WO2009015256A3 - High refractive index ophthalmic device materials - Google Patents

High refractive index ophthalmic device materials Download PDF

Info

Publication number
WO2009015256A3
WO2009015256A3 PCT/US2008/070970 US2008070970W WO2009015256A3 WO 2009015256 A3 WO2009015256 A3 WO 2009015256A3 US 2008070970 W US2008070970 W US 2008070970W WO 2009015256 A3 WO2009015256 A3 WO 2009015256A3
Authority
WO
WIPO (PCT)
Prior art keywords
copolymers
refractive index
high refractive
ophthalmic device
device materials
Prior art date
Application number
PCT/US2008/070970
Other languages
French (fr)
Other versions
WO2009015256A2 (en
Inventor
Charles Freeman
Original Assignee
Alcon Inc
Charles Freeman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Inc, Charles Freeman filed Critical Alcon Inc
Priority to AT08782290T priority Critical patent/ATE511530T1/en
Priority to EP08782290A priority patent/EP2225325B1/en
Publication of WO2009015256A2 publication Critical patent/WO2009015256A2/en
Publication of WO2009015256A3 publication Critical patent/WO2009015256A3/en
Priority to HK10108737.9A priority patent/HK1142349A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L33/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • C08L33/04—Homopolymers or copolymers of esters
    • C08L33/14—Homopolymers or copolymers of esters of esters containing halogen, nitrogen, sulfur, or oxygen atoms in addition to the carboxy oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1808—C8-(meth)acrylate, e.g. isooctyl (meth)acrylate or 2-ethylhexyl (meth)acrylate
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
    • G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
    • G02B1/041—Lenses
    • G02B1/043—Contact lenses
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/102—Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides

Abstract

High refractive index copolymers suitable for use in ophthalmic devices are disclosed. The copolymers comprise two or more aryl hydrophobic monomers and a non-polymerizable propylene oxide-ethylene oxide-propylene oxide block copolymer surfactant having a molecular weight of approximately 3600 and approximately 40% ethylene oxide units by weight. The copolymers have a reduced tendency to form glistenings when stored in water at physiological temperatures compared to similar copolymers lacking the non-polymerizable surfactant.
PCT/US2008/070970 2007-07-25 2008-07-24 High refractive index ophthalmic device materials WO2009015256A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AT08782290T ATE511530T1 (en) 2007-07-25 2008-07-24 HIGH REFRACTIVE INDEX MATERIALS FOR OPHTHALMIC DEVICES
EP08782290A EP2225325B1 (en) 2007-07-25 2008-07-24 High refractive index ophthalmic device materials
HK10108737.9A HK1142349A1 (en) 2007-07-25 2010-09-15 High refractive index ophthalmic device materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95186507P 2007-07-25 2007-07-25
US60/951,865 2007-07-25

Publications (2)

Publication Number Publication Date
WO2009015256A2 WO2009015256A2 (en) 2009-01-29
WO2009015256A3 true WO2009015256A3 (en) 2009-03-12

Family

ID=39797633

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/070970 WO2009015256A2 (en) 2007-07-25 2008-07-24 High refractive index ophthalmic device materials

Country Status (6)

Country Link
US (1) US7790824B2 (en)
EP (1) EP2225325B1 (en)
AT (1) ATE511530T1 (en)
ES (1) ES2365290T3 (en)
HK (1) HK1142349A1 (en)
WO (1) WO2009015256A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE511530T1 (en) 2007-07-25 2011-06-15 Alcon Inc HIGH REFRACTIVE INDEX MATERIALS FOR OPHTHALMIC DEVICES
TW201000155A (en) 2008-05-06 2010-01-01 Alcon Inc High refractive index ophthalmic device materials
US8148445B1 (en) 2009-01-14 2012-04-03 Novartis Ag Ophthalmic and otorhinolaryngological device materials containing a multi-arm PEG macromer
US8293858B1 (en) 2009-01-14 2012-10-23 Novartis Ag Ophthalmic and otorhinolaryngological device materials containing a reactive NVP macromer
US9220590B2 (en) 2010-06-10 2015-12-29 Z Lens, Llc Accommodative intraocular lens and method of improving accommodation
TWI473823B (en) 2010-06-21 2015-02-21 Novartis Ag High refractive index, acrylic ophthalmic device materials with reduced glistenings
US9364318B2 (en) 2012-05-10 2016-06-14 Z Lens, Llc Accommodative-disaccommodative intraocular lens
AU2014357334B2 (en) 2013-12-04 2017-11-09 Alcon Inc. Soft acrylic materials with high refractive index and minimized glistening
CN106999628A (en) 2014-12-16 2017-08-01 诺华股份有限公司 Hydrophobic acrylic acid's ester acrylamide copolymer for Ophthalmoligic instrument
US9921341B2 (en) 2014-12-16 2018-03-20 Novartis Ag Low-water content acrylate-acrylamide copolymers for ophthalmic devices
US10064977B2 (en) 2015-02-16 2018-09-04 Novartis Ag Wet-pack intraocular lens materials with high refractive index
US10512535B2 (en) 2016-08-24 2019-12-24 Z Lens, Llc Dual mode accommodative-disaccomodative intraocular lens

