WO2008064255A3 - Compounds modulating c-fms and/or c-kit activity and uses therefor - Google Patents
Compounds modulating c-fms and/or c-kit activity and uses therefor Download PDFInfo
- Publication number
- WO2008064255A3 WO2008064255A3 PCT/US2007/085289 US2007085289W WO2008064255A3 WO 2008064255 A3 WO2008064255 A3 WO 2008064255A3 US 2007085289 W US2007085289 W US 2007085289W WO 2008064255 A3 WO2008064255 A3 WO 2008064255A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fms
- uses therefor
- kit activity
- compounds modulating
- kit
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES07864681.7T ES2447779T3 (en) | 2006-11-22 | 2007-11-20 | Compounds that modulate the activity of c-fms and / or c-kit and their uses |
NZ577011A NZ577011A (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
JP2009538496A JP2010510321A (en) | 2006-11-22 | 2007-11-20 | Compound for modulating C-FMS and / or C-KIT activity and use thereof |
PL07864681T PL2086972T3 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
UAA200905046A UA97816C2 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-kit and/or c-fms activity and use thereof |
CA2670362A CA2670362C (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
AU2007323644A AU2007323644B2 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
KR1020097012836A KR101506044B1 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
BRPI0721137A BRPI0721137B8 (en) | 2006-11-22 | 2007-11-20 | compounds for modulating the activity of c-fms and/or kit, composition, kit and use of said compounds. |
DK07864681.7T DK2086972T3 (en) | 2006-11-22 | 2007-11-20 | CONNECTIONS MODULATING C-FMS AND / OR C-KIT ACTIVITY AND APPLICATIONS THEREOF |
SI200731415T SI2086972T1 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
EP07864681.7A EP2086972B1 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
CN2007800502453A CN101605787B (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
MX2009005428A MX2009005428A (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor. |
IL198624A IL198624A (en) | 2006-11-22 | 2009-05-07 | Azaindole derivatives modulating c-fms and/or c-kit activity, pharmaceutical compositions comprising them and uses thereof |
ZA2009/03458A ZA200903458B (en) | 2006-11-22 | 2009-05-19 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
NO20091989A NO342175B1 (en) | 2006-11-22 | 2009-05-22 | Chemical compounds, preparations comprising such compounds, such compounds and preparations for the treatment of disease, and sets comprising such compounds |
HK10101543.8A HK1133649A1 (en) | 2006-11-22 | 2010-02-11 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86074906P | 2006-11-22 | 2006-11-22 | |
US60/860,749 | 2006-11-22 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008064255A2 WO2008064255A2 (en) | 2008-05-29 |
WO2008064255A3 true WO2008064255A3 (en) | 2008-08-14 |
Family
ID=39322825
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/083910 WO2008063888A2 (en) | 2006-11-22 | 2007-11-07 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
PCT/US2007/085299 WO2008064265A2 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
PCT/US2007/085289 WO2008064255A2 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/083910 WO2008063888A2 (en) | 2006-11-22 | 2007-11-07 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
PCT/US2007/085299 WO2008064265A2 (en) | 2006-11-22 | 2007-11-20 | Compounds modulating c-fms and/or c-kit activity and uses therefor |
Country Status (35)
Country | Link |
---|---|
US (8) | US7893075B2 (en) |
EP (1) | EP2086972B1 (en) |
JP (4) | JP2010510321A (en) |
KR (1) | KR101506044B1 (en) |
CN (2) | CN103497188B (en) |
AR (1) | AR063878A1 (en) |
AU (1) | AU2007323644B2 (en) |
BR (1) | BRPI0721137B8 (en) |
CA (1) | CA2670362C (en) |
CL (1) | CL2007003326A1 (en) |
CO (1) | CO6180438A2 (en) |
CR (1) | CR10817A (en) |
DK (1) | DK2086972T3 (en) |
EC (1) | ECSP099357A (en) |
ES (1) | ES2447779T3 (en) |
GT (1) | GT200700101A (en) |
HK (1) | HK1133649A1 (en) |
IL (1) | IL198624A (en) |
MX (1) | MX2009005428A (en) |
MY (1) | MY158447A (en) |
NI (1) | NI200900093A (en) |
NO (1) | NO342175B1 (en) |
NZ (1) | NZ577011A (en) |
PE (1) | PE20081226A1 (en) |
PL (1) | PL2086972T3 (en) |
PT (1) | PT2086972E (en) |
RU (1) | RU2452738C2 (en) |
SG (1) | SG176511A1 (en) |
SI (1) | SI2086972T1 (en) |
SV (1) | SV2007002813A (en) |
TW (1) | TWI432431B (en) |
UA (1) | UA97816C2 (en) |
UY (1) | UY30732A1 (en) |
WO (3) | WO2008063888A2 (en) |
ZA (1) | ZA200903458B (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9096593B2 (en) | 2009-11-06 | 2015-08-04 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
US9447089B2 (en) | 2009-04-03 | 2016-09-20 | Plexxikon Inc. | Compositions and uses thereof |
US9487515B2 (en) | 2006-11-22 | 2016-11-08 | Plexxikon Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
Families Citing this family (126)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1696920B8 (en) | 2003-12-19 | 2015-05-06 | Plexxikon Inc. | Compounds and methods for development of ret modulators |
US7498342B2 (en) * | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
EP3088400A1 (en) * | 2005-06-22 | 2016-11-02 | Plexxikon Inc. | Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors |
PE20121126A1 (en) * | 2006-12-21 | 2012-08-24 | Plexxikon Inc | PIRROLO [2,3-B] PYRIDINES COMPOUNDS AS KINASE MODULATORS |
WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
NZ582772A (en) | 2007-07-17 | 2012-06-29 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
PT2247592E (en) * | 2008-02-25 | 2011-11-03 | Hoffmann La Roche | Pyrrolopyrazine kinase inhibitors |
RU2010139284A (en) | 2008-02-25 | 2012-04-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Pyrrolopyrazines as kinase inhibitors |
WO2009106443A1 (en) * | 2008-02-25 | 2009-09-03 | F. Hoffmann-La Roche Ag | Pyrrolopyrazine kinase inhibitors |
ES2372908T3 (en) * | 2008-02-25 | 2012-01-27 | F. Hoffmann-La Roche Ag | INHIBITORS OF PIRROLOPIRAZINA QUINASA. |
EP2247595B1 (en) * | 2008-02-25 | 2011-07-20 | F. Hoffmann-La Roche AG | Pyrrolopyrazine kinase inhibitors |
US8158636B2 (en) | 2008-05-19 | 2012-04-17 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
EP2313411A1 (en) * | 2008-06-10 | 2011-04-27 | Plexxikon, Inc. | 5h-pyrr0l0 [2,3-b]pyrazine derivatives for kinase modulation, and indications therefor |
EP2356116A1 (en) * | 2008-11-20 | 2011-08-17 | OSI Pharmaceuticals, Inc. | Substituted pyrroloý2,3-b¨-pyridines and-pyrazines |
CN105399731A (en) * | 2008-12-24 | 2016-03-16 | 比亚尔-珀特拉和Ca股份公司 | Pharmaceutical Compounds |
TW201041888A (en) | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
EA201290073A1 (en) | 2009-08-24 | 2013-01-30 | Эсэпиен Фармасьютикалз, Инк. | UREA COMPOUNDS CONTAINING 5,6-BICYCLIC HETEROARYL AS KINAZ INHIBITORS |
CN105906631A (en) * | 2009-11-18 | 2016-08-31 | 普莱希科公司 | Compounds and methods for kinase modulation, and indications therefor |
AU2010336524B2 (en) | 2009-12-23 | 2015-10-08 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
CA2784807C (en) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
US8481541B2 (en) | 2010-03-22 | 2013-07-09 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
US8518945B2 (en) | 2010-03-22 | 2013-08-27 | Hoffmann-La Roche Inc. | Pyrrolopyrazine kinase inhibitors |
EP2560966B1 (en) | 2010-03-30 | 2021-01-06 | Verseon International Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
TWI619713B (en) * | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | Compounds and methods for kinase modulation, and indications therefor |
AR081331A1 (en) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME |
AR081626A1 (en) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS |
EP2560488B1 (en) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
AR081039A1 (en) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | QUINASA FUSIONED BICYCLE INHIBITORS |
JP2013526570A (en) | 2010-05-14 | 2013-06-24 | オーエスアイ・ファーマシューティカルズ,エルエルシー | Fused bicyclic kinase inhibitor |
TWI496785B (en) | 2010-05-20 | 2015-08-21 | Hoffmann La Roche | Pyrrolopyrazine kinase inhibitors |
PT2672967T (en) | 2011-02-07 | 2018-12-07 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
TWI558702B (en) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | Solid forms of a pharmaceutically active substance |
