WO2008089003A3 - System for optical stimulation of target cells - Google Patents
System for optical stimulation of target cells Download PDFInfo
- Publication number
- WO2008089003A3 WO2008089003A3 PCT/US2008/050628 US2008050628W WO2008089003A3 WO 2008089003 A3 WO2008089003 A3 WO 2008089003A3 US 2008050628 W US2008050628 W US 2008050628W WO 2008089003 A3 WO2008089003 A3 WO 2008089003A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- target cells
- light
- methods
- vivo
- stimulated
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0622—Optical stimulation for exciting neural tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/10—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person
- A61K41/17—Inactivation or decontamination of a medicinal preparation prior to administration to an animal or a person by ultraviolet [UV] or infrared [IR] light, X-rays or gamma rays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
- A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0083—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the administration regime
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
Abstract
Stimulation of target cells using light, e.g., in vivo, is implemented using a variety of methods and devices. In one example, embodiments involve methods for stimulating target cells using a photosensitive protein that allows the target cells to be stimulated in response to light. In another specific example embodiment, target cells are stimulated using an implantable arrangement. The arrangement includes an electrical light-generation means for generating light and a biological portion. The biological portion has a photosensitive bio-molecular arrangement that responds to the generated light by stimulating target cells in vivo. Other aspects and embodiments are directed to systems and methods for screening chemicals based screening chemicals to identify their effects on cell membrane ion channels and pumps, and to systems and methods for controlling an action potential of neuron (e.g., in vivo and in vitro environments).
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/522,528 US10052497B2 (en) | 2005-07-22 | 2008-01-09 | System for optical stimulation of target cells |
US16/041,647 US20180326221A1 (en) | 2005-07-22 | 2018-07-20 | System for optical stimulation of target cells |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/651,422 | 2007-01-09 | ||
US11/651,422 US8926959B2 (en) | 2005-07-22 | 2007-01-09 | System for optical stimulation of target cells |
US87966907P | 2007-01-10 | 2007-01-10 | |
US60/879,669 | 2007-01-10 | ||
US90430307P | 2007-03-01 | 2007-03-01 | |
US60/904,303 | 2007-03-01 | ||
US95511607P | 2007-08-10 | 2007-08-10 | |
US60/955,116 | 2007-08-10 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US11/651,422 Continuation US8926959B2 (en) | 2005-07-22 | 2007-01-09 | System for optical stimulation of target cells |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/522,528 A-371-Of-International US10052497B2 (en) | 2005-07-22 | 2008-01-09 | System for optical stimulation of target cells |
US16/041,647 Continuation US20180326221A1 (en) | 2005-07-22 | 2018-07-20 | System for optical stimulation of target cells |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008089003A2 WO2008089003A2 (en) | 2008-07-24 |
WO2008089003A3 true WO2008089003A3 (en) | 2008-09-25 |
Family
ID=39636625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/050628 WO2008089003A2 (en) | 2005-07-22 | 2008-01-09 | System for optical stimulation of target cells |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008089003A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8858440B2 (en) | 2008-07-14 | 2014-10-14 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Methods and devices for modulating cellular activity using ultrasound |
US9042201B2 (en) | 2011-10-21 | 2015-05-26 | Thync, Inc. | Method and system for direct communication |
CN107531765B (en) * | 2015-03-19 | 2021-07-16 | 得克萨斯州大学系统董事会 | Compositions of anion channel rhodopsin and methods of use thereof |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2009274482A1 (en) | 2008-05-20 | 2010-01-28 | Eos Neuroscience, Inc. | Vectors for delivery of light-sensitive proteins and methods of use |
EP2384220A2 (en) | 2008-11-26 | 2011-11-09 | Medtronic, Inc. | Patient programmer with automated mri compatibility verification for active implantable medical device |
CN101498723A (en) * | 2009-02-27 | 2009-08-05 | 深圳先进技术研究院 | Ion channel medicament screening apparatus and method |
DE102009015389A1 (en) | 2009-03-20 | 2010-09-30 | Retina Implant Ag | Active retinal implant for eye for serving to counteract loss of vision due to degenerations of retina, has array of stimulation elements that are designed as radiation-emitting elements |
JP5719340B2 (en) * | 2009-03-20 | 2015-05-20 | レティーナ インプラント アーゲー | Active retinal implant |
US20110125078A1 (en) * | 2009-11-25 | 2011-05-26 | Medtronic, Inc. | Optical stimulation therapy |
US20130225664A1 (en) | 2010-04-05 | 2013-08-29 | Alan Horsager | Methods and compositions for decreasing chronic pain |
US20120253261A1 (en) * | 2011-03-29 | 2012-10-04 | Medtronic, Inc. | Systems and methods for optogenetic modulation of cells within a patient |
US10493297B2 (en) | 2011-07-25 | 2019-12-03 | Neuronexus Technologies, Inc. | Neuromodulation transfection system with passive fluid delivery |
EP2736406B1 (en) | 2011-07-25 | 2019-09-04 | NeuroNexus Technologies, Inc. | Neuromodulation transfection system with means for active fluid delivery |
US9782091B2 (en) | 2011-07-25 | 2017-10-10 | Neuronexus Technologies, Inc. | Opto-electrical device for artifact reduction |
US9199080B2 (en) | 2011-09-12 | 2015-12-01 | Okuvision Gmbh | Method for treating an eye |
US8868351B2 (en) | 2011-10-13 | 2014-10-21 | The Cleveland Clinic Foundation | Estimation of neural response for optical stimulation |
WO2014036170A1 (en) | 2012-08-29 | 2014-03-06 | Thync, Inc. | Systems and devices for coupling ultrasound energy to a body |
AU2019368519B2 (en) * | 2018-10-26 | 2022-11-03 | Shandong University | System and method for real-time screening and measurement of cellular specific photosensitive effect |
CN111690683A (en) * | 2020-05-08 | 2020-09-22 | 天津大学 | Design method of photosensitive protein plasmid sensitive to green light |
-
2008
- 2008-01-09 WO PCT/US2008/050628 patent/WO2008089003A2/en active Application Filing
Non-Patent Citations (2)
Title |
---|
BROSENITCH ET AL.: "Physiological Patterns of Electrical Stimulation Can Induce Neuronal Gene Expressing by Activating N-Type Calcium Channels", J. OF NEUROSCIENCE, vol. 21, 2001, pages 2571 - 2579 * |
SONG ET AL.: "Genes responsible for native depolarization-activated K+ currents in neurons", NEUROSCIENCE RES., vol. 42, 2002, pages 7 - 14 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8858440B2 (en) | 2008-07-14 | 2014-10-14 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Methods and devices for modulating cellular activity using ultrasound |
US9403038B2 (en) | 2008-07-14 | 2016-08-02 | Arizona Board Of Regents For And On Behalf Of Arizona State University | Methods and devices for modulating cellular activity using ultrasound |
US9042201B2 (en) | 2011-10-21 | 2015-05-26 | Thync, Inc. | Method and system for direct communication |
CN107531765B (en) * | 2015-03-19 | 2021-07-16 | 得克萨斯州大学系统董事会 | Compositions of anion channel rhodopsin and methods of use thereof |
Also Published As
Publication number | Publication date |
---|---|
WO2008089003A2 (en) | 2008-07-24 |
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