WO2009049105A3 - Methods for inducing satiation - Google Patents

Methods for inducing satiation Download PDF

Info

Publication number
WO2009049105A3
WO2009049105A3 PCT/US2008/079434 US2008079434W WO2009049105A3 WO 2009049105 A3 WO2009049105 A3 WO 2009049105A3 US 2008079434 W US2008079434 W US 2008079434W WO 2009049105 A3 WO2009049105 A3 WO 2009049105A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
inducing satiation
increasing
disclosed
small intestine
Prior art date
Application number
PCT/US2008/079434
Other languages
French (fr)
Other versions
WO2009049105A2 (en
Inventor
Eric Elenko
Eyal S Ron
Yishai Zohar
Original Assignee
Gelesis Inc
Eric Elenko
Eyal S Ron
Yishai Zohar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gelesis Inc, Eric Elenko, Eyal S Ron, Yishai Zohar filed Critical Gelesis Inc
Publication of WO2009049105A2 publication Critical patent/WO2009049105A2/en
Publication of WO2009049105A3 publication Critical patent/WO2009049105A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

Abstract

One aspect of the present invention relates to methods for inducing satiation to prevent or treat obesity and manage weight/body composition by decreasing food intake both during a meal and to increasing the duration of time between meals. Specifically methods to increase the size of a food bolus without increasing the corresponding energy density are disclosed. In addition, methods of inducing satiation through small intestine volume displacement and placement of pressure on the walls of the small intestine in a manner which is non-invasive and does not result in significant pain or discomfort are disclosed.
PCT/US2008/079434 2007-10-09 2008-10-09 Methods for inducing satiation WO2009049105A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97857607P 2007-10-09 2007-10-09
US60/978,576 2007-10-09

Publications (2)

Publication Number Publication Date
WO2009049105A2 WO2009049105A2 (en) 2009-04-16
WO2009049105A3 true WO2009049105A3 (en) 2009-07-16

Family

ID=40549842

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/079434 WO2009049105A2 (en) 2007-10-09 2008-10-09 Methods for inducing satiation

Country Status (1)

Country Link
WO (1) WO2009049105A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9486463B2 (en) 2010-10-19 2016-11-08 Ambra Bioscience Llc Chemosensory receptor ligand-based therapies

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2231212A2 (en) 2007-12-20 2010-09-29 7L, Llc Swallowable self-expanding gastric space occupying device
US8828953B2 (en) 2009-04-20 2014-09-09 NaZura BioHealth, Inc. Chemosensory receptor ligand-based therapies
US9901551B2 (en) 2009-04-20 2018-02-27 Ambra Bioscience Llc Chemosensory receptor ligand-based therapies
US9962275B2 (en) 2010-10-07 2018-05-08 Randy Louis Werneth Temporary gastric device (TGD) and method of use
PT2739270T (en) * 2011-08-01 2020-04-02 Hb Biotechnologies Corp Non-digestible capsules for the delivery of fluid absorbing materials
CN106822097B (en) * 2017-03-10 2022-01-25 中山万汉制药有限公司 Orlistat-containing pharmaceutical composition for losing weight
CN106924270B (en) * 2017-03-10 2020-07-31 中山万汉制药有限公司 Orlistat-containing pharmaceutical composition with weight-losing function
BR102020014545A2 (en) * 2020-07-16 2022-01-25 Edson Luiz Peracchi Long-term resorbable subcutaneous implant with sustained release of pre-concentrated polymer pharmacologically active substance for obesity treatment and process
ES2902196B2 (en) 2020-09-25 2024-01-26 Viscofan Sa Dry collagen powder with satiating properties and method for its preparation
CN114009797A (en) * 2021-11-17 2022-02-08 上海市第十人民医院 Weight-losing composition and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000103732A (en) * 1998-07-28 2000-04-11 Tanabe Seiyaku Co Ltd Intestinal right place release preparation
US6355270B1 (en) * 1999-01-11 2002-03-12 The Regents Of The University Of California Particles for oral delivery of peptides and proteins
US20040219186A1 (en) * 2001-08-16 2004-11-04 Ayres James W. Expandable gastric retention device
US20050042277A1 (en) * 2003-07-17 2005-02-24 Irukulla Srinivas Pharmaceutical compositions having a swellable coating

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000103732A (en) * 1998-07-28 2000-04-11 Tanabe Seiyaku Co Ltd Intestinal right place release preparation
US6355270B1 (en) * 1999-01-11 2002-03-12 The Regents Of The University Of California Particles for oral delivery of peptides and proteins
US20040219186A1 (en) * 2001-08-16 2004-11-04 Ayres James W. Expandable gastric retention device
US20050042277A1 (en) * 2003-07-17 2005-02-24 Irukulla Srinivas Pharmaceutical compositions having a swellable coating

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9486463B2 (en) 2010-10-19 2016-11-08 Ambra Bioscience Llc Chemosensory receptor ligand-based therapies

Also Published As

Publication number Publication date
WO2009049105A2 (en) 2009-04-16

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