US8791112B2 (en) | 2011-03-30 | 2014-07-29 | Arrien Pharmaceuticals Llc | Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors |
CA2836474A1 (en) | 2011-05-17 | 2012-11-22 | Plexxikon Inc. | Kinase modulation and indications therefor |
WO2013014170A1 (en) | 2011-07-27 | 2013-01-31 | Ab Science | Oxazole and thiazole derivatives as selective protein kinase inhibitors (c-kit) |
US8841301B2 (en) * | 2011-09-26 | 2014-09-23 | Bristol-Myers Squibb Company | Selective NR2B antagonists |
WO2013074986A1 (en) | 2011-11-17 | 2013-05-23 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-jun-n-terminal kinase (jnk) |
CN103242225B (en) * | 2012-02-13 | 2016-01-06 | 湖南化工研究院 | Picolinate amino pyridine compound and preparation method thereof |
US9358235B2 (en) * | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
AU2013312477B2 (en) | 2012-09-06 | 2018-05-31 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
EP2912036A1 (en) | 2012-10-04 | 2015-09-02 | Pfizer Limited | Pyrrolo[3,2-c]pyridine tropomyosin-related kinase inhibitors |
US10112927B2 (en) | 2012-10-18 | 2018-10-30 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
WO2014063054A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof |
US9758522B2 (en) | 2012-10-19 | 2017-09-12 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
CA2895239C (en) | 2012-12-21 | 2020-10-27 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US9783805B2 (en) * | 2013-02-28 | 2017-10-10 | City Of Hope | Replication capable rAAV vectors encoding inhibitory siRNA and methods of their use |
AU2014238478B2 (en) | 2013-03-15 | 2018-07-19 | Verseon Corporation | Halogenopyrazoles as inhibitors of thrombin |
US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
CN110101700A (en) | 2013-03-15 | 2019-08-09 | 维颂公司 | The pharmaceutical applications of polysubstituted aromatic compounds as serpin |
RS57733B1 (en) | 2013-03-15 | 2018-12-31 | Plexxikon Inc | Heterocyclic compounds and uses thereof |
MX2015012344A (en) * | 2013-03-15 | 2016-06-02 | Janssen Pharmaceutica Nv | 4-cyano-n-(2-(4,4-dimethylcyclohex-1-en-1-yl)-6-(2,2,6,6-tetrame thyltetrahydro-2h-pyran-4-yl)pyridin-3-yl)-1h-imidazole-2-carbox amide for the treatment of hodgkin's lymphoma. |
WO2014172616A2 (en) * | 2013-04-18 | 2014-10-23 | President And Fellows Of Harvard College | Methods, compositions and kits for promoting motor neuron survival and treating and diagnosing neurodegenerative disorders |
AU2014274093B2 (en) | 2013-05-30 | 2018-11-08 | Plexxikon Inc. | Compounds for kinase modulation, and indications therefor |
WO2015058126A1 (en) | 2013-10-18 | 2015-04-23 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of prolferative diseases |
JP6491202B2 (en) | 2013-10-18 | 2019-03-27 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | Polycyclic inhibitors of cyclin dependent kinase 7 (CDK 7) |
CN104710417B (en) * | 2013-12-11 | 2020-09-08 | 上海科州药物研发有限公司 | Azaindole derivatives and synthesis method thereof |
WO2015134536A1 (en) | 2014-03-04 | 2015-09-11 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
WO2015164614A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
US9862688B2 (en) | 2014-04-23 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
US9580416B2 (en) | 2014-07-02 | 2017-02-28 | Pharmacyclics Llc | Inhibitors of Bruton's tyrosine kinase |
AU2015318233B2 (en) | 2014-09-15 | 2020-03-12 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
CN106687445A (en) | 2014-09-17 | 2017-05-17 | 维颂公司 | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
EP3009435B1 (en) * | 2014-10-15 | 2016-08-17 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Apixaban glycol esters as key intermediates and impurities of the synthesis of Apixaban |
AU2015371251B2 (en) | 2014-12-23 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
BR112017018092A2 (en) | 2015-02-27 | 2018-04-10 | Verseon Corp | compound, pharmaceutical composition, and method for treating and / or preventing a disease or disorder. |
WO2016160617A2 (en) | 2015-03-27 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
US10160755B2 (en) | 2015-04-08 | 2018-12-25 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
TWI660956B (en) * | 2015-05-06 | 2019-06-01 | 美商普雷辛肯公司 | Synthesis of a compound that modulates kinases |
JP6946194B2 (en) * | 2015-05-06 | 2021-10-06 | プレキシコン インコーポレーテッドPlexxikon Inc. | Solid form of compounds that regulate kinases |
JP2018515570A (en) | 2015-05-22 | 2018-06-14 | プレキシコン インコーポレーテッドPlexxikon Inc. | PLX-8394 or PLX-7904 for use in the treatment of BRAF-V600 related diseases |
JP6722200B2 (en) | 2015-05-22 | 2020-07-15 | プレキシコン インコーポレーテッドPlexxikon Inc. | Synthesis of heterocyclic compounds |
WO2016188816A1 (en) | 2015-05-22 | 2016-12-01 | Ucb Biopharma Sprl | Treatment of epilepsy |
US10308615B2 (en) | 2015-05-29 | 2019-06-04 | Pfizer Inc. | Heterocyclic compounds as inhibitors of Vanin-1 enzyme |
EP3307728A4 (en) | 2015-06-12 | 2019-07-17 | Dana Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
CA2993018A1 (en) * | 2015-07-20 | 2017-01-26 | Genzyme Corporation | Colony stimulating factor-1 receptor (csf-1r) inhibitors |
WO2017019804A2 (en) | 2015-07-28 | 2017-02-02 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
EP3347018B1 (en) | 2015-09-09 | 2021-09-01 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
WO2017053243A1 (en) | 2015-09-21 | 2017-03-30 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
JP6862468B2 (en) | 2015-12-07 | 2021-04-21 | プレキシコン インコーポレーテッドPlexxikon Inc. | Compounds and methods for kinase regulation and instructions for them |
JP6921846B6 (en) | 2016-03-16 | 2021-09-15 | プレキシコン インコーポレーテッドPlexxikon Inc. | Compounds and methods for kinase regulation and its indications |
WO2017215521A1 (en) * | 2016-06-17 | 2017-12-21 | 苏州科睿思制药有限公司 | Plx3397 hydrochloride crystal form, preparation method therefor and use thereof |
TW201815766A (en) | 2016-09-22 | 2018-05-01 | 美商普雷辛肯公司 | Compounds and methods for IDO and TDO modulation, and indications therefor |
RU2019113764A (en) * | 2016-10-10 | 2020-11-13 | Девелопмент Сентер Фор Байотекнолоджи | QUINOXALINE COMPOUNDS AS TYPE III RECEPTOR TYROSINKINASE INHIBITORS |
WO2018093591A1 (en) | 2016-11-03 | 2018-05-24 | Juno Therapeutics, Inc. | Combination therapy of a cell based therapy and a microglia inhibitor |
WO2018136202A2 (en) | 2016-12-23 | 2018-07-26 | Plexxikon Inc. | Compounds and methods for cdk8 modulation and indications therefor |
WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
CA3056777A1 (en) | 2017-03-20 | 2018-09-27 | Plexxikon Inc. | Crystalline forms of 4-(1-(1,1-di(pyridin-2-yl)ethyl)-6-(3,5-dimethylisoxazol-4-yl)-1h- pyrrolo[3,2-b]pyridin-3-yl)benzoic acid that inhibits bromodomain |
US10961242B2 (en) | 2017-05-17 | 2021-03-30 | Legochem Biosciences, Inc. | Compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same |
KR101798840B1 (en) | 2017-05-17 | 2017-11-17 | 주식회사 레고켐 바이오사이언스 | Novel Compounds as Autotaxin Inhibitors and Pharmaceutical Compositions Comprising the Same |
JP2020522489A (en) | 2017-06-02 | 2020-07-30 | ジュノー セラピューティクス インコーポレイテッド | Articles of manufacture and methods for treatment with adoptive cell therapy |
EP3631468A1 (en) | 2017-06-02 | 2020-04-08 | Juno Therapeutics, Inc. | Articles of manufacture and methods related to toxicity associated with cell therapy |
US10428067B2 (en) | 2017-06-07 | 2019-10-01 | Plexxikon Inc. | Compounds and methods for kinase modulation |
EP3643715A4 (en) * | 2017-06-19 | 2020-10-28 | Abbisko Therapeutics Co., Ltd. | Nitrogen heteroaryl derivative having csf1r inhibitory activity, and preparation method therefor and application thereof |
AU2018291032A1 (en) | 2017-06-29 | 2020-01-16 | Juno Therapeutics, Inc. | Mouse model for assessing toxicities associated with immunotherapies |
KR102615829B1 (en) | 2017-07-25 | 2023-12-20 | 플렉시콘 인코퍼레이티드 | Preparations of compounds that modulate kinases |
MA50057A (en) | 2017-09-01 | 2020-07-08 | Juno Therapeutics Inc | GENE EXPRESSION AND ASSESSMENT OF A RISK OF DEVELOPING TOXICITY FOLLOWING CELL THERAPY |
JP2020536917A (en) | 2017-10-13 | 2020-12-17 | プレキシコン インコーポレーテッドPlexxikon Inc. | Solid form of compound for regulating kinases |
US11103505B2 (en) | 2017-10-27 | 2021-08-31 | Plexxikon Inc. | Formulations of a compound modulating kinases |
