WO2008124513A3 - Stents with drug reservoir layer and methods of making and using the same - Google Patents

Stents with drug reservoir layer and methods of making and using the same Download PDF

Info

Publication number
WO2008124513A3
WO2008124513A3 PCT/US2008/059280 US2008059280W WO2008124513A3 WO 2008124513 A3 WO2008124513 A3 WO 2008124513A3 US 2008059280 W US2008059280 W US 2008059280W WO 2008124513 A3 WO2008124513 A3 WO 2008124513A3
Authority
WO
WIPO (PCT)
Prior art keywords
stent body
making
stents
methods
same
Prior art date
Application number
PCT/US2008/059280
Other languages
French (fr)
Other versions
WO2008124513A2 (en
Inventor
Liliana Atanasoska
Jan Weber
Robert W Warner
Original Assignee
Boston Scientific Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Scientific Limited filed Critical Boston Scientific Limited
Priority to EP08745022A priority Critical patent/EP2146757B1/en
Priority to AT08745022T priority patent/ATE510573T1/en
Publication of WO2008124513A2 publication Critical patent/WO2008124513A2/en
Publication of WO2008124513A3 publication Critical patent/WO2008124513A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606—Coatings
    • A61L2300/608—Coatings having two or more layers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/08—Coatings comprising two or more layers

Abstract

A method of making drug eluting stents comprises forming ceramic surface coatings of two or more levels of porosity on a stent body. The less porous coating is more conducive to endothelial cell growth, while the more porous coating is better suited for storing and releasing drugs. The surface coatings of different porosities can be produced by coating stent body surface of differing roughness with coatings made by sol-gel method. Differing roughness of the stent body surface can be produced by selective etching of the stent body surface.
PCT/US2008/059280 2007-04-06 2008-04-03 Stents with drug reservoir layer and methods of making and using the same WO2008124513A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP08745022A EP2146757B1 (en) 2007-04-06 2008-04-03 Stents with drug reservoir layer and methods of making and using the same
AT08745022T ATE510573T1 (en) 2007-04-06 2008-04-03 STENTS WITH A DRUG RESERVOIR LAYER AND METHOD FOR THE PRODUCTION AND USE THEREOF

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/697,401 2007-04-06
US11/697,401 US20080249600A1 (en) 2007-04-06 2007-04-06 Stents with drug reservoir layer and methods of making and using the same

Publications (2)

Publication Number Publication Date
WO2008124513A2 WO2008124513A2 (en) 2008-10-16
WO2008124513A3 true WO2008124513A3 (en) 2009-12-23

Family

ID=39525368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/059280 WO2008124513A2 (en) 2007-04-06 2008-04-03 Stents with drug reservoir layer and methods of making and using the same

Country Status (4)