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053347A1 (en) * 1998-04-15 1999-10-21 Alcon Laboratories, Inc. High refractive index ophthalmic device materials
US20070196329A1 (en) * 2006-01-20 2007-08-23 Erning Xia Disinfection efficacy of lens care regimen for rigid gas permeable contact lenses

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4032599A (en) * 1971-04-20 1977-06-28 Contact Lenses (Manufacturing) Limited Hydrophilic copolymers
US4304895A (en) * 1973-06-20 1981-12-08 Wesley-Jessen, Inc. Ultraviolet absorbing corneal contact lenses
US4280970A (en) * 1979-01-19 1981-07-28 Puropore Inc. Polyoxyethylene grafted membrane materials with grafting links derived from a diisocyanate
US4528311A (en) * 1983-07-11 1985-07-09 Iolab Corporation Ultraviolet absorbing polymers comprising 2-hydroxy-5-acrylyloxyphenyl-2H-benzotriazoles
SE444950B (en) * 1984-09-28 1986-05-20 Ytkemiska Inst COVERED ARTICLE, PROCEDURES AND METHODS OF PRODUCING THEREOF AND USING THEREOF
US4871785A (en) * 1986-08-13 1989-10-03 Michael Froix Clouding-resistant contact lens compositions
US4780488A (en) * 1986-08-29 1988-10-25 Ciba-Geigy Corporation Wettable, flexible, oxygen permeable, substantially non-swellable contact lens containing polyoxyalkylene backbone units, and use thereof
US5290548A (en) * 1987-04-10 1994-03-01 University Of Florida Surface modified ocular implants, surgical instruments, devices, prostheses, contact lenses and the like
US4857606A (en) * 1987-06-05 1989-08-15 Ciga-Geigy Corporation Wettable, flexible, oxygen permeable, substantially non-swellable contact lens containing polyoxyalkylene backbone units, and use thereof
NL8701548A (en) * 1987-07-01 1989-02-01 Tno POLYMER NETWORK, METHOD FOR THE PREPARATION THEREOF, THE USE THEREOF FOR CLADING AND / OR IMPREGNATING OR FOR MANUFACTURING EYE LENSES, AND FORMED PROPERTIES, WHOLLY OR FROM AN EXISTINGLY PROVEN POLISH.
US4834750A (en) * 1987-09-17 1989-05-30 Ioptex Research, Inc. Deformable-elastic intraocular lens
US5147394A (en) * 1987-10-09 1992-09-15 Siepser Steven B High refractive index polymeric compositions suitable for use as expansile hydrogel intraocular lenses
ES2068909T3 (en) 1988-02-26 1995-05-01 Ciba Geigy Ag A HUMECTABLE CONTACT LENS, FLEXIBLE, PERMEABLE TO OXYGEN AND CONTAINING UNITS OF POLYOXYALKYLENE SPINE AND USE OF THE SAME.
US5070169A (en) * 1988-02-26 1991-12-03 Ciba-Geigy Corporation Wettable, flexible, oxygen permeable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units and use thereof
US5070166A (en) * 1988-02-26 1991-12-03 Su Kai C Wettable, flexible, oxygen permeable, contact lens containing polyoxyalkylene backbone units, and use thereof
ATE64214T1 (en) 1988-02-26 1991-06-15 Ciba Geigy Ag WETTABLE, FLEXIBLE, OXYGEN-PERMEABLE CONTACT LENS, CONSISTING OF BLOCK COPOLYMERS WITH POLYSILOXANE-POLYOXYALKYLENE LINKS IN THE MAIN CHAIN, AND USE THEREOF.
US5070170A (en) * 1988-02-26 1991-12-03 Ciba-Geigy Corporation Wettable, rigid gas permeable, substantially non-swellable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units, and use thereof
AU637361B2 (en) 1989-04-24 1993-05-27 Novartis Ag Polysiloxane-polyoxyalkylene block copolymers and ophthalmic devices containing them
US5334681A (en) * 1989-06-20 1994-08-02 Ciba-Geigy Corporation Fluorine and/or silicone containing poly(alkylene-oxide)-block copolymer hydrogels and contact lenses thereof
US5039769A (en) * 1989-10-11 1991-08-13 Ciba-Geigy Coproation Wettable, flexible, oxygen permeable, substantially non-swellable contact lens containing polyoxyalkylene backbone units, and use thereof
US5275838A (en) * 1990-02-28 1994-01-04 Massachusetts Institute Of Technology Immobilized polyethylene oxide star molecules for bioapplications
US5077033A (en) * 1990-08-07 1991-12-31 Mediventures Inc. Ophthalmic drug delivery with thermo-irreversible gels of polxoxyalkylene polymer and ionic polysaccharide