WO2019089848A1 (en) | 2017-11-01 | 2019-05-09 | Juno Therapeutics, Inc. | Methods associated with tumor burden for assessing response to a cell therapy |
CN111788195B (en) | 2018-01-31 | 2023-11-21 | 海帕瑞吉尼克斯股份有限公司 | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
JP2021518367A (en) | 2018-03-20 | 2021-08-02 | プレキシコン インコーポレーテッドPlexxikon Inc. | Compounds and methods for IDO and TDO regulation, and signs for them |
US11731968B2 (en) | 2018-06-21 | 2023-08-22 | Heparegenix Gmbh | Tricyclic protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
US11912701B2 (en) | 2018-07-16 | 2024-02-27 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
CN110845476B (en) * | 2018-08-21 | 2022-11-18 | 上海和誉生物医药科技有限公司 | High-selectivity CSF1R inhibitor, preparation method and pharmaceutical application thereof |
US11142525B2 (en) * | 2018-11-15 | 2021-10-12 | Pfizer Inc. | Azalactam compounds as HPK1 inhibitors |
WO2020113194A2 (en) | 2018-11-30 | 2020-06-04 | Juno Therapeutics, Inc. | Methods for treatment using adoptive cell therapy |
JP2022513689A (en) | 2018-11-30 | 2022-02-09 | ジュノー セラピューティクス インコーポレイテッド | Methods for Administration and Treatment of B-Cell Malignancies in Adoptive Cell Therapy |
EP3950063A4 (en) * | 2019-03-29 | 2022-11-30 | Kowa Company, Ltd. | Novel azaindole derivative |
CN113710668A (en) | 2019-04-09 | 2021-11-26 | 普莱希科公司 | Condensed azines for EP300 or CBP modulation and indications therefor |
CN115398231A (en) | 2019-12-06 | 2022-11-25 | 朱诺治疗学股份有限公司 | Methods related to toxicity and response associated with cell therapy for treatment of B cell malignancies |
CN111233857B (en) * | 2020-01-16 | 2021-01-08 | 河南应用技术职业学院 | Synthetic method for continuously producing pexidininib |
WO2021144360A1 (en) | 2020-01-17 | 2021-07-22 | F. Hoffmann-La Roche Ag | Small molecule csf-1r inhibitors in therapeutic and cosmetic uses |
CN113444083A (en) * | 2020-03-25 | 2021-09-28 | 上海天慈国际药业有限公司 | Preparation method of small molecule tyrosine kinase inhibitor |
AR121846A1 (en) * | 2020-04-16 | 2022-07-13 | Teijin Pharma Ltd | DERIVATIVE OF ARYL OR HETEROARYL |
JP2023522949A (en) | 2020-04-23 | 2023-06-01 | オプナ バイオ ソシエテ アノニム | Compounds and methods for modulating CD73 and indications thereof |
IL297838A (en) | 2020-05-01 | 2023-01-01 | Pfizer | Azalactam compounds as hpk1 inhibitors |
US11628176B2 (en) | 2020-08-21 | 2023-04-18 | Opna Bio SA | Combinational drug therapies |
EP4214198A1 (en) * | 2020-09-21 | 2023-07-26 | Hutchison Medipharma Limited | Heteroaromatic compounds and uses thereof |
CN112409353A (en) * | 2020-11-27 | 2021-02-26 | 苏州艾缇克药物化学有限公司 | Preparation method of 7-azaindole derivative |
EP4267573A1 (en) | 2020-12-23 | 2023-11-01 | Genzyme Corporation | Deuterated colony stimulating factor-1 receptor (csf-1r) inhibitors |
KR20240021771A (en) | 2021-06-15 | 2024-02-19 | 존슨 맛쎄이 퍼블릭 리미티드 컴파니 | Manufacturing process of pexidartinib |
CN113816956A (en) * | 2021-10-26 | 2021-12-21 | 湖北工业大学 | Synthesis method of pexidaltinib |
WO2023081923A1 (en) | 2021-11-08 | 2023-05-11 | Frequency Therapeutics, Inc. | Platelet-derived growth factor receptor (pdgfr) alpha inhibitors and uses thereof |
CN114736204A (en) * | 2022-05-06 | 2022-07-12 | 湖北工业大学 | Preparation method of pexidaltinib structural analogue and application of pexidaltinib structural analogue in tumor resistance |
WO2024011253A1 (en) | 2022-07-08 | 2024-01-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Impeding platinum-based chemotherapeutic induced ototoxicity using a colony stimulating factor 1 receptor inhibitor |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005062795A2 (en) * | 2003-12-19 | 2005-07-14 | Plexxikon, Inc. | Compounds and methods for development of ret modulators |
WO2006009755A2 (en) * | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
WO2007013896A2 (en) * | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
WO2007106236A2 (en) * | 2006-02-27 | 2007-09-20 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
Family Cites Families (327)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB145299A (en) | 1919-08-14 | 1920-07-02 | Carl Theodor Thorssell | Improvements in or relating to apparatus for the production of nitrogen products |
US2234705A (en) * | 1940-04-12 | 1941-03-11 | Eastman Kodak Co | Cellulose organic derivative composition containing esters of monoalkoxy benzoic acids |
US2413258A (en) * | 1942-07-07 | 1946-12-24 | United Gas Improvement Co | Polystyrene-type resins plasticized with high boiling fatty acid alkyl esters |
GB1198301A (en) | 1966-10-21 | 1970-07-08 | Minnesota Mining & Mfg | Perfluoroalkylsulfonamides |
AU7915675A (en) | 1974-03-20 | 1976-09-23 | Bayer Ag | Alkoxycarbonylphenylureas |
DE2413258A1 (en) | 1974-03-20 | 1975-10-02 | Bayer Ag | Herbicidal N-(alkoxycarbonyl-phenyl)-N'-methyl-urea derivs - prepd by reacting alkoxycarbonyl-phenyl isocyanates with methylamines |
GB1573212A (en) * | 1976-04-15 | 1980-08-20 | Technicon Instr | Immunoassay for gentamicin |
US4301159A (en) | 1980-06-20 | 1981-11-17 | Shionogi & Co., Ltd. | N-(Diethylaminoethyl)-2-alkoxy-benzamide derivatives |
AU547405B2 (en) | 1981-07-08 | 1985-10-17 | Sanofi | Amidobenzamides |
US4664504A (en) | 1983-01-20 | 1987-05-12 | Tokyo Shibaura Denki Kabushiki Kaisha | Image forming apparatus |
US4568649A (en) * | 1983-02-22 | 1986-02-04 | Immunex Corporation | Immediate ligand detection assay |
US4626513A (en) * | 1983-11-10 | 1986-12-02 | Massachusetts General Hospital | Method and apparatus for ligand detection |
AU567140B2 (en) | 1984-01-06 | 1987-11-12 | Shionogi & Co., Ltd. | Sulphonamido-benzamide derivatives |
ATE56096T1 (en) | 1984-03-15 | 1990-09-15 | Immunex Corp | TEST FOR INSTANT DETECTION OF LIGANDS, TEST KIT AND ITS PREPARATION. |
IT1196133B (en) | 1984-06-06 | 1988-11-10 | Ausonia Farma Srl | FURANIC DERIVATIVES WITH ANTI-ULCER ACTIVITY |
US4714693A (en) | 1986-04-03 | 1987-12-22 | Uop Inc. | Method of making a catalyst composition comprising uniform size metal components on carrier |
DE3642315A1 (en) | 1986-12-11 | 1988-06-23 | Boehringer Mannheim Gmbh | NEW PYRROLOBENZIMIDAZOLES, PROCESS FOR THEIR PRODUCTION AND MEDICINAL PRODUCTS |
US5688655A (en) * | 1988-02-10 | 1997-11-18 | Ict Pharmaceuticals, Inc. | Method of screening for protein inhibitors and activators |
US6054270A (en) * | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
US5700637A (en) * | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
US5658775A (en) * | 1988-05-17 | 1997-08-19 | Sloan-Kettering Institute For Cancer Research | Double copy retroviral vector |
JP2528706B2 (en) | 1988-05-30 | 1996-08-28 | ゼリア新薬工業株式会社 | Pharmaceutical composition of dihydropyridine compound |
EP0432216A1 (en) * | 1988-09-01 | 1991-06-19 | Whitehead Institute For Biomedical Research | Recombinant retroviruses with amphotropic and ecotropic host ranges |
US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
US5143854A (en) * | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5744101A (en) * | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
US5527681A (en) * | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
US5800992A (en) * | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
WO1991018088A1 (en) * | 1990-05-23 | 1991-11-28 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Adeno-associated virus (aav)-based eucaryotic vectors |
DE4022414A1 (en) | 1990-07-13 | 1992-01-16 | Bayer Ag | SUBSTITUTED PYRROLO-PYRIDINE |
US5958930A (en) | 1991-04-08 | 1999-09-28 | Duquesne University Of The Holy Ghost | Pyrrolo pyrimidine and furo pyrimidine derivatives |
EP0580860B2 (en) | 1991-04-16 | 2004-12-15 | Nippon Shinyaku Company, Limited | Method of manufacturing solid dispersion |
JPH06509578A (en) * | 1991-07-26 | 1994-10-27 | ユニバーシティ・オブ・ロチェスター | Cancer treatment using malignant cells |
US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
GB9127531D0 (en) | 1991-12-31 | 1992-02-19 | Fujisawa Pharmaceutical Co | Heterocyclic compound |
FR2687402B1 (en) * | 1992-02-14 | 1995-06-30 | Lipha | NOVEL AZAINDOLES, METHODS OF PREPARATION AND MEDICAMENTS CONTAINING THEM. |
JPH05236997A (en) * | 1992-02-28 | 1993-09-17 | Hitachi Ltd | Chip for catching polynucleotide |
JPH06135946A (en) | 1992-10-30 | 1994-05-17 | Otsuka Pharmaceut Co Ltd | Pyrazine derivative |
