WO2009004082A3 - Anticonvulsive pharmaceutical compositions - Google Patents
Anticonvulsive pharmaceutical compositions Download PDFInfo
- Publication number
- WO2009004082A3 WO2009004082A3 PCT/EP2008/058672 EP2008058672W WO2009004082A3 WO 2009004082 A3 WO2009004082 A3 WO 2009004082A3 EP 2008058672 W EP2008058672 W EP 2008058672W WO 2009004082 A3 WO2009004082 A3 WO 2009004082A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- taurine
- pharmaceutical compositions
- anticonvulsive pharmaceutical
- gaba
- substance
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
The use of a substance selected from the group consisting of taurine, a taurine precursor, a taurine metabolite, a taurine derivative, a taurine analog and a substance required for the taurine biosynthesis, for manufacturing a pharmaceutical composition for preventing or inhibiting the undesirable side-effects caused to a human or an animal organism by an active ingredient that induces a high level of extracellular GABA or increases GABA receptor activation.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010514002A JP2010532331A (en) | 2007-07-05 | 2008-07-04 | Anticonvulsant pharmaceutical composition |
EP08785923A EP2167068A2 (en) | 2007-07-05 | 2008-07-04 | Anticonvulsive pharmaceutical compositions |
US12/667,742 US9308260B2 (en) | 2007-07-05 | 2008-07-04 | Anticonvulsive pharmaceutical compositions |
US15/051,484 US20160193166A1 (en) | 2007-07-05 | 2016-02-23 | Anticonvulsive pharmaceutical compositions |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07301208A EP2011491A1 (en) | 2007-07-05 | 2007-07-05 | Anticonvulsive pharmaceutical compositions |
EP07301208.0 | 2007-07-05 | ||
EP08151851 | 2008-02-22 | ||
EP08151851.6 | 2008-02-22 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/667,742 A-371-Of-International US9308260B2 (en) | 2007-07-05 | 2008-07-04 | Anticonvulsive pharmaceutical compositions |
US15/051,484 Division US20160193166A1 (en) | 2007-07-05 | 2016-02-23 | Anticonvulsive pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009004082A2 WO2009004082A2 (en) | 2009-01-08 |
WO2009004082A3 true WO2009004082A3 (en) | 2009-03-12 |
Family
ID=39720651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/058672 WO2009004082A2 (en) | 2007-07-05 | 2008-07-04 | Anticonvulsive pharmaceutical compositions |
Country Status (4)
Country | Link |
---|---|
US (2) | US9308260B2 (en) |
EP (1) | EP2167068A2 (en) |
JP (2) | JP2010532331A (en) |
WO (1) | WO2009004082A2 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20110172171A1 (en) * | 2008-09-12 | 2011-07-14 | Serge Picaud | Taurine or taurine-like substances for the prevention of brain oedema |
EP2163246A1 (en) * | 2008-09-12 | 2010-03-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Taurine or taurine-like substances for the prevention of the irreversible visual effects of vigabatrin |
EP2393490A1 (en) * | 2009-02-04 | 2011-12-14 | INSERM - Institut National de la Santé et de la Recherche Médicale | Taurine or taurine-like substances for the prevention and treatment of a disease associated with retinal ganglion cell degeneration |
WO2010121969A1 (en) | 2009-04-21 | 2010-10-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Method of treating or preventing a convulsive disorder in a patient in need thereof |
EP2477626A4 (en) * | 2009-09-17 | 2013-05-22 | North Texas Medical Ass | Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury |
AU2016228315B2 (en) * | 2009-09-17 | 2018-01-04 | Bespoke Bioscience, Llc | Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury |
AU2014206220B2 (en) * | 2009-09-17 | 2016-09-29 | Bespoke Bioscience, Llc | Role of n-2 hydroxy-ethyl-piperazine-n'-2-ethane sulfonic acid (hepes) in pain control and reversal of demyelinization injury |
WO2011113904A1 (en) * | 2010-03-17 | 2011-09-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Medicaments for the prevention and treatment of a disease associated with retinal ganglion cell degeneration |
JP5992525B2 (en) | 2011-09-14 | 2016-09-14 | ヌエヴァス オルタナティヴァス ナチュラルズ,エス.エー.ピー.アイ.デ シー.ブイ. | Preparation and composition of highly bioavailable zero-valent sulfur and uses thereof |
