WO2009023672A3 - Abuse resistant drugs, method of use and method of making - Google Patents

Abuse resistant drugs, method of use and method of making Download PDF

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Publication number
WO2009023672A3
WO2009023672A3 PCT/US2008/072914 US2008072914W WO2009023672A3 WO 2009023672 A3 WO2009023672 A3 WO 2009023672A3 US 2008072914 W US2008072914 W US 2008072914W WO 2009023672 A3 WO2009023672 A3 WO 2009023672A3
Authority
WO
WIPO (PCT)
Prior art keywords
layer
polymer
making
barrier layer
abuse resistant
Prior art date
Application number
PCT/US2008/072914
Other languages
French (fr)
Other versions
WO2009023672A2 (en
Inventor
Manish S. Shah
Ray J. Difalco
Original Assignee
Abuse Deterrent Pharmaceutical Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40351440&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2009023672(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to PL08797716T priority Critical patent/PL2187873T3/en
Priority to CN200880103447A priority patent/CN101801350A/en
Priority to BRPI0815387A priority patent/BRPI0815387B8/en
Priority to EP08797716.1A priority patent/EP2187873B1/en
Priority to AU2008286914A priority patent/AU2008286914B2/en
Priority to US12/680,701 priority patent/US10736850B2/en
Priority to MX2010001812A priority patent/MX336789B/en
Priority to CA2696341A priority patent/CA2696341C/en
Priority to JP2010521121A priority patent/JP5965583B2/en
Application filed by Abuse Deterrent Pharmaceutical Llc filed Critical Abuse Deterrent Pharmaceutical Llc
Priority to ES08797716.1T priority patent/ES2692437T3/en
Priority to CA2734075A priority patent/CA2734075C/en
Priority to AU2009282376A priority patent/AU2009282376A1/en
Priority to EP09806994A priority patent/EP2331080A4/en
Priority to PCT/US2009/033919 priority patent/WO2010019279A1/en
Priority to US13/058,757 priority patent/US10314788B2/en
Publication of WO2009023672A2 publication Critical patent/WO2009023672A2/en
Publication of WO2009023672A3 publication Critical patent/WO2009023672A3/en
Priority to US12/950,819 priority patent/US7955619B2/en
Priority to US13/040,979 priority patent/US10688053B2/en
Priority to US13/040,792 priority patent/US10688052B2/en
Priority to US13/040,775 priority patent/US10688051B2/en
Priority to US13/041,024 priority patent/US10688054B2/en
Priority to US13/040,953 priority patent/US11045422B2/en
Priority to US13/041,020 priority patent/US10736851B2/en
Priority to US13/040,701 priority patent/US10695298B2/en
Priority to US13/408,076 priority patent/US10736852B2/en
Priority to US13/408,068 priority patent/US10729656B2/en
Priority to US14/274,319 priority patent/US10702480B2/en
Priority to US14/274,384 priority patent/US10688055B2/en
Priority to US14/485,334 priority patent/US10729657B2/en
Priority to US14/494,148 priority patent/US20150044282A1/en
Priority to US14/536,396 priority patent/US20150064248A1/en
Priority to US14/536,357 priority patent/US11278500B2/en
Priority to US14/536,391 priority patent/US11191730B2/en
Priority to US14/536,459 priority patent/US11285112B2/en
Priority to US14/536,332 priority patent/US20150064247A1/en
Priority to US14/536,478 priority patent/US11291634B2/en
Priority to US16/360,865 priority patent/US20190209480A1/en

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    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
    • Y10T156/10—Methods of surface bonding and/or assembly therefor

Abstract

An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (GI) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided.
PCT/US2008/072914 2007-08-13 2008-08-12 Abuse resistant drugs, method of use and method of making WO2009023672A2 (en)

Priority Applications (36)