AU686115B2 (en) | 1992-11-02 | 1998-02-05 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo (I,2-a) pyridine derivatives as bradykinin antagonists, pharmaceuticals and processes for their preparation |
GB9226855D0 (en) | 1992-12-23 | 1993-02-17 | Erba Carlo Spa | Vinylene-azaindole derivatives and process for their preparation |
US5576319A (en) | 1993-03-01 | 1996-11-19 | Merck, Sharp & Dohme Ltd. | Pyrrolo-pyridine derivatives |
HUT71799A (en) | 1993-03-01 | 1996-02-28 | Merck Sharp & Dohme | Pyrrolo-pyridine derivatives, pharmaceutical compositions containing the same, process for producing them |
DE69420394T2 (en) * | 1993-03-01 | 2000-04-13 | Merck Sharp & Dohme | PYRROLOPYRIDINE DERIVATIVES AS DOPAMINE RECEPTOR LIGANDS |
CA2156410A1 (en) | 1993-03-01 | 1994-09-15 | Raymond Baker | Pyrrolo-pyridine derivatives |
US5840485A (en) * | 1993-05-27 | 1998-11-24 | Selectide Corporation | Topologically segregated, encoded solid phase libraries |
DE69434998T2 (en) * | 1993-05-27 | 2008-03-13 | Aventis Pharmaceuticals Inc. | Topologically separated, encoding solid-phase libraries |
IT1265057B1 (en) | 1993-08-05 | 1996-10-28 | Dompe Spa | TROPIL 7-AZAINDOLIL-3-CARBOXYAMIDE |
US5631236A (en) * | 1993-08-26 | 1997-05-20 | Baylor College Of Medicine | Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk |
US5426039A (en) * | 1993-09-08 | 1995-06-20 | Bio-Rad Laboratories, Inc. | Direct molecular cloning of primer extended DNA containing an alkane diol |
GB9319297D0 (en) | 1993-09-17 | 1993-11-03 | Wellcome Found | Indole derivatives |
US6045996A (en) * | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
US5965452A (en) * | 1996-07-09 | 1999-10-12 | Nanogen, Inc. | Multiplexed active biologic array |
US6468742B2 (en) * | 1993-11-01 | 2002-10-22 | Nanogen, Inc. | Methods for determination of single nucleic acid polymorphisms using bioelectronic microchip |
US5486525A (en) | 1993-12-16 | 1996-01-23 | Abbott Laboratories | Platelet activating factor antagonists: imidazopyridine indoles |
US5360882A (en) | 1994-02-04 | 1994-11-01 | Isp Investments Inc. | Eutectic compositions of divinyl imidazolidone and vinyl caprolactam |
EP1195372A1 (en) | 1994-04-18 | 2002-04-10 | Mitsubishi Pharma Corporation | N-heterocyclic substituted benzamide derivatives with antihypertensive activity |
GB9408577D0 (en) | 1994-04-29 | 1994-06-22 | Fujisawa Pharmaceutical Co | New compound |
US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
GB9412719D0 (en) | 1994-06-24 | 1994-08-17 | Erba Carlo Spa | Substituted azaindolylidene compounds and process for their preparation |
US5763198A (en) * | 1994-07-22 | 1998-06-09 | Sugen, Inc. | Screening assays for compounds |
GB9416162D0 (en) | 1994-08-10 | 1994-09-28 | Merck Sharp & Dohme | Therapeutic agents |
AU699196B2 (en) | 1994-08-10 | 1998-11-26 | Merck Sharp & Dohme Limited | Tetrahydropyridinylmethyl derivatives of pyrrolo 2,3-b pyridine |
GB9416189D0 (en) | 1994-08-10 | 1994-09-28 | Merck Sharp & Dohme | Therapeutic agents |
GB9420521D0 (en) | 1994-10-12 | 1994-11-30 | Smithkline Beecham Plc | Novel compounds |
US5556752A (en) * | 1994-10-24 | 1996-09-17 | Affymetrix, Inc. | Surface-bound, unimolecular, double-stranded DNA |
US5830645A (en) * | 1994-12-09 | 1998-11-03 | The Regents Of The University Of California | Comparative fluorescence hybridization to nucleic acid arrays |
US5837815A (en) | 1994-12-15 | 1998-11-17 | Sugen, Inc. | PYK2 related polypeptide products |
GB2298199A (en) * | 1995-02-21 | 1996-08-28 | Merck Sharp & Dohme | Synthesis of azaindoles |
GB9503400D0 (en) | 1995-02-21 | 1995-04-12 | Merck Sharp & Dohme | Therpeutic agents |
US5959098A (en) * | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
US6117681A (en) * | 1995-03-29 | 2000-09-12 | Bavarian Nordic Research Inst. A/S | Pseudotyped retroviral particles |
GB2299581A (en) | 1995-04-07 | 1996-10-09 | Merck Sharp & Dohme | 3-(Tetrahydropyridin-1-yl-methyl)pyrrolo[2,3-b]pyridine derivatives as ligands for dopamine receptor subtypes |
GB9507291D0 (en) | 1995-04-07 | 1995-05-31 | Merck Sharp & Dohme | Therapeutic agents |
GB9511220D0 (en) | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
US6110456A (en) * | 1995-06-07 | 2000-08-29 | Yale University | Oral delivery or adeno-associated viral vectors |
US5856174A (en) * | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
AU6526896A (en) | 1995-07-22 | 1997-02-18 | Rhone-Poulenc Rorer Limited | Substituted aromatic compounds and their pharmaceutical use |
US5866411A (en) * | 1995-09-08 | 1999-02-02 | Pedersen; Finn Skou | Retroviral vector, a replication system for said vector and avian or mammalian cells transfected with said vector |
US5747276A (en) * | 1995-09-15 | 1998-05-05 | The Scripps Research Institute | Screening methods for the identification of novel antibiotics |
US5721118A (en) * | 1995-10-31 | 1998-02-24 | The Regents Of The University Of California, San Diego | Mammalian artificial chromosomes and methods of using same |
US6022963A (en) * | 1995-12-15 | 2000-02-08 | Affymetrix, Inc. | Synthesis of oligonucleotide arrays using photocleavable protecting groups |
US6013440A (en) * | 1996-03-11 | 2000-01-11 | Affymetrix, Inc. | Nucleic acid affinity columns |
US6025155A (en) * | 1996-04-10 | 2000-02-15 | Chromos Molecular Systems, Inc. | Artificial chromosomes, uses thereof and methods for preparing artificial chromosomes |
US5804585A (en) * | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
US5908401A (en) | 1996-05-08 | 1999-06-01 | The Aps Organization, Llp | Method for iontophoretic delivery of antiviral agents |
US5725838A (en) | 1996-05-31 | 1998-03-10 | Resolution Pharmaceuticals, Inc. | Radiolabeled D4 receptor ligands |
WO1997046313A1 (en) | 1996-06-07 | 1997-12-11 | Eos Biotechnology, Inc. | Immobilised linear oligonucleotide arrays |
EP0923577A2 (en) * | 1996-06-25 | 1999-06-23 | Takeda Chemical Industries, Ltd. | Oxazolone derivatives and their use as anti-helicobacter pylori agent |
JP3669711B2 (en) | 1996-08-12 | 2005-07-13 | 三菱ウェルファーマ株式会社 | Medicament containing Rho kinase inhibitor |
JPH10130269A (en) | 1996-09-04 | 1998-05-19 | Nippon Chemiphar Co Ltd | Carboline derivative |
JPH1087629A (en) | 1996-09-18 | 1998-04-07 | Fujisawa Pharmaceut Co Ltd | New isoquinoline derivative, and its medicinal use |
IL129928A0 (en) | 1996-11-19 | 2000-02-29 | Amgen Inc | Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents |
US6294330B1 (en) * | 1997-01-31 | 2001-09-25 | Odyssey Pharmaceuticals Inc. | Protein fragment complementation assays for the detection of biological or drug interactions |
WO1998039471A1 (en) * | 1997-03-07 | 1998-09-11 | Tropix, Inc. | Protease inhibtor assay |
US5977131A (en) | 1997-04-09 | 1999-11-02 | Pfizer Inc. | Azaindole-ethylamine derivatives as nicotinic acetylcholine receptor binding agents |
WO1998047899A1 (en) | 1997-04-24 | 1998-10-29 | Ortho-Mcneil Corporation, Inc. | Substituted pyrrolopyridines useful in the treatment of inflammatory diseases |
US6096718A (en) * | 1997-06-05 | 2000-08-01 | Gene Targeting Corp. | Tissue specific adenovirus vectors for breast cancer treatment |
SG72827A1 (en) | 1997-06-23 | 2000-05-23 | Hoffmann La Roche | Phenyl-and aminophenyl-alkylsulfonamide and urea derivatives |
AU8096798A (en) | 1997-06-27 | 1999-01-19 | Resolution Pharmaceuticals Inc. | Dopamine d4 receptor ligands |
US6235769B1 (en) * | 1997-07-03 | 2001-05-22 | Sugen, Inc. | Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase |
US6826296B2 (en) * | 1997-07-25 | 2004-11-30 | Affymetrix, Inc. | Method and system for providing a probe array chip design database |
ES2287971T3 (en) | 1997-08-11 | 2007-12-16 | Pfizer Products Inc. | SOLID PHARMACEUTICAL DISPERSIONS WITH INCREASED BIODISPONIBILITY. |
US6161776A (en) * | 1997-08-12 | 2000-12-19 | Nibco Inc. | Multi-layered, porous mat turf irrigation apparatus and method |
CA2300940A1 (en) | 1997-08-15 | 1999-02-25 | Hyseq, Inc. | Methods and compositions for detection or quantification of nucleic acid species |
CN100367023C (en) * | 1997-09-11 | 2008-02-06 | 生物风险公司 | Method of making high density arrays |
US6178384B1 (en) * | 1997-09-29 | 2001-01-23 | The Trustees Of Columbia University In The City Of New York | Method and apparatus for selecting a molecule based on conformational free energy |
US6465178B2 (en) * | 1997-09-30 | 2002-10-15 | Surmodics, Inc. | Target molecule attachment to surfaces |