Country Link
US (1) US20080249600A1 (en)
EP (1) EP2146757B1 (en)
AT (1) ATE510573T1 (en)
WO (1) WO2008124513A2 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7713297B2 (en) 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US7727221B2 (en) 2001-06-27 2010-06-01 Cardiac Pacemakers Inc. Method and device for electrochemical formation of therapeutic species in vivo
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US20070224235A1 (en) 2006-03-24 2007-09-27 Barron Tenney Medical devices having nanoporous coatings for controlled therapeutic agent delivery
US8187620B2 (en) 2006-03-27 2012-05-29 Boston Scientific Scimed, Inc. Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8815275B2 (en) 2006-06-28 2014-08-26 Boston Scientific Scimed, Inc. Coatings for medical devices comprising a therapeutic agent and a metallic material
CA2655793A1 (en) 2006-06-29 2008-01-03 Boston Scientific Limited Medical devices with selective coating
JP2009545407A (en) 2006-08-02 2009-12-24 ボストン サイエンティフィック サイムド，インコーポレイテッド End prosthesis with 3D decomposition control
JP2010503469A (en) 2006-09-14 2010-02-04 ボストン サイエンティフィック リミテッド Medical device having drug-eluting film
DE602007011114D1 (en) 2006-09-15 2011-01-20 Boston Scient Scimed Inc BIODEGRADABLE ENDOPROTHESIS WITH BIOSTABILES INORGANIC LAYERS
WO2008034066A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
JP2010503489A (en) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド Biodegradable endoprosthesis and method for producing the same
WO2008034013A2 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
WO2008036548A2 (en) 2006-09-18 2008-03-27 Boston Scientific Limited Endoprostheses
US7981150B2 (en) 2006-11-09 2011-07-19 Boston Scientific Scimed, Inc. Endoprosthesis with coatings
ES2506144T3 (en) 2006-12-28 2014-10-13 Boston Scientific Limited Bioerodible endoprosthesis and their manufacturing procedure
US8070797B2 (en) 2007-03-01 2011-12-06 Boston Scientific Scimed, Inc. Medical device with a porous surface for delivery of a therapeutic agent
US8431149B2 (en) 2007-03-01 2013-04-30 Boston Scientific Scimed, Inc. Coated medical devices for abluminal drug delivery
US8067054B2 (en) 2007-04-05 2011-11-29 Boston Scientific Scimed, Inc. Stents with ceramic drug reservoir layer and methods of making and using the same
US7976915B2 (en) * 2007-05-23 2011-07-12 Boston Scientific Scimed, Inc. Endoprosthesis with select ceramic morphology
US8002823B2 (en) 2007-07-11 2011-08-23 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7942926B2 (en) 2007-07-11 2011-05-17 Boston Scientific Scimed, Inc. Endoprosthesis coating
WO2009012353A2 (en) 2007-07-19 2009-01-22 Boston Scientific Limited Endoprosthesis having a non-fouling surface
US8815273B2 (en) 2007-07-27 2014-08-26 Boston Scientific Scimed, Inc. Drug eluting medical devices having porous layers
US7931683B2 (en) 2007-07-27 2011-04-26 Boston Scientific Scimed, Inc. Articles having ceramic coated surfaces
WO2009018340A2 (en) 2007-07-31 2009-02-05 Boston Scientific Scimed, Inc. Medical device coating by laser cladding
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US7938855B2 (en) 2007-11-02 2011-05-10 Boston Scientific Scimed, Inc. Deformable underlayer for stent
US8216632B2 (en) 2007-11-02 2012-07-10 Boston Scientific Scimed, Inc. Endoprosthesis coating
US8029554B2 (en) 2007-11-02 2011-10-04 Boston Scientific Scimed, Inc. Stent with embedded material
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
EP2303350A2 (en) 2008-06-18 2011-04-06 Boston Scientific Scimed, Inc. Endoprosthesis coating
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
EP2179752B1 (en) * 2008-10-06 2014-08-13 Biotronik VI Patent AG Implant and method for manufacturing same
US8389083B2 (en) * 2008-10-17 2013-03-05 Boston Scientific Scimed, Inc. Polymer coatings with catalyst for medical devices
US8231980B2 (en) 2008-12-03 2012-07-31 Boston Scientific Scimed, Inc. Medical implants including iridium oxide
EP2403546A2 (en) 2009-03-02 2012-01-11 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8071156B2 (en) 2009-03-04 2011-12-06 Boston Scientific Scimed, Inc. Endoprostheses
US8287937B2 (en) * 2009-04-24 2012-10-16 Boston Scientific Scimed, Inc. Endoprosthese
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
WO2014197749A1 (en) * 2013-06-05 2014-12-11 Sio2 Nanotech Antifogging molecular films and methods of producing same
US10828400B2 (en) 2014-06-10 2020-11-10 The Research Foundation For The State University Of New York Low temperature, nanostructured ceramic coatings

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980566A (en) * 1998-04-11 1999-11-09 Alt; Eckhard Vascular and endoluminal stents with iridium oxide coating
US20050021127A1 (en) * 2003-07-21 2005-01-27 Kawula Paul John Porous glass fused onto stent for drug retention
WO2005082277A1 (en) * 2004-02-18 2005-09-09 Stanford University Drug delivery systems using mesoporous oxide films
US20070036905A1 (en) * 2001-06-12 2007-02-15 Advanced Cardiovascular Systems, Inc. Method and apparatus for spray processing of porous medical devices
US20070071789A1 (en) * 2004-02-18 2007-03-29 Medlogics Device Corporation Bioactive Material Delivery Systems Comprising Sol-Gel Compositions
WO2007133520A2 (en) * 2006-05-12 2007-11-22 Boston Scientific Limited Stent coating comprising titanium oxide or iridium oxide and a therapeutic agent
WO2008024477A2 (en) * 2006-08-25 2008-02-28 Boston Scientific Scimed, Inc. Polymeric/ceramic composite materials for use in medical devices
WO2008033711A2 (en) * 2006-09-14 2008-03-20 Boston Scientific Limited Medical devices with drug-eluting coating
WO2008106223A1 (en) * 2007-03-01 2008-09-04 Boston Scientific Limited Coated medical devices for abluminal drug delivery