Application Number Priority Date Filing Date Title
ES08797716.1T ES2692437T3 (en) 2007-08-13 2008-08-12 Abuse-resistant drugs, method of use and method of preparation
CN200880103447A CN101801350A (en) 2007-08-13 2008-08-12 Abuse resistant drugs, using method and preparation method
JP2010521121A JP5965583B2 (en) 2007-08-13 2008-08-12 Abuse resistant pharmaceutical composition, method of use and preparation
EP08797716.1A EP2187873B1 (en) 2007-08-13 2008-08-12 Abuse resistant drugs, method of use and method of making
AU2008286914A AU2008286914B2 (en) 2007-08-13 2008-08-12 Abuse resistant drugs, method of use and method of making
US12/680,701 US10736850B2 (en) 2007-08-13 2008-08-12 Abuse resistant oral opioid formulations
MX2010001812A MX336789B (en) 2007-08-13 2008-08-12 Abuse resistant drugs, method of use and method of making.
CA2696341A CA2696341C (en) 2007-08-13 2008-08-12 Abuse resistant drugs, method of use and method of making
BRPI0815387A BRPI0815387B8 (en) 2007-08-13 2008-08-12 pharmaceutical composition, method for making a pharmaceutical composition and use of the pharmaceutical composition
PL08797716T PL2187873T3 (en) 2007-08-13 2008-08-12 Abuse resistant drugs, method of use and method of making
EP09806994A EP2331080A4 (en) 2008-08-12 2009-02-12 Pharmaceutical compositions configured to deter dosage form splitting
US13/058,757 US10314788B2 (en) 2007-08-13 2009-02-12 Pharmaceutical compositions configured to deter dosage form splitting
AU2009282376A AU2009282376A1 (en) 2008-08-12 2009-02-12 Pharmaceutical compositions configured to deter dosage form splitting
CA2734075A CA2734075C (en) 2008-08-12 2009-02-12 Pharmaceutical compositions configured to deter dosage form splitting
PCT/US2009/033919 WO2010019279A1 (en) 2008-08-12 2009-02-12 Pharmaceutical compositions configured to deter dosage form splitting
US12/950,819 US7955619B2 (en) 2007-08-13 2010-11-19 Abuse resistant drugs, method of use and method of making
US13/041,020 US10736851B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release morphine with oxycodone, method of use and method of making
US13/040,701 US10695298B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release hydromorphone, method of use and method of making
US13/040,792 US10688052B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release oxymorphone, method of use and method of making
US13/040,979 US10688053B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release hydrocodone, method of use and method of making
US13/040,953 US11045422B2 (en) 2007-08-13 2011-03-04 Abuse resistant drugs, method of use and method of making
US13/040,775 US10688051B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release oxycodone, method of use, and method of making
US13/041,024 US10688054B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release morphine, method of use and method of making
US13/408,076 US10736852B2 (en) 2007-08-13 2012-02-29 Abuse resistant oral opioid formulations
US13/408,068 US10729656B2 (en) 2007-08-13 2012-02-29 Abuse resistant forms of immediate release oxycodone, method of use and method of making
US14/274,319 US10702480B2 (en) 2007-08-13 2014-05-09 Abuse resistant forms of extended release morphine, method of use and method of making
US14/274,384 US10688055B2 (en) 2007-08-13 2014-05-09 Abuse resistant forms of extended release morphine, method of use and method of making
US14/485,334 US10729657B2 (en) 2007-08-13 2014-09-12 Abuse resistant forms of extended release morphine, method of use and method of making
US14/494,148 US20150044282A1 (en) 2007-08-13 2014-09-23 Abuse resistant forms of immediate release oxycodone, method of use and method of making
US14/536,478 US11291634B2 (en) 2007-08-13 2014-11-07 Abuse resistant forms of extended release oxymorphone, method of use and method of making
US14/536,332 US20150064247A1 (en) 2007-08-13 2014-11-07 Abuse resistant forms of immediate release hydrocodone, method of use and method of making
US14/536,459 US11285112B2 (en) 2007-08-13 2014-11-07 Abuse resistant forms of immediate release oxymorphone, method of use and method of making
US14/536,396 US20150064248A1 (en) 2007-08-13 2014-11-07 Abuse resistant forms of extended release hydromorphone, method of use and method of making
US14/536,357 US11278500B2 (en) 2007-08-13 2014-11-07 Abuse resistant forms of extended release hydrocodone, method of use and method of making
US14/536,391 US11191730B2 (en) 2007-08-13 2014-11-07 Abuse resistant forms of immediate release hydromorphone, method of use and method of making
US16/360,865 US20190209480A1 (en) 2007-08-13 2019-03-21 Pharmaceutical compositions configured to deter dosage form splitting

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95558407P 2007-08-13 2007-08-13
US60/955,584 2007-08-13

Related Child Applications (13)

Application Number Title Priority Date Filing Date
US12/680,701 A-371-Of-International US10736850B2 (en) 2007-08-13 2008-08-12 Abuse resistant oral opioid formulations
PCT/US2009/033919 Continuation-In-Part WO2010019279A1 (en) 2007-08-13 2009-02-12 Pharmaceutical compositions configured to deter dosage form splitting
US13/058,757 Continuation-In-Part US10314788B2 (en) 2007-08-13 2009-02-12 Pharmaceutical compositions configured to deter dosage form splitting
US12/950,819 Continuation US7955619B2 (en) 2007-08-13 2010-11-19 Abuse resistant drugs, method of use and method of making
US13/040,979 Continuation US10688053B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release hydrocodone, method of use and method of making
US13/041,020 Continuation US10736851B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release morphine with oxycodone, method of use and method of making
US13/040,701 Continuation US10695298B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release hydromorphone, method of use and method of making
US13/040,953 Continuation US11045422B2 (en) 2007-08-13 2011-03-04 Abuse resistant drugs, method of use and method of making
US13/040,775 Continuation US10688051B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release oxycodone, method of use, and method of making
US13/041,024 Continuation US10688054B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release morphine, method of use and method of making
US13/040,792 Continuation US10688052B2 (en) 2007-08-13 2011-03-04 Abuse resistant forms of extended release oxymorphone, method of use and method of making
US13/408,076 Continuation US10736852B2 (en) 2007-08-13 2012-02-29 Abuse resistant oral opioid formulations
US13/408,068 Continuation US10729656B2 (en) 2007-08-13 2012-02-29 Abuse resistant forms of immediate release oxycodone, method of use and method of making