TR200002618T2 (en) | 1997-12-22 | 2001-04-20 | Bayer Corporation | Inhibition of raf kinase using substituted heterocyclic ureas |
DE69827664T2 (en) | 1997-12-23 | 2005-12-08 | Warner-Lambert Co. Llc | THIOSIDARY COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS |
RS49779B (en) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Byciclic heteroaromatic compounds as protein tyrosine kinase inhibitors |
JP2002510631A (en) | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | Gonadotropin-releasing hormone antagonist |
WO1999051595A1 (en) | 1998-04-02 | 1999-10-14 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
AU3210799A (en) | 1998-04-02 | 1999-10-25 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
AU3117899A (en) | 1998-04-02 | 1999-10-25 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
JP2002510629A (en) | 1998-04-02 | 2002-04-09 | メルク エンド カムパニー インコーポレーテッド | Gonadotropin-releasing hormone antagonist |
EP1070064A1 (en) | 1998-04-02 | 2001-01-24 | Merck & Co., Inc. | Antagonists of gonadotropin releasing hormone |
IL138668A0 (en) | 1998-04-03 | 2001-10-31 | Phylos Inc | Addressable protein arrays |
US6048695A (en) * | 1998-05-04 | 2000-04-11 | Baylor College Of Medicine | Chemically modified nucleic acids and methods for coupling nucleic acids to solid support |
CA2319495A1 (en) * | 1998-06-08 | 1999-12-16 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
US6113913A (en) * | 1998-06-26 | 2000-09-05 | Genvec, Inc. | Recombinant adenovirus |
WO2000012074A2 (en) | 1998-08-28 | 2000-03-09 | Scios Inc. | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase |
JP2002523511A (en) | 1998-08-28 | 2002-07-30 | アストラゼネカ・アクチエボラーグ | New compound |
HUP0200355A3 (en) | 1998-09-18 | 2004-07-28 | Abbott Gmbh & Co Kg | 4-aminopyrrolopyrimidines as kinase inhibitors, pharmaceutical compositions containing them and their use |
US6594527B2 (en) | 1998-09-18 | 2003-07-15 | Nexmed Holdings, Inc. | Electrical stimulation apparatus and method |
US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
US6277628B1 (en) | 1998-10-02 | 2001-08-21 | Incyte Genomics, Inc. | Linear microarrays |
IT1303759B1 (en) | 1998-11-17 | 2001-02-23 | Dompe Spa | IMPROVED PROCEDURE FOR THE PREPARATION OF 7-AZAINDOLYL-3-CARBOXYLIC ACID. |
US6277489B1 (en) * | 1998-12-04 | 2001-08-21 | The Regents Of The University Of California | Support for high performance affinity chromatography and other uses |
US20010001449A1 (en) | 1998-12-30 | 2001-05-24 | Thomas R. Kiliany | Low-pressure hydrocracking process |
CA2366260A1 (en) | 1999-03-05 | 2000-09-14 | Masahiro Imoto | Heterocyclic compounds having effect of activating .alpha.4.beta.2 nicotinic acetylcholine receptors |
US6792306B2 (en) | 2000-03-10 | 2004-09-14 | Biophoretic Therapeutic Systems, Llc | Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor |
IL145357A0 (en) | 1999-03-17 | 2002-06-30 | Astrazeneca Ab | Amide derivatives |
AR028475A1 (en) | 1999-04-22 | 2003-05-14 | Wyeth Corp | DERIVATIVES OF AZAINDOL AND USE OF THE SAME FOR THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DEPRESSION. |
US6653309B1 (en) | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
US6221653B1 (en) * | 1999-04-27 | 2001-04-24 | Agilent Technologies, Inc. | Method of performing array-based hybridization assays using thermal inkjet deposition of sample fluids |
FR2793793B1 (en) * | 1999-05-19 | 2004-02-27 | Adir | NOVEL SUBSTITUTED DIMERIC DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
US6492406B1 (en) | 1999-05-21 | 2002-12-10 | Astrazeneca Ab | Pharmaceutically active compounds |
TWI234557B (en) | 1999-05-26 | 2005-06-21 | Telik Inc | Novel naphthalene ureas as glucose uptake enhancers |
WO2000075139A2 (en) | 1999-06-03 | 2000-12-14 | Basf Aktiengesellschaft | Benzothiazinone and benzoxazinone compounds |
MXPA02001088A (en) | 1999-07-30 | 2003-09-22 | Abbott Gmbh & Co Kg | 2 pyrazolin 5 ones. |
US6653151B2 (en) * | 1999-07-30 | 2003-11-25 | Large Scale Proteomics Corporation | Dry deposition of materials for microarrays using matrix displacement |
WO2001024236A1 (en) | 1999-09-27 | 2001-04-05 | Infineon Technologies North America Corp. | Semiconductor structures having a capacitor and manufacturing methods |
GB9924962D0 (en) | 1999-10-21 | 1999-12-22 | Mrc Collaborative Centre | Allosteric sites on muscarinic receptors |
US6316474B1 (en) | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
US20010008765A1 (en) * | 1999-12-06 | 2001-07-19 | Fuji Photo Film Co., Ltd. | DNA chip and reactive solid carrier |
CO5271715A1 (en) | 1999-12-21 | 2003-04-30 | Sugen Inc | 7-AZA-INDOLIN-2-WAVES SUBSTITUTED IN 4 AND ITS USE AS PROTEIUNA QUINASA INHIBITORS |
US20020010203A1 (en) * | 1999-12-22 | 2002-01-24 | Ken Lipson | Methods of modulating c-kit tyrosine protein kinase function with indolinone compounds |
FR2805259B1 (en) | 2000-02-17 | 2002-03-29 | Inst Nat Sante Rech Med | NOVEL N-MERCAPTOACYL AMINOACID DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US20020061892A1 (en) | 2000-02-22 | 2002-05-23 | Tao Wang | Antiviral azaindole derivatives |
JP2001278886A (en) | 2000-03-28 | 2001-10-10 | Dai Ichi Seiyaku Co Ltd | Benzoxazine derivative and medicament containing the same |
GB0007934D0 (en) | 2000-03-31 | 2000-05-17 | Darwin Discovery Ltd | Chemical compounds |
US6335342B1 (en) | 2000-06-19 | 2002-01-01 | Pharmacia & Upjohn S.P.A. | Azaindole derivatives, process for their preparation, and their use as antitumor agents |
ATE323704T1 (en) | 2000-06-26 | 2006-05-15 | Pfizer Prod Inc | PYRROLO¬2,3-DÄPYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE ACTIVE INGREDIENTS |
MXPA02012659A (en) | 2000-06-26 | 2003-09-22 | Lilly Icos Llc | Chemical compounds. |
EA200300205A1 (en) | 2000-08-31 | 2003-06-26 | Пфайзер Продактс Инк. | DERIVATIVES OF PYRAZOL AND THEIR APPLICATION AS PROTEINKINASE INHIBITORS |
US6618625B2 (en) | 2000-11-29 | 2003-09-09 | Leon M. Silverstone | Method and apparatus for treatment of viral diseases |
RU2003128971A (en) | 2001-02-27 | 2005-03-10 | Астразенека Аб (Se) | PHARMACEUTICAL PRODUCT |
GB0107368D0 (en) | 2001-03-23 | 2001-05-16 | Novartis Ag | Organic compounds |
CA2443918C (en) | 2001-04-11 | 2012-06-05 | Senju Pharmaceutical Co., Ltd. | Visual function disorder improving agents containing rho kinase inhibitors |
AU2002258971A1 (en) | 2001-04-24 | 2002-11-05 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan |
EP1392300A1 (en) | 2001-05-11 | 2004-03-03 | Vertex Pharmaceuticals Incorporated | 2,5-disubstituted pyridine, pyrimidine, pyridazine and 1, 2, 4-triazine derivatives for use as p38 inhibitors |
GB0114417D0 (en) | 2001-06-13 | 2001-08-08 | Boc Group Plc | Lubricating systems for regenerative vacuum pumps |
EP1267111A1 (en) | 2001-06-15 | 2002-12-18 | Dsm N.V. | Pressurized fluid conduit |
US20040171630A1 (en) | 2001-06-19 | 2004-09-02 | Yuntae Kim | Tyrosine kinase inhibitors |
US7291639B2 (en) | 2001-06-20 | 2007-11-06 | Wyeth | Aryloxy-acetic acid compounds useful as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
SE0102300D0 (en) | 2001-06-26 | 2001-06-26 | Astrazeneca Ab | Compounds |
US20030091974A1 (en) | 2001-06-29 | 2003-05-15 | Alain Moussy | Method for screening compounds capable of depleting mast cells |
SE0102439D0 (en) | 2001-07-05 | 2001-07-05 | Astrazeneca Ab | New compounds |
UA75425C2 (en) | 2001-07-09 | 2006-04-17 | Piperazine oxime derivatives with antagonistic activity to nk-1 receptor, use thereof, a pharmaceutical composition based thereon, a method for producing and a method for producing intermediary compounds | |
GB0117583D0 (en) | 2001-07-19 | 2001-09-12 | Astrazeneca Ab | Novel compounds |
US6858860B2 (en) * | 2001-07-24 | 2005-02-22 | Seiko Epson Corporation | Apparatus and method for measuring natural period of liquid |
GB0118479D0 (en) | 2001-07-28 | 2001-09-19 | Astrazeneca Ab | Novel compounds |
WO2003020698A2 (en) | 2001-09-06 | 2003-03-13 | Prochon Biotech Ltd. | Protein tyrosine kinase inhibitors |
WO2003028724A1 (en) | 2001-10-04 | 2003-04-10 | Smithkline Beecham Corporation | Chk1 kinase inhibitors |
US20050014942A1 (en) | 2001-10-30 | 2005-01-20 | Yasufumi Maruyama | Amide derivatives and drugs |
US20030119839A1 (en) | 2001-12-13 | 2003-06-26 | Nan-Horng Lin | Protein kinase inhibitors |