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050070989A1 (en) * 2002-11-13 2005-03-31 Whye-Kei Lye Medical devices having porous layers and methods for making the same
US20060200229A1 (en) * 2005-03-03 2006-09-07 Robert Burgermeister Geometry and material for use in high strength, high flexibility, controlled recoil drug eluting stents
KR100792213B1 (en) 2005-08-11 2008-01-07 삼성전자주식회사 Wrapper circuit for interfacing between a memory controller and a memory
US8008395B2 (en) * 2005-09-27 2011-08-30 Boston Scientific Scimed, Inc. Organic-inorganic hybrid particle material and polymer compositions containing same

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5980566A (en) * 1998-04-11 1999-11-09 Alt; Eckhard Vascular and endoluminal stents with iridium oxide coating
US20070036905A1 (en) * 2001-06-12 2007-02-15 Advanced Cardiovascular Systems, Inc. Method and apparatus for spray processing of porous medical devices
US20050021127A1 (en) * 2003-07-21 2005-01-27 Kawula Paul John Porous glass fused onto stent for drug retention
WO2005082277A1 (en) * 2004-02-18 2005-09-09 Stanford University Drug delivery systems using mesoporous oxide films
US20070071789A1 (en) * 2004-02-18 2007-03-29 Medlogics Device Corporation Bioactive Material Delivery Systems Comprising Sol-Gel Compositions
WO2007133520A2 (en) * 2006-05-12 2007-11-22 Boston Scientific Limited Stent coating comprising titanium oxide or iridium oxide and a therapeutic agent
WO2008024477A2 (en) * 2006-08-25 2008-02-28 Boston Scientific Scimed, Inc. Polymeric/ceramic composite materials for use in medical devices
WO2008033711A2 (en) * 2006-09-14 2008-03-20 Boston Scientific Limited Medical devices with drug-eluting coating
WO2008106223A1 (en) * 2007-03-01 2008-09-04 Boston Scientific Limited Coated medical devices for abluminal drug delivery

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8900292B2 (en) 2007-08-03 2014-12-02 Boston Scientific Scimed, Inc. Coating for medical device having increased surface area
US8920491B2 (en) 2008-04-22 2014-12-30 Boston Scientific Scimed, Inc. Medical devices having a coating of inorganic material
US8932346B2 (en) 2008-04-24 2015-01-13 Boston Scientific Scimed, Inc. Medical devices having inorganic particle layers

Also Published As

Publication number Publication date
WO2008124513A2 (en) 2008-10-16
EP2146757A2 (en) 2010-01-27
EP2146757B1 (en) 2011-05-25
ATE510573T1 (en) 2011-06-15
US20080249600A1 (en) 2008-10-09

Similar Documents

Publication Publication Date Title
WO2008124513A3 (en) Stents with drug reservoir layer and methods of making and using the same
JP2011502579A5 (en) Endoprosthesis with porous reservoir and non-polymer diffusion layer and method of forming same
WO2008079152A3 (en) Ceramic coating and method of preparation thereof
WO2008124519A3 (en) Stents with ceramic drug reservoir layer and methods of making and using the same
WO2009059166A3 (en) Endoprosthesis with porous reservoir and non-polymer diffusion layer
WO2009059165A3 (en) Endoprosthesis coating
SE0203224D0 (en) Method of making structured ceramic coatings and coated devices prepared with the method
WO2006004645A3 (en) Porous coatings for biomedical implants
WO2010053725A3 (en) Porous surface layers with increased surface roughness and implants incorporating the same
WO2009059129A3 (en) Endoprosthesis with porous reservoir and non-polymer diffusion layer
JP2010517620A5 (en)
JP2012500059A5 (en)
EP2165682A3 (en) Medical implant
WO2009059146A3 (en) Endoprosthesis with porous reservoir
WO2010041014A3 (en) Preparation of nanostructured microporous composite foams
WO2009009627A3 (en) Endoprosthesis coating
TW200733460A (en) Method for preparing functional film
WO2009059086A3 (en) Deformable underlayer for stent
JP2010000367A5 (en)
WO2010107228A2 (en) Anode-supported solid oxide fuel cell comprising a nanoporous layer having a pore gradient structure, and a production method therefor
EP1970359A3 (en) Composite article and fabrication method
WO2006037085A3 (en) Ink-jet media having an ink-vehicle permeable coating and a microporous coating
WO2009009781A3 (en) Hybrid composite hydroponic substrate system
WO2008057991A3 (en) Ion bombardment of medical devices
WO2007094803A3 (en) Foamed vitroeous materials for agricultural applications

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08745022

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008745022

Country of ref document: EP