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EP (1) EP2187873B1 (en)
JP (2) JP5965583B2 (en)
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AU (4) AU2008286914B2 (en)
BR (1) BRPI0815387B8 (en)
CA (2) CA2696341C (en)
ES (1) ES2692437T3 (en)
MX (1) MX336789B (en)
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Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
CN101801350A (en) * 2007-08-13 2010-08-11 阿巴斯迪特宁医药有限公司 Abuse resistant drugs, using method and preparation method
US8372432B2 (en) 2008-03-11 2013-02-12 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
EP2262484B1 (en) * 2008-03-11 2013-01-23 Depomed, Inc. Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic
CA2734075C (en) * 2008-08-12 2017-04-18 Inspirion Delivery Technologies, Llc Pharmaceutical compositions configured to deter dosage form splitting
ES2509497T3 (en) * 2008-12-16 2014-10-17 Paladin Labs Inc. Controlled release formulation to prevent misuse
BRPI0924427A2 (en) * 2009-03-18 2016-01-26 Evonik Roehm Gmbh controlled release pharmaceutical composition, its preparation process and its use
WO2011026125A2 (en) * 2009-08-31 2011-03-03 Depomed, Inc. Gastric retentive pharmaceutical compositions for immediate and extended release of acetaminophen
US8597681B2 (en) 2009-12-22 2013-12-03 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
US9198861B2 (en) 2009-12-22 2015-12-01 Mallinckrodt Llc Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans
CN103327969A (en) 2010-12-23 2013-09-25 普渡制药公司 Tamper resistant solid oral dosage forms
US8858963B1 (en) 2011-05-17 2014-10-14 Mallinckrodt Llc Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia
US8741885B1 (en) 2011-05-17 2014-06-03 Mallinckrodt Llc Gastric retentive extended release pharmaceutical compositions
US9050335B1 (en) 2011-05-17 2015-06-09 Mallinckrodt Llc Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and prolonged period of analgesia
WO2017099974A1 (en) * 2015-10-20 2017-06-15 Jun Xia Systems for brain stimulation during sleep and methods of use thereof
FR2979242A1 (en) * 2011-08-29 2013-03-01 Sanofi Sa COMPRESSES AGAINST ABUSIVE USE, BASED ON PARACETAMOL AND OXYCODONE
WO2013038268A1 (en) * 2011-09-16 2013-03-21 Purdue Pharma L.P. Tamper resistant immediate release formulations
JP6067100B2 (en) 2012-04-18 2017-01-25 マリンクロッド エルエルシー Immediate release abuse deterrent pharmaceutical composition
CA2877774C (en) * 2012-07-12 2017-07-18 Mallinckrodt Llc Extended release, abuse deterrent pharmaceutical compositions
US9675587B2 (en) 2013-03-14 2017-06-13 Allergan Holdings Unlimited Company Opioid receptor modulator dosage formulations
JP6255474B2 (en) 2013-03-15 2017-12-27 マリンクロッド エルエルシー Abuse deterrent solid dosage form for immediate release with functional secant
US20150005334A1 (en) * 2013-03-15 2015-01-01 Inspirion Delivery Technologies, Llc Abuse deterrent compositions and methods of use
WO2014146093A2 (en) * 2013-03-15 2014-09-18 Inspirion Delivery Technologies, Llc Abuse deterrent compositions and methods of use
EP2968178B1 (en) * 2013-03-15 2019-10-09 Inspirion Delivery Sciences LLC Pharmaceuticals comprising a ph-dependent component and ph-raising agent