EA007395B3 (en) | 2002-01-22 | 2018-02-28 | Уорнер-Ламберт Компани Ллс | 2-(PYRIDINE-2-YLAMINO)PYRIDO[2,3-d]PYRIMIDIN-7-ONES |
KR101093345B1 (en) | 2002-02-01 | 2011-12-14 | 아스트라제네카 아베 | Quinazoline compounds |
US20030236277A1 (en) | 2002-02-14 | 2003-12-25 | Kadow John F. | Indole, azaindole and related heterocyclic pyrrolidine derivatives |
US20040171062A1 (en) | 2002-02-28 | 2004-09-02 | Plexxikon, Inc. | Methods for the design of molecular scaffolds and ligands |
FR2836914B1 (en) * | 2002-03-11 | 2008-03-14 | Aventis Pharma Sa | SUBSTITUTED INDAZOLES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE |
US6884889B2 (en) | 2002-03-25 | 2005-04-26 | Bristol-Myers Squibb Co. | Processes for the preparation of antiviral 7-azaindole derivatives |
EP1490365B1 (en) | 2002-03-28 | 2010-02-10 | Eisai R&D Management Co., Ltd. | Azaindoles as inhibitors of c-jun n-terminal kinases |
WO2003082868A1 (en) | 2002-03-28 | 2003-10-09 | Eisai Co., Ltd. | 7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders |
JP2005526831A (en) | 2002-04-09 | 2005-09-08 | アステックス テクノロジー リミテッド | Pharmaceutical compounds |
UA78999C2 (en) | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
WO2004005283A1 (en) | 2002-07-09 | 2004-01-15 | Vertex Pharmaceuticals Incorporated | Imidazoles, oxazoles and thiazoles with protein kinase inhibiting activities |
TW200403243A (en) | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
TWI329112B (en) | 2002-07-19 | 2010-08-21 | Bristol Myers Squibb Co | Novel inhibitors of kinases |
EP1388341A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylamino-substituted heteroaromatic compounds and their use as pharmaceuticals |
US6878887B2 (en) | 2002-08-07 | 2005-04-12 | Matsushita Electric Industrial Co., Ltd. | Anti-malfunction mechanism for variable output device |
EP1388541A1 (en) | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
SE0202463D0 (en) | 2002-08-14 | 2002-08-14 | Astrazeneca Ab | Novel compounds |
CA2497792C (en) * | 2002-09-06 | 2014-08-05 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
AU2003272548A1 (en) | 2002-09-16 | 2004-04-30 | Plexxikon, Inc. | Crystal structure of pim-1 kinase |
US6766199B2 (en) | 2002-10-10 | 2004-07-20 | Proventure (Far East), Limited | Skin/hair treatment method and system |
US7183241B2 (en) | 2002-10-15 | 2007-02-27 | Exxonmobil Research And Engineering Company | Long life lubricating oil composition with very low phosphorus content |
GB0226370D0 (en) | 2002-11-12 | 2002-12-18 | Novartis Ag | Organic compounds |
SE0203654D0 (en) | 2002-12-09 | 2002-12-09 | Astrazeneca Ab | New compounds |
US7589207B2 (en) | 2002-12-13 | 2009-09-15 | Smithkline Beecham Corporation | Cyclohexyl compounds as CCR5 antagonists |
BR0317230A (en) | 2002-12-13 | 2005-10-25 | Smithkline Beecham Corp | Compound, composition, methods of antagonizing a ccr-5 chemokine receptor activity, and treating a viral infection in a patient, and use of a compound |
UA80171C2 (en) | 2002-12-19 | 2007-08-27 | Pfizer Prod Inc | Pyrrolopyrimidine derivatives |
US7696225B2 (en) * | 2003-01-06 | 2010-04-13 | Osi Pharmaceuticals, Inc. | (2-carboxamido)(3-Amino) thiophene compounds |
SE0300119D0 (en) | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
SE0300120D0 (en) | 2003-01-17 | 2003-01-17 | Astrazeneca Ab | Novel compounds |
US20050085463A1 (en) * | 2003-01-23 | 2005-04-21 | Weiner David M. | Use of N-desmethylclozapine to treat human neuropsychiatric disease |
CA2509958A1 (en) | 2003-02-03 | 2004-08-19 | Novartis Ag | Pharmaceutical formulation |
US20050048573A1 (en) | 2003-02-03 | 2005-03-03 | Plexxikon, Inc. | PDE5A crystal structure and uses |
CA2515571A1 (en) * | 2003-02-14 | 2004-09-02 | Wyeth | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
SE0300456D0 (en) | 2003-02-19 | 2003-02-19 | Astrazeneca Ab | Novel compounds |
EP1627045A2 (en) | 2003-02-28 | 2006-02-22 | Plexxikon, Inc. | Pyk2 crystal structure and uses |
JP4787150B2 (en) | 2003-03-06 | 2011-10-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | JNK inhibitor |
EP1628975A2 (en) | 2003-05-16 | 2006-03-01 | Eisai Co., Ltd. | Jnk inhibitors |
US20050079548A1 (en) | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
KR100816945B1 (en) | 2003-07-11 | 2008-03-25 | 워너-램버트 캄파니 엘엘씨 | Isethionate salt of a selective cdk4 inhibitor |
US7348338B2 (en) | 2003-07-17 | 2008-03-25 | Plexxikon, Inc. | PPAR active compounds |
RU2356889C2 (en) | 2003-07-17 | 2009-05-27 | Плекссикон, Инк. | Compounds, which are active towards receptors, activated by peroxisome proliferator |
CL2004001884A1 (en) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | DRYING PROCEDURE FOR SPRAYING FOR THE FORMATION OF SOLID DISPERSIONS AMORPHES OF A PHARMACO AND POLYMERS. |
AR045595A1 (en) | 2003-09-04 | 2005-11-02 | Vertex Pharma | USEFUL COMPOSITIONS AS INHIBITORS OF KINASE PROTEINS |
WO2005044181A2 (en) | 2003-09-09 | 2005-05-19 | Temple University-Of The Commonwealth System Of Higher Education | Protection of tissues and cells from cytotoxic effects of ionizing radiation by abl inhibitors |
US20050164300A1 (en) * | 2003-09-15 | 2005-07-28 | Plexxikon, Inc. | Molecular scaffolds for kinase ligand development |
US20060281803A1 (en) | 2003-09-23 | 2006-12-14 | Lindsley Craig W | Pyrazole modulators of metabotropic glutamate receptors |
KR100793095B1 (en) | 2003-10-01 | 2008-01-10 | 주식회사 프로메디텍 | Novel Sulfone Amide Derivatives Capable Of Inhibiting BACE |
CN1863774B (en) | 2003-10-08 | 2010-12-15 | Irm责任有限公司 | Compounds and compositions as protein kinase inhibitors |
DE10357510A1 (en) | 2003-12-09 | 2005-07-07 | Bayer Healthcare Ag | Heteroaryl-substituted benzenes |
US20070066641A1 (en) | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
US7517970B2 (en) | 2003-12-19 | 2009-04-14 | Plexxikon, Inc. | Nucleic acids encoding kinase and phosphatase enzymes, expression vectors and cells containing same |
BRPI0417533B1 (en) | 2003-12-24 | 2016-03-01 | Danisco | variant enzyme glycolipid acyltransferase, use and method for its production, method for preparing a food product and flour baked product, enzymatic refinement process |
GB0330042D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions them |
GB0330043D0 (en) | 2003-12-24 | 2004-01-28 | Pharmacia Italia Spa | Pyrrolo [2,3-b] pyridine derivatives active as kinase inhibitors process for their preparation and pharmaceutical compositions comprising them |
US7968557B2 (en) | 2004-02-14 | 2011-06-28 | Novartis Ag | Substituted pyrrolo[2,3-2]pyrimidines as protein kinase inhibitors |
GB0403635D0 (en) | 2004-02-18 | 2004-03-24 | Devgen Nv | Pyridinocarboxamides with improved activity as kinase inhibitors |
CA2557276A1 (en) | 2004-02-26 | 2005-09-09 | Kyowa Hakko Kogyo Co., Ltd. | Preventive and/or therapeutic agent for neutrophilic inflammatory diseases |
GB0405055D0 (en) | 2004-03-05 | 2004-04-07 | Eisai London Res Lab Ltd | JNK inhibitors |
AU2005221140A1 (en) | 2004-03-08 | 2005-09-22 | Amgen Inc. | Therapeutic modulation of PPAR (gamma) activity |
KR20050091462A (en) | 2004-03-12 | 2005-09-15 | 한국과학기술연구원 | Furopyrimidine compound and ddr2 tyrosine kinase activity inhibitor comprising the same |
TWI372624B (en) | 2004-03-30 | 2012-09-21 | Vertex Pharma | Azaindoles useful as inhibitors of jak and other protein kinases |
JP5019612B2 (en) | 2004-04-02 | 2012-09-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | Azaindoles and other protein kinases useful as inhibitors of ROCK |
JP2008503446A (en) | 2004-05-06 | 2008-02-07 | プレキシコン,インコーポレーテッド | PDE4B inhibitor and use thereof |
EP1773305A2 (en) | 2004-05-25 | 2007-04-18 | Yale University Corporation | Method for treating skeletal disorders resulting from fgfr malfunction |
CA2566160C (en) | 2004-05-27 | 2011-01-18 | Pfizer Products Inc. | Pyrrolopyrimidine derivatives useful in cancer treatment |
WO2005115374A1 (en) | 2004-05-29 | 2005-12-08 | 7Tm Pharma A/S | Crth2 receptor ligands for therapeutic use |
US7498342B2 (en) * | 2004-06-17 | 2009-03-03 | Plexxikon, Inc. | Compounds modulating c-kit activity |
WO2006004984A1 (en) | 2004-06-30 | 2006-01-12 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of protein kinases |
US7140816B2 (en) | 2004-07-20 | 2006-11-28 | H&S Tool, Inc. | Multi-functional tube milling head |
US7452993B2 (en) | 2004-07-27 | 2008-11-18 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
