WO2008103200A3 - Apparatus and method for performing ligand binding assays on microarrays in multiwell plates - Google Patents

Apparatus and method for performing ligand binding assays on microarrays in multiwell plates Download PDF

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Publication number
WO2008103200A3
WO2008103200A3 PCT/US2007/084680 US2007084680W WO2008103200A3 WO 2008103200 A3 WO2008103200 A3 WO 2008103200A3 US 2007084680 W US2007084680 W US 2007084680W WO 2008103200 A3 WO2008103200 A3 WO 2008103200A3
Authority
WO
WIPO (PCT)
Prior art keywords
quantitation
microarrays
ligand binding
binding assays
well
Prior art date
Application number
PCT/US2007/084680
Other languages
French (fr)
Other versions
WO2008103200A2 (en
Inventor
Shane C Dultz
Jeffrey Travis
David Ralin
Original Assignee
Maven Technologies Llc
Shane C Dultz
Jeffrey Travis
David Ralin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Maven Technologies Llc, Shane C Dultz, Jeffrey Travis, David Ralin filed Critical Maven Technologies Llc
Publication of WO2008103200A2 publication Critical patent/WO2008103200A2/en
Publication of WO2008103200A3 publication Critical patent/WO2008103200A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/12—Apparatus specially adapted for use in combinatorial chemistry or with libraries for screening libraries
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties
    • G01N21/211—Ellipsometry
    • G01N2021/212—Arrangement with total internal reflection
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/809—Multifield plates or multicontainer arrays

Abstract

An apparatus and method for real time, label-free imaging and quantitation of binding events at an array of positions are provided. Total internal reflection from a planar side wall of a well of a multiwell plate is used to create an evanescent field in the plane of a pattern of ligands immobilized on the wall. Embodiments include imaging and multiple analyte detection and quantitation of a single wall of a single well as well as the simultaneous imaging and multiple analyte detection and quantitation of a number of wells.
PCT/US2007/084680 2007-02-22 2007-11-14 Apparatus and method for performing ligand binding assays on microarrays in multiwell plates WO2008103200A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/677,674 US7867783B2 (en) 2007-02-22 2007-02-22 Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US11/677,674 2007-02-22

Publications (2)

Publication Number Publication Date
WO2008103200A2 WO2008103200A2 (en) 2008-08-28
WO2008103200A3 true WO2008103200A3 (en) 2008-12-11

Family

ID=39710633

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/084680 WO2008103200A2 (en) 2007-02-22 2007-11-14 Apparatus and method for performing ligand binding assays on microarrays in multiwell plates

Country Status (2)

Country Link
US (1) US7867783B2 (en)
WO (1) WO2008103200A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008057067A1 (en) * 2008-11-13 2010-05-20 BF-BIOlabs Schneider und Zeltz GbR (Vertretungsberechtigten Gesellschafter: Dr. Patric Zeltz 79211 Denzlingen und Stephan Schneider 79211 Denzlingen Apparatus for parallel micro-array experiments, e.g. in DNA analysis, has a micro-titration plate with reaction vessels and a micro-array to one side of them
US9063072B1 (en) 2012-06-12 2015-06-23 Maven Technologies, Llc Birefringence correction for imaging ellipsometric bioassay system and method
CN110702642B (en) * 2019-10-29 2022-03-18 西南大学 Preparation method of micro-well structured SPRi chip, product and application thereof

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Also Published As

Publication number Publication date
WO2008103200A2 (en) 2008-08-28
US20080207463A1 (en) 2008-08-28
US7867783B2 (en) 2011-01-11

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