US10751287B2 (en) 2013-03-15 2020-08-25 Purdue Pharma L.P. Tamper resistant pharmaceutical formulations
US10195153B2 (en) 2013-08-12 2019-02-05 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
US9770514B2 (en) 2013-09-03 2017-09-26 ExxPharma Therapeutics LLC Tamper-resistant pharmaceutical dosage forms
US20150118300A1 (en) 2013-10-31 2015-04-30 Cima Labs Inc. Immediate Release Abuse-Deterrent Granulated Dosage Forms
EA032013B1 (en) * 2013-10-31 2019-03-29 Сайма Лэбс Инк. Immediate release abuse-deterrent granulated dosage forms
US9649279B2 (en) * 2013-12-16 2017-05-16 Massachusetts Institute Of Technology Fortified micronutrient salt formulations
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
KR101471361B1 (en) * 2014-03-18 2014-12-11 (주)앤디포스 Double-sided tape for touch screen panel and manufacturing method thereof
ES2963078T3 (en) 2014-07-03 2024-03-25 SpecGx LLC Abuse-deterrent immediate-release formulations comprising non-cellulosic polysaccharides
CA2910865C (en) 2014-07-15 2016-11-29 Isa Odidi Compositions and methods for reducing overdose
EP3169315B1 (en) 2014-07-17 2020-06-24 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
WO2016043698A1 (en) * 2014-09-15 2016-03-24 Inspirion Delivery Technologies, Llc Orally administrable compositions and methods of deterring abuse by intranasal administration
US10729685B2 (en) 2014-09-15 2020-08-04 Ohemo Life Sciences Inc. Orally administrable compositions and methods of deterring abuse by intranasal administration
US20160078189A1 (en) * 2014-09-16 2016-03-17 Scott Laboratories, Inc. Sedation system and method providing enhanced safety
US20160106737A1 (en) 2014-10-20 2016-04-21 Pharmaceutical Manufacturing Research Services, Inc. Extended Release Abuse Deterrent Liquid Fill Dosage Form
US9849125B1 (en) 2015-11-03 2017-12-26 Banner Lifie Sciences LLC Anti-overingestion dosage forms
JP6131379B1 (en) * 2016-12-28 2017-05-17 森下仁丹株式会社 Formulation containing 4,5-epoxymorphinan derivative
US10335375B2 (en) 2017-05-30 2019-07-02 Patheon Softgels, Inc. Anti-overingestion abuse deterrent compositions
CA3112030A1 (en) 2018-09-25 2020-04-02 SpecGx LLC Abuse deterrent immediate release capsule dosage forms
EP3860579A1 (en) 2018-10-05 2021-08-11 Clexio Biosciences Ltd. Dosage regime of esketamine for treating major depressive disorder
WO2020070706A1 (en) 2018-10-05 2020-04-09 Clexio Biosciences Ltd. Dosage regime of esketamine for treating major depressive disorder
WO2020070547A1 (en) 2018-10-05 2020-04-09 Clexio Biosciences Ltd. Dosage regime of esketamine for treating major depressive disorder
EP3863617A1 (en) 2018-10-11 2021-08-18 Clexio Biosciences Ltd. Esketamine for use in treating major depressive disorder
WO2020225773A1 (en) 2019-05-07 2020-11-12 Clexio Biosciences Ltd. Abuse-deterrent dosage forms containing esketamine
WO2021137148A1 (en) 2019-12-30 2021-07-08 Clexio Biosciences Ltd. Dosage regime with esketamine for treating neuropsychiatric or neurological conditions
WO2021137147A1 (en) 2019-12-30 2021-07-08 Clexio Biosciences Ltd. Dosage regime with esketamine for treating major depressive disorder

