WO2008097277A3 - Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 - Google Patents

Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 Download PDF

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Publication number
WO2008097277A3
WO2008097277A3 PCT/US2007/020215 US2007020215W WO2008097277A3 WO 2008097277 A3 WO2008097277 A3 WO 2008097277A3 US 2007020215 W US2007020215 W US 2007020215W WO 2008097277 A3 WO2008097277 A3 WO 2008097277A3
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WO
WIPO (PCT)
Prior art keywords
mir
cll
lymphocytic leukemia
chronic lymphocytic
regulated
Prior art date
Application number
PCT/US2007/020215
Other languages
French (fr)
Other versions
WO2008097277A2 (en
Inventor
Carlo M Croce
Original Assignee
Univ Ohio State Res Found
Carlo M Croce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ohio State Res Found, Carlo M Croce filed Critical Univ Ohio State Res Found
Priority to AU2007346101A priority Critical patent/AU2007346101B2/en
Priority to AT07872618T priority patent/ATE534752T1/en
Priority to CA002663027A priority patent/CA2663027A1/en
Priority to EP07872618A priority patent/EP2061907B1/en
Priority to ES07872618T priority patent/ES2374446T3/en
Priority to JP2009529212A priority patent/JP5426383B2/en
Priority to US12/442,018 priority patent/US8071292B2/en
Publication of WO2008097277A2 publication Critical patent/WO2008097277A2/en
Publication of WO2008097277A3 publication Critical patent/WO2008097277A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Abstract

The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of chronic lymphocytic leukemia (CLL). The invention also provides methods of identifying anti-CLL agents.
PCT/US2007/020215 2006-09-19 2007-09-17 Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 WO2008097277A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
AU2007346101A AU2007346101B2 (en) 2006-09-19 2007-09-17 TCL1 expression in chronic lymphocytic leukemia (CLL) regulated by miR-29 and miR-181
AT07872618T ATE534752T1 (en) 2006-09-19 2007-09-17 TCL1 EXPRESSION IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) REGULATED BY MIR-29 AND MIR-181
CA002663027A CA2663027A1 (en) 2006-09-19 2007-09-17 Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181
EP07872618A EP2061907B1 (en) 2006-09-19 2007-09-17 Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181
ES07872618T ES2374446T3 (en) 2006-09-19 2007-09-17 EXPRESSION OF TCL1 IN CHRONIC LYMPHOCYTIC LEUKEMIA (LLC) REGULATED BY MIR-29 AND MIR-181.
JP2009529212A JP5426383B2 (en) 2006-09-19 2007-09-17 TCL1 expression regulated by miR-29 and miR-181 in chronic lymphocytic leukemia
US12/442,018 US8071292B2 (en) 2006-09-19 2007-09-17 Leukemia diagnostic methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84565706P 2006-09-19 2006-09-19
US60/845,657 2006-09-19

Publications (2)

Publication Number Publication Date
WO2008097277A2 WO2008097277A2 (en) 2008-08-14
WO2008097277A3 true WO2008097277A3 (en) 2008-10-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/020215 WO2008097277A2 (en) 2006-09-19 2007-09-17 Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181

Country Status (9)

Country Link
US (1) US8071292B2 (en)
EP (1) EP2061907B1 (en)
JP (2) JP5426383B2 (en)
CN (1) CN101535505A (en)
AT (1) ATE534752T1 (en)
AU (1) AU2007346101B2 (en)
CA (1) CA2663027A1 (en)
ES (1) ES2374446T3 (en)
WO (1) WO2008097277A2 (en)

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US8071292B2 (en) 2006-09-19 2011-12-06 The Ohio State University Research Foundation Leukemia diagnostic methods
US8084199B2 (en) 2006-07-13 2011-12-27 The Ohio State University Research Foundation Method of diagnosing poor survival prognosis colon cancer using microRNA-21
US8252538B2 (en) 2006-11-01 2012-08-28 The Ohio State University MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
US8367632B2 (en) 2007-07-31 2013-02-05 Ohio State University Research Foundation Methods for reverting methylation by targeting methyltransferases
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JP5723156B2 (en) * 2007-10-11 2015-05-27 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイションＴｈｅ Ｏｈｉｏ Ｓｔａｔｅ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ｆｏｕｎｄａｔｉｏｎ Methods and compositions for diagnosis and treatment of esophageal adenocarcinoma
CN101918594A (en) * 2007-11-30 2010-12-15 俄亥俄州立大学研究基金会 Micro-RNA expression profiling and targeting in peripheral blood in lung cancer
CN102027129B (en) * 2008-02-28 2014-03-12 俄亥俄州立大学研究基金会 Microrna-based methods and compositions for diagnosis, pronosis and treatment of prostate related disorders
WO2009108856A2 (en) * 2008-02-28 2009-09-03 The Ohio State University Research Foundation Microrna signatures associated with human chronic lymphocytic leukemia (ccl) and uses thereof
KR20100064516A (en) * 2008-12-05 2010-06-15 서울대학교산학협력단 Anticancer agent comprising microrna as an active ingredient and the preparation method thereof
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