WO2008058234A3 - Pharmaceutical formulations for 1,4-dihyrdropyridine compounds having improved solubility - Google Patents

Pharmaceutical formulations for 1,4-dihyrdropyridine compounds having improved solubility Download PDF

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Publication number
WO2008058234A3
WO2008058234A3 PCT/US2007/084068 US2007084068W WO2008058234A3 WO 2008058234 A3 WO2008058234 A3 WO 2008058234A3 US 2007084068 W US2007084068 W US 2007084068W WO 2008058234 A3 WO2008058234 A3 WO 2008058234A3
Authority
WO
WIPO (PCT)
Prior art keywords
dihyrdropyridine
compounds
pharmaceutical formulations
improved solubility
approximately
Prior art date
Application number
PCT/US2007/084068
Other languages
French (fr)
Other versions
WO2008058234A2 (en
Inventor
Ashok Tehim
Original Assignee
Memory Pharm Corp
Ashok Tehim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Memory Pharm Corp, Ashok Tehim filed Critical Memory Pharm Corp
Publication of WO2008058234A2 publication Critical patent/WO2008058234A2/en
Publication of WO2008058234A3 publication Critical patent/WO2008058234A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Abstract

A pharmaceutical composition comprising a 1,4-dihydropyridine pharmaceutical agent, particularly (+)-isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylate), a mixture of glycerol and PEG1500 esters of long fatty acids having a melting point of approximately 44 °C and a hydrophilic/lipophilic balance of approximately 14 (Gelucire 44/14) and d-alpha-tocopheryl polyethylene glycol 1000 succinate (Vitamin E TPGS), and further optionally comprising polyethylene glycol-15-hydroxystearate (Solutol-HS 15) and/or polyoxyl castor oil (Cremophor-EL), exhibits enhanced solubility characteristics.
PCT/US2007/084068 2006-11-08 2007-11-08 Pharmaceutical formulations for 1,4-dihyrdropyridine compounds having improved solubility WO2008058234A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85750406P 2006-11-08 2006-11-08
US60/857,504 2006-11-08

Publications (2)

Publication Number Publication Date
WO2008058234A2 WO2008058234A2 (en) 2008-05-15
WO2008058234A3 true WO2008058234A3 (en) 2008-06-26

Family

ID=39365371

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/084068 WO2008058234A2 (en) 2006-11-08 2007-11-08 Pharmaceutical formulations for 1,4-dihyrdropyridine compounds having improved solubility

Country Status (1)

Country Link
WO (1) WO2008058234A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2164518B1 (en) 2007-05-25 2019-04-24 The University Of British Columbia Formulations for the oral administration of therapeutic agents and related methods
NZ591261A (en) 2008-09-12 2012-12-21 Critical Pharmaceuticals Ltd Improvements in the absorption of therapeutic agents across mucosal membranes or the skin
WO2011050457A1 (en) 2009-10-26 2011-05-05 The University Of British Columbia Stabilized formulation for oral administration of therapeutic agents and related methods
WO2014060855A1 (en) * 2012-10-16 2014-04-24 Wockhardt Limited Pharmaceutical compositions of diclofenac or salts thereof
CN106689775A (en) * 2015-11-12 2017-05-24 北京鑫华乐源科技发展有限公司 Production method of feed used for producing eggs rich in xanthophyll and alpha-linolenic acid
WO2019052471A1 (en) * 2017-09-12 2019-03-21 北京福纳康生物技术有限公司 Fullerene composition and preparation method and use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665740A (en) * 1993-12-10 1997-09-09 Bayer Aktiengesellschaft Isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1, 4-dihydro-2,6-dimethyl-pyridine-3,5-dica rboxylate
US6531139B1 (en) * 1997-07-29 2003-03-11 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds
US6579898B2 (en) * 2001-03-01 2003-06-17 Pfizer Inc. Compositions having improved bioavailability
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US7030155B2 (en) * 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5665740A (en) * 1993-12-10 1997-09-09 Bayer Aktiengesellschaft Isopropyl 2-methoxyethyl 4-(2-chloro-3-cyano-phenyl)-1, 4-dihydro-2,6-dimethyl-pyridine-3,5-dica rboxylate
US6531139B1 (en) * 1997-07-29 2003-03-11 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds
US7030155B2 (en) * 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US20030236236A1 (en) * 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
US6579898B2 (en) * 2001-03-01 2003-06-17 Pfizer Inc. Compositions having improved bioavailability

Also Published As

Publication number Publication date
WO2008058234A2 (en) 2008-05-15

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