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395626A (en) * 1994-03-23 1995-03-07 Ortho Pharmaceutical Corporation Multilayered controlled release pharmaceutical dosage form
US20030198674A1 (en) * 2002-02-01 2003-10-23 Curatolo William J. Controlled release pharmaceutical dosage forms of a cholesteryl ester transfer protein inhibitor
US20050074493A1 (en) * 2003-10-03 2005-04-07 Mehta Atul M. Extended release formulations of opioids and method of use thereof
US20050176646A1 (en) * 2003-09-30 2005-08-11 New River Pharmaceuticals Inc. Pharmaceutical compositions for prevention of overdose or abuse
US20070004797A1 (en) * 2005-06-29 2007-01-04 Weyers Richard G Methods and dosage forms for reducing side effects of carbamate compounds
US20070148097A1 (en) * 2005-12-13 2007-06-28 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device

Family Cites Families (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US70237A (en) * 1867-10-29 James d
US72914A (en) * 1867-12-31 Improvement in locks for travelling-bags
DE2224160C3 (en) * 1972-05-18 1979-10-04 Deutsche Gold- Und Silber-Scheideanstalt Vormals Roessler, 6000 Frankfurt Process for the production of catalysts for the production of pyridine and 3-methylpyridine
US3980766A (en) * 1973-08-13 1976-09-14 West Laboratories, Inc. Orally administered drug composition for therapy in the treatment of narcotic drug addiction
DE2530563C2 (en) * 1975-07-09 1986-07-24 Bayer Ag, 5090 Leverkusen Analgesic drugs with reduced potential for abuse
DD146547A5 (en) 1978-07-15 1981-02-18 Boehringer Sohn Ingelheim MEDICINAL RETARDANT SHAPE WITH UNFORGETTABLE POROESEN DIFFUSION SHELLS
US4423099A (en) 1980-07-28 1983-12-27 Ciba-Geigy Corporation Membrane modified hydrogels
IT1153487B (en) 1982-04-15 1987-01-14 Prophin Lab Spa PHARMACEUTICAL PRODUCTS IN FORM-DELAY AND PROCEDURE TO OBTAIN THEM
GB8521494D0 (en) 1985-08-29 1985-10-02 Zyma Sa Controlled release tablet
IT1201136B (en) 1987-01-13 1989-01-27 Resa Farma TABLET FOR PHARMACEUTICAL USE SUITABLE FOR THE RELEASE OF SUBSTANCES OF ACTIVE SUBSTANCES
FI101344B1 (en) 1988-03-31 1998-06-15 Tanabe Seiyaku Co Process for the preparation of a composition for controlled release of a pharmaceutically active substance
US5047244A (en) * 1988-06-03 1991-09-10 Watson Laboratories, Inc. Mucoadhesive carrier for delivery of therapeutical agent
US4996047A (en) 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
US5206030A (en) * 1990-02-26 1993-04-27 Fmc Corporation Film-forming composition and use for coating pharmaceuticals, foods and the like
US5681585A (en) 1991-12-24 1997-10-28 Euro-Celtique, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5286493A (en) * 1992-01-27 1994-02-15 Euroceltique, S.A. Stabilized controlled release formulations having acrylic polymer coating
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5273760A (en) * 1991-12-24 1993-12-28 Euroceltigue, S.A. Stabilized controlled release substrate having a coating derived from an aqueous dispersion of hydrophobic polymer
US5958459A (en) * 1991-12-24 1999-09-28 Purdue Pharma L.P. Opioid formulations having extended controlled released
US5478577A (en) * 1993-11-23 1995-12-26 Euroceltique, S.A. Method of treating pain by administering 24 hour oral opioid formulations exhibiting rapid rate of initial rise of plasma drug level
SE9301057L (en) 1993-03-30 1994-10-01 Pharmacia Ab Controlled release preparation
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
GB9401894D0 (en) * 1994-02-01 1994-03-30 Rhone Poulenc Rorer Ltd New compositions of matter
US5484608A (en) 1994-03-28 1996-01-16 Pharmavene, Inc. Sustained-release drug delivery system
AT403988B (en) 1994-05-18 1998-07-27 Lannacher Heilmittel SOLID ORAL RETARDED PREPARATION
US6491945B1 (en) 1994-09-16 2002-12-10 Alza Corporation Hydrocodone therapy
US5645858A (en) 1994-10-06 1997-07-08 Ortho Pharmaceutical Corporation Multilayered controlled release pharmaceutical dosage form
AUPN603895A0 (en) * 1995-10-19 1995-11-09 University Of Queensland, The Production of analgesic synergy by co-administration of sub-analgesic doses of two strong opioids
US5783212A (en) * 1996-02-02 1998-07-21 Temple University--of the Commonwealth System of Higher Education Controlled release drug delivery system
IT1282576B1 (en) * 1996-02-06 1998-03-31 Jagotec Ag PHARMACEUTICAL TABLET SUITABLE TO GIVE THE ACTIVE SUBSTANCE IN SUBSEQUENT AND PREDETERMINABLE TIMES
DE19630035A1 (en) 1996-07-25 1998-01-29 Asta Medica Ag Tramadol multiple unit formulations
