WO2008094545A3 - Mic orna-based methods and compositions for the treatment of acute myeloid leukemia - Google Patents

Mic orna-based methods and compositions for the treatment of acute myeloid leukemia Download PDF

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Publication number
WO2008094545A3
WO2008094545A3 PCT/US2008/001157 US2008001157W WO2008094545A3 WO 2008094545 A3 WO2008094545 A3 WO 2008094545A3 US 2008001157 W US2008001157 W US 2008001157W WO 2008094545 A3 WO2008094545 A3 WO 2008094545A3
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WIPO (PCT)
Prior art keywords
compositions
treatment
myeloid leukemia
acute myeloid
orna
Prior art date
Application number
PCT/US2008/001157
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French (fr)
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WO2008094545A2 (en
Inventor
Carlo M Croce
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Univ Ohio State Res Found
Carlo M Croce
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Publication date
Application filed by Univ Ohio State Res Found, Carlo M Croce filed Critical Univ Ohio State Res Found
Priority to US12/523,915 priority Critical patent/US8034560B2/en
Priority to AU2008211142A priority patent/AU2008211142A1/en
Priority to JP2009548281A priority patent/JP2010516291A/en
Priority to EP20080713330 priority patent/EP2109687B1/en
Priority to CA 2674895 priority patent/CA2674895A1/en
Priority to CN2008800037367A priority patent/CN101627134B/en
Publication of WO2008094545A2 publication Critical patent/WO2008094545A2/en
Publication of WO2008094545A3 publication Critical patent/WO2008094545A3/en
Priority to US13/269,407 priority patent/US8431342B2/en
Priority to US13/269,410 priority patent/US8354229B2/en
Priority to US13/269,404 priority patent/US8530159B2/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2545/00—Reactions characterised by their quantitative nature
    • C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
    • C12Q2545/114—Reactions characterised by their quantitative nature the purpose being quantitative analysis involving a quantitation step
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/50—Detection characterised by immobilisation to a surface
    • C12Q2565/501—Detection characterised by immobilisation to a surface being an array of oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML). The invention also provides methods of identifying anti-AML agents.
PCT/US2008/001157 2007-01-31 2008-01-29 Mic orna-based methods and compositions for the treatment of acute myeloid leukemia WO2008094545A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
US12/523,915 US8034560B2 (en) 2007-01-31 2008-01-29 MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML)
AU2008211142A AU2008211142A1 (en) 2007-01-31 2008-01-29 Mic orna-based methods and compositions for the treatment of acute myeloid leukemia
JP2009548281A JP2010516291A (en) 2007-01-31 2008-01-29 MicroRNA-based methods and compositions for diagnosis, prognosis and treatment of acute myeloid leukemia (AML)
EP20080713330 EP2109687B1 (en) 2007-01-31 2008-01-29 Micro-rna-based methods for the treatment of acute myeloid leukemia
CA 2674895 CA2674895A1 (en) 2007-01-31 2008-01-29 Microrna-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (aml)
CN2008800037367A CN101627134B (en) 2007-01-31 2008-01-29 Microrna-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (aml)
US13/269,407 US8431342B2 (en) 2007-01-31 2011-10-07 MiR-182-, miR-191, miR-199a-based methods for the diagnosis and prognosis of acute myeloid leukemia (AML)
US13/269,410 US8354229B2 (en) 2007-01-31 2011-10-07 MiR-25-based methods for the diagnosis and prognosis of acute myeloid leukemia (AML)
US13/269,404 US8530159B2 (en) 2007-01-31 2011-10-07 MiR-29-based methods for the diagnosis and prognosis of acute myeloid leukemia (AML)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89857807P 2007-01-31 2007-01-31
US60/898,578 2007-01-31

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US12/523,915 A-371-Of-International US8034560B2 (en) 2007-01-31 2008-01-29 MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML)
US13/269,407 Division US8431342B2 (en) 2007-01-31 2011-10-07 MiR-182-, miR-191, miR-199a-based methods for the diagnosis and prognosis of acute myeloid leukemia (AML)
US13/269,410 Division US8354229B2 (en) 2007-01-31 2011-10-07 MiR-25-based methods for the diagnosis and prognosis of acute myeloid leukemia (AML)
US13/269,404 Division US8530159B2 (en) 2007-01-31 2011-10-07 MiR-29-based methods for the diagnosis and prognosis of acute myeloid leukemia (AML)

Publications (2)

Publication Number Publication Date
WO2008094545A2 WO2008094545A2 (en) 2008-08-07
WO2008094545A3 true WO2008094545A3 (en) 2008-12-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/001157 WO2008094545A2 (en) 2007-01-31 2008-01-29 Mic orna-based methods and compositions for the treatment of acute myeloid leukemia

Country Status (7)

Country Link
US (4) US8034560B2 (en)
EP (1) EP2109687B1 (en)
JP (1) JP2010516291A (en)
CN (3) CN105256004A (en)
AU (1) AU2008211142A1 (en)
CA (1) CA2674895A1 (en)
WO (1) WO2008094545A2 (en)

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US7943318B2 (en) 2006-01-05 2011-05-17 The Ohio State University Research Foundation Microrna-based methods and compositions for the diagnosis, prognosis and treatment of lung cancer
US7985584B2 (en) 2006-03-20 2011-07-26 The Ohio State University Research Foundation MicroRNA fingerprints during human megakaryocytopoiesis
US8034560B2 (en) 2007-01-31 2011-10-11 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of acute myeloid leukemia (AML)
US8053186B2 (en) 2007-06-15 2011-11-08 The Ohio State University Research Foundation Oncogenic ALL-1 fusion proteins for targeting Drosha-mediated microRNA processing
US8084199B2 (en) 2006-07-13 2011-12-27 The Ohio State University Research Foundation Method of diagnosing poor survival prognosis colon cancer using microRNA-21
US8252538B2 (en) 2006-11-01 2012-08-28 The Ohio State University MicroRNA expression signature for predicting survival and metastases in hepatocellular carcinoma
US8367632B2 (en) 2007-07-31 2013-02-05 Ohio State University Research Foundation Methods for reverting methylation by targeting methyltransferases
US8389210B2 (en) 2006-01-05 2013-03-05 The Ohio State University Research Foundation MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors
US8466119B2 (en) 2007-08-22 2013-06-18 The Ohio State University Research Foundation Methods and compositions for inducing deregulation of EPHA7 and ERK phosphorylation in human acute leukemias
US8658370B2 (en) 2005-08-01 2014-02-25 The Ohio State University Research Foundation MicroRNA-based methods and compositions for the diagnosis, prognosis and treatment of breast cancer

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