WO2008079906A1 - Pyrrolo [2, 3-b] pyridine derivatives as kinase modulators - Google Patents
Pyrrolo [2, 3-b] pyridine derivatives as kinase modulators Download PDFInfo
- Publication number
- WO2008079906A1 WO2008079906A1 PCT/US2007/088237 US2007088237W WO2008079906A1 WO 2008079906 A1 WO2008079906 A1 WO 2008079906A1 US 2007088237 W US2007088237 W US 2007088237W WO 2008079906 A1 WO2008079906 A1 WO 2008079906A1
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- WIPO (PCT)
- Prior art keywords
- lower alkyl
- fluoro
- heteroaryl
- group
- aryl
- Prior art date
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- 0 *c1cnc2[n]ccc2c1 Chemical compound *c1cnc2[n]ccc2c1 0.000 description 2
- GEGJOYGMYFPEAZ-XNWCZRBMSA-N COC(/C=C/c1cc(c(C(c(c(F)c(cc2)NS(c3ccc(C(F)(F)F)cc3)(=O)=O)c2F)=O)c[nH]2)c2nc1)=O Chemical compound COC(/C=C/c1cc(c(C(c(c(F)c(cc2)NS(c3ccc(C(F)(F)F)cc3)(=O)=O)c2F)=O)c[nH]2)c2nc1)=O GEGJOYGMYFPEAZ-XNWCZRBMSA-N 0.000 description 1
- LANUSIVYQPGHDG-UHFFFAOYSA-N COC(CCc1cnc2[nH]cc(C(c(c(F)c(cc3)NS(c4ccc(C(F)(F)F)cc4)(=O)=O)c3F)=O)c2c1)=O Chemical compound COC(CCc1cnc2[nH]cc(C(c(c(F)c(cc3)NS(c4ccc(C(F)(F)F)cc4)(=O)=O)c3F)=O)c2c1)=O LANUSIVYQPGHDG-UHFFFAOYSA-N 0.000 description 1
- BLCFUCCYULXKSI-UHFFFAOYSA-N OC(CCc1cnc2[nH]cc(C(c(c(F)c(cc3)NS(c4ccc(CC(F)(F)F)cc4)(=O)=O)c3F)=O)c2c1)=O Chemical compound OC(CCc1cnc2[nH]cc(C(c(c(F)c(cc3)NS(c4ccc(CC(F)(F)F)cc4)(=O)=O)c3F)=O)c2c1)=O BLCFUCCYULXKSI-UHFFFAOYSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2007336906A AU2007336906A1 (en) | 2006-12-21 | 2007-12-19 | Pyrrolo [2, 3-b] pyridine derivatives as kinase modulators |
EP07855276A EP2097414A1 (en) | 2006-12-21 | 2007-12-19 | Pyrrolo [2, 3-b]pyridine derivatives as kinase modulators |
JP2009543200A JP2010514687A (en) | 2006-12-21 | 2007-12-19 | Pyrrolo [2,3-b] pyridine derivatives as kinase modulators |
BRPI0722088A BRPI0722088A2 (en) | 2006-12-21 | 2007-12-19 | pyrrolo [2,3-b] pyridine derivatives as kinase modulators |
MX2009006162A MX2009006162A (en) | 2006-12-21 | 2007-12-19 | Pyrrolo [2, 3-b] pyridine derivatives as kinase modulators. |
CA002673000A CA2673000A1 (en) | 2006-12-21 | 2007-12-19 | Pyrrolo [2, 3-b] pyridine derivatives as kinase modulators |
NO20092251A NO20092251L (en) | 2006-12-21 | 2009-06-11 | Pyrrolo [2,3-B] pyridine derivatives as kinase modulators |
MA32103A MA31153B1 (en) | 2006-12-21 | 2009-07-16 | COMPOUNDS AND METHODS FOR MODULATING KINASE AND ASSOCIATED INDICATIONS |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87695306P | 2006-12-21 | 2006-12-21 | |
US60/876,953 | 2006-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008079906A1 true WO2008079906A1 (en) | 2008-07-03 |
Family
ID=39281754
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/088231 WO2008079903A1 (en) | 2006-12-21 | 2007-12-19 | Pyrrolo [2, 3-b] pyridine derivatives as kinase modulators |
