WO2008141111A3 - Polymers conjugated with platinum drugs - Google Patents
Polymers conjugated with platinum drugs Download PDFInfo
- Publication number
- WO2008141111A3 WO2008141111A3 PCT/US2008/063128 US2008063128W WO2008141111A3 WO 2008141111 A3 WO2008141111 A3 WO 2008141111A3 US 2008063128 W US2008063128 W US 2008063128W WO 2008141111 A3 WO2008141111 A3 WO 2008141111A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- polymers
- platinum drugs
- polymers conjugated
- conjugated
- platinum
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Various biocompatible polymers having platinum compounds conjugated thereto are prepared. Such polymers are useful for a variety of drug, biomolecule, and imaging agent delivery applications. Also disclosed are methods of using the polymers to treat, diagnose, and/or image a subject.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200880020323.XA CN101730549B (en) | 2007-05-09 | 2008-05-08 | The polymer be combined with platinum medicine |
DK08769347.9T DK2155254T3 (en) | 2007-05-09 | 2008-05-08 | Polymer conjugated with platinum drugs |
JP2010507678A JP2010528122A (en) | 2007-05-09 | 2008-05-08 | Polymer combined with platinum drug |
EP08769347A EP2155254B1 (en) | 2007-05-09 | 2008-05-08 | Polymers conjugated with platinum drugs |
HK10108048.3A HK1141462A1 (en) | 2007-05-09 | 2010-08-23 | Polymers conjugated with platinum drugs |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91685707P | 2007-05-09 | 2007-05-09 | |
US60/916,857 | 2007-05-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008141111A2 WO2008141111A2 (en) | 2008-11-20 |
WO2008141111A3 true WO2008141111A3 (en) | 2009-06-04 |
Family
ID=39615788
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/063128 WO2008141111A2 (en) | 2007-05-09 | 2008-05-08 | Polymers conjugated with platinum drugs |
Country Status (8)
Country | Link |
---|---|
US (1) | US20080279782A1 (en) |
EP (1) | EP2155254B1 (en) |
JP (1) | JP2010528122A (en) |
CN (1) | CN101730549B (en) |
DK (1) | DK2155254T3 (en) |
HK (1) | HK1141462A1 (en) |
TW (1) | TW200906440A (en) |
WO (1) | WO2008141111A2 (en) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9393315B2 (en) | 2011-06-08 | 2016-07-19 | Nitto Denko Corporation | Compounds for targeting drug delivery and enhancing siRNA activity |
WO2007067417A1 (en) | 2005-12-05 | 2007-06-14 | Nitto Denko Corporation | Polyglutamate-amino acid conjugates and methods |
US20080279778A1 (en) * | 2007-05-09 | 2008-11-13 | Nitto Denko Corporation | Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs |
PT2155255E (en) * | 2007-05-09 | 2013-10-15 | Nitto Denko Corp | Compositions that include a hydrophobic compound and a polyamino acid conjugate |
RU2011117935A (en) * | 2008-10-15 | 2012-11-27 | Нитто Денко Корпорейшн | METHOD FOR PRODUCING POLYHLUTAMATE CONJUGATES |
EP2391630A2 (en) * | 2009-01-31 | 2011-12-07 | IGF Oncology, LLC | Anti-cancer protein-platinum conjugates |
BR112012013305A2 (en) * | 2009-12-16 | 2016-03-01 | Nitto Denko Corp | processes for the preparation of polyglutamic acid |
US10196637B2 (en) | 2011-06-08 | 2019-02-05 | Nitto Denko Corporation | Retinoid-lipid drug carrier |
EP2800586A1 (en) | 2012-01-03 | 2014-11-12 | Invictus Oncology Pvt. Ltd. | Ligand-targeted molecules and methods thereof |
EP2836238B1 (en) | 2012-04-12 | 2018-05-02 | Nitto Denko Corporation | Co-polymer conjugates |
US9078926B2 (en) | 2012-05-07 | 2015-07-14 | Nitto Denko Corporation | Polymer conjugates with a linker |
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-
2008
- 2008-05-08 DK DK08769347.9T patent/DK2155254T3/en active
- 2008-05-08 JP JP2010507678A patent/JP2010528122A/en active Pending
- 2008-05-08 CN CN200880020323.XA patent/CN101730549B/en not_active Expired - Fee Related
- 2008-05-08 EP EP08769347A patent/EP2155254B1/en not_active Not-in-force
- 2008-05-08 WO PCT/US2008/063128 patent/WO2008141111A2/en active Application Filing
- 2008-05-08 US US12/117,604 patent/US20080279782A1/en not_active Abandoned
- 2008-05-09 TW TW097117163A patent/TW200906440A/en unknown
-
2010
- 2010-08-23 HK HK10108048.3A patent/HK1141462A1/en not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003017923A2 (en) * | 2001-12-10 | 2003-03-06 | Fannin Bioscience, Inc. | Anticancer polypeptide-metal complexes and compositions, methods of making, and methods of using same |
EP1695991A1 (en) * | 2003-12-10 | 2006-08-30 | TOUDAI TLO, Ltd. | Coordination complex of diaminocyclohexaneplatinum(ii) with block copolymer containing poly(carboxylic acid) segment and antitumor agent comprising the same |
Non-Patent Citations (1)
Title |
---|
YE HAIFENG ET AL: "Poly([gamma],l-glutamic acid)-cisplatin conjugate effectively inhibits human breast tumor xenografted in nude mice", BIOMATERIALS 200612 GB, vol. 27, no. 35, December 2006 (2006-12-01), pages 5958 - 5965, XP002522733, ISSN: 0142-9612 * |
Also Published As
Publication number | Publication date |
---|---|
US20080279782A1 (en) | 2008-11-13 |
WO2008141111A2 (en) | 2008-11-20 |
EP2155254B1 (en) | 2012-11-28 |
CN101730549A (en) | 2010-06-09 |
EP2155254A2 (en) | 2010-02-24 |
HK1141462A1 (en) | 2010-11-12 |
TW200906440A (en) | 2009-02-16 |
JP2010528122A (en) | 2010-08-19 |
DK2155254T3 (en) | 2013-03-04 |
CN101730549B (en) | 2015-12-09 |
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