US6066339A (en) * 1997-10-17 2000-05-23 Elan Corporation, Plc Oral morphine multiparticulate formulation
PT1685839E (en) * 1997-12-22 2013-07-08 Euro Celtique Sa Pharmaceutical oral dosage form comprising a combination of an opioid agonist and opioid antagonist
US6375957B1 (en) * 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
US6372254B1 (en) * 1998-04-02 2002-04-16 Impax Pharmaceuticals Inc. Press coated, pulsatile drug delivery system suitable for oral administration
US6309608B1 (en) * 1998-04-23 2001-10-30 Stephen Matson Method and apparatus for organic synthesis
SE9803871D0 (en) * 1998-11-11 1998-11-11 Pharmacia & Upjohn Ab Therapeutic method and formulation
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
US20060240105A1 (en) * 1998-11-02 2006-10-26 Elan Corporation, Plc Multiparticulate modified release composition
ES2213404T3 (en) 1998-12-17 2004-08-16 Alza Corporation TRANSFORMATION OF GELATINE CAPSULES FILLED WITH LIQUID IN CONTROLLED RELEASE SYSTEMS BY MULTIPLE COATINGS.
FR2787715B1 (en) 1998-12-23 2002-05-10 Synthelabo PHARMACEUTICAL COMPOSITION COMPRISING A HYPNOTIC COMPOUND OR ONE OF ITS PHARMACEUTICALLY ACCEPTABLE SALTS
US6632451B2 (en) * 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
US20030118641A1 (en) * 2000-07-27 2003-06-26 Roxane Laboratories, Inc. Abuse-resistant sustained-release opioid formulation
US6753011B2 (en) 2000-01-14 2004-06-22 Osmotica Corp Combined diffusion/osmotic pumping drug delivery system
HUP0204163A2 (en) 2000-02-08 2003-04-28 Euro-Celtique S.A. Controlled-release composition containing opioid agonist and antagonist and process for its preparation
AR030557A1 (en) * 2000-04-14 2003-08-27 Jagotec Ag A TABLET IN MULTI-MAP OF CONTROLLED RELEASE AND TREATMENT METHOD
US6419954B1 (en) 2000-05-19 2002-07-16 Yamanouchi Pharmaceutical Co., Ltd. Tablets and methods for modified release of hydrophilic and other active agents
US6720005B1 (en) 2000-07-07 2004-04-13 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University Coated, platform-generating tablet
CA2452874A1 (en) 2001-07-06 2003-01-16 Endo Pharmaceuticals, Inc. Oral administration of 6-hydroxy-oxymorphone for use as an analgesic
US20030068375A1 (en) * 2001-08-06 2003-04-10 Curtis Wright Pharmaceutical formulation containing gelling agent
CA2456322A1 (en) * 2001-08-06 2003-02-20 Euro-Celtique, S.A. Compositions and methods to prevent abuse of opioids
US7842307B2 (en) * 2001-08-06 2010-11-30 Purdue Pharma L.P. Pharmaceutical formulation containing opioid agonist, opioid antagonist and gelling agent
US20070066537A1 (en) * 2002-02-22 2007-03-22 New River Pharmaceuticals Inc. Compounds and compositions for prevention of overdose of oxycodone
WO2003072046A2 (en) * 2002-02-22 2003-09-04 New River Pharmaceuticals Inc. Novel sustained release pharmaceutical compounds to prevent abuse of controlled substances
US20060014697A1 (en) * 2001-08-22 2006-01-19 Travis Mickle Pharmaceutical compositions for prevention of overdose or abuse
EP1429728A1 (en) 2001-08-29 2004-06-23 SRL Technologies, Inc. Sustained release preparations
US20030092724A1 (en) * 2001-09-18 2003-05-15 Huaihung Kao Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic
JP2005508325A (en) 2001-09-28 2005-03-31 マクニール−ピーピーシー・インコーポレイテッド Dosage form having an inner core and an outer shell
GB0126064D0 (en) * 2001-10-30 2001-12-19 Reckitt Benckiser Healthcare Improvements in or relating to organic compositions
WO2003051341A1 (en) * 2001-12-18 2003-06-26 Alza Corporation Dosage form for providing time-varying patterns of drug delivery
KR100540035B1 (en) 2002-02-01 2005-12-29 주식회사 태평양 Multi-stage oral drug controlled-release system
DE10208335A1 (en) * 2002-02-27 2003-09-04 Roehm Gmbh Pharmaceutical form and process for its preparation
WO2003082207A2 (en) * 2002-03-29 2003-10-09 Alza Corporation Volume efficient controlled release dosage form
SI2425824T1 (en) * 2002-04-05 2017-06-30 Mundipharma Medical Cee Gmbh Pharmaceutical preparation containing oxycodone and naloxone
JP4133019B2 (en) * 2002-06-21 2008-08-13 日産ディーゼル工業株式会社 Power storage control device for vehicle
CA2491572C (en) 2002-07-05 2010-03-23 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opiods and other drugs
US8557291B2 (en) 2002-07-05 2013-10-15 Collegium Pharmaceutical, Inc. Abuse-deterrent pharmaceutical compositions of opioids and other drugs
US20050266072A1 (en) 2002-08-15 2005-12-01 Euro-Celtique S.A. Pharmaceutical compositions
HUE038446T2 (en) * 2002-09-20 2018-10-29 Alpharma Pharmaceuticals Llc Sequestering subunit and related compositions and methods
