WO2008039445A3 - Polymorphisms in the human xbp-1 gene are associated with inflammatory bowel disease - Google Patents

Polymorphisms in the human xbp-1 gene are associated with inflammatory bowel disease Download PDF

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Publication number
WO2008039445A3
WO2008039445A3 PCT/US2007/020658 US2007020658W WO2008039445A3 WO 2008039445 A3 WO2008039445 A3 WO 2008039445A3 US 2007020658 W US2007020658 W US 2007020658W WO 2008039445 A3 WO2008039445 A3 WO 2008039445A3
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WO
WIPO (PCT)
Prior art keywords
gene
inflammatory bowel
bowel disease
human
xbp
Prior art date
Application number
PCT/US2007/020658
Other languages
French (fr)
Other versions
WO2008039445A2 (en
WO2008039445A9 (en
Inventor
Richard S Blumberg
Laurie H Glimcher
John Rioux
Arthur Kaser
Original Assignee
Harvard College
Brigham & Womens Hospital
Richard S Blumberg
Laurie H Glimcher
John Rioux
Arthur Kaser
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Brigham & Womens Hospital, Richard S Blumberg, Laurie H Glimcher, John Rioux, Arthur Kaser filed Critical Harvard College
Publication of WO2008039445A2 publication Critical patent/WO2008039445A2/en
Publication of WO2008039445A9 publication Critical patent/WO2008039445A9/en
Publication of WO2008039445A3 publication Critical patent/WO2008039445A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes

Abstract

The instant invention is based, at least in part, on the finding that XBP-I plays a role in intestinal inflammation that resembles inflammatory bowel disease and that a single SNP in the 5' untranslated region of the human XBPl gene is significantly associated with IBD predicting a direct role for XBPl in the pathogenesis of this disease. Accordingly, the present invention provides methods for detecting at least one SNP in the human XBP-I gene as well as methods to determine the predisposition of a human subject to develop inflammatory bowel disease.
PCT/US2007/020658 2006-09-25 2007-09-25 Polymorphisms in the human xbp-1 gene are associated with inflammatory bowel disease WO2008039445A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84695006P 2006-09-25 2006-09-25
US60/846,950 2006-09-25

Publications (3)

Publication Number Publication Date
WO2008039445A2 WO2008039445A2 (en) 2008-04-03
WO2008039445A9 WO2008039445A9 (en) 2008-09-18
WO2008039445A3 true WO2008039445A3 (en) 2008-11-27

Family

ID=39230794

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/020658 WO2008039445A2 (en) 2006-09-25 2007-09-25 Polymorphisms in the human xbp-1 gene are associated with inflammatory bowel disease

Country Status (1)

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WO (1) WO2008039445A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010014905A2 (en) * 2008-07-31 2010-02-04 President And Fellows Of Harvard College Polymorphisms associated with inflammatory bowel disease
WO2012109238A2 (en) 2011-02-07 2012-08-16 President And Fellows Of Harvard College Methods for increasing immune responses using agents that directly bind to and activate ire-1
WO2013134774A1 (en) 2012-03-09 2013-09-12 Cornell University Modulation of breast cancer growth by modulation of xbp1 activity
EP3521431A1 (en) 2013-09-25 2019-08-07 Cornell University Compounds for inducing anti-tumor immunity and methods thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632641B1 (en) * 1999-10-08 2003-10-14 Metrigen, Inc. Method and apparatus for performing large numbers of reactions using array assembly with releasable primers

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632641B1 (en) * 1999-10-08 2003-10-14 Metrigen, Inc. Method and apparatus for performing large numbers of reactions using array assembly with releasable primers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
AHERN H.: "Biochemical, reagent kits offer scientists good return on investment", THE SCIENTIST, vol. 9, no. 15, July 1995 (1995-07-01), pages 20 *
KASER A. ET AL.: "Transcription factor Xbp1 regulates paneth cell function and the inflammatory tone of the intestinal epithelium", GASTROENTEROLOGY - ABSTRACT FROM THE 108TH ANNUAL MEETING OF THE AMERICAN-GASTROENTEROLOGICAL-ASSOCIATION, vol. 132, no. 4, SUPPL. 2, April 2007 (2007-04-01), pages A7 - A8 *

Also Published As

Publication number Publication date
WO2008039445A2 (en) 2008-04-03
WO2008039445A9 (en) 2008-09-18

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