US5290892A (en) * 1990-11-07 1994-03-01 Nestle S.A. Flexible intraocular lenses made from high refractive index polymers
US5352714A (en) * 1991-11-05 1994-10-04 Bausch & Lomb Incorporated Wettable silicone hydrogel compositions and methods for their manufacture
US5310779A (en) * 1991-11-05 1994-05-10 Bausch & Lomb Incorporated UV curable crosslinking agents useful in copolymerization
US5480950A (en) * 1992-09-28 1996-01-02 Kabi Pharmacia Ophthalmics, Inc. High refractive index hydrogels and uses thereof
US5331073A (en) * 1992-11-09 1994-07-19 Allergan, Inc. Polymeric compositions and intraocular lenses made from same
US5470932A (en) * 1993-10-18 1995-11-28 Alcon Laboratories, Inc. Polymerizable yellow dyes and their use in opthalmic lenses
US5618316A (en) * 1993-12-14 1997-04-08 Hoffman; Allan S. Polyethylene oxide coated intraocular lens
US5663264A (en) * 1993-12-27 1997-09-02 Hitachi Chemical Company, Ltd. Transparent resin and plastic lens
CA2180147A1 (en) 1994-11-16 1996-05-23 Gerard Llanos Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
US5507804A (en) * 1994-11-16 1996-04-16 Alcon Laboratories, Inc. Cross-linked polyethylene oxide coatings to improve the biocompatibility of implantable medical devices
US5939485A (en) * 1995-06-19 1999-08-17 Medlogic Global Corporation Responsive polymer networks and methods of their use
US5674942A (en) * 1995-03-31 1997-10-07 Johnson & Johnson Vision Products, Inc. Interpenetrating polymer networks for contact lens production
US5824719A (en) * 1995-06-07 1998-10-20 Bausch & Lomb Incorporated Polymer compositions for contact lenses
ES2183953T3 (en) * 1995-06-07 2003-04-01 Alcon Lab Inc IMPROVED MATERIALS OF HIGH REFRACTION OPTIONAL LENSES.
USH1666H (en) 1995-09-15 1997-07-01 The United States Of America As Represented By The Secretary Of The Navy Method of cross-linking poly(ethylene oxide) and poly[oxymethylene-oligo(oxyethylene)] with ultraviolet radiation
US5849222A (en) 1995-09-29 1998-12-15 Johnson & Johnson Vision Products, Inc. Method for reducing lens hole defects in production of contact lens blanks
WO1997022371A1 (en) * 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
SE9600006D0 (en) 1996-01-02 1996-01-02 Pharmacia Ab Foldable intraocular lens materials
US5717049A (en) * 1996-03-25 1998-02-10 Pharmacia Iovision, Inc. High refractive index hydrogels prepared from polymers and copolymers of N-benzyl-N-methylacrylamide
WO1997035906A1 (en) * 1996-03-27 1997-10-02 Novartis Ag High water content porous polymer
US5708094A (en) * 1996-12-17 1998-01-13 Bausch & Lomb Incorporated Polybutadiene-based compositions for contact lenses
US5891931A (en) 1997-08-07 1999-04-06 Alcon Laboratories, Inc. Method of preparing foldable high refractive index acrylic ophthalmic device materials
US6326448B1 (en) * 1997-08-20 2001-12-04 Menicon Co., Ltd. Soft intraocular lens material
JP3641110B2 (en) * 1997-08-20 2005-04-20 株式会社メニコン Materials for soft intraocular lenses
CN1213671A (en) * 1997-10-07 1999-04-14 参天制药株式会社 Four-component copolymer and eye lens formed by same
KR100438477B1 (en) * 1997-12-02 2004-07-03 호야 헬쓰케어 가부시키가이샤 Intraocular lenses and process for producing molded-in type intraocular lenses
US7052131B2 (en) * 2001-09-10 2006-05-30 J&J Vision Care, Inc. Biomedical devices containing internal wetting agents
US6822016B2 (en) * 2001-09-10 2004-11-23 Johnson & Johnson Vision Care, Inc. Biomedical devices containing internal wetting agents
US6353069B1 (en) * 1998-04-15 2002-03-05 Alcon Manufacturing, Ltd. High refractive index ophthalmic device materials
US6087415A (en) * 1998-06-11 2000-07-11 Johnson & Johnson Vision Care, Inc. Biomedical devices with hydrophilic coatings
US6241766B1 (en) * 1998-10-29 2001-06-05 Allergan Sales, Inc. Intraocular lenses made from polymeric compositions