ES2729208T3 (en) * | 2012-07-18 | 2019-10-30 | Pharnext | Baclofen and acamprosate-based therapy of macular degeneration disorders |
EP2705843A1 (en) * | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating epilepsy and related disorders through reduction of epileptogenesis |
US10357469B2 (en) | 2015-02-18 | 2019-07-23 | Aston University | Diagnostic assay and treatment for preeclampsia |
JP7026347B2 (en) | 2015-05-04 | 2022-02-28 | コンフルーエンス ファーマシューティカルズ,エルエルシー | Acamprosate sprinkle formulation |
WO2017024129A1 (en) * | 2015-08-04 | 2017-02-09 | Confluence Pharmaceuticals, Llc | Combination therapy using acamprosate and d-cycloserine |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6713497B1 (en) * | 2003-03-17 | 2004-03-30 | Brookhaven Science Associates, Llc | Use of vitamin B6 to mitigate visual field defects associated with the use of GABAergic drugs in mammals |
EP1407785A1 (en) * | 2001-06-14 | 2004-04-14 | Otsuka Pharmaceutical Co., Ltd. | Medicinal compositions |
US20050129783A1 (en) * | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5084089B2 (en) * | 2001-06-14 | 2012-11-28 | 大塚製薬株式会社 | Pharmaceutical composition |
US20060057065A1 (en) * | 2004-09-11 | 2006-03-16 | Yanming Wang | Composition and method to prevent and treat brain and spinal cord injuries |
-
2008
- 2008-07-04 WO PCT/EP2008/058672 patent/WO2009004082A2/en active Application Filing
- 2008-07-04 US US12/667,742 patent/US9308260B2/en not_active Expired - Fee Related
- 2008-07-04 JP JP2010514002A patent/JP2010532331A/en active Pending
- 2008-07-04 EP EP08785923A patent/EP2167068A2/en not_active Withdrawn
-
2014
- 2014-07-04 JP JP2014138522A patent/JP5900988B2/en not_active Expired - Fee Related
-
2016
- 2016-02-23 US US15/051,484 patent/US20160193166A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050129783A1 (en) * | 2001-04-19 | 2005-06-16 | Mccleary Edward L. | Composition and method for treatment of neurophysiological conditions and maintenance of neurophysiological health |
EP1407785A1 (en) * | 2001-06-14 | 2004-04-14 | Otsuka Pharmaceutical Co., Ltd. | Medicinal compositions |
US6713497B1 (en) * | 2003-03-17 | 2004-03-30 | Brookhaven Science Associates, Llc | Use of vitamin B6 to mitigate visual field defects associated with the use of GABAergic drugs in mammals |
Non-Patent Citations (6)
Title |
---|
ANYANWU E ET AL: "The involvement of taurine in the action mechanism of sodium valproate (VPA)in the treatment of epilepsy", ACTA PHYSIOLOGICA, PHARMACOLOGICA ET THERAPEUTICA LATINOAMERICANA, ASOCIACION LATINOAMERICANA DE CIENCIAS FISIOLOGICAS, BUENOS AI, AR, vol. 43, no. 1-2, 1993, pages 20 - 27, XP008086580, ISSN: 0327-6309 * |
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1995, HUANG, FENGHE ET AL: "Anticonvulsant effect of taurine and its influence on GABA and taurine level in brain of mice", XP002462443, retrieved from STN Database accession no. 1996:207287 * |
GUANGDONG YAOXUEYUAN XUEBAO , 11(4), 220-3 CODEN: GYXUF8, 1995 * |
MUHLING J ET AL: "Effects of propofol and taurine on intracellular free amino acid profiles and immune function markers in neutrophils in vitro", CLINICAL CHEMISTRY AND LABORATORY MEDICINE, WALTER DE GRUYTER UND CO, DE, vol. 40, no. 2, 2002, pages 111 - 121, XP008086698, ISSN: 1434-6621 * |
SCHMIDT S Y ET AL: "Retinal degeneration in cats fed casein. III. Taurine deficiency and ERG amplitudes", INVESTIGATIVE OPHTHALMOLOGY AND VISUAL SCIENCE 1977 UNITED STATES, vol. 16, no. 7, 1977, pages 673 - 678, XP002462442, ISSN: 0146-0404 * |
SMIRNOV V YU ET AL: "Metabolic effects of mixture containing branched-chain amino acids and taurine during subchronic poisoning with barbiturates.", BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE MAY 2004, vol. 137, no. 5, May 2004 (2004-05-01), pages 443 - 446, XP002462441, ISSN: 0007-4888 * |
Also Published As
Publication number | Publication date |
---|---|
US20160193166A1 (en) | 2016-07-07 |
WO2009004082A2 (en) | 2009-01-08 |
EP2167068A2 (en) | 2010-03-31 |
JP2010532331A (en) | 2010-10-07 |
JP5900988B2 (en) | 2016-04-06 |
US9308260B2 (en) | 2016-04-12 |
JP2014208689A (en) | 2014-11-06 |
US20100184707A1 (en) | 2010-07-22 |
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