CA2498798A1 (en) 2002-09-20 2004-04-01 Alpharma, Inc. Sustained-release opioid formulations and methods of use
CA2499994C (en) * 2002-09-23 2012-07-10 Verion, Inc. Abuse-resistant pharmaceutical compositions
DE10250084A1 (en) 2002-10-25 2004-05-06 Grünenthal GmbH Dosage form protected against abuse
DE10250543A1 (en) * 2002-10-29 2004-05-19 Röhm GmbH & Co. KG Multilayer dosage form
JP4865330B2 (en) 2002-12-13 2012-02-01 デュレクト コーポレーション Oral drug delivery system
US20060210633A1 (en) * 2003-04-03 2006-09-21 Sun Pharmaceutical Industries Limited Programmed drug delivery system
JP2004320263A (en) * 2003-04-14 2004-11-11 Nikon Corp Image reading device, program, and image reading method
US8906413B2 (en) 2003-05-12 2014-12-09 Supernus Pharmaceuticals, Inc. Drug formulations having reduced abuse potential
DK1644019T4 (en) * 2003-05-29 2018-04-23 Shire Llc AMPHETAMINE COMPOUNDS RESISTANT TO ABUSE
US20050013863A1 (en) * 2003-07-18 2005-01-20 Depomed, Inc., A Corporation Of The State Of California Dual drug dosage forms with improved separation of drugs
DE10336400A1 (en) * 2003-08-06 2005-03-24 Grünenthal GmbH Anti-abuse dosage form
AU2003279702A1 (en) * 2003-08-12 2005-03-10 Endo Pharmaceuticals, Inc. Method for deterring abuse of opioids by combination with non-release formulation of emetic
CA2540056C (en) 2003-09-26 2015-03-24 Alza Corporation Controlled release formulations of opioid and nonopioid analgesics
US7494028B2 (en) * 2003-10-15 2009-02-24 Zavida Coffee Company Inc. Fluid dispensing system suitable for dispensing liquid flavorings
US7201920B2 (en) 2003-11-26 2007-04-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
US20070269505A1 (en) * 2003-12-09 2007-11-22 Flath Robert P Tamper Resistant Co-Extruded Dosage Form Containing An Active Agent And An Adverse Agent And Process Of Making Same
CA2551946A1 (en) 2003-12-31 2005-07-21 Actavis Group Hf Immediate, controlled and sustained release formulations of galantamine
US20050163843A1 (en) 2003-12-31 2005-07-28 Garth Boehm Alprazolam formulations
MY139427A (en) 2004-03-26 2009-09-30 Eisai R&D Man Co Ltd Controlled-release pharmaceutical composition and method for producing the same
CN1679955A (en) * 2004-03-30 2005-10-12 美时化学制药股份有限公司 Compositions for improving drug safety
TWI354569B (en) 2004-05-28 2011-12-21 Bristol Myers Squibb Co Coated tablet formulation and method
EP3326617A1 (en) * 2004-06-12 2018-05-30 Collegium Pharmaceutical, Inc. Abuse-deterrent drug formulations
WO2006022996A2 (en) * 2004-08-04 2006-03-02 Sovereign Pharmaceuticals, Ltd. Dosage form containing multiple drugs
GB2419838A (en) * 2004-11-03 2006-05-10 Reckitt Benckiser Nv Making a tablet of three layers
AR051950A1 (en) 2004-11-10 2007-02-21 Osmotica Pharmaceutical Argent MULTI-PAD COMPRESSED WITH SEPARATING LAYERS
US7205385B2 (en) * 2004-11-12 2007-04-17 General Electric Company Polymerization method for the synthesis of polypeptide imaging agents
US20060110327A1 (en) * 2004-11-24 2006-05-25 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
US20080152595A1 (en) 2004-11-24 2008-06-26 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of orally administered pharmaceutical products
MX2007009162A (en) * 2005-01-28 2007-10-23 Euro Celtique Sa Alcohol resistant dosage forms.
US20060189635A1 (en) 2005-02-04 2006-08-24 Michelle Kramer Enhanced efficacy benzisoxazole derivative dosage forms and methods
US7424221B2 (en) * 2005-03-04 2008-09-09 Tellabs Petaluma, Inc. Optical network terminal with illegal transmission detection circuitry
IS7748A (en) 2005-03-17 2006-09-18 Actavis Group Composition for tablets containing topiramate
JP2008534530A (en) * 2005-03-29 2008-08-28 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング Multiparticulate drug form containing pellets with a substance having a modulating effect on active ingredient release
PL1895994T3 (en) * 2005-05-13 2011-02-28 Alza Corp Multilayer drug delivery system with barrier against reservoir material flow
US20060263429A1 (en) * 2005-05-20 2006-11-23 Hengsheng Feng Compressible mixture, compressed pharmaceutical compositions, and method of preparation thereof
WO2007013975A2 (en) * 2005-07-20 2007-02-01 Pharmorx Inc. Composition containing an opioid agonist and a partial opioid agonist, preferably buprenorphine , for controlling abuse of medications
JP5269595B2 (en) * 2005-09-09 2013-08-21 アンジェリーニ ラボファーム リミテッド ライアビリティ カンパニー Trazodone composition for once daily administration
GB0612326D0 (en) 2005-10-31 2006-08-02 Alza Corp Methods of reducing alcohol-induced dose dumping for opioid sustained release oral dosage forms
