR (1) KR20100083819A (en)
CN (1) CN101918375A (en)
AU (1) AU2008323945B2 (en)
BR (1) BRPI0820477A2 (en)
CA (1) CA2703005A1 (en)
IL (1) IL205562A0 (en)
MX (1) MX2010004857A (en)
NZ (1) NZ584842A (en)
RU (1) RU2010122902A (en)
UA (1) UA99839C2 (en)
WO (1) WO2009061916A2 (en)
ZA (1) ZA201002764B (en)

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US20060025388A1 (en) 1999-04-30 2006-02-02 Glick Gary D Compositions and methods relating to novel compounds and targets thereof
NZ568254A (en) 2005-11-01 2011-06-30 Univ Michigan 1,4-Benzodiazepine-2,5-diones for regulating cell death and treating autoimmune diseases
US8097612B2 (en) 2006-06-09 2012-01-17 The Regents Of The University Of Michigan Compositions and methods relating to novel compounds and targets thereof
NZ579507A (en) * 2007-03-09 2011-11-25 Univ Michigan Compositions and methods relating to novel compounds and targets thereof
EP2200977B1 (en) 2007-09-14 2016-11-09 The Regents of the University of Michigan F1f0-atpase inhibitors and related methods
US8188072B2 (en) 2007-11-06 2012-05-29 The Regents Of The University Of Michigan Benzodiazepinone compounds useful in the treatment of skin conditions
AU2009291632B2 (en) 2008-09-11 2013-04-04 The Regents Of The University Of Michigan Aryl guanidine F1F0-ATPase inhibitors and related methods
US8604023B2 (en) 2009-04-17 2013-12-10 The Regents Of The University Of Michigan 1,4-benzodiazepinone compounds and their use in treating cancer
US8673897B2 (en) 2009-09-18 2014-03-18 The Regents Of The University Of Michigan Benzodiazepinone compounds and methods of treatment using same
CN102753544A (en) 2009-11-17 2012-10-24 密执安大学评议会 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
JP5856063B2 (en) 2009-11-17 2016-02-09 ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン 1,4-Benzodiazepine-2,5-dione and related compounds having therapeutic properties
WO2015130891A2 (en) 2014-02-26 2015-09-03 Illumicure Inc. Ultraviolet phototherapy apparatuses and methods
WO2017139514A1 (en) 2016-02-09 2017-08-17 Luma Therapeutics, Inc. Methods, compositions and apparatuses for treating psoriasis by phototherapy
AU2017272889B2 (en) * 2016-06-03 2020-04-30 Avexxin As Combination therapy comprising a polyunsaturated ketone and a calcineurin inhibitor
AU2017329957B2 (en) 2016-09-21 2020-05-07 Avexxin As Pharmaceutical composition

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US20120040971A1 (en) 2012-02-16
RU2010122902A (en) 2011-12-20
US20090118244A1 (en) 2009-05-07
JP5539212B2 (en) 2014-07-02
US8759340B2 (en) 2014-06-24
CA2703005A1 (en) 2009-05-14
KR20100083819A (en) 2010-07-22
NZ584842A (en) 2012-06-29
US8188072B2 (en) 2012-05-29
ZA201002764B (en) 2011-06-29
EP2217576A2 (en) 2010-08-18
BRPI0820477A2 (en) 2015-06-16
MX2010004857A (en) 2010-07-28
AU2008323945A1 (en) 2009-05-14
IL205562A0 (en) 2010-12-30
US20130274197A1 (en) 2013-10-17
UA99839C2 (en) 2012-10-10
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WO2009061916A2 (en) 2009-05-14
CN101918375A (en) 2010-12-15
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EP2217576B1 (en) 2016-05-11

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