WO2008096722A1 - 脳表血管出血抑制剤 - Google Patents

脳表血管出血抑制剤 Download PDF

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Publication number
WO2008096722A1
WO2008096722A1 PCT/JP2008/051804 JP2008051804W WO2008096722A1 WO 2008096722 A1 WO2008096722 A1 WO 2008096722A1 JP 2008051804 W JP2008051804 W JP 2008051804W WO 2008096722 A1 WO2008096722 A1 WO 2008096722A1
Authority
WO
WIPO (PCT)
Prior art keywords
agent
meq
cerebral cortical
surgery
cortical vein
Prior art date
Application number
PCT/JP2008/051804
Other languages
English (en)
French (fr)
Inventor
Yasutaka Fujita
Kazuhisa Doi
Shuji Kamikawa
Original Assignee
Otsuka Pharmaceutical Factory, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Factory, Inc. filed Critical Otsuka Pharmaceutical Factory, Inc.
Priority to EP08704431.9A priority Critical patent/EP2123287B1/en
Priority to AU2008212289A priority patent/AU2008212289B2/en
Priority to CN2008800043705A priority patent/CN101657205B/zh
Priority to KR1020097017316A priority patent/KR101344136B1/ko
Priority to JP2008557108A priority patent/JPWO2008096722A1/ja
Priority to CA2677657A priority patent/CA2677657C/en
Priority to US12/526,322 priority patent/US8926548B2/en
Publication of WO2008096722A1 publication Critical patent/WO2008096722A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A61K33/10—Carbonates; Bicarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

　本発明は、ナトリウムイオン120～160 mEq/L、カルシウムイオン1～5 mEq/L、及び塩素イオン75～165mEq/Lを含有する水溶液からなる脳表血管出血抑制剤；更に、カリウムイオンを1～5 mEq/L含有する脳表血管出血抑制剤；並びにこれらの脳表血管出血抑制剤を収容した容器の包装体を提供するものである。 　本発明の脳表血管出血抑制剤によれば、頭蓋内手術などの脳神経外科領域において、脳表血管からの出血を効果的に防止乃至抑制して、手術時の視野の確保や術後の障害の発生を抑制できる。
PCT/JP2008/051804 2007-02-08 2008-02-05 脳表血管出血抑制剤 WO2008096722A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP08704431.9A EP2123287B1 (en) 2007-02-08 2008-02-05 Agent for preventing bleeding from cerebral cortical vein
AU2008212289A AU2008212289B2 (en) 2007-02-08 2008-02-05 Agent for preventing bleeding from cerebral cortical vein
CN2008800043705A CN101657205B (zh) 2007-02-08 2008-02-05 防止脑皮层静脉出血的药剂
KR1020097017316A KR101344136B1 (ko) 2007-02-08 2008-02-05 뇌표 혈관 출혈 억제제
JP2008557108A JPWO2008096722A1 (ja) 2007-02-08 2008-02-05 脳表血管出血抑制剤
CA2677657A CA2677657C (en) 2007-02-08 2008-02-05 Agent for preventing bleeding from cerebral cortical vein
US12/526,322 US8926548B2 (en) 2007-02-08 2008-02-05 Agent for preventing bleeding from cerebral cortical vein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-028975 2007-02-08
JP2007028975 2007-02-08

Publications (1)

Publication Number Publication Date
WO2008096722A1 true WO2008096722A1 (ja) 2008-08-14

Family

ID=39681631

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/051804 WO2008096722A1 (ja) 2007-02-08 2008-02-05 脳表血管出血抑制剤

Country Status (9)

Country Link
US (1) US8926548B2 (ja)
EP (1) EP2123287B1 (ja)
JP (1) JPWO2008096722A1 (ja)
KR (1) KR101344136B1 (ja)
CN (1) CN101657205B (ja)
AU (1) AU2008212289B2 (ja)
CA (1) CA2677657C (ja)
TW (1) TWI394592B (ja)
WO (1) WO2008096722A1 (ja)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2390774B1 (es) * 2011-04-29 2013-10-21 Combino Pharm, S.L. Kit que comprende un envase multi-cámara

Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6317474A (ja) 1986-07-10 1988-01-25 Canon Inc 放電装置
JPS6320550B2 (ja) 1980-09-16 1988-04-28 Nitsushoo Kk
JPS63309263A (ja) 1987-06-09 1988-12-16 Otsuka Pharmaceut Factory Inc 輸液バッグ
JPH024671A (ja) 1988-06-10 1990-01-09 Material Eng Tech Lab Inc 内容物入り容器
JPH03112358A (ja) 1989-09-26 1991-05-13 Matsushita Electric Ind Co Ltd 磁気クラッチ
JPH058318A (ja) 1990-09-14 1993-01-19 Toppan Printing Co Ltd 積層包装材料の製造方法
WO1997048365A1 (fr) 1996-06-17 1997-12-24 Otsuka Pharmaceutical Factory, Inc. EMBALLAGE POUR RECIPIENT A MEDICAMENT LIQUIDE CONTENANT DU BICARBONATE ET UN INDICATEUR DE pH
JPH11197215A (ja) 1997-10-27 1999-07-27 Senju Pharmaceut Co Ltd 眼灌流・洗浄液バッグ包装体
JPH11276547A (ja) 1998-03-26 1999-10-12 Otsuka Pharmaceut Factory Inc 複室容器
WO2001044385A1 (fr) 1999-12-15 2001-06-21 Toppan Printing Co., Ltd. Composition d'encre detectant le co2, indicateur de co2 l'utilisant et appareil comportant ledit indicateur
JP2002173422A (ja) 2000-12-04 2002-06-21 Shimizu Pharmaceutical Co Ltd 脳室洗浄製剤
JP2002234102A (ja) 2001-02-07 2002-08-20 Mitsui Chemicals Inc 輸液容器用積層体およびその製造方法
JP2003267451A (ja) 2002-03-14 2003-09-25 Material Eng Tech Lab Inc バリアフィルム及び同フィルムが適用された容器
JP2005349182A (ja) 2004-05-10 2005-12-22 Otsuka Pharmaceut Factory Inc 薬剤容器
US20060057065A1 (en) * 2004-09-11 2006-03-16 Yanming Wang Composition and method to prevent and treat brain and spinal cord injuries
WO2006115057A1 (ja) 2005-04-19 2006-11-02 Otsuka Pharmaceutical Factory, Inc. 人工髄液

