WO2009008000A3 - A process for the preparation of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidino ethoxy) benzoyl]benzo[b]thiophene - Google Patents

A process for the preparation of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidino ethoxy) benzoyl]benzo[b]thiophene Download PDF

Info

Publication number
WO2009008000A3
WO2009008000A3 PCT/IN2008/000273 IN2008000273W WO2009008000A3 WO 2009008000 A3 WO2009008000 A3 WO 2009008000A3 IN 2008000273 W IN2008000273 W IN 2008000273W WO 2009008000 A3 WO2009008000 A3 WO 2009008000A3
Authority
WO
WIPO (PCT)
Prior art keywords
thiophene
benzo
hydroxyphenyl
benzoyl
hydroxy
Prior art date
Application number
PCT/IN2008/000273
Other languages
French (fr)
Other versions
WO2009008000A2 (en
Inventor
Rajamannar Thennati
Srinivasu Kilaru
Nileshkumar Sureshbhai Patel
Yesha Vijaykumar Patel
Original Assignee
Sun Pharmaceutical Industries Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Pharmaceutical Industries Ltd. filed Critical Sun Pharmaceutical Industries Ltd.
Publication of WO2009008000A2 publication Critical patent/WO2009008000A2/en
Publication of WO2009008000A3 publication Critical patent/WO2009008000A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Abstract

The present invention related to a process for preparing 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2- piperidinoethoxy)benzoyl]benzo[b]thiophene, compound of formula (I), said process comprising: deprotecting compound of formula (II) with base in dimethyl sulfoxide to yield substantially pure compound of formula (I) with HPLC purity of 99 % or more by area and optionally converting to its pharmaceutically acceptable salt.
PCT/IN2008/000273 2007-04-12 2008-04-15 A process for the preparation of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidino ethoxy) benzoyl]benzo[b]thiophene WO2009008000A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN723MU2007 2007-04-12
IN723/MUM/2007 2007-04-12

Publications (2)

Publication Number Publication Date
WO2009008000A2 WO2009008000A2 (en) 2009-01-15
WO2009008000A3 true WO2009008000A3 (en) 2011-08-11

Family

ID=40229220

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000273 WO2009008000A2 (en) 2007-04-12 2008-04-15 A process for the preparation of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidino ethoxy) benzoyl]benzo[b]thiophene

Country Status (1)

Country Link
WO (1) WO2009008000A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011029088A2 (en) * 2009-09-07 2011-03-10 Dr. Reddy's Laboratories Ltd. Preparation of raloxifene and its salts
IT1403083B1 (en) * 2010-10-25 2013-10-04 Fidia Farmaceutici NEW POLYMORPHIC SHAPE OF RALOXIFENE CHLORIDRATE

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes

Also Published As

Publication number Publication date
WO2009008000A2 (en) 2009-01-15

Similar Documents

Publication Publication Date Title
WO2010073124A3 (en) Processes for preparing highly pure rotigotine or a pharmaceutically acceptable salt thereof
WO2006035277A3 (en) Novel processes for preparing amorphous rosuvastatin calcium and a novel polymorphic form of rosuvastatin sodium
WO2007031933A3 (en) Stable pharmaceutical composition comprising a pyrimidine-sulfamide
TW200728307A (en) Novel spirochromanone derivatives
PE20070833A1 (en) PYRIMIDINYL BENZOTHIOPHENE COMPOUNDS
IL190551A0 (en) Novel process for the preparation of acid chlorides
AU2008299921A8 (en) Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof
WO2007017728A3 (en) Novel heterocyclic compounds
WO2007109578A3 (en) Substituted gamma lactams as prostaglandin ep2 agonists
WO2012004658A8 (en) Process for preparation of n-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-benzofuranyl]methanesulfonamide, acid addition salts and product thereof
UA99447C2 (en) Process for the preparation of sildenafil
WO2008130312A8 (en) A new process for the manufacturing of the compound 2-hydroxy-3-[5-(morpholin-4-ylmethyl)pyridin-2-yl]1h-indole-5-carbonitrile 701
WO2009154754A3 (en) Synthesis of deuterated morpholine derivatives
PL1831152T3 (en) Tetralin and indane derivatives and uses thereof as 5-ht antagonists
NZ602450A (en) Agomelatine hydrochloride hydrate and preparation thereof
WO2010011811A3 (en) 3-(phenoxyphenylmethyl)pyrrolidine compounds
WO2009047499A3 (en) Processes for the preparation of paliperidone and pharmaceutically acceptable salts thereof and intermediates for use in the processes
WO2009156837A3 (en) Amorphous form of a 3-pyrrole substituted 2-indolinone malate salt
WO2010046926A3 (en) Novel stilbene analogs
WO2014006637A3 (en) Improved process for preparing benzofuran-2-carboxamide derivatives
WO2009008000A3 (en) A process for the preparation of 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidino ethoxy) benzoyl]benzo[b]thiophene
WO2008081476A3 (en) Process for preparing duloxetine hydrochloride
WO2010140139A3 (en) Crystalline forms of 6-(1h- imadazol- 1-yl) -2-phenylquinazoline
WO2007133481A3 (en) Method for increasing the bioavailability of benzhydryl piperazine containing compounds
TW200631952A (en) Benzdioxan piperazine derivatives with a combination of affinity for dopamine-D2 receptors and serotonin reuptake sites

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08826121

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08826121

Country of ref document: EP

Kind code of ref document: A2