WO2008076868A3 - Methods and compositions related to modulation of receptor tyrosine kinase orphan receptor-1 (ror-1) - Google Patents
Methods and compositions related to modulation of receptor tyrosine kinase orphan receptor-1 (ror-1) Download PDFInfo
- Publication number
- WO2008076868A3 WO2008076868A3 PCT/US2007/087542 US2007087542W WO2008076868A3 WO 2008076868 A3 WO2008076868 A3 WO 2008076868A3 US 2007087542 W US2007087542 W US 2007087542W WO 2008076868 A3 WO2008076868 A3 WO 2008076868A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ror
- methods
- receptor
- tyrosine kinase
- modulation
- Prior art date
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- G01N2333/91205—Phosphotransferases in general
- G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
- G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
The present invention relates to the discovery of the role of tyrosine kinase orphan receptor-1 (ROR-1) and its interactions with glucose-regulated protein 78 (GRP78) and Wnt in processes such as angiogenesis and apoptosis. The invention provides diagnostic methods based on ROR-1 and GRP78, as well as methods of modulating ROR-1, antibodies specific for ROR-1, GRP78, and Wnt, and related screening methods.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87548106P | 2006-12-18 | 2006-12-18 | |
US60/875,481 | 2006-12-18 |
Publications (2)
Publication Number | Publication Date |
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WO2008076868A2 WO2008076868A2 (en) | 2008-06-26 |
WO2008076868A3 true WO2008076868A3 (en) | 2008-10-09 |
Family
ID=39345130
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/087542 WO2008076868A2 (en) | 2006-12-18 | 2007-12-14 | Methods and compositions related to modulation of receptor tyrosine kinase orphan receptor-1 (ror-1) |
Country Status (1)
Country | Link |
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WO (1) | WO2008076868A2 (en) |
Cited By (7)
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US8843187B2 (en) | 2003-08-22 | 2014-09-23 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US8915849B2 (en) | 2003-08-01 | 2014-12-23 | Dexcom, Inc. | Transcutaneous analyte sensor |
US9107623B2 (en) | 2003-12-09 | 2015-08-18 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
US9320466B2 (en) | 2009-07-02 | 2016-04-26 | Dexcom, Inc. | Analyte sensor |
US9523695B2 (en) | 2011-01-14 | 2016-12-20 | The Regents Of The University Of California | Therapeutic antibodies against ROR-1 protein and methods for use of same |
US9538946B2 (en) | 2003-11-19 | 2017-01-10 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
CN108103192B (en) * | 2017-11-20 | 2021-08-13 | 广东医科大学 | Cancer early stage screening kit based on detection of peripheral blood GRP78 gene promoter methylation |
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US9282925B2 (en) | 2002-02-12 | 2016-03-15 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US8260393B2 (en) | 2003-07-25 | 2012-09-04 | Dexcom, Inc. | Systems and methods for replacing signal data artifacts in a glucose sensor data stream |
US9247901B2 (en) | 2003-08-22 | 2016-02-02 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
US8761856B2 (en) | 2003-08-01 | 2014-06-24 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
US20140121989A1 (en) | 2003-08-22 | 2014-05-01 | Dexcom, Inc. | Systems and methods for processing analyte sensor data |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US8452368B2 (en) | 2004-07-13 | 2013-05-28 | Dexcom, Inc. | Transcutaneous analyte sensor |
US20060020192A1 (en) | 2004-07-13 | 2006-01-26 | Dexcom, Inc. | Transcutaneous analyte sensor |
US20080306444A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
EP2227132B1 (en) | 2007-10-09 | 2023-03-08 | DexCom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
CA2715628A1 (en) | 2008-02-21 | 2009-08-27 | Dexcom, Inc. | Systems and methods for processing, transmitting and displaying sensor data |
WO2010111660A1 (en) | 2009-03-27 | 2010-09-30 | Dexcom, Inc. | Methods and systems for promoting glucose management |
US20110004085A1 (en) | 2009-04-30 | 2011-01-06 | Dexcom, Inc. | Performance reports associated with continuous sensor data from multiple analysis time periods |
GB2476293A (en) * | 2009-12-18 | 2011-06-22 | Biolnvent Internat Ab | Therapeutic inhibition of ROR-1 |
WO2011079902A2 (en) * | 2009-12-18 | 2011-07-07 | Biolnvent International Ab | Biological materials and uses thereof |