US6329485B1 (en) * 1998-12-11 2001-12-11 Bausch & Lomb Incorporated High refractive index hydrogel compositions for ophthalmic implants
JP3449406B2 (en) * 1999-04-07 2003-09-22 Ｈｏｙａヘルスケア株式会社 Novel pyrazolone compound and ophthalmic plastic lens using the same
US6281319B1 (en) * 1999-04-12 2001-08-28 Surgidev Corporation Water plasticized high refractive index polymer for ophthalmic applications
US6271281B1 (en) * 1999-08-26 2001-08-07 Medennium, Inc. Homopolymers containing stable elasticity inducing crosslinkers and ocular implants made therefrom
ATE286685T1 (en) * 1999-09-02 2005-01-15 Alcon Inc HYDROPHILIC COATING AGENT, HYDROPHOBIC BONDED TO SURGICAL IMPLANTS
US6632905B2 (en) * 1999-09-02 2003-10-14 Alcon Universal Ltd. Covalently-bound, hydrophilic coating compositions for surgical implants
WO2001018079A1 (en) 1999-09-07 2001-03-15 Alcon Universal Ltd. Ophthalmic and otorhinolaryngological device materials
BR0007069B1 (en) 1999-09-07 2010-02-09 collapsible ophthalmic and ENT device materials.
CA2394653A1 (en) * 2000-01-05 2001-07-12 Novartis Ag Hydrogels
US6517933B1 (en) * 2000-01-18 2003-02-11 Nano-Tex, Llc Hybrid polymer materials
JP3456462B2 (en) * 2000-02-28 2003-10-14 日本電気株式会社 Semiconductor device and manufacturing method thereof
EP1249249A1 (en) * 2000-12-12 2002-10-16 Menicon Co., Ltd. Ophthalmic composition
US20010037150A1 (en) 2000-04-10 2001-11-01 Chan Kwan Y. Intraocular lens materials with low incidence of posterior capsule opacification
US6555030B1 (en) * 2000-04-21 2003-04-29 Advanced Medical Optics, Inc. Method for making an accommodating intraocular lens
US6255360B1 (en) * 2000-05-15 2001-07-03 Novartis Ag Process for the manufacture of moldings
US20030044468A1 (en) * 2001-03-20 2003-03-06 Francesco Cellesi Two-phase processing of thermosensitive polymers for use as biomaterials
US6703466B1 (en) * 2001-06-18 2004-03-09 Alcon, Inc. Foldable intraocular lens optics having a glassy surface
US7005031B2 (en) * 2002-01-16 2006-02-28 3M Innovative Properties Company Pressure sensitive adhesives having quaternary ammonium functionality, articles, and methods
US6673847B2 (en) * 2002-04-01 2004-01-06 Rohm And Haas Company Water immiscible porogen removal process
WO2004007579A1 (en) * 2002-07-16 2004-01-22 Alcon, Inc. Ophthalmic and otorhinolaryngological device materials
CA2500540A1 (en) 2002-09-30 2004-04-15 Bausch & Lomb Incorporated Bacterial attachment reduction to biomaterials and biomedical devices
US7037469B2 (en) * 2003-03-19 2006-05-02 Bausch & Lomb, Inc. Method and composition for reducing contact lens swelling
ATE432484T1 (en) 2003-04-03 2009-06-15 Seed Co Ltd CONTACT LENSES WITH SUSTAINED DRUG RELEASE CAPABILITY AND PROTECTIVE SOLUTIONS THEREOF
US6872793B1 (en) * 2003-08-07 2005-03-29 Alcon, Inc. Ophthalmic and otorhinolaryngological device materials
WO2005047349A1 (en) * 2003-11-05 2005-05-26 Benz Research And Development Corporation Materials for making hydrophobic intraocular lens
US8197841B2 (en) * 2004-12-22 2012-06-12 Bausch & Lomb Incorporated Polymerizable surfactants and their use as device forming comonomers
EP1857477B1 (en) * 2005-03-09 2012-06-27 Hoya Corporation (meth)acrylate compound, process for production of the compound, (meth)acrylate copolymer, process for production of the copolymer, and soft intraocular lens
JP4618640B2 (en) 2005-03-14 2011-01-26 Ｈｏｙａ株式会社 (Meth) acrylate copolymer and soft intraocular lens
US7495061B2 (en) * 2005-05-27 2009-02-24 Bausch + Lomb Incorporated High refractive-index, hydrophilic monomers and polymers, and ophthalmic devices comprising such polymers
ATE511530T1 (en) 2007-07-25 2011-06-15 Alcon Inc HIGH REFRACTIVE INDEX MATERIALS FOR OPHTHALMIC DEVICES
TW201000155A (en) 2008-05-06 2010-01-01 Alcon Inc High refractive index ophthalmic device materials