PL116330U1 (en) * 2005-10-31 2007-04-02 Alza Corp Method for the reduction of alcohol provoked rapid increase in the released dose of the orally administered opioide with prolonged liberation
US20090082466A1 (en) 2006-01-27 2009-03-26 Najib Babul Abuse Resistant and Extended Release Formulations and Method of Use Thereof
US20090022798A1 (en) 2007-07-20 2009-01-22 Abbott Gmbh & Co. Kg Formulations of nonopioid and confined opioid analgesics
JP2009523833A (en) * 2006-01-21 2009-06-25 アボット ゲーエムベーハー ウント カンパニー カーゲー Formulations and methods for drug delivery
NZ570039A (en) * 2006-01-27 2011-07-29 Eurand Inc Drug delivery systems comprising weakly basic selective serotonin 5-HT3 blocking agent and organic acids
ZA200807571B (en) 2006-03-01 2009-08-26 Ethypharm Sa Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion
US20070212414A1 (en) 2006-03-08 2007-09-13 Penwest Pharmaceuticals Co. Ethanol-resistant sustained release formulations
CA2645855C (en) 2006-03-16 2015-02-03 Tris Pharma, Inc. Modified release formulations containing drug-ion exchange resin complexes
US20090110717A1 (en) * 2006-05-02 2009-04-30 Amarjit Singh Transmucosal composition
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
US20080069891A1 (en) 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
WO2008011596A2 (en) 2006-07-21 2008-01-24 Lab International Srl Hydrophilic abuse deterrent delivery system
US20080072914A1 (en) * 2006-08-25 2008-03-27 Hendricksen Michael J Bronchial Isolation Devices for Placement in Short Lumens
SA07280459B1 (en) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. Tamper Resistant Oral Pharmaceutical Dosage Forms Comprising an Opioid Analgesic
WO2008025535A1 (en) 2006-08-30 2008-03-06 Jagotec Ag Controlled release oral dosage formulations comprising a core and one or more barrier layers
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
US20080085305A1 (en) * 2006-10-10 2008-04-10 Penwest Pharmaceuticals Co. Robust sustained release formulations of oxymorphone
DE102006051020A1 (en) 2006-10-26 2008-04-30 Evonik Röhm Gmbh Use of enteric (meth)acrylate copolymers in controlled-release oral pharmaceutical dosage forms as drug matrix formers to reduce the effect of ethanol-induced release rate increase or decrease in vitro
EP2155167A2 (en) * 2007-06-04 2010-02-24 Egalet A/S Controlled release pharmaceutical compositions for prolonged effect
US8110226B2 (en) * 2007-07-20 2012-02-07 Mylan Pharmaceuticals Inc. Drug formulations having inert sealed cores
CN101801350A (en) 2007-08-13 2010-08-11 阿巴斯迪特宁医药有限公司 Abuse resistant drugs, using method and preparation method
JP5204847B2 (en) 2007-09-21 2013-06-05 エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング PH-dependent controlled release pharmaceutical opioid composition resistant to the effects of ethanol
ES2393805T3 (en) * 2007-09-21 2012-12-28 Evonik Röhm Gmbh PH-dependent controlled release pharmaceutical composition for non-opioid compounds with resistance against the influence of ethanol
TW200950776A (en) 2008-01-24 2009-12-16 Abbott Gmbh & Co Kg Abuse resistant melt extruded formulation having reduced alcohol interaction
US20100099696A1 (en) * 2008-10-16 2010-04-22 Anthony Edward Soscia Tamper resistant oral dosage forms containing an embolizing agent
WO2010051312A1 (en) 2008-10-31 2010-05-06 Mcneil-Ppc, Inc. Osmotic tablet with a compressed outer coating
GB0909680D0 (en) * 2009-06-05 2009-07-22 Euro Celtique Sa Dosage form
WO2014144661A1 (en) * 2013-03-15 2014-09-18 Aprecia Pharmaceuticals Compny Rapidly dispersible dosage form of topiramate

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395626A (en) * 1994-03-23 1995-03-07 Ortho Pharmaceutical Corporation Multilayered controlled release pharmaceutical dosage form
US20030198674A1 (en) * 2002-02-01 2003-10-23 Curatolo William J. Controlled release pharmaceutical dosage forms of a cholesteryl ester transfer protein inhibitor
US20050176646A1 (en) * 2003-09-30 2005-08-11 New River Pharmaceuticals Inc. Pharmaceutical compositions for prevention of overdose or abuse
US20050074493A1 (en) * 2003-10-03 2005-04-07 Mehta Atul M. Extended release formulations of opioids and method of use thereof
US20070004797A1 (en) * 2005-06-29 2007-01-04 Weyers Richard G Methods and dosage forms for reducing side effects of carbamate compounds
US20070148097A1 (en) * 2005-12-13 2007-06-28 Biodelivery Sciences International, Inc. Abuse resistant transmucosal drug delivery device

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