WO2008143957A3 - Hydrogel materials - Google Patents

Hydrogel materials Download PDF

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Publication number
WO2008143957A3
WO2008143957A3 PCT/US2008/006264 US2008006264W WO2008143957A3 WO 2008143957 A3 WO2008143957 A3 WO 2008143957A3 US 2008006264 W US2008006264 W US 2008006264W WO 2008143957 A3 WO2008143957 A3 WO 2008143957A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyelectrophilic
polynucleophilic
biomaterial
precursors
water
Prior art date
Application number
PCT/US2008/006264
Other languages
French (fr)
Other versions
WO2008143957A2 (en
Inventor
Paul D Drumheller
Original Assignee
Gore Enterprise Holdings Inc
Paul D Drumheller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gore Enterprise Holdings Inc, Paul D Drumheller filed Critical Gore Enterprise Holdings Inc
Priority to CA002686920A priority Critical patent/CA2686920A1/en
Priority to EP08767731A priority patent/EP2162155A2/en
Priority to JP2010508432A priority patent/JP2010528125A/en
Priority to AU2008254954A priority patent/AU2008254954A1/en
Publication of WO2008143957A2 publication Critical patent/WO2008143957A2/en
Publication of WO2008143957A3 publication Critical patent/WO2008143957A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001Use of materials characterised by their function or physical properties
    • A61L24/0031Hydrogels or hydrocolloids
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3324Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33303Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
    • C08G65/33306Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group acyclic
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33331Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
    • C08G65/33337Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32Polymers modified by chemical after-treatment
    • C08G65/329Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33348Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing isocyanate group
    • C08G65/33355Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing isocyanate group cyclic
    • C08G65/33358Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing isocyanate group cyclic aromatic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00Applications
    • C08L2203/02Applications for biomedical use

Abstract

The present invention relates to biocompatible crosslinked biomate rials made from polycondensation polymerization reactions involving polynucleophilic- polyelectrophilic precursors that address the limitations of steric hindrance, viscosity, and diffusion currently reducing gelation rates and curing thoroughness of the biomaterials. A cross-linking scheme is utilized in the invention that permits rapid gelation and thorough curing of the biomaterial. The biomaterial is made by polycondensation polymerization of polynucleophilic-polyelectrophilic precursors to form a water-soluble polymer crosslinked with a water-soluble crosslinker having at most one core cyclic structure.
PCT/US2008/006264 2007-05-18 2008-05-15 Hydrogel materials WO2008143957A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002686920A CA2686920A1 (en) 2007-05-18 2008-05-15 Hydrogel materials
EP08767731A EP2162155A2 (en) 2007-05-18 2008-05-15 Hydrogel materials
JP2010508432A JP2010528125A (en) 2007-05-18 2008-05-15 Hydrogel material
AU2008254954A AU2008254954A1 (en) 2007-05-18 2008-05-15 Hydrogel materials

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/750,673 US20080287633A1 (en) 2007-05-18 2007-05-18 Hydrogel Materials
US11/750,673 2007-05-18

Publications (2)

Publication Number Publication Date
WO2008143957A2 WO2008143957A2 (en) 2008-11-27
WO2008143957A3 true WO2008143957A3 (en) 2009-01-08

Family

ID=39798089

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/006264 WO2008143957A2 (en) 2007-05-18 2008-05-15 Hydrogel materials

Country Status (6)

Country Link
US (1) US20080287633A1 (en)
EP (1) EP2162155A2 (en)
JP (1) JP2010528125A (en)
AU (1) AU2008254954A1 (en)
CA (1) CA2686920A1 (en)
WO (1) WO2008143957A2 (en)

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US6566406B1 (en) * 1998-12-04 2003-05-20 Incept, Llc Biocompatible crosslinked polymers
EP2247645B1 (en) * 2008-02-13 2017-12-06 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
JP5241764B2 (en) * 2010-03-31 2013-07-17 テルモ株式会社 Evaluation method for biocompatible materials
CN105885027A (en) * 2015-01-26 2016-08-24 中国科学院上海药物研究所 PEG modified polymyxin and preparation method and application thereof
JP2018536484A (en) 2015-11-25 2018-12-13 インセプト・リミテッド・ライアビリティ・カンパニーIncept,Llc Shape-changing drug delivery device and method
EP3898840A4 (en) * 2018-12-19 2022-11-02 Taproot Medical Technologies, LLC Hydrogel compositions based on polysaccharides and zwitterionic polymers, and methods for their use
RU2705571C1 (en) * 2019-02-15 2019-11-08 Федеральное государственное бюджетное образовательное учреждение высшего образования "Южно-Уральский государственный аграрный университет" Method for prevention and treatment of nodular dermatitis in cattle
US11230497B2 (en) 2019-04-10 2022-01-25 Saudi Arabian Oil Company Cement additives
US11858039B2 (en) 2022-01-13 2024-01-02 Saudi Arabian Oil Company Direct ink printing of multi-material composite structures

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Also Published As

Publication number Publication date
CA2686920A1 (en) 2008-11-27
JP2010528125A (en) 2010-08-19
EP2162155A2 (en) 2010-03-17
US20080287633A1 (en) 2008-11-20
AU2008254954A1 (en) 2008-11-27
WO2008143957A2 (en) 2008-11-27

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