US7626021B2 (en) * | 2004-07-27 | 2009-12-01 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
EP1781654A1 (en) * | 2004-07-27 | 2007-05-09 | SGX Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
US7709645B2 (en) * | 2004-07-27 | 2010-05-04 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
US20060024361A1 (en) | 2004-07-28 | 2006-02-02 | Isa Odidi | Disintegrant assisted controlled release technology |
WO2006010637A2 (en) | 2004-07-30 | 2006-02-02 | Gpc Biotech Ag | Pyridinylamines |
CA2583428A1 (en) | 2004-09-03 | 2006-03-09 | Plexxikon, Inc. | Bicyclic heteroaryl pde4b inhibitors |
EP1819673A2 (en) | 2004-11-30 | 2007-08-22 | Plexxikon, Inc. | Indole derivatives for use as ppar active compounds |
JP2008521831A (en) | 2004-11-30 | 2008-06-26 | プレキシコン,インコーポレーテッド | PPAR active compounds |
US20060160135A1 (en) | 2004-12-08 | 2006-07-20 | Weiru Wang | SF-1 and LRH-1 modulator development |
WO2006063167A1 (en) | 2004-12-08 | 2006-06-15 | Smithkline Beecham Corporation | 1h-pyrrolo[2,3-b]pyridines |
AU2006239632B2 (en) | 2005-04-25 | 2012-03-15 | Merck Patent Gmbh | Novel AZA- heterocycles serving as kinase inhibitors |
FR2884821B1 (en) | 2005-04-26 | 2007-07-06 | Aventis Pharma Sa | SUBSTITUTED PYRROLOPYRIDINES, COMPOSITIONS CONTAINING SAME, METHOD OF MANUFACTURE AND USE |
ZA200710379B (en) | 2005-05-20 | 2009-05-27 | Vertex Pharma | Pyrrolopyridines useful as inhibitors of protein kinase |
EP1883625A2 (en) | 2005-05-23 | 2008-02-06 | Teva Pharmaceutical Industries Ltd | Amorphous cinacalcet hydrochloride and preparation thereof |
MX295245B (en) | 2005-06-21 | 2012-01-26 | Mitsui Chemicals Inc | Amide derivative and pesticide containing such compound. |
EP3088400A1 (en) | 2005-06-22 | 2016-11-02 | Plexxikon Inc. | Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors |
DE102005034406A1 (en) | 2005-07-22 | 2007-02-01 | Ratiopharm Gmbh | New salts of rosiglitazone |
GB0516156D0 (en) | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
US7754717B2 (en) | 2005-08-15 | 2010-07-13 | Amgen Inc. | Bis-aryl amide compounds and methods of use |
NZ567162A (en) | 2005-09-07 | 2011-06-30 | Plexxikon Inc | 1, 3-disubstituted indole derivatives for use as PPAR modulators |
GT200600407A (en) | 2005-09-07 | 2007-04-10 | ACTIVE PPAR COMPOUNDS | |
JP2009509932A (en) | 2005-09-07 | 2009-03-12 | プレキシコン,インコーポレーテッド | PPAR active compounds |
JP2009530415A (en) | 2006-03-20 | 2009-08-27 | バーテックス ファーマシューティカルズ インコーポレイテッド | Pharmaceutical composition |
US7963673B2 (en) | 2006-05-30 | 2011-06-21 | Finn Bruce L | Versatile illumination system |
HUE035868T2 (en) | 2006-11-15 | 2018-05-28 | Ym Biosciences Australia Pty | Inhibitors of kinase activity |
WO2008063888A2 (en) * | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
GB0624084D0 (en) | 2006-12-01 | 2007-01-10 | Selamine Ltd | Ramipril amino acid salts |
US8093246B2 (en) | 2006-12-14 | 2012-01-10 | Lexicon Pharmaceuticals, Inc. | O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer |
PE20121126A1 (en) * | 2006-12-21 | 2012-08-24 | Plexxikon Inc | PIRROLO [2,3-B] PYRIDINES COMPOUNDS AS KINASE MODULATORS |
WO2008079909A1 (en) * | 2006-12-21 | 2008-07-03 | Plexxikon, Inc. | Pyrrolo [2,3-b] pyridines as kinase modulators |
MX2009006688A (en) | 2006-12-21 | 2009-06-30 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor. |
BRPI0808196A2 (en) | 2007-03-08 | 2014-07-08 | Plexxikon Inc | PPAR ACTIVE COMPOUNDS |
PE20090159A1 (en) | 2007-03-08 | 2009-02-21 | Plexxikon Inc | INDOL-PROPIONIC ACID DERIVED COMPOUNDS AS PPARs MODULATORS |
CN101702878B (en) | 2007-05-11 | 2012-11-28 | 弗·哈夫曼-拉罗切有限公司 | Pharmaceutical compositions for poorly soluble drugs |
CL2008001540A1 (en) * | 2007-05-29 | 2009-05-22 | Sgx Pharmaceuticals Inc | Compounds derived from pyrrolopyridines and pyrazolopyridines; pharmaceutical composition; and use in the treatment of cancer. |
NZ582772A (en) | 2007-07-17 | 2012-06-29 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
EA021645B1 (en) | 2007-07-23 | 2015-08-31 | Фарматен С.А. | Solid dosage form as a tablet and method for the preparation thereof |
CA2639416C (en) | 2007-09-11 | 2019-12-31 | F. Hoffmann-La Roche Ag | Diagnostic test for susceptibility to b-raf kinase inhibitors |
CL2009000447A1 (en) | 2008-02-29 | 2010-01-04 | Array Biopharma Inc Y Genentech Inc | Compounds derived from (1h-pyrrolo {2,3-b} pyridin-5-yl) -sulfonamido-substituted benzamide; preparation procedure; pharmaceutical composition; and its use in the treatment of cancer, through the inhibition of raf. |
CA2716949A1 (en) | 2008-02-29 | 2009-09-11 | Array Biopharma Inc. | N- (6-aminopyridin-3-yl) -3- (sulfonamido) benzamide derivatives as b-raf inhibitors for the treatment of cancer |
JP2011513329A (en) | 2008-02-29 | 2011-04-28 | アレイ バイオファーマ、インコーポレイテッド | Imidazo [4,5-b] pyridine derivatives used as RAF inhibitory compounds |
MX2010009411A (en) | 2008-02-29 | 2010-11-30 | Array Biopharma Inc | Pyrazole [3, 4-b] pyridine raf inhibitors. |
WO2009115084A2 (en) | 2008-03-20 | 2009-09-24 | Schebo Biotech Ag | Novel pyrrolopyrimidine derivatives and the use thereof |
UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
PE20091846A1 (en) | 2008-05-19 | 2009-12-16 | Plexxikon Inc | PIRROLO [2,3-d] -PYRIMIDINE DERIVATIVES AS KINE MODULATORS |
US8158636B2 (en) | 2008-05-19 | 2012-04-17 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
EP2313411A1 (en) | 2008-06-10 | 2011-04-27 | Plexxikon, Inc. | 5h-pyrr0l0 [2,3-b]pyrazine derivatives for kinase modulation, and indications therefor |
WO2009152087A1 (en) | 2008-06-10 | 2009-12-17 | Plexxikon, Inc. | Bicyclic heteroaryl compounds and methods for kinase modulation, and indications therefor |
JP4884570B2 (en) | 2008-08-20 | 2012-02-29 | ファイザー・インク | Pyrrolo [2,3-d] pyrimidine compound |
JP5743897B2 (en) | 2008-11-20 | 2015-07-01 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC | Compound |
MY161861A (en) | 2009-03-11 | 2017-05-15 | Plexxikon Inc | Pyrrolo [2,3-] pyridine kinase inhibitors |
AR076105A1 (en) | 2009-03-11 | 2011-05-18 | Plexxikon Inc | PIRROL DERIVATIVES [2,3-B] PIRIDINE TO INHIBIT THE RAF QUINASA |
WO2010111527A1 (en) | 2009-03-26 | 2010-09-30 | Plexxikon, Inc. | Pyrazolo [ 3, 4 -b] pyridines as kinase inhibitors and their medical use |
EA031116B1 (en) | 2009-04-03 | 2018-11-30 | Ф. Хоффманн-Ля Рош Аг | PROPANE-1-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-b]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}AMIDE CRYSTALLINE POLYMORPH FORMS |
SG175877A1 (en) | 2009-05-04 | 2011-12-29 | Plexxikon Inc | Compounds and methods for inhibition of renin, and indications therefor |
TW201041888A (en) | 2009-05-06 | 2010-12-01 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
US8329724B2 (en) | 2009-08-03 | 2012-12-11 | Hoffmann-La Roche Inc. | Process for the manufacture of pharmaceutically active compounds |
MX2012005284A (en) | 2009-11-06 | 2012-06-28 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor. |
WO2011060216A1 (en) | 2009-11-12 | 2011-05-19 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
CN105906631A (en) | 2009-11-18 | 2016-08-31 | 普莱希科公司 | Compounds and methods for kinase modulation, and indications therefor |
AU2010336524B2 (en) | 2009-12-23 | 2015-10-08 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
TWI619713B (en) | 2010-04-21 | 2018-04-01 | 普雷辛肯公司 | Compounds and methods for kinase modulation, and indications therefor |
FR2964757B1 (en) | 2010-09-09 | 2013-04-05 | Giroptic | OPTICAL DEVICE FOR CAPTURING IMAGES ACCORDING TO A 360 ° FIELD |
US20120208837A1 (en) | 2010-09-13 | 2012-08-16 | Roger Tung | Substituted azaindoles |
US8642606B2 (en) | 2010-09-29 | 2014-02-04 | Plexxikon Inc. | ZAP-70 active compounds |
PT2672967T (en) | 2011-02-07 | 2018-12-07 | Plexxikon Inc | Compounds and methods for kinase modulation, and indications therefor |
TWI558702B (en) | 2011-02-21 | 2016-11-21 | 普雷辛肯公司 | Solid forms of a pharmaceutically active substance |
WO2012138809A1 (en) | 2011-04-05 | 2012-10-11 | Dawei Zhang | Heterocyclic compounds as kinase inhibitors |
CA2836474A1 (en) | 2011-05-17 | 2012-11-22 | Plexxikon Inc. | Kinase modulation and indications therefor |
US20130172375A1 (en) | 2011-12-13 | 2013-07-04 | Hoffmann-La Roche Inc. | Pharmaceutical composition |