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053347A1 (en) * 1998-04-15 1999-10-21 Alcon Laboratories, Inc. High refractive index ophthalmic device materials
US20070196329A1 (en) * 2006-01-20 2007-08-23 Erning Xia Disinfection efficacy of lens care regimen for rigid gas permeable contact lenses

Also Published As

Publication number Publication date
US20090043006A1 (en) 2009-02-12
ATE511530T1 (en) 2011-06-15
US7790824B2 (en) 2010-09-07
ES2365290T3 (en) 2011-09-28
HK1142349A1 (en) 2010-12-03
EP2225325B1 (en) 2011-06-01
WO2009015256A2 (en) 2009-01-29
EP2225325A2 (en) 2010-09-08

Similar Documents

Publication Publication Date Title
WO2009015256A3 (en) High refractive index ophthalmic device materials
AR071616A1 (en) MATERIALS FOR HIGH REFRACTION OPHTHALMIC DEVICES
WO2008005643A3 (en) Carboxylic siloxanyl monomers with pendant polymerizable groups
WO2010039628A3 (en) POLYMER BLENDS WITH ETHYLENE/α-OLEFIN INTERPOLYMERS
IN2012DN06574A (en)
MX346220B (en) Low-tack, hydrophobic ophthalmic device materials.
MX2011009195A (en) Fast drying ampholytic polymers for cleaning compositions.
BR112014029253A2 (en) nanogel polymers and materials and methods of fabrication and use thereof
WO2011022523A3 (en) Low application temperature hot melt adhesive
WO2007075320A3 (en) Cationic hydrophilic siloxanyl monomers
BRPI0817929B8 (en) ophthalmic or otorhinolaryngological device, and its polymeric material
WO2012135077A3 (en) Ophthalmic inspection lens
WO2010147864A3 (en) Biomedical devices, polymeric materials and contact lenses comprising the same
WO2007084444A3 (en) Side-chain crystallizable polymers for medical applications
WO2008039655A3 (en) Pendant end-capped low modulus cationic siloxanyls
WO2010099254A3 (en) Electrically isolating polymer composition
WO2010135527A3 (en) Elastin for soft tissue augmentation
WO2013043796A3 (en) Modified polyethylene compositions
WO2010068862A3 (en) Zwitterionic polymers with therapeutic moieties
WO2010147875A3 (en) Biomedical devices, polymeric materials and contact lenses comprising the same
WO2012006135A3 (en) Fluorinated polymers and lubricious coatings
MY143508A (en) Copolymers useful as demulsifiers and clarifiers
WO2013151687A8 (en) Polymers, polymer blends, and articles made therefrom
WO2011053562A3 (en) Absorbable polyethylene diglycolate copolymers to reduce microbial adhesion to medical devices and implants
WO2012005594A3 (en) Biodegradable phase separated segmented multi block co-polymers and release of biologically active polypeptides

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08782290

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008782290

Country of ref document: EP