US9242014B2 (en) | 2010-06-15 | 2016-01-26 | The Regents Of The University Of California | Receptor tyrosine kinase-like orphan receptor 1 (ROR1) single chain Fv antibody fragment conjugates and methods of use thereof |
EP2621954A1 (en) * | 2010-10-01 | 2013-08-07 | Oxford Biotherapeutics Ltd. | Anti-rori antibodies |
GB201020995D0 (en) * | 2010-12-10 | 2011-01-26 | Bioinvent Int Ab | Biological materials and uses thereof |
WO2012090939A1 (en) * | 2010-12-27 | 2012-07-05 | 国立大学法人名古屋大学 | Method for suppressing receptor tyrosine kinase-mediated prosurvival signaling in cancer cells |
DK3575796T3 (en) | 2011-04-15 | 2021-01-18 | Dexcom Inc | ADVANCED ANALYZE SENSOR CALIBRATION AND ERROR DETECTION |
DK2888283T3 (en) | 2012-08-24 | 2018-11-19 | Univ California | ANTIBODIES AND VACCINES FOR TREATING ROR1 CANCER AND INHIBITIVE METASTASE |
EP2789630A1 (en) | 2013-04-09 | 2014-10-15 | EngMab AG | Bispecific antibodies against CD3e and ROR1 |
JP6708635B2 (en) | 2014-10-09 | 2020-06-10 | エンクマフ エスアーエールエル | Bispecific antibodies to CD3ε and ROR1 |
JP5770908B1 (en) * | 2014-10-24 | 2015-08-26 | 比奈子 山崎 | Clothesline |
JP2018524284A (en) | 2015-05-18 | 2018-08-30 | ユーリカ セラピューティックス, インコーポレイテッド | Anti-ROR1 antibody |
AU2016345681A1 (en) | 2015-10-30 | 2018-05-10 | Nbe-Therapeutics Ag | Anti-ROR1 antibodies |
UA125718C2 (en) | 2016-01-20 | 2022-05-25 | Зе Скріппс Ресеарч Інстітьют | Ror1 antibody compositions and related methods |
US10688181B2 (en) | 2016-06-27 | 2020-06-23 | The Regents Of The University Of California | Cancer treatment combinations |
CA3030841A1 (en) | 2016-07-14 | 2018-01-18 | Fred Hutchinson Cancer Research Center | Multiple bi-specific binding domain constructs with different epitope binding to treat cancer |
KR102486090B1 (en) | 2017-08-07 | 2023-01-10 | 엔비이-테라퓨틱스 아게 | Antibody drug conjugates with high in vivo tolerance |
AU2018354120A1 (en) | 2017-10-24 | 2020-04-23 | Dexcom, Inc. | Pre-connected analyte sensors |
US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
WO2019225777A1 (en) * | 2018-05-23 | 2019-11-28 | 에이비엘바이오 주식회사 | Anti-ror1 antibody and use thereof |
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WO2006039173A2 (en) * | 2004-09-22 | 2006-04-13 | Abbott Laboratories | Uses of an endothelial cell receptor |
-
2007
- 2007-12-14 WO PCT/US2007/087542 patent/WO2008076868A2/en active Application Filing
Patent Citations (2)
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WO2004094641A2 (en) * | 2003-04-16 | 2004-11-04 | Wyeth | A novel method of modulating bone-realted activity |
WO2006039173A2 (en) * | 2004-09-22 | 2006-04-13 | Abbott Laboratories | Uses of an endothelial cell receptor |
Non-Patent Citations (2)
Title |
---|
CHEN LIGUANG ET AL: "Expression of ROR1 in chronic lymphocytic leukemia cells enhances cells survival by Wnt5a signaling", BLOOD, vol. 110, no. 11, Part 1, November 2007 (2007-11-01), & 49TH ANNUAL MEETING OF THE AMERICAN-SOCIETY-OF-HEMATOLOGY; ATLANTA, GA, USA; DECEMBER 08 -11, 2007, pages 107A, XP009100073, ISSN: 0006-4971 * |
KATOH MASUKO ET AL: "Comparative genomics on ROR1 and ROR2 orthologs", ONCOLOGY REPORTS, NATIONAL HELLENIC RESEARCH FOUNDATION, ATHENS, GR, vol. 14, no. 5, 1 November 2005 (2005-11-01), pages 1381 - 1384, XP009100071, ISSN: 1021-335X * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8915849B2 (en) | 2003-08-01 | 2014-12-23 | Dexcom, Inc. | Transcutaneous analyte sensor |
US8843187B2 (en) | 2003-08-22 | 2014-09-23 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US9427183B2 (en) | 2003-08-22 | 2016-08-30 | Dexcom, Inc. | Systems and methods for replacing signal artifacts in a glucose sensor data stream |
US9538946B2 (en) | 2003-11-19 | 2017-01-10 | Dexcom, Inc. | Integrated receiver for continuous analyte sensor |
US9107623B2 (en) | 2003-12-09 | 2015-08-18 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
US9498155B2 (en) | 2003-12-09 | 2016-11-22 | Dexcom, Inc. | Signal processing for continuous analyte sensor |
US9320466B2 (en) | 2009-07-02 | 2016-04-26 | Dexcom, Inc. | Analyte sensor |
US9523695B2 (en) | 2011-01-14 | 2016-12-20 | The Regents Of The University Of California | Therapeutic antibodies against ROR-1 protein and methods for use of same |
CN108103192B (en) * | 2017-11-20 | 2021-08-13 | 广东医科大学 | Cancer early stage screening kit based on detection of peripheral blood GRP78 gene promoter methylation |
Also Published As
Publication number | Publication date |
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WO2008076868A2 (en) | 2008-06-26 |
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