WO2008091364A3 - Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance - Google Patents

Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance Download PDF

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Publication number
WO2008091364A3
WO2008091364A3 PCT/US2007/072297 US2007072297W WO2008091364A3 WO 2008091364 A3 WO2008091364 A3 WO 2008091364A3 US 2007072297 W US2007072297 W US 2007072297W WO 2008091364 A3 WO2008091364 A3 WO 2008091364A3
Authority
WO
WIPO (PCT)
Prior art keywords
tags
nanoparticles
nuclear magnetic
resonance
magnetic resonance
Prior art date
Application number
PCT/US2007/072297
Other languages
French (fr)
Other versions
WO2008091364A2 (en
Inventor
Chang-Min Park
Shriram Ramanathan
Xing Su
Original Assignee
Intel Corp
Chang-Min Park
Shriram Ramanathan
Xing Su
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intel Corp, Chang-Min Park, Shriram Ramanathan, Xing Su filed Critical Intel Corp
Publication of WO2008091364A2 publication Critical patent/WO2008091364A2/en
Publication of WO2008091364A3 publication Critical patent/WO2008091364A3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/10Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using electron paramagnetic resonance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/587Nanoparticles
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/30Sample handling arrangements, e.g. sample cells, spinning mechanisms
    • G01R33/302Miniaturized sample handling arrangements for sampling small quantities, e.g. flow-through microfluidic NMR chips
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/32Excitation or detection systems, e.g. using radio frequency signals
    • G01R33/34Constructional details, e.g. resonators, specially adapted to MR
    • G01R33/341Constructional details, e.g. resonators, specially adapted to MR comprising surface coils
    • G01R33/3415Constructional details, e.g. resonators, specially adapted to MR comprising surface coils comprising arrays of sub-coils, i.e. phased-array coils with flexible receiver channels
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/46NMR spectroscopy
    • G01R33/465NMR spectroscopy applied to biological material, e.g. in vitro testing

Abstract

Embodiments of the invention relate to detecting biological molecules with ultra-sensitivity and convenience. The embodiments are especially directed to utilizing nanoparticles as tags and identifying the tags using a nuclear magnetic resonance device. The probes containing the nanoparticles can be used in solution or attached to a substrate.
PCT/US2007/072297 2006-06-30 2007-06-27 Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance WO2008091364A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47769606A 2006-06-30 2006-06-30
US11/477,696 2006-06-30

Publications (2)

Publication Number Publication Date
WO2008091364A2 WO2008091364A2 (en) 2008-07-31
WO2008091364A3 true WO2008091364A3 (en) 2008-12-11

Family

ID=39645010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/072297 WO2008091364A2 (en) 2006-06-30 2007-06-27 Nanoparticles as tags for bioanalyte detection by nuclear magnetic resonance or electron spin resonance

Country Status (1)

Country Link
WO (1) WO2008091364A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104535601A (en) * 2014-12-19 2015-04-22 上海师范大学 Dual-mode sensor for detecting Cd<2+> based on magnetic nanoparticles and preparation method of dual-mode sensor

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102269758B (en) * 2010-06-04 2013-11-20 国家纳米科学中心 Method for visual detection of antigen-antibody reaction, kit and application thereof
DE202011051402U1 (en) * 2010-09-27 2011-11-25 Aspect Magnet Technologies Ltd. Microwells MRI readable markers
US20150338401A1 (en) * 2012-11-16 2015-11-26 Ayal Ram Multiplexed bioassay techniques
KR102489353B1 (en) 2015-06-01 2023-01-17 캘리포니아 인스티튜트 오브 테크놀로지 Compositions and methods for screening T cells with antigens to specific populations
EP3112853A1 (en) * 2015-07-03 2017-01-04 Memscap S.A. Apparatus for an atomic clock
EP3857247B1 (en) * 2018-09-24 2023-10-25 Ecole Polytechnique Federale De Lausanne (Epfl) Miniaturized mr device comprising a cell culture micro-chamber and method for manufacturing such a device

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981297A (en) * 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
WO2003054523A2 (en) * 2001-12-21 2003-07-03 Koninklijke Philips Electronics N.V. Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array
US20030143598A1 (en) * 2001-11-09 2003-07-31 Viswanadham Garimella Bioconjugate-nanoparticle probes
WO2005073695A1 (en) * 2004-01-26 2005-08-11 Koninklijke Philips Electronics N.V. Method and device for on-chip magnetic resonance spectroscopy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981297A (en) * 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
US20030143598A1 (en) * 2001-11-09 2003-07-31 Viswanadham Garimella Bioconjugate-nanoparticle probes
WO2003054523A2 (en) * 2001-12-21 2003-07-03 Koninklijke Philips Electronics N.V. Sensor and method for measuring the areal density of magnetic nanoparticles on a micro-array
WO2005073695A1 (en) * 2004-01-26 2005-08-11 Koninklijke Philips Electronics N.V. Method and device for on-chip magnetic resonance spectroscopy

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104535601A (en) * 2014-12-19 2015-04-22 上海师范大学 Dual-mode sensor for detecting Cd<2+> based on magnetic nanoparticles and preparation method of dual-mode sensor
CN104535601B (en) * 2014-12-19 2017-01-11 上海师范大学 Dual-mode sensor for detecting Cd2+ based on magnetic nanoparticles and preparation method of dual-mode sensor

Also Published As

Publication number Publication date
WO2008091364A2 (en) 2008-07-31

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