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2751326A (en) * 1952-01-24 1956-06-19 Armour & Co Assay method for digitalis preparation and other cardiotonic substances
JPS6317474Y2 (ja) 1980-10-29 1988-05-18
WO1999021527A1 (fr) * 1997-10-27 1999-05-06 Otsuka Pharmaceutical Factory, Inc. Sachet de perfusat ophtalmique et de fluide nettoyant conditionne
US20060073098A1 (en) * 2004-10-02 2006-04-06 Yanming Wang Irrigating solution for neurosurgical procedures
US20060128797A1 (en) * 2004-12-15 2006-06-15 Yanming Wang Method and composition for resuscitation
JP3112358U (ja) 2005-05-09 2005-08-11 株式会社大塚製薬工場 ハイバリア容器

Patent Citations (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6320550B2 (ja) 1980-09-16 1988-04-28 Nitsushoo Kk
JPS6317474A (ja) 1986-07-10 1988-01-25 Canon Inc 放電装置
JPS63309263A (ja) 1987-06-09 1988-12-16 Otsuka Pharmaceut Factory Inc 輸液バッグ
JPH024671A (ja) 1988-06-10 1990-01-09 Material Eng Tech Lab Inc 内容物入り容器
JPH03112358A (ja) 1989-09-26 1991-05-13 Matsushita Electric Ind Co Ltd 磁気クラッチ
JPH058318A (ja) 1990-09-14 1993-01-19 Toppan Printing Co Ltd 積層包装材料の製造方法
WO1997048365A1 (fr) 1996-06-17 1997-12-24 Otsuka Pharmaceutical Factory, Inc. EMBALLAGE POUR RECIPIENT A MEDICAMENT LIQUIDE CONTENANT DU BICARBONATE ET UN INDICATEUR DE pH
JPH11197215A (ja) 1997-10-27 1999-07-27 Senju Pharmaceut Co Ltd 眼灌流・洗浄液バッグ包装体
JPH11276547A (ja) 1998-03-26 1999-10-12 Otsuka Pharmaceut Factory Inc 複室容器
WO2001044385A1 (fr) 1999-12-15 2001-06-21 Toppan Printing Co., Ltd. Composition d'encre detectant le co2, indicateur de co2 l'utilisant et appareil comportant ledit indicateur
JP2002173422A (ja) 2000-12-04 2002-06-21 Shimizu Pharmaceutical Co Ltd 脳室洗浄製剤
JP2002234102A (ja) 2001-02-07 2002-08-20 Mitsui Chemicals Inc 輸液容器用積層体およびその製造方法
JP2003267451A (ja) 2002-03-14 2003-09-25 Material Eng Tech Lab Inc バリアフィルム及び同フィルムが適用された容器
JP2005349182A (ja) 2004-05-10 2005-12-22 Otsuka Pharmaceut Factory Inc 薬剤容器
US20060057065A1 (en) * 2004-09-11 2006-03-16 Yanming Wang Composition and method to prevent and treat brain and spinal cord injuries
WO2006115057A1 (ja) 2005-04-19 2006-11-02 Otsuka Pharmaceutical Factory, Inc. 人工髄液

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KOMACHI H.: "Ishiki Shogai Oyobi Nokekkan Shogai no Yueki Ryoho", IGAKU NO AYUMI, vol. 168, no. 5, 29 January 1994 (1994-01-29), pages 397 - 400, XP008112375 *
See also references of EP2123287A4 *
YANAGIHASHI Y. ET AL.: "Kogashima-Ken ni Okeru In'yosui no Seibun to Junkankei Shikkan Shibo tono Kankei", MINZOKU EISEI, vol. 55, no. 5, 1989, pages 244 - 252, XP003021978 *

Also Published As

Publication number Publication date
EP2123287B1 (en) 2017-08-16
EP2123287A1 (en) 2009-11-25
TWI394592B (zh) 2013-05-01
KR101344136B1 (ko) 2013-12-20
US20100178363A1 (en) 2010-07-15
CN101657205B (zh) 2012-02-29
KR20090110356A (ko) 2009-10-21
EP2123287A4 (en) 2014-06-18
TW200836768A (en) 2008-09-16
CA2677657C (en) 2016-01-05
US8926548B2 (en) 2015-01-06
JPWO2008096722A1 (ja) 2010-05-20
CA2677657A1 (en) 2008-08-14
AU2008212289B2 (en) 2012-07-12
AU2008212289A1 (en) 2008-08-14
CN101657205A (zh) 2010-02-24

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