PCT/US2007/088237 WO2008079906A1 (en) | 2006-12-21 | 2007-12-19 | Pyrrolo [2, 3-b] pyridine derivatives as kinase modulators |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/088231 WO2008079903A1 (en) | 2006-12-21 | 2007-12-19 | Pyrrolo [2, 3-b] pyridine derivatives as kinase modulators |
Country Status (24)
Country | Link |
---|---|
US (2) | US7863289B2 (en) |
EP (1) | EP2097414A1 (en) |
JP (1) | JP2010514687A (en) |
KR (1) | KR20090095654A (en) |
CN (1) | CN101668757A (en) |
AR (1) | AR064476A1 (en) |
AU (1) | AU2007336906A1 (en) |
BR (1) | BRPI0722088A2 (en) |
CA (1) | CA2673000A1 (en) |
CL (1) | CL2007003797A1 (en) |
CO (1) | CO6190519A2 (en) |
CR (1) | CR10860A (en) |
EC (1) | ECSP099444A (en) |
HN (1) | HN2009001202A (en) |
MA (1) | MA31153B1 (en) |
MX (1) | MX2009006162A (en) |
MY (1) | MY148468A (en) |
NO (1) | NO20092251L (en) |
PE (2) | PE20081581A1 (en) |
RU (1) | RU2009122436A (en) |
TW (1) | TW200845975A (en) |
UA (1) | UA98629C2 (en) |
UY (1) | UY30816A1 (en) |
WO (2) | WO2008079903A1 (en) |
Cited By (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010129567A1 (en) * | 2009-05-06 | 2010-11-11 | Plexxikon, Inc. | Pyrrolo [2, 3. b] pyridines which inhibit raf protein kinase |
WO2011025965A1 (en) | 2009-08-28 | 2011-03-03 | Genentech, Inc. | Raf inhibitor compounds and methods of use thereof |
WO2011025968A1 (en) | 2009-08-28 | 2011-03-03 | Array Biopharma Inc. | 1h-pyrazolo [ 3, 4-b] pyridine compounds for inhibiting raf kinase |
WO2011025951A1 (en) | 2009-08-28 | 2011-03-03 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
WO2011025940A1 (en) | 2009-08-28 | 2011-03-03 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
WO2011025947A1 (en) | 2009-08-28 | 2011-03-03 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
WO2011025938A2 (en) | 2009-08-28 | 2011-03-03 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
WO2011060216A1 (en) | 2009-11-12 | 2011-05-19 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
WO2012037060A1 (en) | 2010-09-13 | 2012-03-22 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
US8338452B2 (en) | 2008-02-29 | 2012-12-25 | Array Biopharma Inc. | Raf inhibitor compounds and methods of use thereof |
US8394795B2 (en) | 2008-02-29 | 2013-03-12 | Array Biopharma Inc. | Pyrazole [3, 4-B] pyridine Raf inhibitors |
US8404700B2 (en) | 2006-11-22 | 2013-03-26 | Plexxikon Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
US8410112B2 (en) | 2008-11-10 | 2013-04-02 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
JP2013511541A (en) * | 2009-11-18 | 2013-04-04 | プレキシコン インコーポレーテッド | Compounds and methods for kinase regulation and indications thereof |
US8415469B2 (en) | 2005-06-22 | 2013-04-09 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
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US20110092538A1 (en) | 2011-04-21 |
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RU2009122436A (en) | 2011-01-27 |
US7863289B2 (en) | 2011-01-04 |
CL2007003797A1 (en) | 2008-07-18 |
AR064476A1 (en) | 2009-04-01 |
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