WO2008097277A3 - Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 - Google Patents
Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 Download PDFInfo
- Publication number
- WO2008097277A3 WO2008097277A3 PCT/US2007/020215 US2007020215W WO2008097277A3 WO 2008097277 A3 WO2008097277 A3 WO 2008097277A3 US 2007020215 W US2007020215 W US 2007020215W WO 2008097277 A3 WO2008097277 A3 WO 2008097277A3
- Authority
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- WIPO (PCT)
- Prior art keywords
- mir
- cll
- lymphocytic leukemia
- chronic lymphocytic
- regulated
- Prior art date
Links
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 title abstract 2
- 108091055042 miR-181 stem-loop Proteins 0.000 title 1
- 108091029162 miR-29 stem-loop Proteins 0.000 title 1
- 230000001105 regulatory effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000004393 prognosis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Abstract
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT07872618T ATE534752T1 (en) | 2006-09-19 | 2007-09-17 | TCL1 EXPRESSION IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) REGULATED BY MIR-29 AND MIR-181 |
US12/442,018 US8071292B2 (en) | 2006-09-19 | 2007-09-17 | Leukemia diagnostic methods |
CA002663027A CA2663027A1 (en) | 2006-09-19 | 2007-09-17 | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
JP2009529212A JP5426383B2 (en) | 2006-09-19 | 2007-09-17 | TCL1 expression regulated by miR-29 and miR-181 in chronic lymphocytic leukemia |
AU2007346101A AU2007346101B2 (en) | 2006-09-19 | 2007-09-17 | TCL1 expression in chronic lymphocytic leukemia (CLL) regulated by miR-29 and miR-181 |
ES07872618T ES2374446T3 (en) | 2006-09-19 | 2007-09-17 | EXPRESSION OF TCL1 IN CHRONIC LYMPHOCYTIC LEUKEMIA (LLC) REGULATED BY MIR-29 AND MIR-181. |
EP07872618A EP2061907B1 (en) | 2006-09-19 | 2007-09-17 | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84565706P | 2006-09-19 | 2006-09-19 | |
US60/845,657 | 2006-09-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008097277A2 WO2008097277A2 (en) | 2008-08-14 |
WO2008097277A3 true WO2008097277A3 (en) | 2008-10-09 |
Family
ID=39682247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/020215 WO2008097277A2 (en) | 2006-09-19 | 2007-09-17 | Tcl1 expression in chronic lymphocytic leukemia (cll) regulated by mir-29 and mir-181 |
Country Status (9)
Country | Link |
---|---|
US (1) | US8071292B2 (en) |
EP (1) | EP2061907B1 (en) |
JP (2) | JP5426383B2 (en) |
CN (1) | CN101535505A (en) |
AT (1) | ATE534752T1 (en) |
AU (1) | AU2007346101B2 (en) |
CA (1) | CA2663027A1 (en) |
ES (1) | ES2374446T3 (en) |
WO (1) | WO2008097277A2 (en) |
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US8034560B2 (en) | 2007-01-31 | 2011-10-11 | The Ohio State University Research Foundation | MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML) |
US8053186B2 (en) | 2007-06-15 | 2011-11-08 | The Ohio State University Research Foundation | Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing |
US8071292B2 (en) | 2006-09-19 | 2011-12-06 | The Ohio State University Research Foundation | Leukemia diagnostic methods |
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JP2010503420A (en) | 2010-02-04 |
JP2014113146A (en) | 2014-06-26 |
EP2061907B1 (en) | 2011-11-23 |
AU2007346101B2 (en) | 2013-08-15 |
ATE534752T1 (en) | 2011-12-15 |
ES2374446T3 (en) | 2012-02-16 |
EP2061907A2 (en) | 2009-05-27 |
US20100004322A1 (en) | 2010-01-07 |
CA2663027A1 (en) | 2008-08-14 |
US8071292B2 (en) | 2011-12-06 |
AU2007346101A1 (en) | 2008-08-14 |
JP5426383B2 (en) | 2014-02-26 |
EP2061907A4 (en) | 2010-08-04 |
CN101535505A (en) | 2009-09-16 |
WO2008097277A2 (en) | 2008-08-14 |
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