WO2009036712A3 - Dosage form containing tramadol with controlled 24-hour release and a process for manufacturing the same - Google Patents

Dosage form containing tramadol with controlled 24-hour release and a process for manufacturing the same Download PDF

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Publication number
WO2009036712A3
WO2009036712A3 PCT/CZ2008/000112 CZ2008000112W WO2009036712A3 WO 2009036712 A3 WO2009036712 A3 WO 2009036712A3 CZ 2008000112 W CZ2008000112 W CZ 2008000112W WO 2009036712 A3 WO2009036712 A3 WO 2009036712A3
Authority
WO
WIPO (PCT)
Prior art keywords
manufacturing
controlled
same
dosage form
form containing
Prior art date
Application number
PCT/CZ2008/000112
Other languages
French (fr)
Other versions
WO2009036712A2 (en
Inventor
Beata Vladovicova
Juraj Zeleznik
Viera Kormanova
Viera Hubinova
Original Assignee
Zentiva As
Beata Vladovicova
Juraj Zeleznik
Viera Kormanova
Viera Hubinova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zentiva As, Beata Vladovicova, Juraj Zeleznik, Viera Kormanova, Viera Hubinova filed Critical Zentiva As
Publication of WO2009036712A2 publication Critical patent/WO2009036712A2/en
Publication of WO2009036712A3 publication Critical patent/WO2009036712A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Abstract

A dosage form containing tramadol or its pharmacologically acceptable salts, wherein releasing of the active ingredient for 24 hours is controlled by a hydrophobic polymer membrane, which contains 30 to 95% by weight of the active ingredient in the form of microparticles and 5 to 25 % by weight of a hydrophobic polymer, and a process for manufacturing the same.
PCT/CZ2008/000112 2007-09-20 2008-09-22 Dosage form containing tramadol with controlled 24-hour release and a process for manufacturing the same WO2009036712A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20070658A CZ300468B6 (en) 2007-09-20 2007-09-20 Tramadol-containing, 24 hours controlled release medicamentous formulation and process for preparing thereof
CZPV2007-658 2007-09-20

Publications (2)

Publication Number Publication Date
WO2009036712A2 WO2009036712A2 (en) 2009-03-26
WO2009036712A3 true WO2009036712A3 (en) 2009-05-07

Family

ID=40351686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2008/000112 WO2009036712A2 (en) 2007-09-20 2008-09-22 Dosage form containing tramadol with controlled 24-hour release and a process for manufacturing the same

Country Status (2)

Country Link
CZ (1) CZ300468B6 (en)
WO (1) WO2009036712A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19630035A1 (en) * 1996-07-25 1998-01-29 Asta Medica Ag Tramadol multiple unit formulations
WO2001015667A1 (en) * 1999-08-31 2001-03-08 Grünenthal GmbH Oral dosage forms
EP1190712A1 (en) * 2000-09-22 2002-03-27 SMB Technology Oral once daily tramadol beads composition
WO2002066026A2 (en) * 2001-02-21 2002-08-29 Grünenthal GmbH Tramadol-based medicament
US20070104788A1 (en) * 2005-11-10 2007-05-10 Seamus Mulligan Once-daily administration of central nervous system drugs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
NZ260408A (en) * 1993-05-10 1996-05-28 Euro Celtique Sa Controlled release preparation comprising tramadol
GB9404544D0 (en) * 1994-03-09 1994-04-20 Euro Celtique Sa Controlled release formulation
US6156342A (en) * 1998-05-26 2000-12-05 Andex Pharmaceuticals, Inc. Controlled release oral dosage form

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19630035A1 (en) * 1996-07-25 1998-01-29 Asta Medica Ag Tramadol multiple unit formulations
US6436438B1 (en) * 1996-07-25 2002-08-20 Asto-Medica Ag Tramadol multiple unit formulations
WO2001015667A1 (en) * 1999-08-31 2001-03-08 Grünenthal GmbH Oral dosage forms
EP1190712A1 (en) * 2000-09-22 2002-03-27 SMB Technology Oral once daily tramadol beads composition
WO2002066026A2 (en) * 2001-02-21 2002-08-29 Grünenthal GmbH Tramadol-based medicament
US20070104788A1 (en) * 2005-11-10 2007-05-10 Seamus Mulligan Once-daily administration of central nervous system drugs

Also Published As

Publication number Publication date
CZ2007658A3 (en) 2009-04-01
WO2009036712A2 (en) 2009-03-26
CZ300468B6 (en) 2009-05-27

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