US9358235B2 (en) | 2012-03-19 | 2016-06-07 | Plexxikon Inc. | Kinase modulation, and indications therefor |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
DE102012213092B3 (en) | 2012-07-25 | 2013-08-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Transmission device and sensor system |
AU2013312477B2 (en) | 2012-09-06 | 2018-05-31 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
CA2895239C (en) | 2012-12-21 | 2020-10-27 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
RS57733B1 (en) | 2013-03-15 | 2018-12-31 | Plexxikon Inc | Heterocyclic compounds and uses thereof |
AU2014274093B2 (en) | 2013-05-30 | 2018-11-08 | Plexxikon Inc. | Compounds for kinase modulation, and indications therefor |
WO2015134536A1 (en) | 2014-03-04 | 2015-09-11 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
AU2015318233B2 (en) | 2014-09-15 | 2020-03-12 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
-
2007
- 2007-11-07 WO PCT/US2007/083910 patent/WO2008063888A2/en unknown
- 2007-11-14 GT GT200700101A patent/GT200700101A/en unknown
- 2007-11-16 PE PE2007001602A patent/PE20081226A1/en active IP Right Grant
- 2007-11-20 PT PT78646817T patent/PT2086972E/en unknown
- 2007-11-20 CA CA2670362A patent/CA2670362C/en active Active
- 2007-11-20 BR BRPI0721137A patent/BRPI0721137B8/en active IP Right Grant
- 2007-11-20 SI SI200731415T patent/SI2086972T1/en unknown
- 2007-11-20 MY MYPI20092040A patent/MY158447A/en unknown
- 2007-11-20 NZ NZ577011A patent/NZ577011A/en unknown
- 2007-11-20 AU AU2007323644A patent/AU2007323644B2/en active Active
- 2007-11-20 DK DK07864681.7T patent/DK2086972T3/en active
- 2007-11-20 EP EP07864681.7A patent/EP2086972B1/en active Active
- 2007-11-20 PL PL07864681T patent/PL2086972T3/en unknown
- 2007-11-20 JP JP2009538496A patent/JP2010510321A/en not_active Ceased
- 2007-11-20 MX MX2009005428A patent/MX2009005428A/en active IP Right Grant
- 2007-11-20 RU RU2009117475/04A patent/RU2452738C2/en active
- 2007-11-20 KR KR1020097012836A patent/KR101506044B1/en active IP Right Grant
- 2007-11-20 CL CL200703326A patent/CL2007003326A1/en unknown
- 2007-11-20 CN CN201310470059.2A patent/CN103497188B/en active Active
- 2007-11-20 UA UAA200905046A patent/UA97816C2/en unknown
- 2007-11-20 WO PCT/US2007/085299 patent/WO2008064265A2/en active Application Filing
- 2007-11-20 CN CN2007800502453A patent/CN101605787B/en active Active
- 2007-11-20 ES ES07864681.7T patent/ES2447779T3/en active Active
- 2007-11-20 SG SG2011086592A patent/SG176511A1/en unknown
- 2007-11-20 WO PCT/US2007/085289 patent/WO2008064255A2/en active Application Filing
- 2007-11-21 AR ARP070105161A patent/AR063878A1/en active IP Right Grant
- 2007-11-21 US US11/986,667 patent/US7893075B2/en active Active
- 2007-11-21 UY UY30732A patent/UY30732A1/en not_active Application Discontinuation
- 2007-11-22 TW TW096144344A patent/TWI432431B/en active
- 2007-11-22 SV SV2007002813A patent/SV2007002813A/en unknown
-
2009
- 2009-05-07 IL IL198624A patent/IL198624A/en active IP Right Grant
- 2009-05-19 ZA ZA2009/03458A patent/ZA200903458B/en unknown
- 2009-05-21 CO CO09052610A patent/CO6180438A2/en active IP Right Grant
- 2009-05-21 EC EC2009009357A patent/ECSP099357A/en unknown
- 2009-05-21 CR CR10817A patent/CR10817A/en unknown
- 2009-05-21 NI NI200900093A patent/NI200900093A/en unknown
- 2009-05-22 NO NO20091989A patent/NO342175B1/en unknown
-
2010
- 2010-02-11 HK HK10101543.8A patent/HK1133649A1/en unknown
- 2010-12-01 US US12/958,379 patent/US8461169B2/en active Active
-
2012
- 2012-07-11 US US13/546,923 patent/US8404700B2/en active Active
-
2013
- 2013-02-25 US US13/776,547 patent/US8722702B2/en active Active
- 2013-12-19 JP JP2013262181A patent/JP5919253B2/en not_active Expired - Fee Related
-
2014
- 2014-04-10 US US14/250,331 patent/US9169250B2/en active Active
-
2015
- 2015-04-30 JP JP2015092955A patent/JP6203781B2/en active Active
- 2015-06-08 US US14/733,830 patent/US9487515B2/en active Active
-
2016
- 2016-10-07 US US15/288,558 patent/US20170247370A1/en not_active Abandoned
-
2017
- 2017-08-30 JP JP2017165022A patent/JP6461263B2/en active Active
-
2018
- 2018-10-01 US US16/148,244 patent/US20190263800A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005062795A2 (en) * | 2003-12-19 | 2005-07-14 | Plexxikon, Inc. | Compounds and methods for development of ret modulators |
WO2006009755A2 (en) * | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
WO2006009797A1 (en) * | 2004-06-17 | 2006-01-26 | Plexxikon, Inc. | Azaindoles modulating c-kit activity and uses therefor |
WO2007013896A2 (en) * | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
WO2007106236A2 (en) * | 2006-02-27 | 2007-09-20 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9487515B2 (en) | 2006-11-22 | 2016-11-08 | Plexxikon Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
US9447089B2 (en) | 2009-04-03 | 2016-09-20 | Plexxikon Inc. | Compositions and uses thereof |
US9096593B2 (en) | 2009-11-06 | 2015-08-04 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2008063888A3 (en) | Compounds modulating c-fms and/or c-kit activity and uses therefor | |
WO2007013896A3 (en) | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors | |
UA98629C2 (en) | Compounds and methods for kinase modulation | |
MX2009006688A (en) | Compounds and methods for kinase modulation, and indications therefor. | |
WO2006015124A3 (en) | Fused ring heterocycle kinase modulators | |
TW200616632A (en) | Compounds modulating c-kit activity and uses therefor | |
WO2006078287A3 (en) | Pde4b inhibitors and uses therefor | |
WO2004089286A3 (en) | Novel compounds and compositions as protein kinase inhibitors | |
UA95244C2 (en) | Compounds and methods for kinase modulation, and indications therefor | |
WO2007106236A3 (en) | Pyrrolo-pyridine kinase modulators | |
EA200971077A1 (en) | HETEROCYCLIC KINASE MODULATORS | |
WO2007109120A3 (en) | Imidazolothiazole compounds for the treatment of disease | |
WO2007101864A3 (en) | Compounds that modulate ppar activity, their preparation and use | |
WO2008124849A3 (en) | Pyrrolo-pyridine kinase modulators | |
WO2005020921A3 (en) | C-kit modulators and methods of use | |
WO2009044173A3 (en) | Methods of treating cancer using notch pathway inhibitors | |
WO2008051805A3 (en) | Triazolo-pyridazine protein kinase modulators | |
WO2007109330A3 (en) | S1p receptor modulating compounds | |
EP2532657A3 (en) | Compounds and methods of use | |
WO2006060456A3 (en) | Indole derivatives for use as ppar ppar active compounds | |
WO2006113432A3 (en) | Compounds, compositions and methods | |
WO2010068500A3 (en) | PROGESTATIONAL 3-(6,6-ETHYLENE-17b-HYDROXY-3-OXO-17a-PREGNA-4-ENE-17a -YL) PROPIONIC ACID g-LACTONES | |
WO2009124330A3 (en) | Treatment of tumors | |
WO2007072201A3 (en) | 3-aminocyclopentanecarboxamides as modulators of chemokine receptors | |
MX2009006812A (en) | Modulators of c3a receptor and methods of use thereof. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200780050245.3 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07864681 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 198624 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 577011 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007864681 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2009538496 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1879/KOLNP/2009 Country of ref document: IN Ref document number: 2009050746 Country of ref document: EG |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2670362 Country of ref document: CA Ref document number: 2007323644 Country of ref document: AU Ref document number: CR2009-010817 Country of ref document: CR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12009501009 Country of ref document: PH Ref document number: MX/A/2009/005428 Country of ref document: MX |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2007323644 Country of ref document: AU Date of ref document: 20071120 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020097012836 Country of ref document: KR |
|
ENP | Entry into the national phase |
Ref document number: 2009117475 Country of ref document: RU Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: A200905046 Country of ref document: UA |
|
ENP | Entry into the national phase |
Ref document number: PI0721137 Country of ref document: BR Kind code of ref document: A2 Effective date: 20090522 |